I-TASSER results

I-TASSER results for job id Rv3338

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (214 residues)
MSSAVLADHVERQLDELGWETSHIVGNSLGGWVAFELERRGRARSVTGIAPAGGWTRWSP
VKFEVIAKFIAGAPILAVAHILGQRALRLPFSRLLATLPISATPDGVSERELSGIIDDAA
HCPAYFQLLVKALVLPGLQELEHTAVPSHVVLCEQDRVVPPSRFSRHFTDSLPAGHRLTV
LDGVGHVPMFEAPGRITELITSFIEECCPHVRAS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MSSAVLADHVERQLDELGWETSHIVGNSLGGWVAFELERRGRARSVTGIAPAGGWTRWSPVKFEVIAKFIAGAPILAVAHILGQRALRLPFSRLLATLPISATPDGVSERELSGIIDDAAHCPAYFQLLVKALVLPGLQELEHTAVPSHVVLCEQDRVVPPSRFSRHFTDSLPAGHRLTVLDGVGHVPMFEAPGRITELITSFIEECCPHVRAS
Prediction	CCHHHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCCCCCHHCHHHHHHHHHHHHHHHCHHCCCC
Conf.Score	9899999999999999899986898658889999999877755478998578888888765578888887655455566667788776677777654666789677559999999865456689999999876787578776589987999857888889899999999989999889997898777664559999999999999865555689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MSSAVLADHVERQLDELGWETSHIVGNSLGGWVAFELERRGRARSVTGIAPAGGWTRWSPVKFEVIAKFIAGAPILAVAHILGQRALRLPFSRLLATLPISATPDGVSERELSGIIDDAAHCPAYFQLLVKALVLPGLQELEHTAVPSHVVLCEQDRVVPPSRFSRHFTDSLPAGHRLTVLDGVGHVPMFEAPGRITELITSFIEECCPHVRAS
Prediction	3415410422231244060430122213100100111034321210000000122344443324212422443323223431233223332333123332323222033420231144242130012002313435235304403114246145453112144003301621264020100240130112520430052145237514545678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEHCCCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCCCCCHHCHHHHHHHHHHHHHHHCHHCCCC
MSSAVLADHVERQLDELGWETSHIVGNSLGGWVAFELERRGRARSVTGIAPAGGWTRWSPVKFEVIAKFIAGAPILAVAHILGQRALRLPFSRLLATLPISATPDGVSERELSGIIDDAAHCPAYFQLLVKALVLPGLQELEHTAVPSHVVLCEQDRVVPPSRFSRHFTDSLPAGHRLTVLDGVGHVPMFEAPGRITELITSFIEECCPHVRAS

4q3lA

0.17

0.16

0.95

1.76

MUSTER

YTQTIQVELLKNLLEHLGIAQANIVGISYGASIALQFAAKYP-KRMVVANVVAKTSPWLKDIGDGWNEVAKTGNGLAYYHITIPYIYSPQFYTLHN------DWMEKRKELLVPLFSTRTFLDRMIRLTKSAETHDVIKDLPNIKTPTLIISSEEDYLTP-PFEQKYLQEHL-QNAELVSIPNCGHASMYEVPKTFTALVLGFFGQTKLDYQI-

4q3lA

0.17

0.16

0.96

1.58

dPPAS

YTQTIQVELLKNLLEHLGIAQANIVGISYGASIALQFAAPTMIKRMVVANVVAKTSPWLKDIGDGWNEVAKTGNGLAYYHITIPYIYSPQFYTLHN------DWMEKRKELLVPLFSTRTFLDRMIRLTKSAETHDVIKDLPNIKTPTLIISSEEDYLTPPFEQKYLQEHL--QNAELVSIPNCGHASMYEVPKTFTALVLGFFGQTKLDYQI-

