I-TASSER results

I-TASSER results for job id Rv3228

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (330 residues)
MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGRWGCVLGGRPDRRITAM
RARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVLRRTADDTDPTERVVVANA
DQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKTDLAPAEPFGKQFADLELTVT
AAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEADRAVGEVTEIGRGRHTSTR
SVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVLLAFSDLAEATRECPRGCGHMGPPA
DPECALDTLSGPAARRAAAARRLLAVLSQT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGRWGCVLGGRPDRRITAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVLRRTADDTDPTERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKTDLAPAEPFGKQFADLELTVTAAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEADRAVGEVTEIGRGRHTSTRSVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVLLAFSDLAEATRECPRGCGHMGPPADPECALDTLSGPAARRAAAARRLLAVLSQT
Prediction	CCCCCCCCCCCCCCCCCCCCHHHHHCHHHHCCCCCEEEEEHCCEEEEEHCCCCCEEEEEEEHCCCCCCCCCCCEEEEEEHCCCCCCCCEEEEEEEHCCCCEEEHCCCCCCCCEEEEEEHCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHCCCCHHHCCCHCCCCCCCCCEEEEEEEHCCCCCCCCEEEEHCCCCCCHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCC
Conf.Score	985567754544568866554565456776666668999988899999889876699999855678888866878999857788889768999997776589966899888657899867889999866799999789999999999989988999966779999999999978897999966888899999985998999986899988999999868744444644457899876557999975556889869997899875446789989999987989999858999975579988987899999998967999999999999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGRWGCVLGGRPDRRITAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVLRRTADDTDPTERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKTDLAPAEPFGKQFADLELTVTAAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEADRAVGEVTEIGRGRHTSTRSVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVLLAFSDLAEATRECPRGCGHMGPPADPECALDTLSGPAARRAAAARRLLAVLSQT
Prediction	755562545413124545524454545636614301001123220102256544221120304645443000001000223353474230102302514110303256544312000000310000000431503251011000001237030000002220255630251057140100002335105303722642000000223010000001014424242440364553442222021031345163100000012123030330346203400310360176232103033475123000350176054025104301511668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCHHHHHCHHHHCCCCCEEEEEHCCEEEEEHCCCCCEEEEEEEHCCCCCCCCCCCEEEEEEHCCCCCCCCEEEEEEEHCCCCEEEHCCCCCCCCEEEEEEHCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHCCCCHHHCCCHCCCCCCCCCEEEEEEEHCCCCCCCCEEEEHCCCCCCHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCC
MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGRWGCVLGGRPDRRITAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVLRRTADDTDPTERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKTDLAPAEPFGKQFADLELTVTAAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEADRAVGEVTEIGRGRHTSTRSVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVLLAFSDLAEATRECPRGCGHMGPPADPECALDTLSGPAARRAAAARRLLAVLSQT

2rcnA

0.25

0.20

0.81

2.47

MUSTER

---------------------------LFGEPAEGIVISRFGMHADVESADGE---VHRCNIRRTIR-SLVTGDRVVWRPG-----KVKGIVEAVHERTSVLTRPV-------KPIAANIDQIVIVSAI-LPELSLNIIDRYLVGCETLQVEPLIVLNKIDLLDVNEQMDIYRNIGYLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLG-----------LQNEILTNTAARLYHF----PHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGHCKYDCKHDA---DPGCAIREAVENGAIAETRFENYHRILESM

2rcnA

0.25

0.20

0.81

3.41

dPPAS

---------------------------LFGEPAEGIVISRFGMHADVESADGE---VHRCNIRRTIRS-LVTGDRVVWRPG-----KVKGIVEAVHERTSVLTRPV-------KPIAANIDQIVIVSAI-LPELSLNIIDRYLVGCETLQVEPLIVLNKIDLLDVNEQMDIYRNIGYLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLG-----------LQNEILTNTAARLYHF----PHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGHCKYDCKHDA---DPGCAIREAVENGAIAETRFENYHRILESM

