I-TASSER results

I-TASSER results for job id Rv3267

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (498 residues)
MMSAQRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIFHMSAPSLGHGGDDGAI
DILLVGLDSRTDAHGNPLSAEELATLHAGDEEATNTDTIILIRVPNNGKSATAISIPRDS
YVAAPGLGKTKINGVYGQTRETKRAGLVQAGASPTEAAAAGTEAGREALIKTVADLTGVT
VDHYAEIGLLGFALIADALGGVDVCLKEPVYEPLSGADFPAGRQKLNGPQALSFVRQRHD
LPRGDLDRVVRQQAVMAALAHRVISGQTLSSPATLKRLEQAVQRSVVLSSGWDIMDFVRQ
LQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVDPRQVQDWVVGLLHEQDQGKTDELAYT
PAKTTANVVNDTDINGLAAAVSKVLSSKGFTTGSVGNNDGDHVPGSQVRAAKADDLGAQQ
VAKELGGLPVVADASIAPGSVRVVLANDYSGPGSGLGGSDPNGVVSPARAFNLGSADDTT
PPPSPILTAGSDAPECIN

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MMSAQRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIFHMSAPSLGHGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATNTDTIILIRVPNNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTRETKRAGLVQAGASPTEAAAAGTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIADALGGVDVCLKEPVYEPLSGADFPAGRQKLNGPQALSFVRQRHDLPRGDLDRVVRQQAVMAALAHRVISGQTLSSPATLKRLEQAVQRSVVLSSGWDIMDFVRQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVDPRQVQDWVVGLLHEQDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTTGSVGNNDGDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLANDYSGPGSGLGGSDPNGVVSPARAFNLGSADDTTPPPSPILTAGSDAPECIN
Prediction	CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEHCCCCCCHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEHCHHHHHHHHHHHCCEEHCCCCCCCCCCCCCCCCCCEEHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHCCCHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCCCCCCEEEEEEHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHCCEEEHCCCCCCCCCCEEEEEHCCCCHHHHHHHHHHHCCCCEEHCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	998778876478999999999999999999999999998756654456777888888886899999855899888887656665456788888876589999995999989999976887765799988876544456655545445566776456677666658999999999998999874899867999999988687898579998778889878897577799999999998648999978999999999999999998668777999999999998755455776789999999976888877999985788887656885789997999999999999756888888888899875699998699998689999999999899577568889887655899978998999999999979975676688888779999968888888888888888888887778888888888888878788889998899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MMSAQRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIFHMSAPSLGHGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATNTDTIILIRVPNNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTRETKRAGLVQAGASPTEAAAAGTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIADALGGVDVCLKEPVYEPLSGADFPAGRQKLNGPQALSFVRQRHDLPRGDLDRVVRQQAVMAALAHRVISGQTLSSPATLKRLEQAVQRSVVLSSGWDIMDFVRQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVDPRQVQDWVVGLLHEQDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTTGSVGNNDGDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLANDYSGPGSGLGGSDPNGVVSPARAFNLGSADDTTPPPSPILTAGSDAPECIN
Prediction	745543452221001000011022112211111000231343144354354566565310000000000041444452444434334245543110100000001376430100001320202015254420110102234333443344434444234213210050014003711704010000000500230000002030304440416434140440403030630010001024246100200400020032005203545203315203400520442041442220030022125144530211101134242232300000020126303500450144454454554544455030201102545220540152037340431423334555253030302554450043007306345134466254220100002005324444445445444444444544455554345434142466435128
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEHCCCCCCHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEHCHHHHHHHHHHHCCEEHCCCCCCCCCCCCCCCCCCEEHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHCCCHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCCCCCCEEEEEEHCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHCCEEEHCCCCCCCCCCEEEEEHCCCCHHHHHHHHHHHCCCCEEHCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MMSAQRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIFHMSAPSLGHGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATNTDTIILIRVPNNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTRETKRAGLVQAGASPTEAAAAGTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIADALGGVDVCLKEPVYEPLSGADFPAGRQKLNGPQALSFVRQRHDLPRGDLDRVVRQQAVMAALAHRVISGQTLSSPATLKRLEQAVQRSVVLSSGWDIMDFVRQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVDPRQVQDWVVGLLHEQDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTTGSVGNNDGDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLANDYSGPGSGLGGSDPNGVVSPARAFNLGSADDTTPPPSPILTAGSDAPECIN

3telA

0.22

0.14

0.62

1.64

MUSTER

IKSSQNTDLTVNYLAAYKSLIAVLNSVFENIIELEYPDYASKIKKIKKVEAPKTSKNQSFNIYVSGIDTY-----------------GPISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLESGG--NYKVNSQDLKGMDLPSYAMPDSLYVMEIDDSSLAVVKAAIQDVMEGR--------------------------------------------------------------------------------------------------------------------------------------------------

