I-TASSER results

I-TASSER results for job id Rv3256c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (346 residues)
MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEGELDLLRGSDRPRSVIW
VTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWVGPLDVLIVAGDDPGDPALVGAAAI
GVRRGARVVVVAPYEGPLRDSTAGRVAVLEPRLRVPDEFGLSRYLAAGLAALQTVDPKLR
IDLASLADELDAEALRNSAGREVFTNPAKALAARVSGCQLALAGDNAATLALARHGSSVM
LRIANQVVAATRLSDAVVALRAGTPPDALFHDEEIDGPAPQRLRVLALALAGERTVVAAR
VAGLDDAYLVAAEDVPELLDAPVGSGGAVLAVRLEMAAVYLRLVRG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEGELDLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWVGPLDVLIVAGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRVAVLEPRLRVPDEFGLSRYLAAGLAALQTVDPKLRIDLASLADELDAEALRNSAGREVFTNPAKALAARVSGCQLALAGDNAATLALARHGSSVMLRIANQVVAATRLSDAVVALRAGTPPDALFHDEEIDGPAPQRLRVLALALAGERTVVAARVAGLDDAYLVAAEDVPELLDAPVGSGGAVLAVRLEMAAVYLRLVRG
Prediction	CCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEEHCCCHHHHHHHHHHHHHCCCCCCCEEHCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHCCEEEEEHCCCCHHHHHHCCCCCEHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
Conf.Score	9887778887599999978787899999975799999999998484555567898679999679768999999999986888986897688987778875999986999999999999999998998999968998678886577756568888887655799999999999997666456599999999999999898766567889999999959967998588668999999999999996964435655677776655778777777877888877775899986688875677787777765545655555567887578999999999999999999859
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEGELDLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWVGPLDVLIVAGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRVAVLEPRLRVPDEFGLSRYLAAGLAALQTVDPKLRIDLASLADELDAEALRNSAGREVFTNPAKALAARVSGCQLALAGDNAATLALARHGSSVMLRIANQVVAATRLSDAVVALRAGTPPDALFHDEEIDGPAPQRLRVLALALAGERTVVAARVAGLDDAYLVAAEDVPELLDAPVGSGGAVLAVRLEMAAVYLRLVRG
Prediction	3534641305216203711353003300510210130041044140660474520000000013210110020000000450300000035001102030000000223514100300330141301000001552203311464400100203124312001000000000120354234304400520351056142635424120330043037100000011200200021003002410310020130121033244445432001045245663220000000044644223332441451431424434444645422100000010100000110258
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEEHCCCHHHHHHHHHHHHHCCCCCCCEEHCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHCCEEEEEHCCCCHHHHHHCCCCCEHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEGELDLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWVGPLDVLIVAGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRVAVLEPRLRVPDEFGLSRYLAAGLAALQTVDPKLRIDLASLADELDAEALRNSAGREVFTNPAKALAARVSGCQLALAGDNAATLALARHGSSVMLRIANQVVAATRLSDAVVALRAGTPPDALFHDEEIDGPAPQRLRVLALALAGERTVVAARVAGLDDAYLVAAEDVPELLDAPVGSGGAVLAVRLEMAAVYLRLVRG

1x9iB

0.14

0.11

0.82

1.34

MUSTER

--------------------SQLLQDYLNWENYILRRVDFPTSYVVEGEVVRIEAMPRLYISGMGGSGVVADLIRDFSLWNWEVEVIAVKDY-FLKARDGLLIAVSYSGNTIETLYTVEYAKRRRIPAVAITT-GGRLAQM--GVPTVIVPK-ASAPRAALPQLLTAALHVVAKVYGIDVKIPEGL--------------EPPNEALIHKLVEEFQKRPTIIAA--ESMRGVAYRVKNEFNENAKIEPSVEILPEAHHNWIEGSERA-----------------VVALTSPHIPKEHQERVKATVEIVG-GSIYAVEMH----PKGVLSFLRDVGIASVKLAEIRG

1x9iB

0.12

0.10

0.82

1.42

dPPAS

--------------------SQLLQDYLNWENYILRRVDFPTSYVVEGEVVRIEAMPRLYISGMGGSGVVADLIRDFSLTNWEVEVIAVKDY-FLKARDGLLIAVSYSGNTIETLYTVEYAKRRRIPAVAITTGG----RLAQMGVPTVIVPKASAPRAALPQLLTAALHVVAKVYGIDVKIPEGL--------------EPPNEALIHKLVEEFQKRPTIIAAE--SMRGVAYRVKNEFNENAKIEPSVEILPEAHHNWIEGSERA-----------------VVALTSPHIPKEHQERVKATVEIVGGSIYAV-----EMHPKGVLSFLRDVGIASVKLAEIRG