4q3lA

0.16

0.15

0.95

2.39

wdPPAS

YTQTIQVELLKNLLEHLGIAQANIVGISYGASIALQFAAKYPTMIKRMVVANVVAKTSLKDIGDGWNEVAKTGNGLAYYHITIPYIYSPQFYTLHN------DWMEKRKELLVPLFSTRTFLDRMIRLTKSAETHDVIKDLPNIKTPTLIISSEEDYLTPPFEQKYLQEH---QNAELVSIPNCGHASMYEVPKTFTALVLGFFGQTKLDYQI-

4q3lA

0.16

0.15

0.96

2.08

wMUSTER

YTQTIQVELLKNLLEHLGIAQANIVGISYGASIALQFAAKYPTMIKRMVVANVVAKTSPKDIGDGWNEVAKTGNGLAYYHITIPYIYSPQFYTLHND------WMEKRKELLVPLFSTRTFLDRMIRLTKSAETHDVIKDLPNIKTPTLIISSEEDYLTP-PFEQKYLQEHL-QNAELVSIPNCGHASMYEVPKTFTALVLGFFGQTKLDYQI-

4q3lA

0.16

0.15

0.95

2.51

wPPAS

YTQTIQVELLKNLLEHLGIAQANIVGISYGASIALQFAAKYPTMIKRMVVANVVAKTSLKDIGDGWNEVAKTGNGLAYYHITIPYIYSPQFYTLHN------DWMEKRKELLVPLFSTRTFLDRMIRLTKSAETHDVIKDLPNIKTPTLIISSEEDYLTPPFEQKYLQEH---QNAELVSIPNCGHASMYEVPKTFTALVLGFFGQTKLDYQI-

4q3lA

0.17

0.16

0.96

2.39

dPPAS2

YTQTIQVELLKNLLEHLGIAQANIVGISYGASIALQFAAPTMIKRMVVANVVAKTSPWLKDIGDGWNEVAKTGNGLAYYHITIPYIYSPQFYTLHN------DWMEKRKELLVPLFSTRTFLDRMIRLTKSAETHDVIKDLPNIKTPTLIISSEEDYLTPPFEQKYLQEHL--QNAELVSIPNCGHASMYEVPKTFTALVLGFFGQTKLDYQI-

4q3lA

0.17

0.16

0.95

2.27

PPAS

YTQTIQVELLKNLLEHLGIAQANIVGISYGASIALQFAAKYP-KRMVVANVVAKTSPWLKDIGDGWNEVAKTGNGLAYYHITIPYIYSPQFYTLHN------DWMEKRKELLVPLFSTRTFLDRMIRLTKSAETHDVIKDLPNIKTPTLIISSEEDYLTPPFEQKYLQEH---QNAELVSIPNCGHASMYEVPKTFTALVLGFFGQTKLDYQI-

1hkhA

0.11

0.10

0.96

2.54

Env-PPAS

YDYDTFAADLHTVLETLDLRDVVLVGFSMGTGELARYVAHERVAKLAFLASLEPFLVQRDDNPEGVPQEVFDGIEAAAKGDRFAWFTDFYKNFYNLDENLGSRISEQAVTGSWNVAIGSAPVAAYAVVPAWIEDFSDVEAVRAAGKPTLILHGTKDNILPIDATARRFHQAV-PEADYVEVEGAPHGLLWTHADEVNAALKTFLAK--------

3hi4A

0.14

0.95

1.66

MUSTER

NDYDTFADDIAQLIEHLDLKEVTLVGFSMGGGDVARYIARGSARVAGLVLLGAVTPLFGQPDYPQGVPLDVFARFKTELLKDRAQFISDFNAPFYGINKGQVVSQGVQTQTLQIALLA--SLKATVDCVTAFAETDFRPDMAKIDVPTLVIHGDGDQIVPFETTGKVAAELI-KGAELKVYKDAPHGFAVTHAQQLNEDLLAFLKR--------

