I-TASSER results

I-TASSER results for job id Rv3311

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (420 residues)
MVADLVPIRLSLSAGDRYTLWAPRWRDAGDEWEAFLGKDDDLYGFESVSDLVAFVRTDTE
NDLVDHPAWQDLTGAHAHNLNPAEDNQFDLVVVEELLAEKPTAESVAALAASLAIVSAIG
SVCELAAVSKFFNGNPILGTVSGGLEHFTGKAGNKRWNSIAEVIGRSWDDVLAAIDEIIS
TPEVDAELSEKVAEELAEEPEGAEEVAAEVEATQDTQEAAESDDEEADAPGDSVVLGGDR
DFWLQVGIDPIQIMTGTATFYTLRCYLDDRPIFLGRNGRISVFGSERALARYLADEHDHD
LSDLSTYDDIRTAATDGSLAVAVTDDNVYVLSGLVDDFADGPDAVDREQLDLAVELLRDI
GDYSEDSAVDKALETTRPLGQLVAYVLDPHSVGKPTAPYAAAVREWEKLERFVESRLRRE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVADLVPIRLSLSAGDRYTLWAPRWRDAGDEWEAFLGKDDDLYGFESVSDLVAFVRTDTENDLVDHPAWQDLTGAHAHNLNPAEDNQFDLVVVEELLAEKPTAESVAALAASLAIVSAIGSVCELAAVSKFFNGNPILGTVSGGLEHFTGKAGNKRWNSIAEVIGRSWDDVLAAIDEIISTPEVDAELSEKVAEELAEEPEGAEEVAAEVEATQDTQEAAESDDEEADAPGDSVVLGGDRDFWLQVGIDPIQIMTGTATFYTLRCYLDDRPIFLGRNGRISVFGSERALARYLADEHDHDLSDLSTYDDIRTAATDGSLAVAVTDDNVYVLSGLVDDFADGPDAVDREQLDLAVELLRDIGDYSEDSAVDKALETTRPLGQLVAYVLDPHSVGKPTAPYAAAVREWEKLERFVESRLRRE
Prediction	CCCCEEEEEEHCCCCCEEEEHCCCCCCCCCEEEEHCCCCCEEEHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCEEEEEHCCCCEEEEEEEHCCCEEEHCCCCEEEEHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCEEHCCCCEEEHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
Conf.Score	998767799985899789996788788996577756899859985999898888855999986558747877765876677778985888635788758999889999999999999999998776889987578545446655545689778999999999999757899999987543678985789999999998665556777666777776666655556655567767788877757876887499998898589999886995677567988999689999999998599997544896899998667887655657885798656778877586659999999999999999999899588999858985999999998899999999985999999999999999986689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVADLVPIRLSLSAGDRYTLWAPRWRDAGDEWEAFLGKDDDLYGFESVSDLVAFVRTDTENDLVDHPAWQDLTGAHAHNLNPAEDNQFDLVVVEELLAEKPTAESVAALAASLAIVSAIGSVCELAAVSKFFNGNPILGTVSGGLEHFTGKAGNKRWNSIAEVIGRSWDDVLAAIDEIISTPEVDAELSEKVAEELAEEPEGAEEVAAEVEATQDTQEAAESDDEEADAPGDSVVLGGDRDFWLQVGIDPIQIMTGTATFYTLRCYLDDRPIFLGRNGRISVFGSERALARYLADEHDHDLSDLSTYDDIRTAATDGSLAVAVTDDNVYVLSGLVDDFADGPDAVDREQLDLAVELLRDIGDYSEDSAVDKALETTRPLGQLVAYVLDPHSVGKPTAPYAAAVREWEKLERFVESRLRRE
Prediction	744400203010472210000004036666302000046320100520020000012556210441440650473425504146633010110042016414343053024004002200400505302500442210320430342031650362034004100540440042035204235145632540454144355455655554555555565556555655565555446545410150102003030555311000011353000004603021142231003002654522034253064036305444252423452212052025204502730337003300300220041171630352046443013000100426663414321552263055015303730478
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEEEHCCCCCEEEEHCCCCCCCCCEEEEHCCCCCEEEHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCEEEEEHCCCCEEEEEEEHCCCEEEHCCCCEEEEHCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCEEHCCCCEEEHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
MVADLVPIRLSLSAGDRYTLWAPRWRDAGDEWEAFLGKDDDLYGFESVSDLVAFVRTDTENDLVDHPAWQDLTGAHAHNLNPAEDNQFDLVVVEELLAEKPTAESVAALAASLAIVSAIGSVCELAAVSKFFNGNPILGTVSGGLEHFTGKAGNKRWNSIAEVIGRSWDDVLAAIDEIISTPEVDAELSEKVAEELAEEPEGAEEVAAEVEATQDTQEAAESDDEEADAPGDSVVLGGDRDFWLQVGIDPIQIMTGTATFYTLRCYLDDRPIFLGRNGRISVFGSERALARYLADEHDHDLSDLSTYDDIRTAATDGSLAVAVTDDNVYVLSGLVDDFADGPDAVDREQLDLAVELLRDIGDYSEDSAVDKALETTRPLGQLVAYVLDPHSVGKPTAPYAAAVREWEKLERFVESRLRRE

