I-TASSER results

I-TASSER results for job id Rv3294c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (269 residues)
MGLPRRPCCDTTGSARYRESVRRYPRIGEDSAAYRRRLCRESAKARNVDRVVKRDAADVS
NLQRIADLPRLIRLLAARSASELNLSSLATDAEIPVRTLPPYLDLLETLYLIDRIPAWST
NLSKRVVDRPKVLLLDSGLAARLVNVSPTGAGPHANPNAAGAIIETFVIAELRRQLGWSQ
QAPRLFHYRDRDGAEVDLILETADGLIAAIEIKSAATLRGRDTRSISRLRDKVGARFAGG
VILHTGPQAQPFGDRLAAVPIDILWSPSG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MGLPRRPCCDTTGSARYRESVRRYPRIGEDSAAYRRRLCRESAKARNVDRVVKRDAADVSNLQRIADLPRLIRLLAARSASELNLSSLATDAEIPVRTLPPYLDLLETLYLIDRIPAWSTNLSKRVVDRPKVLLLDSGLAARLVNVSPTGAGPHANPNAAGAIIETFVIAELRRQLGWSQQAPRLFHYRDRDGAEVDLILETADGLIAAIEIKSAATLRGRDTRSISRLRDKVGARFAGGVILHTGPQAQPFGDRLAAVPIDILWSPSG
Prediction	CCCCCHHHHHHHCCCHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEHCCCCCCHHHHHCCCCCEEHCCHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCEEEEEEEHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHCCCCEEEHCCCEEEEEHHHHHHCCC
Conf.Score	99885566665555558899854566548876677778899999999999999999998589999999999999999978888999999998999999999999999985557646777855654346886676588999998798865444556764678999999999999997445567657789858997899999979957999999779999879999999999985986565899959985588679879988767765789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MGLPRRPCCDTTGSARYRESVRRYPRIGEDSAAYRRRLCRESAKARNVDRVVKRDAADVSNLQRIADLPRLIRLLAARSASELNLSSLATDAEIPVRTLPPYLDLLETLYLIDRIPAWSTNLSKRVVDRPKVLLLDSGLAARLVNVSPTGAGPHANPNAAGAIIETFVIAELRRQLGWSQQAPRLFHYRDRDGAEVDLILETADGLIAAIEIKSAATLRGRDTRSISRLRDKVGARFAGGVILHTGPQAQPFGDRLAAVPIDILWSPSG
Prediction	77154452363245340340012003103244435542325401430032003400442271642620330041004210340314300641703360034004001300202314312443354144342220210000102221323324434434110200110000001222233433130221235532100000237743000000022563465124103401751566122000001265514275401000000002478
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHCCCHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEEHCCCCCCHHHHHCCCCCEEHCCHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCEEEEEEEHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHCCCCEEEHCCCEEEEEHHHHHHCCC
MGLPRRPCCDTTGSARYRESVRRYPRIGEDSAAYRRRLCRESAKARNVDRVVKRDAADVSNLQRIADLPRLIRLLAARSASELNLSSLATDAEIPVRTLPPYLDLLETLYLIDRIPAWSTNLSKRVVDRPKVLLLDSGLAARLVNVSPTGAGPHANPNAAGAIIETFVIAELRRQLGWSQQAPRLFHYRDRDGAEVDLILETADGLIAAIEIKSAATLRGRDTRSISRLRDKVGARFAGGVILHTGPQAQPFGDRLAAVPIDILWSPSG

5cwpA

0.13

0.11

0.84

0.74

MUSTER

----MSSDEEEAR--ELIERAKEAAERAQE-AAERTGDPRVRELARELKRLAQEAAEEVKRDPSSSDVNEALKLIVEAIEAAVRALEAAERTGDPRELARELVRLAVEAAEEVQRNPSSSDVNEAL----KLIVEAIEAAVRAL-----EAAERTGD-PEVRELARELVRLAVEAAEEVQRNPSSEEVNEALKKIVKAIQEAVESLREAEE-SGDPEKREKARERVREAVERAEEVQRDP----SGWLE--------------------

5cwiA

0.14

0.12

0.85

0.63

dPPAS

---DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCIKAASEAAEAASK--AAELAQRHPDSRDAIKLASQAAEAVKLACELAQEHPNIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRH------PDSQKARDEIKEASQKAEEVKERCER------------------------------

