I-TASSER results

I-TASSER results for job id Rv3277

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (272 residues)
MNEVTAGVRELATAIMVSRHLTGVLAGHGSQTVTYHFASILCSSVHSLVVSFADATIARL
PGVVQPYAQRHHELIKFAIVGGTTFIIDTAIFYTLKLTVLEPKPVTAKVIAGIVAVIASY
VLNREWSFRDRGGRERHHEALLFFAFSGVGVLLSMAPLWFSSYILQLRVPTVSLTMENIA
DFISAYIIGNLLQMAFRFWAFRRWVFPDEFARNPDKALESALTAGGIAEVFEDVLEGGFE
DGNVTLLRAWRNRANRFAQLGDSSEPRVSKTS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MNEVTAGVRELATAIMVSRHLTGVLAGHGSQTVTYHFASILCSSVHSLVVSFADATIARLPGVVQPYAQRHHELIKFAIVGGTTFIIDTAIFYTLKLTVLEPKPVTAKVIAGIVAVIASYVLNREWSFRDRGGRERHHEALLFFAFSGVGVLLSMAPLWFSSYILQLRVPTVSLTMENIADFISAYIIGNLLQMAFRFWAFRRWVFPDEFARNPDKALESALTAGGIAEVFEDVLEGGFEDGNVTLLRAWRNRANRFAQLGDSSEPRVSKTS
Prediction	CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	97567889988875555544444345667656888865444555444679999999998555667789999999999999999999999999999998657757999999999999999999843565568997589999999999999999999999999998776654556677789999999999999999999999834566787778876556666677777766665667777777766666667777777778888888888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MNEVTAGVRELATAIMVSRHLTGVLAGHGSQTVTYHFASILCSSVHSLVVSFADATIARLPGVVQPYAQRHHELIKFAIVGGTTFIIDTAIFYTLKLTVLEPKPVTAKVIAGIVAVIASYVLNREWSFRDRGGRERHHEALLFFAFSGVGVLLSMAPLWFSSYILQLRVPTVSLTMENIADFISAYIIGNLLQMAFRFWAFRRWVFPDEFARNPDKALESALTAGGIAEVFEDVLEGGFEDGNVTLLRAWRNRANRFAQLGDSSEPRVSKTS
Prediction	75402400330232122334343134243434131423241343033202420430053134224412520210111131321023113201201212334331230010012102220120022003434644420210020211021112313112121111111322313213333032111332112213231333212001465456646544654455663463356445445663444445444445544553555755545658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MNEVTAGVRELATAIMVSRHLTGVLAGHGSQTVTYHFASILCSSVHSLVVSFADATIARLPGVVQPYAQRHHELIKFAIVGGTTFIIDTAIFYTLKLTVLEPKPVTAKVIAGIVAVIASYVLNREWSFRDRGGRERHHEALLFFAFSGVGVLLSMAPLWFSSYILQLRVPTVSLTMENIADFISAYIIGNLLQMAFRFWAFRRWVFPDEFARNPDKALESALTAGGIAEVFEDVLEGGFEDGNVTLLRAWRNRANRFAQLGDSSEPRVSKTS

4hzuS

0.14

0.07

0.53

1.00

wPPAS

--------------------------------------MTKGSLKENTIAAVLIAMTVALSILLCEVGIYTSAIL---RMGLLVGGASGFLIDILT---YPVWCLFSLVIHGTQGLVVGWLLPR----HHKG-------IRSMLLPLLVGSLVMVIGYCLATTLL------WPAGLASIFGNVVQVGFGAGVTLSIVGPLTR--LKPD----------------------------------------------------------------

4ke2A

0.10

0.07

0.71

1.42

dPPAS2

IDPAARAAAAAAASKAAVTAADAAAAAATIAAS----AASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATT-----AAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------------------------------------------------

5kbwA

0.08

0.05

0.57

1.16

dPPAS2

---------------------------------------------SSIKKISFVGIFSALATLVMFLESEIPALIVSFLLGPGVGMFVVLVKDILFFLMKSGDGIAMNAVLGMSFVGIAGLIYHR------NKSRATAIKGMIVATLFATAFALGLNALIVPLYFEAPFELYLKFFPFILAFNLVKFGIDSVVTFFVYKKVSSIL-------------------------------------------------------------------

