I-TASSER results

I-TASSER results for job id Rv3230c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (380 residues)
MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARE
LRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAAS
GSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGI
TPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRL
DLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGT
VTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHE
PGTRVQTCVSAASGDCVLDI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI
Prediction	CCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEEEEEEHCCCEEEEEEHCCCCCCCCCCCCEEEEEEEEHCCEEEEEEEHCCCCCCCCCCCEEEEEEEHCCCCCHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCEEEEHCCCCHHHHHHHHHHHHHHCCCCCEEEEHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCHHHHHHHCCCCCCCEEEEHCCHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCEEEEEEHCCEEEEHCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEHCCCCHHHHCCCCEEEEEEHCCCCCEEEHC
Conf.Score	98888765643334445555655666789999999999876776567888756788887699999999995599899999779998899999868999998599569998756789889998769999998678984788998758999899996778998789999996899975875789999999999989998599998589855657999999999987996999996788899999999997888889889996978999999999999799865578875899988899877999996997999879988999999989998877678887658999887588658986664459989998865788858869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI
Prediction	71432430212014113432224412500430030024103422252035215221335403020241250053022024316544414030101000103175542210100000133573121010104326603002100420343134402423434204674532000001323100000002102544470300000000226201024104501750440201011335511021620361045145010101035211520150057241423011222223534577542303033443415056632002003726151310241300000303134231433136625366420000002051502026
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEEEEEEHCCCEEEEEEHCCCCCCCCCCCCEEEEEEEEHCCEEEEEEEHCCCCCCCCCCCEEEEEEEHCCCCCHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCEEEEHCCCCHHHHHHHHHHHHHHCCCCCEEEEHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCHHHHHHHCCCCCCCEEEEHCCHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCEEEEEEHCCEEEEHCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEEEEHCCCCHHHHCCCCEEEEEEHCCCCCEEEHC
MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI

2piaA

0.22

0.18

0.82

3.28

MUSTER

---------------------------------------------------TTPQED-GFLRLKIASKEKIARDIWSFELTDPQGAPLPFEAGANLTVAVPNGS---RRTYSLCNDSQERN---RYVIAVKRDSNGRGSISFIDDTSEGDAVEVSLPRNEFPLDKRA-KSFILVAGGIGITPMLSMARQLRAEG-LRSFRLYYLTRDPEGTAFFDELTSDEWR-SDVKIHHDHGDPTKAFDFWSVFEKSKP--AQHVYCCGPQALMDTVRDMTG--HWPGTVHFESFGATNTNARETPFTVRLSRSGTSFEIPANRSILEVLRDANVRVPSSCESGTCGSCKTALCSGEADHVLRDDEK--GTQIMVCVSRAKSALVLDL

2piaA

0.22

0.18

0.83

6.63

dPPAS

----------------------------------------------------TTPQEDGFLRLKIASKEKIARDIWSFELTDPQGAPLPFEAGANLTVAVPNGS---RRTYSLCNDSQERN---RYVIAVKRDSNGRGSISFIDDTSEGDAVEVSLPRNEFPLDKRA-KSFILVAGGIGITPMLSMARQLRAEG-LRSFRLYYLTRDPEGTAFFDELTSDEW-RSDVKIHHDHGDPTKAFDFWSVFEKSKP--AQHVYCCGPQALMDTVRDMTGHWP-SGTVHFESFGATNTNARNTPFTVRLSRSGTSFEIPANRSILEVLRDANVRVPSSCESGTCGSCKTALCSGEADHRDMVRDDEKGTQIMVCVSRAKSALVLDL

2piaA

0.21

0.18

0.82

6.28

wdPPAS

----------------------------------------------------TTPQEDGFLRLKIASKEKIARDIWSFELTDPQGAPLPFEAGANLTVAVPNGS---RRTYSLCNDSQERN---RYVIAVKRDSNGRGSISFIDDTSEGDAVEVSLPRNEFPLDKRA-KSFILVAGGIGITPMLSMARQLRAEG-LRSFRLYYLTRDPEGTAFFDELTSDEWRS-DVKIHHDHGDPTKAFDFWSVFEKSKP--AQHVYCCGPQALMDTVRDMTG--HWPGTVHFESFGATNTNARNTPFTVRLSRSGTSFEIPANRSILEVLRDANVRVPSSCESGTCGSCKTALCSGEADHVLRDDEK--GTQIMVCVSRAKSALVLDL