4tqlA

0.09

0.05

0.54

1.07

dPPAS2

-----------------------------------------------------------------------------------------------------YKQMVQELEKARDRMEKLYKEMV-ELIQKAIE---LMRKIFQEVK----QEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGGDKQEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEM---------------------------------------KQRMEEVKKKMDDELLEKIKNIDDLKKIAED-------------LIKKAEENIKEAKKIA-EQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLKG--------------------------------

5cwiA

0.12

0.07

0.55

1.03

dPPAS2

--------------------------------------------------------------------------------------------------------DIEKLCKKAESEAREARSK--AEELRQRHPDSQAARDAQKLA----SQAEEAVKLACELAQEHPNADIAKLCIKAAS---EAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKLCIKAASEA-------------------------------------AEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKL--------------ACELAQEHPNA---DIAKKCIKAASEAAEEASKAAEEAQRHPD-------------------SQKARDEIKEASQKAEEVKERCER-

5j65A

0.11

0.10

0.90

0.74

MUSTER

--HSLIHTIKLNSNKKY----GPGDMTNGN---QFIISKQE------WATIGAYIQTG---GLVNEQQLRTHVNLSQDISIPSDSQLYDVYCSDKTSAEWWNKNLYPLIIKSANDIASYGFKVAQDELDNIVDNNSDDDAIAKAIKDF--KARCGILIKEAKQYEEAAKNIVTSLDQFLHGDQKKLEGVINIQKRLKEVQTALNQAHGESSPAHKELLEKVKNLKTTLERTIKAEQDLEKKVEYSFLLGPLLGFVVYEILENIKNQIDE----IKK--QLDSAQHDLDRDVKII----GMLNSINTIDNLYSQGQE----IKVFQKLQGIWATIGAQIENLRTTSLQEVQDSADEIQIELEDAS--DAWLVVA---QEARDFTLNAYSTSNLEY-KCPENNFMIYWYNNSDWYN---NSD

4k1pA

0.09

0.07

0.80

0.71

dPPAS

-----------------------------------IAPNTLSNSIRMLGSQSPLIQA----------YGLVILQQPDIKVNAMSSLTNHQKFAKANVREWIDEYNPKLIDLNQEMMRYSIRFNSYYSKLYELAGNINEDEQSKADF----TNAYGKLQLQVQSIQENMEQDLLELNRFKTVLDKDSNNLSIKADEAIKTLQGSGDIVKLREDIKRIQGEIQAELTTILNRPQEIIKGS-------INIGKQVFTITTKTIDFVSIGTLSNEIVNAADSQTREAALRIQQKQKELLPLIQKLSQTEAEATQITFVED-----------------QVSSFTELIDRQITTLETLLTDWKVLNNNMIQIQKNVEEGTYTDSSLLQKHFNQ-----------IKKVSDEMNKQTNQFEDYVTNV

5j65A

0.11

0.08

0.78

0.58

wdPPAS

-----------------HSL-GPG--NGN----QFIISKQE------WATIGAYIQTG----LVNEQQLRTHVNLSQDISIPSD----QLYDVYCSDKTSAEWWNKNLYPLIIKSANDIASYGFQDELDNIVDNNSDDDAIAKAIKDF--KARCGILIKEAKQYEEAAKNIVTSLDQFLHGDQKKLEGVINIQKRLKEVQTANQAHGESSPAHKELLEKVKNLKTTLERTIKAEQDLEKKVEYSFLLGPLLGFVVYEI-----------------------LENTAVQHIKNQIDEIKKQLDSAQ--HDLDRDVK--------------MLNSINTDIDN------YSQGQEAIKVFQKLQGIW--ATIGAQIE---NLRTTSLQEVQDSDDAD----LEDASDAWLVVAQEARDFTLNA