4o6yA

0.08

0.06

0.71

1.11

dPPAS2

VVRVLGFIIAALVLTWTVHYRGGLALSSDNKDHIFNVHP-VMMVIGLILFNGEAMLAYKSVQGTKNLKKLVHLTLQLTAFILSLIGVWAALKFHIDKGIENFYLGLACLFLFAFQWAAGFVTYWY---PGGSRNASLMPWHVFLGISIYALALVTATTGILEKVTFLRYSTEAMLVNTMGVLILILGGFVILGVVT----------------------------------------------------------------------------

3wxvA

0.10

0.08

0.79

1.10

dPPAS2

GNIWTHLLGFVLFLFLGILTMLRMYFMAPL--------QEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQ----WDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAE---GFVKATTVMGWFFLMAVMYITGAGLYAAR----------------IPERFFPGKFDIWFQSNLQEFRYGLEGGCTDDT---------------------------

4bwzA2

0.07

0.05

0.69

1.09

dPPAS2

VALPFLGGYLYGLEIGFETLPALFLGT-------------ALVATSVGITARVLQELGVLSRPYSRIILGAAVIDDVLGLIVLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFL--------GALTQGVRSALTVGCGMAPRGEVGLIVAALGLKAGAVNEEEYAIVLFMVVFTTLFAPFALKPLIAWTER-----ERAAKE-----------------------------------------------------------

4wisA

0.09

0.97

0.83

MUSTER

HPFLNFWRATAQTLTFSEKELPTREFQINPARISNQMFYFTVTAQIVNFATEVVVPYIKQQAFQAEFLQRVREECTYDVSGDYREMVMQFGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISSR-IPWRTDSIGPWLTALSFLSWLGSITSSAIVYLCSNASPL------KAWGLLLSILFAEHFYLVVQLAVRFVLSKSPGLQKERKERFQTKKRLLQENLGQDAAAAPGIEHSEKITREALEEEARQAMFWQRQRGMQETIEIGRRM

4ke2A

0.10

0.07

0.71

0.85

dPPAS

IDPAARAAAAAAASKAAVTAADAAAAAATIAAS----AASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATT-----AAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------------------------------------------------

5kbwA

0.10

0.06

0.56

0.94

wdPPAS

---------------------------------------------SSIKKISFVGIFSALATLVMFLESEIPALIVSFLLGPGVGMFVVLVKDILFFLMKSGDGIAMNAVLGMSFVGIAGLIYHR--------NKSRATAIKGMIVATLFATAFALGLNALIVPLYFEAP-FELYLKFFPFILAFNLVKFGIDSVVTFFVYKKIL-------------------------------------------------------------------

5b43A3

0.10

0.09

0.90

0.85

wMUSTER

IDRIYKTYADQCLQLVQLDLSAAIDSYRKEKTE--ETRNALIEEQATYRNAIHDYFIGRTDNLTDAINKRHAEIYKGL--------FKAELFNGKVLKQLTTTEHENALLRSFTTYFSGFYENRKNVFSAEDISRIVQDNFPKFKENCHIFTRLITAVPSLREHFEIGIFVSTSIEEVFSFPFYNQLLTQTQIDLYNQLLG---ISRE----------AGTEKIKGLNEVLNLAIQKNDETAHIIASLPHRFIPLFKQILSDRN--TLSFI-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.88

Estimated TM-score = 0.30±0.10

Estimated RMSD = 15.5±3.3Å

Download Model 2

C-score=-4.40

Download Model 3

C-score=-4.46

Download Model 4

C-score=-4.35

Download Model 5

C-score=-4.78

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4ke2A	0.606	3.05	0.104	0.706
2	1jadA	0.505	4.13	0.057	0.654
3	4dylA1	0.481	4.95	0.081	0.691
4	1vw1A	0.478	4.82	0.050	0.684
5	1ciiA	0.476	4.89	0.034	0.688
6	4tqlA	0.472	3.55	0.059	0.581
7	2w6dA	0.470	4.55	0.072	0.662
8	1f5nA	0.463	5.29	0.059	0.684
9	4mu6A	0.457	4.17	0.029	0.592
10	4gnkE	0.454	4.36	0.040	0.592