4xqkA1

0.16

0.07

0.44

0.64

wdPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------KQTFDDLINQINTGTLFEKLTLAYLKNEPTYKALYQNVWLLSESYGIPVDLVAEQKNGDLVAIQAKYTNKVGKSEINSFVAELG--KSYYQRGLIVSTMDD--QNEKGIEIIGLSDLRNSQI

5hafA

0.11

0.96

0.72

wMUSTER

----LEVLFQGPVSDEALTLLFSAVENGDQ-DLLCNLALRNDDLGHRVEKFLFDLFSGKRT--GSSDIDKKINQACLVLHQIANNDITKDNTEWKKLHAPSRLLYMAGSAT--TDLSKKIGIAHKIMENGARMLSSDELAAATQGL-VQESPLLSVNYPIGLI-ENILSTQLLEKIAQSGLSHNEVFLVNTGDHWLLCLFYKLAEKIKCLIFNTYYDLNENTKQEIIEAAKIAGSESDEVNFIEMNQNNVPNGCGLFCYHTIQLLSNAG

5id6A2

0.11

0.08

0.77

0.65

wPPAS

-----------------------LVED----KRAEDYKGVKKLLDRYYLSFINDVLHSI-KLKNLNNYISLFRKKTRTEKENKELENLEINLR--AKAFKGYKSLFKKDIIETILPEAAKDEIALVNSFNGFAF--TGFFDNRENFSEEAKSTS--NENLTRYISNDIFEKVDAIFDKHEVQ-EIKEKILNSDYDVEFVLTQEG-----IDV---VTESGEKIKGLNEYINLYNAKTKQAL-----PKFKPLYKQV-------------

4xqkA1

0.16

0.07

0.45

1.15

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------KQTFDDLINQINTGTLFEKLTLAYLKNEPTYKALYQNVWLLSESYGIPVDLVAEQKNGDLVAIQAKYTNKVGKSEINSFVAELG--KSYYQRGLIVSTMDDWDQNEKGIEIIGLSDLRNSQI

5cwpA

0.13

0.10

0.83

0.81

PPAS

---MSSDEEEAR---ELIERAKEAAERAQE-AAERTGDPRVRELARELKRLAQEAAEEVKRDPSSSDVNEALKLIVEAIEAAVRALEAAERTGDPEVRELARELVRLAV-----------EAAEEVQRNPSSSDVNEALKLIVEAIEAAVRAL-RTGDPEVRELARELVRLAVEAAEEVQRNPSSEEVNEALKKIVKAIQEAVESLREAEESPEKREKARERVREAVERAEEVQRDPSGWLE---------------------------

1jhhA

0.09

0.06

0.70

0.71

Env-PPAS

-----------------------------------------------------KAL-----TARQQEVFDLIRDHISQTGMPPTRAEIAQRLGFSPNAAEEHLKALARKGVIEIVSGASRGIRLLQEEEEGLPLVGRLAQQHIEGHYQVDPSLFKPNADF--LLR--VSGMAMKDIGIMD-GDLLAVHKTQDVRNGQVVVARIDDEVTVKRLKKQGNKVE-----LLPENSEFKP-----IVVDLR------QQSFTIEGLAVVIRN--

5hafA

0.11

0.97

0.72

MUSTER

---GLEVLFQGPVSDEALTLLFSAVENGDQNDLLCNLALRNDDLGHRVEKFLFDLFSGKRT--GSSDIDKKINQACLVLHQIANNDITKDNTEWKKLHAPSRLLYMAGSAT--TDLSKKIGIAHKIMENGARMLSSDELAAATQGL-VQESPLLSVNYPIGLIHENILSTQLLEKIAQSGLSHNEVFLVNTGDHWLLCLFYKLAEKIKCLIFNTYYDLNENTKQEIIEAAKIAGSESDEVNFIEMNQNNVPNGCGLFCYHTIQLLSNAG

5hafA

0.07

0.92

0.63

dPPAS

----------------------GLEVLFQGPVSDEALTLLFSAVENGDQNCIDLLCNLALRNDDLGHRVEKFLFDLFSGKRTGSSDIDKKINQACLVLHQIANNDITKDNTEWKKLHAPSRLLYMAGSATTDLSKKIGIAHKIMENLWCGARMLSSDELAAATQGLILSTQLLEKIAQSGLSHNEVFLVNTGDHWLLCLFYKLAEKIKCLIFNTYYDLNENTKQEIIEAAKIAGISESDEVNFIEMNLQNNVPNGCGLFCYHTIQLLSN