1a8sA

0.14

0.13

0.95

1.57

dPPAS

NDMDTYADDLAQLIEHLDLRDAVLFGFSTGGGEVARYIGTARVAKAGLISAVPPLMLKTEANPGGLPMEVFDGIRQASLAD-RSQLYKDLASGPFFGFNQPGAKSSAGMVDWFWLQGMAAGHKNAYDCIKAFSETDFTEDLKKIDVPTLVVHGDADQVVPIEASGIASAAL-VKGSTLKIYSGAPHGLTDTHKDQLNADLLAFIKG--------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.50

Estimated TM-score = 0.78±0.10

Estimated RMSD = 4.5±3.0Å

Download Model 2

C-score=-2.15

Download Model 3

C-score=-2.45

Download Model 4

C-score=-5.00

Download Model 5

C-score=-2.42

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4q3lA	0.898	1.51	0.171	0.958
2	5d6oA	0.819	2.34	0.149	0.944
3	5e4yA	0.818	2.43	0.118	0.949
4	3vvlA	0.803	2.63	0.164	0.939
5	3e3aB	0.802	2.35	0.173	0.921
6	2vatA	0.797	2.66	0.167	0.930
7	4i3fA	0.786	2.75	0.177	0.925
8	3vdxA	0.778	2.93	0.128	0.935
9	4uhcA	0.778	2.77	0.154	0.916
10	4qloA	0.777	3.16	0.135	0.963

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.21	31	3ia2D	J6Z	Rep, Mult	28,29,52,132,158,186
2	0.10	18	1xqxA	PCS	Rep, Mult	28,29,121,125,128,132,157,186
3	0.05	9	1g42A	CP2	Rep, Mult	28,61,69,87,91,95,157,158,186
4	0.05	8	4uheA	MLT	Rep, Mult	28,29,32,63,132,186
5	0.02	4	1g4hA	1BO	Rep, Mult	28,61,62,65,69,95,157,186
6	0.02	4	2vaxK	CSC	Rep, Mult	28,86,87,186,187,189,190
7	0.02	4	2wj6C	ZZ8	Rep, Mult	27,28,29,95,121,125,186
8	0.02	3	2d0dA	CL	Rep, Mult	28,29
9	0.02	4	3hssB	MLA	Rep, Mult	85,113,117,187,190
10	0.02	3	1y37A	MG	Rep, Mult	1,2,3,6,128,131,136
11	0.01	1	1iunB	ACT	Rep, Mult	179,195,198
12	0.01	2	2og1A	GOL	Rep, Mult	106,107
13	0.01	1	2wm2A	CL	Rep, Mult	69,73,76,125
14	0.01	2	1xrpA	PRO	Rep, Mult	28,29,119,121,124,125,128
15	0.01	1	2xuaH	SHF	Rep, Mult	66,82,85,86,116,125,158
16	0.01	1	1uk8A	LEA	Rep, Mult	165,168,169,178
17	0.01	1	1cqwA	IOD	Rep, Mult	95,99,186
18	0.01	2	1iup0	III	Rep, Mult	147,154,169,173,174,175,176,177,178,179,180,181,182,183,195,198,199,202,206
19	0.01	1	1g4hA	1BO	Rep, Mult	177,203,206
20	0.01	1	3v1nA	HPK	Rep, Mult	90,95,107,111,187,190