2piaA

0.22

0.18

0.82

4.25

wMUSTER

---------------------------------------------------TTPQED-GFLRLKIASKEKIARDIWSFELTDPQGAPLPFEAGANLTVAVPNGS---RRTYSLCNDSQERN---RYVIAVKRDSNGRGSISFIDDTSEGDAVEVSLPRNEFPLDKRA-KSFILVAGGIGITPMLSMARQLRAEG-LRSFRLYYLTRDPEGTAFFDELTSDEWR-SDVKIHHDHGDPTKAFDFWSVFEKSKP--AQHVYCCGPQALMDTVRDMTG--HWPGTVHFESFGATNTNARETPFTVRLSRSGTSFEIPANRSILEVLRDANVRVPSSCESGTCGSCKTALCSGEADHVLRDDEK--GTQIMVCVSRAKSALVLDL

2piaA

0.21

0.18

0.82

4.80

wPPAS

---------------------------------------------------TTPQED-GFLRLKIASKEKIARDIWSFELTDPQGAPLPFEAGANLTVAVPNGS---RRTYSLCNDSQERN---RYVIAVKRDSNGRGSISFIDDTSEGDAVEVSLPRNEFPLDKR-AKSFILVAGGIGITPMLSMARQLRAEG-LRSFRLYYLTRDPEGTAFFDELTSDEWRS-DVKIHHDHGDPTKAFDFWSVFEKSKP--AQHVYCCGPQALMDTVRDMTG--HWPGTVHFESFGATNTNAENTPFTVRLSRSGTSFEIPANRSILEVLRDANVRVPSSCESGTCGSCKTALCSGEADHVLRDDEK--GTQIMVCVSRAKSALVLDL

2piaA

0.21

0.18

0.82

7.23

dPPAS2

----------------------------------------------------TTPQEDGFLRLKIASKEKIARDIWSFELTDPQGAPLPFEAGANLTVAVPNGS---RRTYSLCNDSQERN---RYVIAVKRDSNGRGSISFIDDTSEGDAVEVSLPRNEFPLDKRA-KSFILVAGGIGITPMLSMARQLRAEG-LRSFRLYYLTRDPEGTAFFDELTSDEW-RSDVKIHHDHGDPTKAFDFWSVFEKSKP--AQHVYCCGPQALMDTVRDMTG--HWPGTVHFESFGATNTNARNTPFTVRLSRSGTSFEIPANRSILEVLRDANVRVPSSCESGTCGSCKTALCSGEADHVLRDDEK--GTQIMVCVSRAKSALVLDL

2piaA

0.21

0.18

0.83

4.33

PPAS

----------------------------------------------------TTPQEDGFLRLKIASKEKIARDIWSFELTDPQGAPLPFEAGANLTVAVPNGS---RRTYSLCNDSQERN---RYVIAVKRDSNGRGSISFIDDTSEGDAVEVSLPRNEFPLDKR-AKSFILVAGGIGITPMLSMARQLRAEGL-RSFRLYYLTRDPEGTAFFDELTSDEWRS-DVKIHHDHGDPTKAFDFWSVFEKSKP--AQHVYCCGPQALMDTVRDMTGHWP-SGTVHFESFGATNTNAENTPFTVRLSRSGTSFEIPANRSILEVLRDANVRVPSSCESGTCGSCKTALCSGEADHVLRDDEK--GTQIMVCVSRAKSALVLDL

2piaA

0.21

0.18

0.83

5.92

Env-PPAS

----------------------------------------------------TTPQEDGFLRLKIASKEKIARDIWSFELTDPQGAPLPFEAGANLTVAVPNGS---RRTYSLCNDSQERN---RYVIAVKRDSNGRGSISFIDDTSEGDAVEVSLPRNEFPLDKR-AKSFILVAGGIGITPMLSMARQLRAEGLR-SFRLYYLTRDPEGTAFFDELTSDEWRS-DVKIHHDHGDPTKAFDFWSVFEKSKP--AQHVYCCGPQALMDTVRDMTGHWP-SGTVHFESFGATNTNAENTPFTVRLSRSGTSFEIPANRSILEVLRDANVRVPSSCESGTCGSCKTALCSGEADHVLRDDEK--GTQIMVCVSRAKSALVLDL