5j65A

0.12

0.10

0.82

0.65

wMUSTER

LIHTIK-----LNSNK----YGPGDMTNGN---QFIISKQE------WATIGAYIQTG---GLVNEQQLRTHVNLSQDISIPSD----QLYDVYCSDKTSAEWWNKNLYPLIIKSANDIASYGFQDELDNIVDNNSDDDAIAKAIKDF--KARCGILIKEAKQYEEAAKNIVTSLDQFLHGDQKKLEGVINIQKRLKEVQTALNQAHGESSPAHKELLEKVKNLKTTLERTIKAEQDLEKKVEYSFLLGPL----------------------LG--FVVYEILENTAVQHIKNQ-----------IDEIKKQLD--SAQHDLDRDVKIILNSINTDIDN------YSQGQEAIKVFQKLQGIW--ATIGAQIE---NLRTTSLQEVQDSDDAD-QIELEDASDAWLVVAQEARDFTLLE

1iirA

0.16

0.12

0.75

0.56

wPPAS

M---VLLATCG-SRGDTE----P-----------LVGAD-RMCA---PPDCAERLA---EVGVPHVPTAEDVRRFTTEAI----ATQFDE--IPAAA-EGCAAVVTTGLLAAAIGVRSVAEKLGIPYFY--AFHCPSYVP----SPYYPPIDIPAQWERNNQSAYQRYGGLLNSHRDAIGLPPVEDIFTFGYTDHP--------------------------------DPVLAPLQPTDLDAVQTGAW-----ILPDERPLSLAAFLGPPPVYLG-------FGAPADAVRVAID-----IRAHGR---ILSRGWADLVLPDD-GADCFAFGGTHVAARAG---AP--QI--LLPQMADQPYYA--GRVAELHDGPISLSAALATALTPE--HARATAVAGTTDGAAVAARLLLDAVSRE

5cwnA

0.15

0.07

0.48

0.96

dPPAS2

-------------------------------------------------------------------------------------------------------------------------------------------------------------MDPEEILERAKESLERAREASERGDEEEFRKAAEKALELAKRLVEQAKKEGDPELVLEAAKVALRVAELAAKNGDKEVFKKAAESALEV---------------------------------------AKRLVEVASKEGD---------PELVLEAAKVALRV------------AELAAKNGDKEVFKKAAESALEVAKRLVEVASKEGDPELVEEAAKVAEEVRKLAKKQGDEE---VYEKARETAREVKEELKRVREEK

5j65A

0.11

0.09

0.83

0.76

PPAS

--HSLIHTIK-LNSNK----YGPGDMTNGN---QFIISKQE------WATIGAYIQTG---GLVNEQQLRTHVNLSQDISIPSD----QLYDVYCSDKTSAEWWNKNLYPLIIKSANDIASYGFQDELDNIVDNNSDDDAIAKAIKDF--KARCGILIKEAKQYEEAAKNIVTSLDQFLHGDQKKLEGVINIQKRLKEVQTALNQAHGESSPAHKELLEKVKNLKTTLERTIKAEQDLEKKVEYSFLLGPLLGFVVYE-------------ILENTAVQ-----HIKNQIDEIKKQLDSAQHDLDRDVKIIGM-----------------LNSINTDIDN------YSQGQEAIKVFQKLQGIW--ATIGAQI--ENLRTTSLQEVQDSDDADEIQIELEDASDAWLVVAQEARDFTLNA

3gobA

0.10

0.08

0.77

0.68

Env-PPAS

MATFVYVAALPLSEKPGRTIL-------DTPLALYRQPDGVVAALLDIAPLSDILVNGH---LQYH-GL---------EFDGGGQ----CVHNPH--GNGARPASLN--VRSFPVVERDALI--------WIWPGDPALADPGAIPDF-GCRVDPAYRTVGGHVDCNYKLLVDNLMDLGHAQYVHRANAQTDAFDRLEREVIVGDGEIQAL--------------------MKIPGGTPSVLMAKFLRGA------NTPVDAWNDIRWNKVSAM----LNFIA---------VAPEGTPKEQSIHSRGTH--------ILTPETEASCHYFFGSSR-----NFGIDDPEMDGVLRSWQAQALVKEDKVVVEAI---ERRRAYVEAN----GIRPAMLSCDEAAVRVSREIEKLEQLEAAR