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.433	1mt3A	0.695	3.62	0.130	0.865	3.4.11.5	28,156,186
2	0.405	1iunB	0.758	2.73	0.180	0.892	3.7.1.9	156,186
3	0.318	1zoiA	0.771	2.65	0.149	0.911	3.1.1.-	28,50,156,186
4	0.308	1a88A	0.772	2.65	0.128	0.911	1.11.1.10	28,156,186
5	0.266	1qj4A	0.652	3.56	0.115	0.827	4.1.2.37	28,156,186
6	0.261	2vf2A	0.761	2.88	0.161	0.902	3.7.1.8	29
7	0.252	1dwoA	0.651	3.55	0.126	0.827	4.1.2.37	28,156,186
8	0.250	3e3aB	0.802	2.35	0.173	0.921	1.11.1.-	NA
9	0.173	2pu5A	0.748	2.93	0.178	0.892	3.7.1.8	NA
10	0.162	3hjuA	0.686	3.75	0.132	0.860	3.1.1.23	28
11	0.100	2og1A	0.749	2.94	0.178	0.892	3.7.1.8	23
12	0.092	1j1iA	0.715	2.65	0.183	0.841	3.7.1.8	28,159
13	0.084	1ehyA	0.717	3.32	0.134	0.897	3.3.2.10	186
14	0.075	3bf7A	0.666	3.23	0.146	0.832	3.1.-.-	28,186
15	0.067	2r11D	0.680	3.27	0.183	0.841	3.1.1.1	29,52,187,193
16	0.060	2cjpA	0.741	3.64	0.153	0.949	3.3.2.3	156,186
17	0.060	2zjfA	0.758	3.69	0.145	0.963	3.3.2.3	184,192,199
18	0.060	1u2eA	0.735	3.08	0.141	0.892	3.7.1.-	28,156,186
19	0.060	1a8sA	0.770	2.77	0.143	0.916	1.11.1.10	28,156,186
20	0.060	2qvbB	0.709	3.56	0.117	0.911	3.8.1.5	186
21	0.060	1va4A	0.768	2.59	0.130	0.902	3.1.1.2	36
22	0.060	3nwoA	0.680	3.61	0.172	0.841	3.4.11.5	28
23	0.060	1hlgB	0.685	3.93	0.145	0.897	3.1.1.3	127
24	0.060	3a2lA	0.724	3.30	0.128	0.911	3.8.1.5	NA
25	0.060	1k8qA	0.676	3.82	0.136	0.883	3.1.1.3	28
26	0.060	2v9zA	0.708	3.24	0.115	0.897	3.8.1.5	NA
27	0.060	2ocgA	0.679	2.61	0.141	0.794	3.1.-.-	28,30,34,52,156,159,178,186
28	0.060	1mj5A	0.709	3.44	0.107	0.897	3.8.1.5	NA
29	0.060	1m33A	0.719	2.98	0.161	0.865	3.1.1.1	29,160
30	0.060	1c4xA	0.744	2.95	0.196	0.906	3.7.1.8	28
31	0.060	2pl5A	0.754	2.91	0.151	0.906	2.3.1.31	28,156,186
32	0.060	1a8qA	0.766	2.68	0.149	0.906	1.11.1.10	28,156,186
33	0.060	1a7uA	0.773	2.63	0.133	0.911	1.11.1.10	28,156,186
34	0.060	1y37A	0.731	3.52	0.126	0.930	3.8.1.3	48,148