4eh1A

0.27

0.16

0.59

2.21

MUSTER

---------------------------------------------------------RDGRTFVVREKQVESAYVTSFVLVPADGGAVDYQPGQYIGIEVTPEGSDEIRQYSLSHASNGRE----YRISVKREGPGLVSHYLHNNVKVGDSVKLYAPAGDFFYVE-RERPVVLISAGVGATPMQAILHTLAKQNKS-GVTYLYACNSAKEHTFAQETAQLIAQQGWMQQVWYRDESQGEMQ---LAELILPIEDGDFYLCGPIGFMQYVVKQLLALGVDARIHYEVFGP-------------------------------------------------------------------------------------------

4eh1A

0.27

0.16

0.59

4.54

dPPAS

---------------------------------------------------------RDGRTFVVREKQVESAYVTSFVLVPADGGALDYQPGQYIGIEVTPEGSDEIRQYSLSHASNGRE----YRISVKREGPGLVSHYLHNNVKVGDSVKLYAPAGDFFYVER-ERPVVLISAGVGATPMQAILHTLAKQNK-SGVTYLYACNSAKEHTFAQETAQLIAQQGWMQQVWYRDESQGEMQ---LAELILPIEDGDFYLCGPIGFMQYVVKQLLALGVDARIHYEVFGP-------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.64

Estimated TM-score = 0.80±0.09

Estimated RMSD = 5.3±3.4Å

Download Model 2

C-score=-1.66

Download Model 3

C-score=-0.52

Download Model 4

C-score=-3.02

Download Model 5

C-score=-2.94

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2piaA	0.806	1.19	0.213	0.826
2	1gvhA	0.645	3.44	0.219	0.732
3	4g1bA	0.635	3.51	0.184	0.732
4	1tllA	0.603	4.37	0.129	0.745
5	1ja0A	0.588	4.20	0.121	0.711
6	4p6vF	0.583	3.87	0.145	0.684
7	2bf4A	0.578	4.26	0.095	0.708
8	4wqmA	0.564	3.67	0.175	0.655
9	1krhA	0.561	3.64	0.191	0.660
10	2rc6A	0.549	3.10	0.167	0.624

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.65	82	4fk8A	FAD	Rep, Mult	95,109,110,111,112,129,130,131,133,136,137,138,139,178,181,285,286,287,288,289
2	0.03	8	2bpoA	NAP	Rep, Mult	131,133,176,177,178,205,206,232,233,238,240,262,263,264,265
3	0.02	3	2vzlA	NAD	Rep, Mult	112,131,178,179,260,261,262,285,288
4	0.02	3	2piaA	FES	Rep, Mult	331,332,333,334,336,337,338,339,341,366,368
5	0.02	5	3ozwA	UUU	Rep, Mult	1,4,5,8,10,12,33,36,37,40,289,290
6	0.02	5	1ja0A	NAP	Rep, Mult	112,176,177,178,179,205,232,233,238,240,260,261,262,264,265,268,285,286
7	0.01	3	1ddiA	NAP	Rep, Mult	176,177,205,206,232,233,240,265,268
8	0.01	2	2bsaA	UUU	Rep, Mult	109,110,111,112,129,131,133,135,136,137,138,139,176,177,178,204,205,206,232,260,261,262,264,265,285,286
9	0.01	2	1cqxB	HEM	Rep, Mult	1,4,5,8,10,33,36,37,40
10	0.01	3	1gjrA	NAP	Rep, Mult	131,133,176,177,178,205,206,232,233,261,262,287
11	0.00	1	3mhpA	III	Rep, Mult	67,69,70,71,72,77,118,188,208,209,211,213,215,216
12	0.00	1	3ozuA	UUU	Rep, Mult	1,5,8,10,12,29,32,33,36,37,40
13	0.00	1	2ok7E	FAD	Rep, Mult	110,285
14	0.00	1	1qufA	NAP	Rep, Mult	74,75,131,132,134,177,204,205,206,210,232,233
15	0.00	1	2xnjB	FAD	Rep, Mult	95,109,110,111,112,124,125,126,128,130,136,137,138,139,178,287
16	0.00	1	1w87B	NAP	Rep, Mult	175,179,181