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1gzlA	III	Rep, Mult	73,74,77,80,81,84
2	0.04	2	3mylX	POP	Rep, Mult	82,83,84,87,88,89,121
3	0.04	2	1y66A	DIO	Rep, Mult	150,153,154
4	0.04	2	4zzbC	XE	Rep, Mult	86,117,120
5	0.04	2	1cviC	UUU	Rep, Mult	121,123
6	0.04	2	3ffzA	NA	Rep, Mult	93,94,110,111,113,114
7	0.02	1	2bq8X	ZN	Rep, Mult	177,181
8	0.02	1	2xctS	CPF	Rep, Mult	131,132
9	0.02	1	2yktA	III	Rep, Mult	71,74,75,77,78,135,136,137,139,143
10	0.02	1	1jb0M	CLA	Rep, Mult	107,111
11	0.02	1	1kgpC	MN	Rep, Mult	135,139
12	0.02	1	1lghA	BCL	Rep, Mult	107,110,111,114,115,128
13	0.02	1	1zww0	III	Rep, Mult	2,3,6,13,167,168,170,171,174,175,177,178,181,182,185,186,188,189,192,193,195,196,199,202,203
14	0.02	1	2q6qA	CO	Rep, Mult	69,73
15	0.02	1	1qiyL	IPH	Rep, Mult	192,195
16	0.02	1	4amiA	2CV	Rep, Mult	75,79
17	0.02	1	1zx1A	CB1	Rep, Mult	17,77
18	0.02	1	3qmkB	SO4	Rep, Mult	68,140,144
19	0.02	1	4n78F	III	Rep, Mult	197,201,205

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1clqA	0.337	5.68	0.029	0.540	2.7.7.7	202
2	0.060	3btaA	0.399	4.37	0.036	0.540	3.4.24.69	NA
3	0.060	3djlA	0.345	5.40	0.073	0.507	1.3.99.-	NA
4	0.060	3g61A	0.414	4.80	0.031	0.559	3.6.3.44	75
5	0.060	2pmzQ	0.259	6.34	0.058	0.449	2.7.7.6	93
6	0.060	2pffA	0.354	5.18	0.038	0.526	2.3.1.41,2.3.1.86	NA
7	0.060	1is2A	0.357	5.18	0.044	0.533	1.3.3.6	85
8	0.060	1serB	0.285	6.60	0.056	0.518	6.1.1.11	NA
9	0.060	1h7aA	0.357	5.58	0.075	0.555	1.17.4.2	NA
10	0.060	1e6yE	0.332	5.33	0.056	0.511	2.8.4.1	NA
11	0.060	3h0gA	0.352	5.82	0.060	0.559	2.7.7.6	191
12	0.060	1mhsA	0.427	5.84	0.050	0.699	3.6.3.6	NA
13	0.060	1z0hB	0.223	6.40	0.037	0.393	3.4.24.69	NA
14	0.060	2du3A	0.347	6.20	0.049	0.599	6.1.1.27	NA
15	0.060	1zvuA	0.357	5.72	0.031	0.555	5.99.1.-	NA
16	0.060	3errA	0.337	6.63	0.051	0.607	6.1.1.11	NA
17	0.060	2ohyB	0.310	5.74	0.050	0.478	5.4.3.6	NA
18	0.060	2np0A	0.408	4.40	0.046	0.548	3.4.24.69	NA
19	0.060	1mo7A	0.172	5.81	0.057	0.287	3.6.3.9	82