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.22

Estimated TM-score = 0.35±0.12

Estimated RMSD = 14.9±3.6Å

Download Model 2

C-score=-4.50

Download Model 3

C-score=-4.88

Download Model 4

C-score=-5.00

Download Model 5

C-score=-4.71

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5j65A	0.777	2.57	0.091	0.841
2	2nrjA	0.606	3.68	0.104	0.719
3	4k1pA	0.587	4.38	0.060	0.743
4	1qoyA	0.470	4.41	0.043	0.588
5	4c3oA	0.406	5.93	0.047	0.581
6	4a01A	0.403	5.97	0.043	0.583
7	5aa5C	0.394	5.65	0.050	0.550
8	4ry2A	0.391	6.58	0.045	0.598
9	3ayxA	0.390	6.23	0.055	0.567
10	1ubmL	0.388	5.91	0.066	0.552

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	4	5ebzD	PDX	Rep, Mult	147,151,156
2	0.05	3	1jqkA	SF4	Rep, Mult	248,249,253,254,284,290,293
3	0.04	2	3u7qB	IMD	Rep, Mult	31,34
4	0.04	2	1oaoA	SF4	Rep, Mult	26,28,45,116,119
5	0.04	2	2o78A	TCA	Rep, Mult	261,264
6	0.04	2	3wmn2	BCL	Rep, Mult	175,179
7	0.04	2	1so2D	MG	Rep, Mult	299,300
8	0.02	1	1w1yB	TYP	Rep, Mult	69,168
9	0.02	1	4r9xA	CA	Rep, Mult	226,336
10	0.02	1	1ocoO	HEA	Rep, Mult	122,160,161
11	0.02	1	2wpnB	SBY	Rep, Mult	52,55,105,109,110
12	0.02	1	3i04B	SF4	Rep, Mult	120,121,123,157
13	0.02	1	2wpnB	FCO	Rep, Mult	107,108,171,174
14	0.02	1	3u7eB	MG	Rep, Mult	62,176
15	0.02	1	2x2vH	DPV	Rep, Mult	163,171
16	0.02	1	2q8hA	TF4	Rep, Mult	51,101,175,346,349
17	0.02	1	3ibjA	MG	Rep, Mult	269,315
18	0.02	1	3fvyA	MG	Rep, Mult	274,275,278