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.516	2piaA	0.806	1.19	0.213	0.826	1.18.1.-	111,112,260,285
2	0.418	1krhA	0.561	3.64	0.191	0.660	1.18.1.3	111,112,260,287
3	0.409	1i7pA	0.517	3.27	0.157	0.603	1.6.2.2	111
4	0.408	3fpkA	0.515	2.68	0.215	0.574	1.18.1.2	111
5	0.398	2bgjA	0.525	2.98	0.206	0.592	1.18.1.2	111
6	0.392	1a8pA	0.529	2.75	0.209	0.590	1.18.1.2	111
7	0.252	2cndA	0.516	2.74	0.158	0.579	1.7.1.1	114,131,179,181,210,261
8	0.212	2b5oB	0.546	3.03	0.178	0.621	1.18.1.2	112,139
9	0.199	1qfjA	0.502	2.77	0.168	0.560	1.5.1.29,	NA
10	0.181	2rc6A	0.549	3.10	0.167	0.624	1.18.1.2	112,131,161,206,262,264
11	0.167	3jqqC	0.543	2.73	0.178	0.605	1.18.1.2	112,131
12	0.111	2ok7C	0.542	2.75	0.178	0.605	1.18.1.2	111,112,260,285
13	0.094	1cqxA	0.537	4.83	0.199	0.705	1.14.12.17	111
14	0.086	1fdrA	0.509	2.76	0.217	0.568	1.18.1.2	111
15	0.067	1cneA	0.514	2.80	0.154	0.579	1.7.1.1,1.6.6.1	NA
16	0.067	2b5oA	0.546	3.03	0.178	0.621	1.18.1.2	95,260,285
17	0.067	1bx0A	0.546	3.24	0.194	0.624	1.18.1.2	95,260
18	0.067	1jb9A	0.545	3.23	0.147	0.626	1.18.1.2	112,260,285
19	0.067	1gawB	0.544	3.11	0.188	0.618	1.18.1.2	112,260,285
20	0.066	1ddgA	0.546	2.96	0.179	0.616	1.8.1.2	112,260
21	0.060	1cqxB	0.536	4.93	0.199	0.708	1.14.12.17	283
22	0.060	1fnbA	0.545	3.25	0.198	0.624	1.18.1.2	112,131,139,206
23	0.060	2rc5A	0.546	3.20	0.171	0.626	1.18.1.2	95,260,285
24	0.060	2r6hC	0.519	2.79	0.167	0.579	1.6.5.-	NA
25	0.060	1qfyA	0.546	3.13	0.174	0.624	1.18.1.2	112,260,285
26	0.060	1umkA	0.518	3.03	0.185	0.592	1.6.2.2	111
27	0.060	1ddgB	0.547	2.94	0.179	0.616	1.8.1.2	NA
28	0.060	1qfjD	0.501	2.74	0.168	0.558	1.5.1.29,1.16.1.3	95,112
29	0.060	1ewyA	0.547	3.21	0.180	0.629	1.18.1.2	112,260,285
30	0.060	1ja1A	0.596	4.01	0.112	0.716	1.6.2.4	111
31	0.060	3fjoA	0.545	2.96	0.112	0.618	1.6.2.4	111,112,260
32	0.060	1tllA	0.603	4.37	0.129	0.745	1.14.13.39	112,260
33	0.060	1wkvB	0.408	6.15	0.059	0.624	2.5.1.47	178
34	0.060	1ep1B	0.532	3.34	0.134	0.611	1.3.3.1	NA
35	0.060	1tvcA	0.505	3.53	0.179	0.605	1.14.13.25	111
36	0.060	2eixA	0.507	3.07	0.148	0.584	1.6.2.2	111

