I-TASSER results

I-TASSER results for job id Rv3333c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (281 residues)
MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALLEKKEIPAVANVPRVID
AAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTTTMTRFISAAVEIYCPNHH
SKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVSDMTIMSPGWREPTGAMLASV
LGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPPPRPAPPQQPPPPPPEVEPPAGV
PQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGFIRLAP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALLEKKEIPAVANVPRVIDAAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTTTMTRFISAAVEIYCPNHHSKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVSDMTIMSPGWREPTGAMLASVLGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPPPRPAPPQQPPPPPPEVEPPAGVPQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGFIRLAP
Prediction	CCCCCCCCHHHHHHHHHHHHCCEEHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCC
Conf.Score	97765565578999999997644547887778999668999999986886456885899999999998658998679999999876546888667858889999999998877534789875688887689998888764455545666678776765444445788777888634555554467899999999999999987767889998889999999999999999998999999998888878888888888888888898999999987545589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALLEKKEIPAVANVPRVIDAAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTTTMTRFISAAVEIYCPNHHSKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVSDMTIMSPGWREPTGAMLASVLGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPPPRPAPPQQPPPPPPEVEPPAGVPQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGFIRLAP
Prediction	73332343110000000100110113434333435433301000357504215403300320240043136414043004303531243544444224402310031021004010144453013032344434643333023233320442442343024123133324432121012002104544441463441424342153213333133334554445764544456263444125533333433334333343624253544443232214238
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHHHHHHHCCEEHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCC
MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALLEKKEIPAVANVPRVIDAAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTTTMTRFISAAVEIYCPNHHSKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVSDMTIMSPGWREPTGAMLASVLGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPPPRPAPPQQPPPPPPEVEPPAGVPQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGFIRLAP

4nl6A

0.15

0.14

0.95

0.86

MUSTER

MAMSSGGSGGGVPEQ----EDSVLFRRGTGQSDDSDDD---TALIKAYDKAVASFKHALKNICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQIYPATIASIDFKRETCVVV-YTGYGNREEQNLSDLLSPICEVANNI--EQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMSGYHTGYYMGFRQNQKEGRCSHSLN---

4nl6A

0.15

0.95

0.76

dPPAS

----MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDDD---TALIKAYDKAVASFKHALKNICETSGKPKTTPKRKPAKKNKSQKKNTAASLQCIYPATIASIDFKRETCVV-VYTGYGNREEQNLSDLLSPICEVANNI--EQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMSGYHTGYYMGFRQNQKEGRCSHSLN---

4nl6A

0.16

0.15

0.91

0.58

wdPPAS

MAMSSGGSGGGVPEQ----EDSVLFRRGTGQSDDSDDD---TALIKAYDKAVASFKHALKNICETSGKPKTTPKRKPAKKNKSQKAWSEDG--CIYPATIASIDFKRETCVV-VYTGYGNRNLSDLLSPICEVANNIEQNAQENENESVSTDESENSRSPGNKSDNIKPKSAP---------WNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADA-SGYHTG-MG-FRQNQKEGRCSHSLN---

3otgA

0.18

0.15

0.84

0.65

wMUSTER

HFAGTHGHTYPLLPLATAARAAVTF-----AT----GEGFAGTLRKLGFEPVATGPVFDGFLAALRIRFDTDSPTPEQLSELPQIVFG---------RVIPQRVFDELQPVIERLRP-D---VQEISN--------YGAGLAALKAGI---------PTICHGVGRDTPDDLTRSIEEEVRGLAQRGLD--LPPGRIDGFGNPFIDIFPPEPEFRARPRRPVPFAEQGDLPAWLSRDTARP-TLGTSSGGTAGLDSGPS----LDVSGLGEVPANVESWVP

3otgA1

0.17

0.12

0.72

0.59

wPPAS

LFASLGTHATAARAAVTFATG----------------EGFAGTLRKLGFEPVATGPVFDGFLAALRIRFDTDSPEGLTPEQLSELPQ------IVFGRVIPQRVFDELQPVIERLRP-D---VQEISNYGAG--------LAALKAGI---------PTICHGVGRDTP-DDLTRSIEEEVRGLAQG---LD-LPPGRIDGFGNPFIDIFPPSLQEPEFRARPRRHE------LRP---VPFAEPG-------------------PDEVVRLLPGF---S-