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1h2rL	0.386	5.88	0.060	0.548	1.12.2.1	108,113,172,352
2	0.060	2vz8B	0.343	7.32	0.056	0.591	2.3.1.85	NA
3	0.060	2frvD	0.384	5.83	0.049	0.543	1.12.2.1	NA
4	0.060	1vdkA	0.343	5.54	0.052	0.479	4.2.1.2	NA
5	0.060	1yfmA	0.342	5.59	0.060	0.479	4.2.1.2	NA
6	0.060	1ffyA	0.340	6.65	0.025	0.538	6.1.1.5	NA
7	0.060	3czoB	0.360	6.55	0.039	0.555	4.3.1.3	NA
8	0.060	2nyfA	0.350	6.49	0.053	0.540	4.3.1.5	NA
9	0.060	2o6yA	0.344	6.87	0.056	0.548	4.3.1.-	NA
10	0.060	2jfdA	0.241	7.22	0.027	0.407	2.3.1.85	NA
11	0.060	3cf4A	0.347	7.13	0.038	0.579	1.2.99.2	49
12	0.060	1jswB	0.337	5.60	0.060	0.476	4.3.1.1	355
13	0.060	1h2aL	0.387	6.04	0.059	0.555	1.12.2.1	NA
14	0.060	3g61A	0.343	6.60	0.033	0.533	3.6.3.44	119,162,169
15	0.060	3i39X	0.370	6.78	0.045	0.598	1.2.99.2	141,392
16	0.060	1yqwR	0.379	5.61	0.062	0.531	1.12.2.1	NA
17	0.060	2vdcA	0.334	6.85	0.051	0.543	1.4.1.13	NA
18	0.060	1j3uA	0.344	5.39	0.069	0.474	4.3.1.1	257
19	0.060	1y2mB	0.362	6.18	0.066	0.543	4.3.1.24	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.777	2.57	0.09	0.84	5j65A	GO:0030435
1	0.11	0.591	4.43	0.06	0.75	4k1pB	GO:0009405 GO:0016020
2	0.07	0.616	3.76	0.09	0.74	2nrjA	GO:0005576 GO:0009405 GO:0016020 GO:0016021 GO:0019835 GO:0020002 GO:0033644 GO:0044179
3	0.07	0.470	4.41	0.04	0.59	1qoyA	GO:0005576 GO:0009405 GO:0016020 GO:0016021 GO:0019835 GO:0020002 GO:0033644 GO:0042597 GO:0042802 GO:0044179 GO:0044532 GO:0051715
4	0.06	0.390	6.23	0.06	0.57	3ayxA	GO:0008901 GO:0016151 GO:0016491 GO:0046872 GO:0055114
5	0.06	0.388	5.94	0.05	0.55	1frvB	GO:0008901 GO:0016151 GO:0016491 GO:0042597 GO:0046872 GO:0047806 GO:0055114
6	0.06	0.380	5.72	0.05	0.54	1e3dB	GO:0008901 GO:0016151 GO:0016491 GO:0046872 GO:0055114
7	0.06	0.394	5.65	0.05	0.55	5aa5C	GO:0016151
8	0.06	0.366	5.69	0.06	0.51	4kl8L	GO:0008901 GO:0016151 GO:0016491 GO:0046872 GO:0051536 GO:0051539 GO:0055114
9	0.06	0.406	5.93	0.05	0.58	4c3oA	GO:0008901 GO:0016151 GO:0016491 GO:0046872 GO:0055114
10	0.06	0.379	6.02	0.05	0.54	5a4mL	GO:0005886 GO:0006113 GO:0008901 GO:0009055 GO:0009061 GO:0016020 GO:0016151 GO:0016491 GO:0030288 GO:0033748 GO:0044569 GO:0046872 GO:0055114
11	0.06	0.410	5.81	0.06	0.58	4iubL	GO:0005886 GO:0008901 GO:0016020 GO:0016151 GO:0016491 GO:0033748 GO:0046872 GO:0055114
12	0.06	0.387	6.04	0.06	0.55	1h2aL	GO:0008901 GO:0016151 GO:0016491 GO:0042597 GO:0046872 GO:0047806 GO:0055114
13	0.06	0.398	5.70	0.07	0.56	3myrD	GO:0008901 GO:0016151 GO:0016491 GO:0046872 GO:0055114
14	0.06	0.371	5.66	0.06	0.51	2wpnB	GO:0008901 GO:0016151 GO:0016491 GO:0046872 GO:0051536 GO:0051539 GO:0055114
15	0.06	0.270	5.70	0.07	0.38	4hea4	GO:0005886 GO:0006810 GO:0016020 GO:0016491 GO:0016651 GO:0048038 GO:0050136 GO:0051287 GO:0055114
16	0.06	0.379	5.61	0.07	0.53	3curH	GO:0008901 GO:0016151 GO:0016491 GO:0042597 GO:0046872 GO:0047806 GO:0055114
17	0.06	0.318	6.80	0.02	0.50	1w07B	GO:0000062 GO:0001676 GO:0003995 GO:0003997 GO:0005777 GO:0005829 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0009506 GO:0009611 GO:0009620 GO:0009695 GO:0016491 GO:0016627 GO:0033539 GO:0046686 GO:0050660 GO:0052890 GO:0055088 GO:0055114
18	0.06	0.311	6.08	0.06	0.47	4ci0A	GO:0008901 GO:0016151 GO:0016491 GO:0046872 GO:0050454 GO:0050660 GO:0051536 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0008901	GO:0042802	GO:0016151
GO-Score	0.07	0.07	0.07
Biological Processes	GO:0051704	GO:0030154	GO:0043934	GO:0048646
GO-Score	0.45	0.41	0.41	0.41
Cellular Component	GO:0005576	GO:0016021	GO:0020002	GO:0042597
GO-Score	0.13	0.13	0.13	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.