3telA2

0.23

0.12

0.53

3.04

dPPAS

-----------------------------------------------KVEAPKTSKNQSFNIYVSGIDTY-----------------GPISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLESGG--NYKVNSQDLKGDLPSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR--------------------------------------------------------------------------------------------------------------------------------------------------

3telA2

0.23

0.12

0.53

4.39

wdPPAS

-----------------------------------------------KVEAPKTSKNQSFNIYVSGIDTYGP-----------------ISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLESGG--NYKVNSQDLKGDLPSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR--------------------------------------------------------------------------------------------------------------------------------------------------

3telA

0.20

0.13

0.62

2.07

wMUSTER

DLTVNQSSSYLAAYKSLIA-AIVLNSVFENIIELEYPDYASKIKKIKKVEAPKTSKNQSFNIYVSGIDTY-----------------GPISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLESGG--NYKVNSQDLKGMDLPSYAMDSNLYVMEIDDSSLAVVKAAIQDVMEGR--------------------------------------------------------------------------------------------------------------------------------------------------

3telA2

0.23

0.12

0.53

3.52

wPPAS

-----------------------------------------------KVEAPKTSKNQSFNIYVSGIDTYGP-----------------ISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLES---GNYKVNSQDLKGDLPSYAMPDSNLYVMEIDDSSLAVVKAAIQ--------------------DVMEGR------------------------------------------------------------------------------------------------------------------------------

3telA2

0.23

0.12

0.53

6.74

dPPAS2

-----------------------------------------------KVEAPKTSKNQSFNIYVSGIDTY-----------------GPISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLESGG--NYKVNSQDLKGDLPSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR--------------------------------------------------------------------------------------------------------------------------------------------------

3telA2

0.23

0.12

0.53

3.00

PPAS

-----------------------------------------------KVEAPKTSKNQSFNIYVSGIDTY-----------------GPISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLESGG--NYKVNSQDLKGDLPSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR--------------------------------------------------------------------------------------------------------------------------------------------------

3telA2

0.23

0.12

0.53

5.33

Env-PPAS

-----------------------------------------------KVEAPKTSKNQSFNIYVSGIDTYGP-----------------ISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLESGG--NYKVNSQDLKGDLPSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR--------------------------------------------------------------------------------------------------------------------------------------------------

3telA2

0.23

0.12

0.53

1.59

MUSTER

-----------------------------------------------KVEAPKTSKNQSFNIYVSGIDTY-----------------GPISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLESGG--NYKVNSQDLKGMDLPSYAMDSNLYVMEIDDSSLAVVKAAIQDVMEGR--------------------------------------------------------------------------------------------------------------------------------------------------

3telA

0.20

0.12

0.62

2.74

dPPAS

DLTVNQSSSYLAAYKSLIAKAIVLNSVFENIIELEYPDYASKIKKIKKVEAPKTSKNQSFNIYVSGIDTY-----------------GPISSVSRSDVNILMTVNRDTKKILLTTTPADAYVPIADGGNNQKD----------------------KLTHAGIY-GVDSSIHTLENLYGVDINYYVRLNFTSFLKMIDLLGGVDVHNDQEFSALHGKFHFPVGNVHLDSEQALGFVRERYSLADGDRDRGRNQQKVIVAILQKLTSTEALKNSTIINSLQDSIQTNVPLETMINLVNAQLESGG--NYKVNSQDLKGDLPSYAMPDSNLYVMEIDDSSLAVVKAAIQDVMEGR--------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.60

Estimated TM-score = 0.41±0.14

Estimated RMSD = 13.7±4.0Å

Download Model 2

C-score=-3.18

Download Model 3

C-score=-3.33

Download Model 4

C-score=-3.31

Download Model 5

C-score=-3.51

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3telA	0.591	2.06	0.206	0.623
2	3qfiA	0.484	2.23	0.202	0.516
3	3okzA	0.475	3.30	0.222	0.534
4	3pe5A	0.425	3.82	0.207	0.502
5	3mejA	0.423	2.59	0.235	0.458
6	4obmA	0.410	2.90	0.081	0.458
7	3nroA	0.403	2.84	0.272	0.444
8	3nxhA	0.383	2.38	0.217	0.412
9	1bxrA	0.379	7.00	0.078	0.600
10	4gnsB	0.373	6.98	0.044	0.582

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.54	12	3tepA	ZTP	Rep, Mult	60,62,64,66,67,68,97,98,102,104,111,118,187,188,189,192,235,236,238,248,252,259,260,263,264,269,294,307
2	0.08	2	3telA	MN	Rep, Mult	68,95,97