2zj4A

0.10

0.94

2.02

wdPPAS

--------------MKGNFSSFMQKEIFEQPESVVNTMRGGLKDHIKEIQRCR----RLILIACGTSYHAGVATRQVLEELTELPVMV-DRNTP-VFRDDVCFFLSQSGETADTLMGLRYCKERGALTVGITNGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRQERRKEIMLGLKRLPDLIKEVLSM-DDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRG

1x9iB

0.13

0.11

0.82

1.72

wMUSTER

--------------------SQLLQDYLNWENYILRRVDFPTSYVVEGEVVRIEAMPRLYISGMGGSGVVADLIRDFSLWNWEVEVIAVKDY-FLKARDGLLIAVSYSGNTIETLYTVEYAKRRRIPAVAITT-GGRLAQM--GVPTVIVPK-ASAPRAALPQLLTAALHVVAKVYGIDVKIP--------------EGLEPPNEALIHKLVEEFQKRPTIIAA--ESMRGVAYRVKNEFNENAKIEPSVEILPEAHHNWIEGSERA-----------------VVALTSPHIPKEHQERVKATVEIVG-GSIYAVEMH----PKGVLSFLRDVGIASVKLAEIRG

1x9iB

0.14

0.11

0.81

2.57

wPPAS

--------------------SQLLQDYLNWENYILRRVDFPTSYVVEGEVVRIEAMPRLYISGMGGSGVVADLIRDFSLTNWEVEVIAVYFLK---ARDGLLIAVSYSGNTIETLYTVEYAKRRRIPAVAITT-GGRLAQM--GVPTVIVPK-ASAPRAALPQLLTAALHVVAKVYGID----VKIPEGLE----------PPNEALIHKLVEEFQKRPTIIAAE--SMRGVAYRVKNEFNENAKIEPSVEILPEAHHNWIEGSERA-----------------VVALTSPHIPKEHQERVKATVEIVGGSIYAV-----EMHPKGVLSFLRDVGIASVKLAEIRG

1x9iB

0.13

0.11

0.82

3.30

dPPAS2

--------------------SQLLQDYLNWENYILRRVDFPTSYVVEGEVVRIEAMPRLYISGMGGSGVVADLIRDFSLTNWEVEVIAVKDY-FLKARDGLLIAVSYSGNTIETLYTVEYAKRRRIPAVAITTGG---RLAQMGVPTVIVP-KASAPRAALPQLLTAALHVVAKVYGIDVKIPEGL--------------EPPNEALIHKLVEEFQKRPTIIAAE--SMRGVAYRVKNEFNENAKIEPSVEILPEAHHNWIEGSERA-----------------VVALTSPHIPKEHQERVKATVEIVGGSIYAV-----EMHPKGVLSFLRDVGIASVKLAEIRG

1x9iB

0.13

0.11

0.82

2.11

PPAS

--------------------SQLLQDYLNWENYILRRVDFPTSYVVEGEVVRIEAMPRLYISGMGGSGVVADLIRDFSLTNWEVEVIAVKDY-FLKARDGLLIAVSYSGNTIETLYTVEYAKRRRIPAVAITT-GGRLAQMGV--PTVIVPK-ASAPRAALPQLLTAALHVVAKVYGID-----------VKIPEGLEPPNE---ALIHKLVEEFQKRPTIIAA--ESMRGVAYRVKNEFNENAKIEPSVEILPEAHHNWIEGSERA-----------------VVALTSPHIPKEHQERVKATVEIVG-GSIYAVEMH----PKGVLSFLRDVGIASVKLAEIRG

1x9iB

0.13

0.11

0.82

3.02

Env-PPAS

--------------------SQLLQDYLNWENYILRRVDFPTSYVVEGEVVRIEAMPRLYISGMGGSGVVADLIRDFSLTNWEVEVIAVKDY-FLKARDGLLIAVSYSGNTIETLYTVEYAKRRRIPAVAIT-TGGRLAQMGV--PTVIVP-KASAPRAALPQLLTAALHVVAKVYGIDVKIPEGL--------------EPPNEALIHKLVEEFQKRPTIIAA--ESMRGVAYRVKNEFNENAKIEPSVEILPEAHHNWIEGSERA-----------------VVALTSPHIPKEHQERVKATVEIVGG-SIYAVEMH----PKGVLSFLRDVGIASVKLAEIRG

