I-TASSER results

I-TASSER results for job id Rv3271c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (222 residues)
METTTEHRDESTLDSPVSVAREAEWQRNVRWARWLAWVSLAVLLTEGAVGLWQGIAVGSV
ALTGWALGGGSEGLASAMVLWRFTGDRTWSATAEHRAQRGVAVSFWLTAPYLVAESIRHL
AGEHRAETSVIGIGLTAIALLLMPVLGWANHRVGERLGSGATAGEGTQNYLCAAQAAAVL
LGLAITAVWSNGWWIDPAIGLAIAGIAVWQGIRTWRGHGCGC

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| METTTEHRDESTLDSPVSVAREAEWQRNVRWARWLAWVSLAVLLTEGAVGLWQGIAVGSVALTGWALGGGSEGLASAMVLWRFTGDRTWSATAEHRAQRGVAVSFWLTAPYLVAESIRHLAGEHRAETSVIGIGLTAIALLLMPVLGWANHRVGERLGSGATAGEGTQNYLCAAQAAAVLLGLAITAVWSNGWWIDPAIGLAIAGIAVWQGIRTWRGHGCGC
Prediction	CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
Conf.Score	998877777777777777667689999999999999999999999999999999998567999999999999999999999997488898764668899999999999999999999999789898864799999999999999999999999998899899999999999999999999999999997575789999999999999999999997888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| METTTEHRDESTLDSPVSVAREAEWQRNVRWARWLAWVSLAVLLTEGAVGLWQGIAVGSVALTGWALGGGSEGLASAMVLWRFTGDRTWSATAEHRAQRGVAVSFWLTAPYLVAESIRHLAGEHRAETSVIGIGLTAIALLLMPVLGWANHRVGERLGSGATAGEGTQNYLCAAQAAAVLLGLAITAVWSNGWWIDPAIGLAIAGIAVWQGIRTWRGHGCGC
Prediction	674556447544365644464555245123202200121133133333313321331323013122311201231121000001335455742431012011221333132113200320144441423211122133033312212300331045361400301031230013112113212231333343131112102200210231003103455177
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
METTTEHRDESTLDSPVSVAREAEWQRNVRWARWLAWVSLAVLLTEGAVGLWQGIAVGSVALTGWALGGGSEGLASAMVLWRFTGDRTWSATAEHRAQRGVAVSFWLTAPYLVAESIRHLAGEHRAETSVIGIGLTAIALLLMPVLGWANHRVGERLGSGATAGEGTQNYLCAAQAAAVLLGLAITAVWSNGWWIDPAIGLAIAGIAVWQGIRTWRGHGCGC

3j1zP1

0.20

0.18

0.90

2.22

MUSTER

MTQTSQYD---------------------FWVKLASRASVATALTLITIKLLAWLYSGSASMLASLTDSFADTLASIINFIAIRYARYGHGKAEPLAALAQSAFIMGSAFLLLFYGGERLLNPSPVENATLGVVVSVVAIVLTLALVLLQKRALAATNSTVVEADSLHYKSDLFLNAAVLLALVLS--QYGWWWADGLFAVLIACYIGQQAFDLGYRSIQAL

3j1zP1

0.19

0.17

0.90

1.82

dPPAS

------------MTQTSQYDF---------WVKLASRASVATALTLITIKLLAWLYSGSASMLASLTDSFADTLASIINFIAIRYARYGHGKAEPLAALAQSAFIMGSAFLLLFYGGERLLNPSPVENATLGVVVSVVAIVLTLALVLLQKRALAATNSTVVEADSLHYKSDLFLNAAVLLALVLS--QYGWWWADGLFAVLIACYIGQQAFDLGYRSIQAL

3j1zP1

0.19

0.17

0.88

3.34

wdPPAS

MTQTSQYDFWVK---------------------LASRASVATALTLITIKLLAWLYSGSASMLASLTDSFADTLASIINFIAIRY-RYGHGKAEPLAALAQSAFIMGSAFLLLFYGGERLLNPSPVENATLGVVVSVVAIVLTLALVLLQKRALAATNSTVVEADSLHYKSDLFLNAAVLLALVLS--QYGWWWADGLFAVLIACYIGQQAFDLGYRSI---