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.90

Estimated TM-score = 0.29±0.09

Estimated RMSD = 15.5±3.3Å

Download Model 2

C-score=-4.38

Download Model 3

C-score=-3.97

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cwpA	0.707	2.96	0.119	0.836
2	5cwiA	0.623	3.20	0.070	0.769
3	5cwoA	0.622	3.86	0.115	0.799
4	1xmeA	0.527	5.67	0.050	0.825
5	3ripA	0.514	4.15	0.081	0.673
6	2yevA	0.511	5.54	0.068	0.807
7	1fftA	0.510	5.67	0.048	0.818
8	3mk7A	0.498	5.75	0.044	0.795
9	5cwfA	0.497	3.53	0.068	0.639
10	4xydA	0.497	5.77	0.060	0.795

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	1bpyA	MG	Rep, Mult	195,197
2	0.07	3	3dtuC	DXC	Rep, Mult	136,139,140,143,169,172
3	0.06	3	5ie9C	MN	Rep, Mult	168,171,172,195,198,199
4	0.02	1	2ia5C	MG	Rep, Mult	190,197
5	0.02	1	3wjoA	IPE	Rep, Mult	55,58,126
6	0.02	1	2wieA	CVM	Rep, Mult	167,170
7	0.02	1	3s8gA	OLC	Rep, Mult	102,106,137,138,140
8	0.02	1	3j0eG	NUC	Rep, Mult	70,73
9	0.02	1	3omiC	TRD	Rep, Mult	135,138,142
10	0.02	1	4o6mA	MPG	Rep, Mult	74,135,139
11	0.02	1	1qizD	RCO	Rep, Mult	102,103
12	0.02	1	1kprA	III	Rep, Mult	105,192
13	0.02	1	4c7rC	CM5	Rep, Mult	62,64,68,72
14	0.02	1	3fyeA	DMU	Rep, Mult	47,74,75,78,79,82
15	0.02	1	3syyA	MG	Rep, Mult	197,211,212
16	0.02	1	3odhA	CA	Rep, Mult	165,197
17	0.02	1	3slpA	CA	Rep, Mult	197,211

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1xmeA	0.527	5.67	0.050	0.825	1.9.3.1	NA
2	0.060	1b0pA	0.411	5.77	0.041	0.651	1.2.7.1	NA
3	0.060	2bixA	0.411	5.84	0.035	0.680	1.14.99.-	NA
4	0.060	1fbvA	0.453	5.02	0.085	0.647	6.3.2.19	NA
5	0.060	1no3A	0.407	6.37	0.055	0.703	1.13.11.12	NA
6	0.060	1m56A	0.492	5.78	0.054	0.799	1.9.3.1	NA
7	0.060	2pdaA	0.417	5.93	0.045	0.665	1.2.7.1	81
8	0.060	1mhsA	0.415	5.93	0.057	0.695	3.6.3.6	NA
9	0.060	3b8cB	0.403	6.13	0.047	0.669	3.6.3.6	79,108,177
10	0.060	3djlA	0.417	4.79	0.060	0.591	1.3.99.-	NA
11	0.060	1peuA	0.412	6.30	0.074	0.703	1.17.4.1	NA
12	0.060	3c66A	0.405	6.65	0.036	0.747	2.7.7.19	NA
13	0.060	1iduA	0.426	6.61	0.058	0.755	1.11.1.10	NA
14	0.060	1n1hA	0.423	5.91	0.060	0.688	2.7.7.48	145
15	0.060	3h0lA	0.403	6.14	0.050	0.662	6.3.5.-	NA
16	0.060	3b8eC	0.430	6.22	0.053	0.744	3.6.3.9	78,80,96,162
17	0.060	3ixzA	0.439	6.11	0.043	0.736	3.6.3.10	NA
18	0.060	1mo7A	0.271	6.33	0.051	0.476	3.6.3.9	50,80,142
19	0.060	2r7oA	0.404	5.68	0.050	0.639	2.7.7.48	73