2a3nA

0.13

0.11

0.86

1.12

MUSTER

---------------LGFNQDEYLTSAREIIAARQKAEQVADEIYQAGFSS-------LFFASVGGSLAP--AINEFAKELTTLPVYVEQKGNKRLNKDSVVITLSKSGDTKESVAIAEWCKAQGIRVVAITKADSPLAQAAT----WHIPRHKNGVEYEYLLYWLFFRVLSRNNEFA---SYDRFASQLEILPANLLKAKQKFDPQADAIASRYHNSD---YWVGGAEWGEVYLFSCILEE-QWKRTRPVSSAEFFHGALELLEKDVP---------------LILVKGEGKCRALDERVERFASKIPKAYALDGIDDEFRWIAPCVVSTLLVDRLAAHFEKYTG

2a3nA

0.14

0.12

0.86

0.95

dPPAS

---------------LGFNQDEYLTSAREIIAARQKAEQVADEIYQAGFSS-------LFFASVGGSLAP--AINEFAKELTTLPVYVEHKGNKRLNKDSVVITLSKSGDTKESVAIAEWCKAQGIRVVAITKADSPLAQAAT----WHIPRHKNGVEYEYLLYWLFFRVLSRNNEFASYDRFASQLEILPANLLKA---KQKFDPQADAIASRYHNSDYWVGGAE---WGEVYLFSCILEE-QWKRTRPVSSAEFFHGALELLEKDVP---------------LILVKGEGKCRALDERVERFASKITDNYALDGIDDEFRWIAPCVVSTLLVDRLAAHFEKYTG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.77

Estimated TM-score = 0.62±0.14

Estimated RMSD = 8.2±4.5Å

Download Model 2

C-score=-2.10

Download Model 3

C-score=-2.38

Download Model 4

C-score=-2.79

Download Model 5

C-score=-1.26

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1x9iB	0.782	1.53	0.127	0.818
2	2j6hA	0.761	3.26	0.093	0.899
3	2zj4A	0.757	3.27	0.094	0.890
4	2pocB	0.738	3.37	0.114	0.884
5	3tbfA	0.737	3.20	0.123	0.867
6	4s1wA	0.735	3.31	0.116	0.873
7	2amlA	0.733	3.51	0.092	0.879
8	3fj1A	0.722	3.23	0.125	0.847
9	3i0zA	0.722	3.57	0.110	0.873
10	3c3jA	0.716	3.41	0.119	0.856

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.30	11	1tzcA	PA5	Rep, Mult	64,65,66,67,106,107,108,111,157,158,242
2	0.02	1	3oojA	G6Q	Rep, Mult	80,229,322,326
3	0.02	1	4b3eJ	CO3	Rep, Mult	121,123
4	0.02	1	3h87A	MG	Rep, Mult	100,108,111
5	0.02	1	2g9zA	MG	Rep, Mult	272,276
6	0.02	1	2idkA	C2F	Rep, Mult	232,240
7	0.02	1	3l26B	MG	Rep, Mult	85,93
8	0.02	1	3rbxA	CA	Rep, Mult	263,293
9	0.02	1	2wtfA	CA	Rep, Mult	188,191
10	0.02	1	1g87B	MG	Rep, Mult	10,11
11	0.02	1	1g3uA	MG	Rep, Mult	108,317