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.454	4.36	0.04	0.59	4gnkE	GO:0003073 GO:0004435 GO:0004629 GO:0004871 GO:0005509 GO:0005516 GO:0005654 GO:0005829 GO:0005913 GO:0006629 GO:0006892 GO:0007165 GO:0007186 GO:0007223 GO:0007268 GO:0008081 GO:0016020 GO:0016042 GO:0016787 GO:0035556 GO:0042383 GO:0043234 GO:0043647 GO:0098609 GO:0098641
1	0.07	0.515	4.22	0.06	0.67	1jadA	GO:0004435 GO:0004629 GO:0004871 GO:0005509 GO:0005829 GO:0006629 GO:0007165 GO:0008081 GO:0016042 GO:0016787 GO:0035556
2	0.06	0.460	4.73	0.03	0.65	4dylA	GO:0000166 GO:0001578 GO:0004672 GO:0004713 GO:0004715 GO:0005524 GO:0005737 GO:0005794 GO:0005829 GO:0005856 GO:0005886 GO:0005925 GO:0006468 GO:0006935 GO:0007173 GO:0007275 GO:0008017 GO:0008283 GO:0008289 GO:0008360 GO:0010976 GO:0015630 GO:0016020 GO:0016023 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0030054 GO:0030155 GO:0031116 GO:0031234 GO:0031410 GO:0034987 GO:0035091 GO:0038083 GO:0042127 GO:0043304 GO:0045087 GO:0045595 GO:0045639 GO:0046777 GO:0051297 GO:0060627 GO:2000145 GO:2000251
3	0.06	0.241	6.85	0.02	0.45	1m1cA	GO:0019012 GO:0019028
4	0.06	0.278	5.27	0.02	0.41	3cfoA	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0039693 GO:0071897 GO:0090305
5	0.06	0.191	6.46	0.02	0.33	3wsyA	GO:0000042 GO:0001540 GO:0004888 GO:0005576 GO:0005615 GO:0005641 GO:0005768 GO:0005769 GO:0005783 GO:0005794 GO:0005802 GO:0005887 GO:0006605 GO:0006622 GO:0006629 GO:0006810 GO:0006869 GO:0006892 GO:0006897 GO:0006898 GO:0007165 GO:0008202 GO:0008203 GO:0014910 GO:0016020 GO:0016021 GO:0030169 GO:0030306 GO:0031985 GO:0032091 GO:0032460 GO:0034362 GO:0043407 GO:0045053 GO:0045732 GO:0050768 GO:0051604 GO:0055037 GO:0070062 GO:0070863 GO:1901215 GO:1902430 GO:1902771 GO:1902948 GO:1902953 GO:1902955 GO:1902960 GO:1902963 GO:1902966 GO:1902997 GO:2001137
6	0.06	0.269	5.37	0.04	0.41	3vz2B	GO:0000166 GO:0008152 GO:0016491 GO:0016620 GO:0055114
7	0.06	0.230	5.27	0.04	0.35	4mjtA	GO:0046872
8	0.06	0.202	3.61	0.03	0.25	4ug1B	GO:0005737 GO:0007049 GO:0008360 GO:0051301
9	0.06	0.242	6.68	0.06	0.43	5d0uA	GO:0000166 GO:0003676 GO:0004386 GO:0005524 GO:0008026 GO:0016787
10	0.06	0.187	6.55	0.05	0.33	4f8xA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0045493
11	0.06	0.248	6.33	0.07	0.44	2y51A	GO:0000166 GO:0008152 GO:0016491 GO:0016620 GO:0055114
12	0.06	0.206	5.32	0.04	0.33	2wm9A	GO:0005085 GO:0005829 GO:0005913 GO:0007264 GO:0007596 GO:0012505 GO:0016020 GO:0043547 GO:0098609 GO:0098641
13	0.06	0.189	6.87	0.04	0.34	4k6nA	GO:0003824 GO:0004084 GO:0005737 GO:0006532 GO:0008152 GO:0008696 GO:0009098 GO:0009099 GO:0016829 GO:0030170 GO:0046654 GO:0046656
14	0.06	0.194	5.06	0.08	0.27	4xydB	GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0016966 GO:0020037 GO:0055114
15	0.06	0.191	6.08	0.06	0.33	2qv7A	GO:0000166 GO:0003951 GO:0004143 GO:0005524 GO:0006629 GO:0008152 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046872
16	0.06	0.190	5.48	0.02	0.29	2i79A	GO:0008080 GO:0016740
17	0.06	0.226	6.00	0.07	0.38	3gb8A	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0007062 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0016032 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0043488 GO:0046825 GO:0051028 GO:0075733
18	0.06	0.214	5.93	0.01	0.35	3gjxA	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005487 GO:0005634 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0046825 GO:0051028

Consensus prediction of GO terms

Molecular Function	GO:0005509	GO:0004435	GO:0004871	GO:0098641	GO:0005516	GO:0004715	GO:0035091	GO:0008017	GO:0034987	GO:0005524	GO:0008408	GO:0003677	GO:0003887
GO-Score	0.13	0.13	0.13	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.06	0.06	0.06
Biological Processes	GO:0035556	GO:0016042	GO:0003073	GO:0006892	GO:0098609	GO:0007186	GO:0007223	GO:0043647	GO:0007268	GO:0010976	GO:0045087	GO:2000251	GO:0043304	GO:0006935	GO:0045639	GO:0051297	GO:0030155	GO:0007173	GO:0031116	GO:0001578	GO:0008360	GO:0042127	GO:0038083	GO:2000145	GO:0039693	GO:0071897	GO:0090305
GO-Score	0.13	0.13	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.06	0.06	0.06
Cellular Component	GO:0044444
GO-Score	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.