1jvrA

0.27

0.11

0.41

0.75

dPPAS2

----------------------------------------------------------------------------------------------------------------------HMGQIHGLSPTPAPRGLSTHHWLAAYRLQPGPSDFDFQQRFLKLALKTPIWLNPIDSLLASLI---PKGYPNQVSPSAPAAPVP------TPICPTTTPPPPPPPSPEAHVPPPYVEPTT--TQCF-------------------------------------

4nl6A

0.15

0.14

0.93

0.90

PPAS

MAMSSGGSGGGVPEQ----EDSVLFRRGTGQSDDSDDD---TALIKAYDKAVASFKHALKNICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQIYPATIASIDFKRETCVVV-YGNREEQNLSDLLSPICEVANNIEQNAQENESQVSTDESENSRSPGNKSDNIKPKSAPWNS-------FLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGS-SGYHTGYYMGFRQNQKEGRCSHSLN---

5b04A

0.15

0.12

0.85

0.71

Env-PPAS

FLQDDPEITMPVAAIEALVQ--LL-----SRSQAKTISEFMDILQNGSVQNNISLSAGCDIFQRFVTRSLHDVGFEQCKRHLVENGKLFYPLIRDGSVILTRGVAAVLLAAAKRFVPSGSG---CLMTRTLKNACIPTCMVVSFTMNRVDVGAEGVVENGGLINQ-------IGTFQLAVFAKH-AHKPFY-----AVAE---SHKFVRMFPLS----QYDIPFSRP---ILEFDDPSPE---------TPTPSDAIHNELIMNEEQIRNPTPPEFVSGSK

3otgA1

0.18

0.14

0.75

0.69

MUSTER

LFASLGTHTYPLLPLATAARAAVTF----ATG-----EGFAGTLRKLGFEPVATGPVFDGFLAALRIRFDTDSPEGLTPEQLSELPQ------IVFGRVIPQRVFDELQPVIERLRPD------LVVQEIS----NYGAGLAALKAGI---------PTICHGVGRDTPDDLTRSIEEEVRGLAQRGLDLPPG----RIDGFGNPFIDIFPPSLQEPEFRARPRRHE------LRP---VPF------------------AEPG-PDEVVRLLPGF---AS

5gaoE

0.14

1.00

0.74

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.20

Estimated TM-score = 0.36±0.12

Estimated RMSD = 13.8±3.9Å

Download Model 2

C-score=-4.30

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4nl6A	0.865	2.21	0.126	0.961
2	4be4A	0.434	6.50	0.060	0.765
3	1q83A	0.428	6.29	0.076	0.744
4	1r8wA	0.427	6.49	0.053	0.772
5	5e7pA	0.426	6.30	0.067	0.733
6	3i6mA	0.425	6.46	0.039	0.751
7	2f3oA	0.424	6.55	0.066	0.744
8	2x4bA	0.420	6.17	0.045	0.698
9	2pm8A	0.419	6.35	0.047	0.726
10	1qo9A	0.418	6.11	0.074	0.708

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	5	4rkuA	CLA	Rep, Mult	59,62,63
2	0.07	3	4ep5A	SO4	Rep, Mult	43,46,57
3	0.07	3	3fd5A	MG	Rep, Mult	38,70
4	0.07	3	1ocoB	HEA	Rep, Mult	58,59
5	0.04	2	1xqaA	MG	Rep, Mult	63,113
6	0.02	1	1maaD	UUU	Rep, Mult	28,30,31,32,39
7	0.02	1	2y2vB	P15	Rep, Mult	36,40,43
8	0.02	1	1lqpA	MN	Rep, Mult	63,96,113
9	0.02	1	3by9A	CA	Rep, Mult	58,59,70
10	0.02	1	4fevD	KAN	Rep, Mult	7,8
11	0.02	1	3fa3J	MN	Rep, Mult	28,80,90
12	0.02	1	3bk0B	CNU	Rep, Mult	90,103