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.39	0.806	1.19	0.21	0.83	2piaA	GO:0009055 GO:0016491 GO:0046872 GO:0051536 GO:0051537 GO:0055114
1	0.38	0.546	2.04	0.27	0.58	4eh1A	GO:0004155 GO:0005344 GO:0005623 GO:0006810 GO:0006879 GO:0008941 GO:0009636 GO:0015671 GO:0016491 GO:0019825 GO:0020037 GO:0046872 GO:0051409 GO:0055114 GO:0071949
2	0.27	0.561	3.64	0.19	0.66	1krhA	GO:0008860 GO:0009055 GO:0016491 GO:0019439 GO:0042203 GO:0046872 GO:0051536 GO:0051537 GO:0055114
3	0.27	0.645	3.44	0.22	0.73	1gvhA	GO:0005344 GO:0005504 GO:0005737 GO:0006810 GO:0008941 GO:0009636 GO:0015671 GO:0016491 GO:0019825 GO:0020037 GO:0032843 GO:0046872 GO:0051409 GO:0055114 GO:0071949
4	0.25	0.583	3.87	0.14	0.68	4p6vF	GO:0005829 GO:0005886 GO:0006810 GO:0006811 GO:0006814 GO:0008137 GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0016655 GO:0046872 GO:0051536 GO:0051537 GO:0055114 GO:0071949
5	0.23	0.564	3.67	0.17	0.66	4wqmA	GO:0008860 GO:0009055 GO:0016491 GO:0019439 GO:0042203 GO:0046872 GO:0051536 GO:0051537 GO:0055114
6	0.21	0.514	2.80	0.15	0.58	1cneA	GO:0009703 GO:0016491 GO:0020037 GO:0030151 GO:0042128 GO:0046872 GO:0055114
7	0.21	0.635	3.51	0.18	0.73	4g1bA	GO:0000166 GO:0016491 GO:0019825 GO:0020037 GO:0046872 GO:0055114
8	0.20	0.517	3.25	0.16	0.60	3w5hA	GO:0004128 GO:0005737 GO:0005739 GO:0005741 GO:0005783 GO:0005789 GO:0006629 GO:0006694 GO:0006695 GO:0008202 GO:0008203 GO:0016020 GO:0016126 GO:0016491 GO:0050660 GO:0055114 GO:0071949
9	0.20	0.546	3.20	0.17	0.63	2rc5A	GO:0000166 GO:0004324 GO:0016491 GO:0046872 GO:0055114
10	0.20	0.537	4.83	0.20	0.71	1cqxA	GO:0005344 GO:0005737 GO:0006810 GO:0008941 GO:0009636 GO:0015671 GO:0016491 GO:0019825 GO:0020037 GO:0046872 GO:0051409 GO:0055114 GO:0071949
11	0.19	0.507	3.07	0.15	0.58	2eixA	GO:0000166 GO:0004128 GO:0016020 GO:0016021 GO:0016491 GO:0055114
12	0.18	0.545	3.24	0.15	0.63	3lvbA	GO:0000166 GO:0004324 GO:0016491 GO:0055114
13	0.17	0.517	3.27	0.16	0.60	1i7pA	GO:0004128 GO:0005737 GO:0005739 GO:0005741 GO:0005743 GO:0005783 GO:0005789 GO:0005811 GO:0006629 GO:0006694 GO:0006695 GO:0008202 GO:0008203 GO:0016020 GO:0016126 GO:0016208 GO:0016491 GO:0043531 GO:0050660 GO:0051287 GO:0055114 GO:0070062 GO:0071949
14	0.16	0.505	3.53	0.18	0.61	1tvcA	GO:0004497 GO:0006730 GO:0009055 GO:0015049 GO:0015050 GO:0015947 GO:0016491 GO:0046872 GO:0051536 GO:0051537 GO:0055114
15	0.07	0.542	2.72	0.17	0.60	2r6hC	GO:0000166 GO:0005886 GO:0006810 GO:0006811 GO:0006814 GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0016655 GO:0046872 GO:0051536 GO:0051537 GO:0055114
16	0.07	0.509	3.53	0.08	0.61	2gpjA	GO:0000166 GO:0016491 GO:0055114
17	0.06	0.284	6.79	0.07	0.48	3q2iA	GO:0000166 GO:0008152 GO:0016491 GO:0055114
18	0.06	0.355	6.19	0.05	0.55	1qmgA	GO:0000287 GO:0004455 GO:0008652 GO:0009082 GO:0009097 GO:0009099 GO:0009507 GO:0009536 GO:0016491 GO:0042803 GO:0046872 GO:0055114 GO:0070402

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0009055	GO:0051537	GO:0071949	GO:0008941	GO:0020037	GO:0005344	GO:0019825	GO:0016731	GO:0008289	GO:0016671	GO:0033293	GO:0050136	GO:0004155
GO-Score	0.85	0.67	0.67	0.66	0.55	0.55	0.55	0.55	0.53	0.53	0.53	0.53	0.51	0.38
Biological Processes	GO:0055114	GO:0015671	GO:0051409	GO:0009636	GO:0042178	GO:0072491	GO:0018970	GO:0015672	GO:0030001	GO:0006879
GO-Score	0.85	0.55	0.55	0.55	0.53	0.53	0.53	0.51	0.51	0.38
Cellular Component	GO:0071944	GO:0044444	GO:0031224
GO-Score	0.51	0.51	0.41

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.