3j1zP1

0.19

0.17

0.90

3.12

wMUSTER

---------------------MTQTSQYDFWVKLASRASVATALTLITIKLLAWLYSGSASMLASLTDSFADTLASIINFIAIRYARYGHGKAEPLAALAQSAFIMGSAFLLLFYGGERLLNPSPVENATLGVVVSVVAIVLTLALVLLQKRALAATNSTVVEADSLHYKSDLFLNAAVLLALVLS--QYGWWWADGLFAVLIACYIGQQAFDLGYRSIQAL

3j1zP1

0.20

0.18

0.88

4.65

wPPAS

MTQTSQYD---------------------FWVKLASRASVATALTLITIKLLAWLYSGSASMLASLTDSFADTLASIINFIAIRY-RYGHGKAEPLAALAQSAFIMGSAFLLLFYGGERLLNPSPVENATLGVVVSVVAIVLTLALVLLQKRALAATNSTVVEADSLHYKSDLFLNAAVLLALVLS--QYGWWWADGLFAVLIACYIGQQAFDLGYRSI---

3j1zP1

0.19

0.17

0.88

4.40

dPPAS2

------------MTQTSQYDF---------WVKLASRASVATALTLITIKLLAWLYSGSASMLASLTDSFADTLASIINFIAIRYARYGHGKAEPLAALAQSAFIMGSAFLLLFYGGERLLNPSPVENATLGVVVSVVAIVLTLALVLLQKRALAATNSTVVEADSLHYKSDLFLNAAVLLALVLS--QYGWWWADGLFAVLIACYIGQQAFDLGYRSI---

3j1zP1

0.20

0.18

0.87

3.36

PPAS

MTQTSQYD---------------------FWVKLASRASVATALTLITIKLLAWLYSGSASMLASLTDSFADTLASIINFIAIRY-RYGHGKAEPLAALAQSAFIMGSAFLLLFYGGERLLNPSPVENATLGVVVSVVAIVLTLALVLLQKRALAATNSTVVEADSLHYKSDLFLNAAVLLALVLS--QYGWWWADGLFAVLIACYIGQQAFDLGYRS----

3j1zP1

0.20

0.18

0.90

5.89

Env-PPAS

MTQTSQYD---------------------FWVKLASRASVATALTLITIKLLAWLYSGSASMLASLTDSFADTLASIINFIAIRYARYGHGKAEPLAALAQSAFIMGSAFLLLFYGGERLLNPSPVENATLGVVVSVVAIVLTLALVLLQKRALAATNSTVVEADSLHYKSDLFLNAAVLLALVLS--QYGWWWADGLFAVLIACYIGQQAFDLGYRSIQAL

2qfiA1

0.18

0.16

0.87

1.81

MUSTER

---------------------------YGRLVSRAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASLTNLLVVRYSLQGHGKAESLAALAQSMFISGSALFLFLTGIQHLISPTPMTDPGVGVIVTIVALICTIILVSFQRWVVRRTQSQAVRADMLHYQSDVMMNGAILLALGLS--WYGWHRADALFALGIGIYILYSALRMGYEAVQSL

2qfiA1

0.18

0.16

0.87

1.34

dPPAS

---------------------------YGRLVSRAAIAATAMASLLLLIKIFAWWYTGSVSILAALVDSLVDIGASLTNLLVVRNHSFGHGKAESLAALAQSMFISGSALFLFLTGIQHLISPTPMTDPGVGVIVTIVALICTIILVSFQRWVVRRTQSQAVRADMLHYQSDVMMNGAILLALGLS--WYGWHRADALFALGIGIYILYSALRMGYEAVQSL

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.12

Estimated TM-score = 0.73±0.11

Estimated RMSD = 5.3±3.4Å

Download Model 2

C-score=-1.40

Download Model 3

C-score=0.22

Download Model 4

C-score=-1.42

Download Model 5

C-score=-2.86

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3j1zP	0.865	1.11	0.191	0.896
2	2qfiA1	0.578	3.99	0.127	0.806
3	4a01A	0.543	4.95	0.075	0.820
4	4av3A	0.514	5.47	0.057	0.829
5	3ahqA	0.498	5.43	0.052	0.793
6	1rp4A	0.496	5.78	0.024	0.860
7	4j72A	0.494	4.59	0.063	0.721
8	4wj1A	0.489	4.49	0.069	0.703
9	3ayfA2	0.487	5.36	0.051	0.779
10	2yevA3	0.484	4.74	0.046	0.703