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2pm8A	0.419	6.35	0.047	0.726	3.1.1.8	NA
2	0.060	1llwA	0.390	6.55	0.066	0.683	1.4.7.1	NA
3	0.060	1b41A	0.423	6.45	0.057	0.747	3.1.1.7	NA
4	0.060	1qo9A	0.418	6.11	0.074	0.708	3.1.1.7	NA
5	0.060	2c6fA	0.379	6.37	0.079	0.655	3.4.15.1	NA
6	0.060	1zyzA	0.342	6.14	0.050	0.577	1.17.4.1	NA
7	0.060	1h16A	0.396	6.80	0.056	0.726	2.3.1.54	NA
8	0.060	1f6wA	0.403	6.76	0.064	0.737	3.1.1.13,3.1.1.3	NA
9	0.060	1y791	0.392	6.34	0.030	0.669	3.4.15.5	45
10	0.060	2fhbA	0.363	6.19	0.054	0.616	3.2.1.41	NA
11	0.060	2zuwC	0.388	6.27	0.055	0.658	2.4.1.211	64
12	0.060	3mogA	0.388	6.27	0.073	0.662	1.1.1.157	112
13	0.060	1z0hB	0.316	5.86	0.036	0.512	3.4.24.69	36
14	0.060	2qubA	0.306	6.10	0.036	0.512	3.1.1.3	NA
15	0.060	2pflA	0.406	6.83	0.072	0.747	2.3.1.54	NA
16	0.060	1larA	0.385	6.34	0.023	0.655	3.1.3.48	NA
17	0.060	1kdgB	0.379	6.11	0.051	0.644	1.1.99.18,	NA
18	0.060	1ea0A	0.373	6.80	0.035	0.687	1.4.1.13	NA
19	0.060	1c7sA	0.392	5.91	0.041	0.619	3.2.1.52	6