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.171	2puwB	0.716	3.29	0.116	0.850	2.6.1.16	NA
2	0.131	2zj3A	0.758	3.28	0.091	0.893	2.6.1.16	NA
3	0.068	1zzgB	0.683	3.94	0.090	0.861	5.3.1.9	NA
4	0.060	2vf4X	0.754	3.23	0.092	0.884	2.6.1.16	NA
5	0.060	1tzbA	0.781	1.56	0.127	0.818	5.3.1.9,5.3.1.8	NA
6	0.060	3b9jJ	0.228	7.13	0.038	0.410	1.17.1.4,1.17.3.2	172
7	0.060	1j5xA	0.681	3.44	0.074	0.821	3.5.99.6	NA
8	0.060	1e1cA	0.456	6.06	0.074	0.711	5.4.99.2	111
9	0.060	3bicB	0.449	5.92	0.064	0.694	5.4.99.2	116
10	0.060	2pocB	0.738	3.37	0.114	0.884	2.6.1.16	NA
11	0.060	1reqA	0.456	6.04	0.071	0.708	5.4.99.2	70
12	0.060	1rm6A	0.421	5.53	0.081	0.633	1.3.99.20	NA
13	0.060	3ljkA	0.667	4.35	0.095	0.873	5.3.1.9	25
14	0.060	3bicA	0.450	5.96	0.071	0.694	5.4.99.2	108
15	0.060	1x9hA	0.781	1.55	0.127	0.818	5.3.1.9,5.3.1.8	NA
16	0.060	3hjbA	0.685	4.32	0.095	0.884	5.3.1.9	NA
17	0.060	1b0zA	0.673	4.39	0.109	0.881	5.3.1.9	NA
18	0.060	1moqA	0.758	3.27	0.114	0.887	2.6.1.16	66
19	0.060	1zzgA	0.683	3.95	0.087	0.861	5.3.1.9	NA
20	0.060	2e1qA	0.355	7.04	0.050	0.630	1.17.3.2,1.17.1.4	NA
21	0.060	2cvpA	0.687	4.22	0.100	0.879	5.3.1.9	NA
22	0.060	3euaF	0.670	3.67	0.128	0.815	3.5.-.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.27	0.738	3.37	0.11	0.88	2pocB	GO:0004360 GO:0005975 GO:0006031 GO:0006038 GO:0006042 GO:0006048 GO:0006487 GO:0006541 GO:0008483 GO:0016740 GO:0030246 GO:0030448 GO:0035690 GO:1901137
1	0.26	0.736	3.16	0.12	0.86	3fj1A	GO:0005975 GO:0030246
2	0.25	0.758	3.28	0.09	0.89	2zj3A	GO:0004360 GO:0005829 GO:0005975 GO:0006002 GO:0006042 GO:0006047 GO:0006048 GO:0006112 GO:0006541 GO:0008483 GO:0009744 GO:0016597 GO:0016740 GO:0030246 GO:0032868 GO:0032869 GO:0032922 GO:0036498 GO:0045719 GO:0048511 GO:0051289 GO:0070062 GO:1901137
3	0.24	0.716	3.29	0.12	0.85	2puwB	GO:0004360 GO:0005975 GO:0006031 GO:0006038 GO:0006042 GO:0006048 GO:0006487 GO:0006541 GO:0008483 GO:0016740 GO:0030246 GO:0030448 GO:0035690 GO:1901137
4	0.22	0.708	3.22	0.12	0.83	3hbaB	GO:0004360 GO:0005975 GO:0008483 GO:0016740 GO:0030246
5	0.22	0.781	1.56	0.13	0.82	1tzbA	GO:0003824 GO:0004347 GO:0004476 GO:0005975 GO:0008152 GO:0016853 GO:0030246
6	0.21	0.701	3.38	0.11	0.83	3knzA	GO:0004360 GO:0005829 GO:0005975 GO:0006002 GO:0006047 GO:0030246
7	0.19	0.749	3.20	0.11	0.88	3tbfC	GO:0004360 GO:0005737 GO:0005975 GO:0006541 GO:0008483 GO:0016740 GO:0030246 GO:1901137
8	0.19	0.701	2.96	0.11	0.81	2decA	GO:0005975 GO:0030246
9	0.18	0.718	3.26	0.10	0.85	3g68B	GO:0005975 GO:0016853 GO:0030246
10	0.17	0.702	2.94	0.12	0.81	2cb0B	GO:0005975 GO:0008483 GO:0016740 GO:0030246
11	0.17	0.683	3.56	0.13	0.83	3fkjA	GO:0004360 GO:0005975 GO:0006002 GO:0006047 GO:0016853 GO:0030246
12	0.16	0.730	3.35	0.12	0.87	3c3jA	GO:0005975 GO:0016853 GO:0016861 GO:0030246
13	0.16	0.705	3.68	0.12	0.86	2a3nA	GO:0004360 GO:0005975 GO:0006002 GO:0006047 GO:0008483 GO:0016740 GO:0030246
14	0.15	0.765	3.44	0.10	0.91	4amvA	GO:0004360 GO:0005737 GO:0005829 GO:0005975 GO:0006002 GO:0006048 GO:0006541 GO:0008483 GO:0016740 GO:0030246 GO:1901137
15	0.15	0.670	3.67	0.13	0.81	3euaF	GO:0004360 GO:0005975 GO:0006002 GO:0006047 GO:0016787 GO:0030246
16	0.13	0.726	3.58	0.11	0.88	3odpA	GO:0005975 GO:0016853 GO:0030246
17	0.13	0.729	3.52	0.11	0.88	3i0zA	GO:0005975 GO:0016853 GO:0030246
18	0.12	0.733	3.51	0.09	0.88	2amlA

Consensus prediction of GO terms

Molecular Function	GO:0030246	GO:0004360	GO:0031406
GO-Score	0.76	0.68	0.50
Biological Processes	GO:0006042	GO:0006541	GO:0006048	GO:0034285	GO:0051262	GO:0070874	GO:0044707	GO:0019637	GO:0010468	GO:0007623	GO:0032868	GO:0006796	GO:0051260	GO:0005979	GO:2000113	GO:0071375	GO:0030968	GO:0006038	GO:0035690	GO:0030448	GO:0006487
GO-Score	0.59	0.59	0.59	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.50	0.45	0.45	0.45	0.45
Cellular Component	GO:0044444	GO:0031988	GO:1903561
GO-Score	0.50	0.50	0.50

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.