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.28	0.492	5.78	0.05	0.80	1m56A	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
1	0.20	0.490	5.78	0.06	0.79	3o0rB	GO:0004129 GO:0005506 GO:0005886 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0016966 GO:0019333 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
2	0.18	0.496	5.73	0.05	0.80	1occA	GO:0004129 GO:0005506 GO:0005739 GO:0005743 GO:0006119 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0045277 GO:0046872 GO:0055114 GO:0070469 GO:1902600
3	0.07	0.499	5.69	0.04	0.79	5djqA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006119 GO:0009055 GO:0009060 GO:0015078 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016705 GO:0019411 GO:0019646 GO:0019825 GO:0020037 GO:0045154 GO:0045278 GO:0046872 GO:0055114 GO:0070069 GO:0070469 GO:0070470 GO:1902600
4	0.07	0.511	5.54	0.07	0.81	2yevA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015002 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0022904 GO:0046872 GO:0055114 GO:0070469 GO:1902600
5	0.07	0.481	5.93	0.04	0.80	1qleA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
6	0.07	0.349	5.20	0.03	0.51	5flzB	GO:0000226 GO:0000922 GO:0000923 GO:0000928 GO:0005200 GO:0005634 GO:0005737 GO:0005813 GO:0005815 GO:0005816 GO:0005822 GO:0005824 GO:0005856 GO:0005874 GO:0007020 GO:0007126 GO:0030472 GO:0031122 GO:0043015 GO:0051011 GO:0051298 GO:0051415 GO:0090307
7	0.07	0.531	5.67	0.05	0.83	3eh3A	GO:0004129 GO:0005506 GO:0005886 GO:0006119 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
8	0.06	0.510	5.67	0.05	0.82	1fftA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006811 GO:0009055 GO:0009060 GO:0009319 GO:0009486 GO:0015078 GO:0015453 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016682 GO:0019646 GO:0020037 GO:0046872 GO:0048039 GO:0055114 GO:0070469
9	0.06	0.514	4.15	0.08	0.67	3ripA	GO:0000226 GO:0000922 GO:0000923 GO:0000930 GO:0005200 GO:0005737 GO:0005813 GO:0005815 GO:0005816 GO:0005829 GO:0005856 GO:0005874 GO:0006461 GO:0007020 GO:0007126 GO:0008274 GO:0015630 GO:0016020 GO:0031122 GO:0043015 GO:0044732 GO:0051011 GO:0051298 GO:0051415 GO:0055037 GO:0090307
10	0.06	0.379	3.96	0.06	0.50	5flzA	GO:0000226 GO:0000922 GO:0000923 GO:0000928 GO:0005200 GO:0005634 GO:0005737 GO:0005813 GO:0005815 GO:0005816 GO:0005822 GO:0005824 GO:0005856 GO:0005874 GO:0007020 GO:0007126 GO:0031122 GO:0043015 GO:0051011 GO:0051298 GO:0051415 GO:0090307
11	0.06	0.337	5.70	0.04	0.55	3mm5B	GO:0006790 GO:0009055 GO:0016020 GO:0016491 GO:0018551 GO:0020037 GO:0046872 GO:0051536 GO:0051539 GO:0055114
12	0.06	0.304	6.88	0.06	0.57	3ga7A	GO:0005737 GO:0008152 GO:0016787 GO:0052689
13	0.06	0.314	6.11	0.03	0.53	2p5oB	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0039693 GO:0071897 GO:0090305
14	0.06	0.260	6.72	0.03	0.49	3v7pA	GO:0009234 GO:0016787 GO:0016810 GO:0046872
15	0.06	0.263	6.11	0.03	0.43	5ekqD	GO:0009279 GO:0016020 GO:0043165 GO:0051205 GO:1990063
16	0.06	0.325	6.24	0.03	0.57	3gdeA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0006260 GO:0006281 GO:0006310 GO:0006974 GO:0007049 GO:0016874 GO:0046872 GO:0051103 GO:0051301 GO:0071897
17	0.06	0.257	3.09	0.07	0.31	4iwbA	GO:0044780
18	0.06	0.242	5.17	0.06	0.35	2wgbB	GO:0003677 GO:0006351 GO:0006355

Consensus prediction of GO terms

Molecular Function	GO:0004129	GO:0020037	GO:0005506	GO:0016662	GO:0005507
GO-Score	0.59	0.59	0.59	0.41	0.37
Biological Processes	GO:0009060	GO:1902600	GO:0006119	GO:0071941	GO:0022900
GO-Score	0.59	0.59	0.48	0.41	0.33
Cellular Component	GO:0016021	GO:0005886	GO:0098803	GO:0070069	GO:0031966	GO:0019866
GO-Score	0.59	0.50	0.36	0.36	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.