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	3	3es3A	AU	Rep, Mult	72,168,172
2	0.08	3	3e2cB	EDO	Rep, Mult	40,43,44,80,146,150,165,169
3	0.08	3	1bfrA	MN	Rep, Mult	51,73,143,169,172
4	0.08	3	4zttC	OXY	Rep, Mult	44,73,76,143,146,169,172
5	0.06	2	4ittB	FE	Rep, Mult	54,65,68,69,140,175
6	0.03	1	3h90A	ZN	Rep, Mult	86,90
7	0.03	1	2qfiB	ZN	Rep, Mult	176,179,196,203
8	0.03	1	3rkoN	LFA	Rep, Mult	143,146,147,150,172,173
9	0.03	1	3gaiA	B12	Rep, Mult	82,86,94,95,98

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1uzrB	0.459	5.15	0.076	0.712	1.17.4.1	NA
2	0.060	1frvB	0.466	4.84	0.095	0.707	1.12.2.1	NA
3	0.060	3e6sF	0.436	3.39	0.078	0.545	1.16.3.1	49,51,67
4	0.060	2idxC	0.464	4.17	0.075	0.644	2.5.1.17	139
5	0.060	2occN	0.440	5.74	0.060	0.752	1.9.3.1	NA
6	0.060	1h2aL	0.464	4.90	0.071	0.707	1.12.2.1	NA
7	0.060	1biqB	0.471	4.99	0.051	0.725	1.17.4.1	NA
8	0.060	1rsrB	0.473	5.01	0.051	0.730	1.17.4.1	NA
9	0.060	3a68R	0.461	3.40	0.051	0.568	1.16.3.1	146
10	0.060	1yfmA	0.460	4.90	0.071	0.680	4.2.1.2	NA
11	0.060	1i0aA	0.368	5.35	0.089	0.595	4.3.2.1	NA
12	0.060	1occA	0.442	5.87	0.060	0.761	1.9.3.1	NA
13	0.060	2g2dA	0.444	4.22	0.059	0.604	2.5.1.17	145
14	0.060	1h2rL	0.464	4.90	0.071	0.707	1.12.2.1	NA
15	0.060	1tj7A	0.443	4.47	0.058	0.649	4.3.2.1	NA
16	0.060	3e04D	0.450	4.60	0.065	0.658	4.2.1.2	NA
17	0.060	2pfmA	0.444	4.66	0.063	0.649	4.3.2.2	NA
18	0.060	1f1oA	0.419	5.04	0.045	0.640	4.3.2.2	NA
19	0.060	1yrqI	0.465	4.85	0.077	0.703	1.12.2.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.865	1.11	0.19	0.90	3j1zP	GO:0005886 GO:0006810 GO:0006812 GO:0008324 GO:0010043 GO:0015086 GO:0015093 GO:0015341 GO:0015684 GO:0016020 GO:0016021 GO:0055085 GO:0061088 GO:0070574 GO:0071577 GO:1903874
1	0.09	0.572	4.12	0.10	0.81	2qfiA	GO:0005215 GO:0005886 GO:0006810 GO:0006811 GO:0006812 GO:0006829 GO:0006876 GO:0006882 GO:0008324 GO:0010043 GO:0015086 GO:0015093 GO:0015341 GO:0015684 GO:0015691 GO:0016020 GO:0016021 GO:0046873 GO:0055072 GO:0055085 GO:0061088 GO:0070574 GO:0071577 GO:0098655 GO:1903874
2	0.07	0.543	4.95	0.07	0.82	4a01A	GO:0004427 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0009678 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0055085
3	0.07	0.515	5.15	0.07	0.81	4av6A	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
4	0.07	0.530	5.22	0.10	0.84	4av3B	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
5	0.06	0.317	5.80	0.04	0.55	5bv7A	GO:0004607 GO:0004623 GO:0005576 GO:0005615 GO:0006629 GO:0006644 GO:0006656 GO:0008202 GO:0008203 GO:0008374 GO:0016740 GO:0016746 GO:0030301 GO:0034186 GO:0034364 GO:0034372 GO:0034375 GO:0034435 GO:0042157 GO:0042158 GO:0042632 GO:0043691 GO:0046470 GO:0046688 GO:0051384 GO:0070062 GO:0090107
6	0.06	0.320	5.51	0.04	0.50	3l0mA	GO:0000166 GO:0003824 GO:0005085 GO:0005524 GO:0005576 GO:0005622 GO:0006612 GO:0008152 GO:0008289 GO:0009405 GO:0016020 GO:0016740 GO:0016779 GO:0017137 GO:0018117 GO:0018260 GO:0033644 GO:0043087 GO:0043547 GO:0044161 GO:0044162 GO:0044600 GO:0070273 GO:0070733