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1nekA	0.358	7.43	0.051	0.592	1.3.99.1,	248
2	0.060	1clqA	0.316	7.35	0.017	0.518	2.7.7.7	NA
3	0.060	1hi8A	0.333	6.93	0.058	0.510	2.7.7.48	259
4	0.060	1bxrA	0.379	7.00	0.078	0.600	6.3.5.5	NA
5	0.060	2jlgC	0.311	7.93	0.043	0.534	2.7.7.48	67,168
6	0.060	1q16A	0.340	7.78	0.051	0.580	1.7.99.4	NA
7	0.060	1yq3A	0.349	7.62	0.046	0.584	1.3.5.1	NA
8	0.060	1kf6A	0.346	7.64	0.064	0.580	1.3.99.1	NA
9	0.060	1r9mB	0.326	7.73	0.055	0.550	3.4.14.5	183
10	0.060	2gtqA	0.357	6.79	0.046	0.544	3.4.11.2	NA
11	0.060	1ea0A	0.349	7.69	0.048	0.592	1.4.1.13	31
12	0.060	1knpA	0.332	7.30	0.031	0.538	1.4.3.16	166,183
13	0.060	2wdqA	0.361	7.46	0.050	0.602	1.3.99.1	NA
14	0.060	2ckjA	0.303	8.10	0.034	0.532	1.17.1.4,1.17.3.2	NA
15	0.060	1jnrA	0.370	7.64	0.061	0.621	1.8.99.2	NA
16	0.060	3cirM	0.301	7.56	0.046	0.500	1.3.99.1	262
17	0.060	1qlaD	0.340	7.53	0.063	0.564	1.3.99.1	193,249
18	0.060	2dqmA	0.358	6.91	0.044	0.548	3.4.11.2	NA
19	0.060	2vdcA	0.352	7.57	0.029	0.584	1.4.1.13	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.37	0.595	2.10	0.20	0.63	4de8A	GO:0006260 GO:0016020 GO:0016021
1	0.29	0.420	2.56	0.28	0.46	3nroB	GO:0016020 GO:0016021
2	0.27	0.433	2.58	0.23	0.47	3mejA	GO:0005886 GO:0006351 GO:0006355 GO:0016020 GO:0016021
3	0.18	0.393	2.38	0.22	0.42	3nxhA	GO:0005886 GO:0006351 GO:0006355 GO:0016020 GO:0016021
4	0.18	0.442	3.84	0.20	0.52	3pe5A	GO:0016020 GO:0016021
5	0.12	0.255	7.49	0.03	0.42	2jkbA	GO:0004308 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0052794 GO:0052795 GO:0052796
6	0.06	0.292	7.02	0.08	0.46	3pyzA	GO:0000166 GO:0004326 GO:0005524 GO:0009058 GO:0009396 GO:0016874 GO:0046901
7	0.06	0.218	7.15	0.03	0.36	4xgcD	GO:0000808 GO:0003677 GO:0003688 GO:0005634 GO:0005664 GO:0006260 GO:0006270
8	0.06	0.207	6.30	0.03	0.31	2iwcA	GO:0008658 GO:0046677
9	0.06	0.139	5.89	0.05	0.20	3o13A	GO:0005576 GO:0009405
10	0.06	0.170	6.60	0.04	0.26	1aym1	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0051259 GO:0075509
11	0.06	0.153	5.20	0.03	0.20	2r73A	GO:0005215 GO:0005550 GO:0005576 GO:0006810
12	0.06	0.172	5.64	0.04	0.24	2rciA	GO:0005576 GO:0009405 GO:0030435
13	0.06	0.128	5.99	0.02	0.18	4wf9C	GO:0003723 GO:0003735 GO:0005840 GO:0006412 GO:0019843 GO:0022626 GO:0030529
14	0.06	0.132	4.88	0.07	0.17	3cfyA	GO:0000160 GO:0000166 GO:0003677 GO:0005524 GO:0005622 GO:0006351 GO:0006355 GO:0008134 GO:0043565
15	0.06	0.111	4.61	0.06	0.14	2cpcA	GO:0000226 GO:0005737 GO:0005794 GO:0005813 GO:0005815 GO:0005856 GO:0007010 GO:0007030 GO:0007088 GO:0008093 GO:0014704 GO:0030018 GO:0031430 GO:0034067 GO:0048471 GO:0050775 GO:0055003 GO:1990393
16	0.06	0.111	4.02	0.06	0.13	3wx4A	GO:0004518 GO:0004519 GO:0016032 GO:0016787 GO:0090305
17	0.06	0.122	5.18	0.01	0.16	5palA	GO:0005509 GO:0046872
18	0.06	0.085	4.58	0.05	0.11	3fksQ	GO:0005739 GO:0005743 GO:0005756 GO:0006754 GO:0006810 GO:0006811 GO:0015986 GO:0015992 GO:0016020 GO:0016787 GO:0016887 GO:0045261 GO:0046933 GO:0046961

Consensus prediction of GO terms

Molecular Function
GO-Score
Biological Processes	GO:0006355	GO:0006260
GO-Score	0.40	0.37
Cellular Component	GO:0016021	GO:0005886
GO-Score	0.78	0.40

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.