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.865	2.21	0.13	0.96	4nl6A	GO:0000245 GO:0000387 GO:0003723 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006353 GO:0006397 GO:0007399 GO:0008380 GO:0015030 GO:0030018 GO:0032797 GO:0034719 GO:0036464 GO:0042802 GO:0043005 GO:0043204 GO:0051170 GO:0097504
1	0.07	0.434	6.50	0.06	0.77	4be4A	GO:0016787
2	0.07	0.422	6.43	0.06	0.75	4bdtA	GO:0001507 GO:0001540 GO:0001919 GO:0002076 GO:0003990 GO:0004104 GO:0005518 GO:0005576 GO:0005605 GO:0005615 GO:0005634 GO:0005794 GO:0005886 GO:0006260 GO:0006581 GO:0006656 GO:0007155 GO:0007399 GO:0007416 GO:0007517 GO:0008283 GO:0009611 GO:0009986 GO:0016020 GO:0016787 GO:0017171 GO:0030054 GO:0031225 GO:0031594 GO:0031623 GO:0032223 GO:0042135 GO:0042136 GO:0042166 GO:0042803 GO:0042982 GO:0043083 GO:0043236 GO:0043621 GO:0045202 GO:0045212 GO:0048471 GO:0050714 GO:0051262 GO:0052689 GO:0060041
3	0.06	0.427	6.54	0.03	0.77	1crlA	GO:0004806 GO:0006629 GO:0016042 GO:0016787
4	0.06	0.426	6.50	0.04	0.77	1cleA	GO:0004806 GO:0006629 GO:0008202 GO:0008203 GO:0016042 GO:0016787
5	0.06	0.345	6.84	0.03	0.63	4fnmA	GO:0016787
6	0.06	0.397	6.73	0.05	0.73	1aknA	GO:0004771 GO:0004806 GO:0004872 GO:0005576 GO:0005615 GO:0005737 GO:0005887 GO:0006629 GO:0007158 GO:0007416 GO:0009986 GO:0016042 GO:0016787 GO:0042043 GO:0045202 GO:0050804 GO:0052689
7	0.06	0.337	6.50	0.03	0.59	3bl8A	GO:0001966 GO:0002087 GO:0004872 GO:0005615 GO:0005886 GO:0005887 GO:0007155 GO:0007158 GO:0007416 GO:0007630 GO:0009986 GO:0016020 GO:0016021 GO:0019233 GO:0030054 GO:0032024 GO:0032230 GO:0035176 GO:0035418 GO:0035641 GO:0042043 GO:0042734 GO:0045202 GO:0045211 GO:0050804 GO:0050808 GO:0050839 GO:0050885 GO:0051965 GO:0051968 GO:0052689 GO:0060076 GO:0060077 GO:0072553 GO:0097104 GO:0097105 GO:0097116 GO:0097119 GO:0097151 GO:1902474 GO:1904862 GO:2000311 GO:2000463 GO:2000809
8	0.06	0.418	6.11	0.07	0.71	1qo9A	GO:0001507 GO:0003990 GO:0004104 GO:0005615 GO:0005737 GO:0005886 GO:0006581 GO:0007268 GO:0016020 GO:0016787 GO:0030054 GO:0031225 GO:0042135 GO:0042331 GO:0042426 GO:0042803 GO:0043083 GO:0045202 GO:0052689
9	0.06	0.352	6.61	0.05	0.63	5a2gA	GO:0016787
10	0.06	0.424	6.44	0.04	0.75	1eveA	GO:0001507 GO:0003990 GO:0004104 GO:0005886 GO:0016020 GO:0016787 GO:0030054 GO:0031225 GO:0042135 GO:0043083 GO:0045202 GO:0052689
11	0.06	0.289	7.37	0.03	0.58	1zxvA	GO:0003824 GO:0005576 GO:0006508 GO:0008237 GO:0009405 GO:0046872
12	0.06	0.427	6.37	0.06	0.75	4bc0A	GO:0001919 GO:0002076 GO:0003990 GO:0004104 GO:0005518 GO:0005576 GO:0005605 GO:0005615 GO:0005794 GO:0005886 GO:0006581 GO:0007155 GO:0009986 GO:0016020 GO:0016787 GO:0017171 GO:0030054 GO:0031225 GO:0031594 GO:0031623 GO:0042135 GO:0042166 GO:0042803 GO:0043236 GO:0043621 GO:0045202 GO:0045212 GO:0048471 GO:0051262 GO:0052689 GO:0060041
13	0.06	0.348	6.48	0.04	0.61	1thgA	GO:0004806 GO:0005576 GO:0006629 GO:0016042 GO:0016787
14	0.06	0.418	6.50	0.03	0.74	3o9mA	GO:0001540 GO:0003824 GO:0003990 GO:0004104 GO:0005576 GO:0005615 GO:0005641 GO:0005783 GO:0005788 GO:0007584 GO:0007612 GO:0008285 GO:0014016 GO:0016020 GO:0016787 GO:0016788 GO:0019695 GO:0019899 GO:0033265 GO:0042493 GO:0042802 GO:0043279 GO:0050783 GO:0050805 GO:0051384 GO:0051593 GO:0052689 GO:0072562
15	0.06	0.344	6.38	0.02	0.60	1gz7A	GO:0004806 GO:0006629 GO:0016042 GO:0016787
16	0.06	0.330	6.68	0.04	0.60	1mx9D	GO:0005615 GO:0005783 GO:0005788 GO:0006805 GO:0008152 GO:0009636 GO:0016787 GO:0030855 GO:0047374 GO:0052689
17	0.06	0.333	6.46	0.04	0.58	2ogsA	GO:0016787
18	0.06	0.314	7.28	0.07	0.63	3k9bB	GO:0005615 GO:0005783 GO:0005788 GO:0006805 GO:0008152 GO:0009636 GO:0016787 GO:0030855 GO:0047374 GO:0052689

Consensus prediction of GO terms

Molecular Function	GO:0005515	GO:0003676	GO:0003824
GO-Score	0.42	0.42	0.33
Biological Processes	GO:0048731	GO:0006351	GO:0022618	GO:0006913	GO:0000398
GO-Score	0.52	0.42	0.42	0.42	0.42
Cellular Component	GO:0035770	GO:0016604	GO:0043025	GO:0042995	GO:0031674	GO:0043234
GO-Score	0.42	0.42	0.42	0.42	0.42	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
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