7	0.06	0.322	4.96	0.08	0.50	3k5pA	GO:0004617 GO:0006564 GO:0008152 GO:0016491 GO:0016597 GO:0016616 GO:0051287 GO:0055114
8	0.06	0.310	4.98	0.05	0.46	3l0iC	GO:0000166 GO:0003824 GO:0005085 GO:0005524 GO:0005576 GO:0005622 GO:0006612 GO:0008152 GO:0008289 GO:0009405 GO:0016020 GO:0016740 GO:0016779 GO:0017137 GO:0018117 GO:0018260 GO:0033644 GO:0043087 GO:0043547 GO:0044161 GO:0044162 GO:0044600 GO:0070273 GO:0070733
9	0.06	0.281	6.48	0.06	0.53	3v76A	GO:0016491 GO:0055114
10	0.06	0.274	4.71	0.07	0.41	2ipaB	GO:0004725 GO:0016491 GO:0016787 GO:0030612 GO:0035335 GO:0046685 GO:0055114
11	0.06	0.262	6.03	0.03	0.46	5b6oA	GO:0000166 GO:0000175 GO:0001172 GO:0003676 GO:0003723 GO:0003725 GO:0003727 GO:0003968 GO:0004197 GO:0004386 GO:0004482 GO:0004483 GO:0004518 GO:0004519 GO:0004527 GO:0005524 GO:0006351 GO:0006370 GO:0006508 GO:0008168 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0016788 GO:0016817 GO:0016896 GO:0019079 GO:0019082 GO:0019083 GO:0030430 GO:0030683 GO:0032259 GO:0033644 GO:0036265 GO:0036459 GO:0039502 GO:0039503 GO:0039519 GO:0039520 GO:0039549 GO:0039579 GO:0039595 GO:0039604 GO:0039644 GO:0039648 GO:0039657 GO:0039690 GO:0039694 GO:0039714 GO:0044172 GO:0044220 GO:0046872 GO:0071108 GO:0080009 GO:0090305 GO:0090503 GO:1990380 GO:2000158
12	0.06	0.193	4.69	0.02	0.29	3k3cA	GO:0000155 GO:0000160 GO:0000287 GO:0003824 GO:0004035 GO:0005622 GO:0006355 GO:0016311 GO:0016791 GO:0023014 GO:0030145
13	0.06	0.266	6.51	0.04	0.51	4gmvB	GO:0005737 GO:0005856 GO:0005886 GO:0007165 GO:0016020 GO:0030027 GO:0030175 GO:0031252 GO:0042995 GO:0048675
14	0.06	0.271	6.05	0.06	0.49	2wlkA	GO:0005242 GO:0005244 GO:0006810 GO:0006811 GO:0006813 GO:0016020 GO:0016021 GO:0034765 GO:0071805
15	0.06	0.213	4.61	0.03	0.31	1vipA	GO:0004623 GO:0005509 GO:0005576 GO:0006629 GO:0016042 GO:0016787 GO:0046872
16	0.06	0.234	4.53	0.05	0.33	1flcB	GO:0001681 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0016788 GO:0019012 GO:0019031 GO:0019062 GO:0019064 GO:0020002 GO:0033644 GO:0039654 GO:0039663 GO:0046718 GO:0046789 GO:0055036
17	0.06	0.211	4.34	0.05	0.30	2zztA	GO:0005385 GO:0005886 GO:0006810 GO:0006812 GO:0008324 GO:0010043 GO:0016020 GO:0016021 GO:0055085 GO:0061088 GO:0071577 GO:0098655
18	0.06	0.195	3.98	0.08	0.26	3byrA	GO:0005886 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0046872 GO:0055085 GO:0098655

Consensus prediction of GO terms

Molecular Function	GO:0015341	GO:0015093	GO:0015086	GO:0016462	GO:0043169	GO:0015405
GO-Score	0.40	0.40	0.40	0.37	0.37	0.37
Biological Processes	GO:0070574	GO:0071577	GO:0061088	GO:0010043	GO:1903874	GO:0015672	GO:0006818
GO-Score	0.40	0.40	0.40	0.40	0.40	0.37	0.37
Cellular Component	GO:0016021	GO:0005886
GO-Score	0.51	0.48

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.