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.802	2.35	0.17	0.92	3e3aB	GO:0003824 GO:0004601 GO:0009062 GO:0016298 GO:0016491 GO:0055114 GO:0098869
1	0.32	0.765	2.70	0.12	0.91	1hkhA	GO:0003824 GO:0004601 GO:0098869
2	0.29	0.744	2.95	0.20	0.91	1c4xA	GO:0016787 GO:0018774
3	0.28	0.680	3.61	0.17	0.84	3nwoA	GO:0006508 GO:0008233 GO:0016787
4	0.27	0.770	2.77	0.14	0.92	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
5	0.27	0.761	2.63	0.16	0.89	4opmA	GO:0004806 GO:0016787
6	0.27	0.758	2.73	0.18	0.89	1iunB	GO:0003824 GO:0016787
7	0.24	0.768	2.67	0.13	0.91	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
8	0.23	0.735	3.08	0.14	0.89	1u2eA	GO:0003824 GO:0005737 GO:0016787 GO:0018771 GO:0019380 GO:0019439 GO:0019622 GO:0042803 GO:0052823
9	0.21	0.785	2.38	0.18	0.89	2xuaH	GO:0016787 GO:0042952 GO:0047570
10	0.20	0.695	3.62	0.13	0.86	1mt3A	GO:0004177 GO:0006508 GO:0008233 GO:0016787
11	0.20	0.818	2.43	0.12	0.95	5e4yA	GO:0004414 GO:0005737 GO:0008652 GO:0009086 GO:0016740 GO:0016746
12	0.19	0.736	3.48	0.15	0.92	4rncA	GO:0016787 GO:0052689
13	0.17	0.715	2.65	0.18	0.84	1j1iA	GO:0016787
14	0.17	0.789	2.72	0.13	0.93	3v48A	GO:0006212 GO:0016787 GO:0016811 GO:0019740
15	0.16	0.786	2.75	0.18	0.93	4i3fA	GO:0016787
16	0.16	0.781	2.78	0.13	0.93	4qesA	GO:0003723 GO:0003824 GO:0004601 GO:0005198 GO:0005576 GO:0005654 GO:0005829 GO:0005886 GO:0016020 GO:0016032 GO:0016491 GO:0017000 GO:0019012 GO:0019061 GO:0019062 GO:0019064 GO:0019065 GO:0019068 GO:0019070 GO:0019072 GO:0019076 GO:0019083 GO:0030666 GO:0030683 GO:0031904 GO:0039573 GO:0039660 GO:0042025 GO:0046761 GO:0055036 GO:0055114 GO:0075733 GO:0098869
17	0.16	0.790	2.75	0.10	0.94	2b61A	GO:0004414 GO:0005737 GO:0008652 GO:0009086 GO:0009092 GO:0016740 GO:0016746
18	0.16	0.780	2.79	0.11	0.93	3i1iA	GO:0004414 GO:0005737 GO:0008652 GO:0009086 GO:0016740 GO:0016746 GO:0016787
19	0.16	0.773	2.56	0.12	0.91	3fobA	GO:0003824 GO:0004601 GO:0009636 GO:0016491 GO:0016691 GO:0016787 GO:0019806 GO:0055114 GO:0098869
20	0.15	0.761	2.88	0.16	0.90	2vf2A	GO:0005618 GO:0005886 GO:0006629 GO:0006694 GO:0016042 GO:0016787 GO:0018774 GO:0019439 GO:0034820 GO:0044117 GO:0102296
21	0.15	0.749	2.94	0.18	0.89	2og1A	GO:0003824 GO:0016787 GO:0016823 GO:0018771 GO:0018774 GO:0019439
22	0.15	0.761	2.59	0.17	0.89	1womA	GO:0016787
23	0.15	0.778	2.50	0.18	0.89	3om8B	GO:0016787 GO:0042952 GO:0047570
24	0.14	0.771	2.65	0.15	0.91	1zoiA
25	0.14	0.743	3.33	0.17	0.93	4f0jA	GO:0003824 GO:0016787
26	0.13	0.725	3.79	0.11	0.94	5aljA	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0006805 GO:0006874 GO:0006954 GO:0008152 GO:0008217 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0017144 GO:0019373 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0045909 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0072593 GO:0090181
27	0.10	0.762	2.83	0.16	0.91	2xmzA	GO:0009234 GO:0016787 GO:0016829 GO:0070205
28	0.08	0.720	2.53	0.20	0.84	4ns4A	GO:0016787 GO:0016788
29	0.08	0.730	3.16	0.16	0.88	4lxhA	GO:0016787
30	0.07	0.693	3.81	0.18	0.89	1q0rA	GO:0016787 GO:0017000 GO:0052689
31	0.07	0.679	2.61	0.14	0.79	2ocgA	GO:0005739 GO:0005741 GO:0006520 GO:0006805 GO:0009636 GO:0016787 GO:0047658 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0004601	GO:0016823	GO:0016298
GO-Score	0.67	0.58	0.34
Biological Processes	GO:0098869	GO:0019538	GO:0055114	GO:0009062
GO-Score	0.67	0.56	0.52	0.34
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.