2rcnA

0.25

0.20

0.81

4.56

wdPPAS

---------------------------LFGEPAEGIVISRFGMHADVESADGE---VHRCNIRRTIRS-LVTGDRVVWRPG-----KVKGIVEAVHERTSVLTRPV-------KPIAANIDQIVIVSAI-LPELSLNIIDRYLVGCETLQVEPLIVLNKIDLLDVNEQMDIYRNIGYLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLG-----------LQNEILTNTAARLYHF----PHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGHCKYDCKHDA---DPGCAIREAVENGAIAETRFENYHRILESM

2rcnA

0.25

0.20

0.81

3.43

wMUSTER

---------------------------LFGEPAEGIVISRFGMHADVESADGE---VHRCNIRRTIRS-LVTGDRVVWRPG-----KVKGIVEAVHERTSVLTRPV-------KPIAANIDQIVIVSAI-LPELSLNIIDRYLVGCETLQVEPLIVLNKIDLLDVNEQMDIYRNIGYLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLG-----------LQNEILTNTAARLYHF----PHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGHCKYDCKHDA---DPGCAIREAVENGAIAETRFENYHRILESM

2rcnA

0.25

0.20

0.81

4.63

wPPAS

---------------------------LFGEPAEGIVISRFGMHADVESADGE---VHRCNIRRTIR-SLVTGDRVVWRPG-----KVKGIVEAVHERTSVLTRPV-------KPIAANIDQIVIVSAI-LPELSLNIIDRYLVGCETLQVEPLIVLNKIDLLDVNEQMDIYRNIGYLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLGL-----------QNEILTNTAARLYHF----PHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGHCKYDCKHDA---DPGCAIREAVENGAIAETRFENYHRILESM

2rcnA

0.25

0.20

0.81

6.53

dPPAS2

---------------------------LFGEPAEGIVISRFGMHADVESADGE---VHRCNIRRTIRS-LVTGDRVVWRPG-----KVKGIVEAVHERTSVLTRPV-------KPIAANIDQIVIVSAI-LPELSLNIIDRYLVGCETLQVEPLIVLNKIDLLDVNEQMDIYRNIGYLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLG-----------LQNEILTNTAARLYHF----PHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGHCKYDCKHDA---DPGCAIREAVENGAIAETRFENYHRILESM

2rcnA

0.25

0.20

0.81

3.94

PPAS

---------------------------LFGEPAEGIVISRFGMHADVESADGE---VHRCNIRRTIR-SLVTGDRVVWRPG-----KVKGIVEAVHERTSVLTRPV-------KPIAANIDQIVIVSAI-LPELSLNIIDRYLVGCETLQVEPLIVLNKIDLLDVNEQMDIYRNIGYLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLG-----------LQNEILTNTAARLYHF----PHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGHCKYDCKHDA---DPGCAIREAVENGAIAETRFENYHRILESM

2rcnA

0.25

0.20

0.81

5.34

Env-PPAS

---------------------------LFGEPAEGIVISRFGMHADVESADGE---VHRCNIRRTIR-SLVTGDRVVWRPG-----KVKGIVEAVHERTSVLTRPV-------KPIAANIDQIVIVSAI-LPELSLNIIDRYLVGCETLQVEPLIVLNKIDLLDVNEQMDIYRNIGYLMVSSHTQDGLKPLEEALTGRISIFAGQSGVGKSSLLNALLG-----------LQNEILTNTAARLYHF----PHGGDVIDSPGVREFGLWHLEPEQITQGFVEFHDYLGHCKYDCKHDA---DPGCAIREAVENGAIAETRFENYHRILESM

2yv5A

0.25

0.20

0.82

2.41

MUSTER

--------------------------MGKKELKRGLVVDREAQMIGVYLFEDG--KTYRGIPRGKVLTKIYAGDYVWGEVV----DPNTFAIEEVEERKNLLIRPK----------VANVDRVIIVETLKMPEFNNYLLDNMLVVYEYFKVEPVIVFNKIDLLNLERWISIYRDAGYDVLKAKTGEGIDELVDYLEGFICILAGPSGVGKSSILSRLTGE---------ELRTQEVTTTGVRLIPF----GKGSFVGDTPGFSKVEATFVKPREVRNYFREFLRYQCKYP-DCTHTN---EPGCAVKEAVKNGEISCERYKSYLKIIKVY

2yv5A

0.24

0.20

0.83

3.38

dPPAS

--------------------------MGKKELKRGLVVDREAQMIGVYLFEDGKTYRGIPRGKVLKKTKIYAGDYVWGEVV----DPNTFAIEEVEERKNLLIRPK----------VANVDRVIIVETLKMPEFNNYLLDNMLVVYEYFKVEPVIVFNKIDLLNLERWISIYRDAGYDVLKAKTGEGIDELVDYLEGFICILAGPSGVGKSSILSRLTG---------EELRTQEVTTTGVRLIPF----GKGSFVGDTPGFSKVEAMFVKPREVRNYFREFLRYQCKY-PDCTHTN---EPGCAVKEAVKNGEISCERYKSYLKIIKVY

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.09

Estimated TM-score = 0.70±0.12

Estimated RMSD = 6.6±4.0Å

Download Model 2

C-score=-1.48

Download Model 3

C-score=-3.22

Download Model 4

C-score=-2.57

Download Model 5

C-score=-0.41

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2rcnA	0.762	1.80	0.254	0.812
2	1u0lA	0.718	2.41	0.233	0.794
3	2yv5A	0.705	2.83	0.244	0.803
4	1t9hA	0.698	2.74	0.206	0.794
5	1kc7A	0.420	6.45	0.092	0.697
6	2dijA	0.415	6.42	0.056	0.688
7	1cygA	0.407	6.35	0.045	0.673
8	4jclA	0.406	6.64	0.046	0.697
9	4txgA	0.406	6.28	0.064	0.658
10	1mhsA	0.404	6.14	0.037	0.651

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.28	9	1u0lC	GDP	Rep, Mult	158,159,161,183,206,207,208,209,210,211,212
2	0.20	7	1t9hA	ZN	Rep, Mult	289,293,295,304
3	0.07	4	1tu4B	CO	Rep, Mult	211,258
4	0.06	3	2ykrW	NUC	Rep, Mult	40,41,42,43,44,59,62,63,64,65,66,67,104,138,141,205,242,259,261,264,290,291,301,302
5	0.04	2	4bs1B	ADP	Rep, Mult	161,206,207,209,210,211,212
6	0.02	1	1t9hA	CA	Rep, Mult	176,178
7	0.02	1	2rh1A	CLR	Rep, Mult	125,151

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1mhsA	0.404	6.14	0.037	0.651	3.6.3.6	NA
2	0.060	1vbgA	0.388	6.77	0.050	0.682	2.7.9.1	NA
3	0.060	3aboA	0.384	5.93	0.056	0.594	4.3.1.7	NA
4	0.060	2vtfA	0.378	6.46	0.044	0.615	3.2.1.96	151
5	0.060	1cgtA	0.409	6.61	0.049	0.691	2.4.1.19	NA
6	0.060	1bxrA	0.371	6.81	0.052	0.651	6.3.5.5	72
7	0.060	2x0sA	0.391	6.41	0.067	0.648	2.7.9.1	NA
8	0.060	9cgtA	0.409	6.46	0.039	0.682	2.4.1.19	181,215
9	0.060	1qhoA	0.400	6.38	0.064	0.664	3.2.1.133	161
10	0.060	1d7fA	0.414	6.62	0.038	0.700	2.4.1.19	NA
11	0.060	3nqbA	0.373	6.69	0.056	0.633	3.5.4.2	NA
12	0.060	1pn0C	0.375	6.27	0.063	0.606	1.14.13.7	NA
13	0.060	3djlA	0.375	6.32	0.071	0.621	1.3.99.-	148
14	0.060	3f9vA	0.392	5.49	0.034	0.561	3.-.-.-	321
15	0.060	5acnA	0.370	6.34	0.064	0.597	4.2.1.3	NA
16	0.060	1cygA	0.407	6.35	0.045	0.673	2.4.1.19	178
17	0.060	3ikmD	0.375	6.48	0.042	0.627	2.7.7.7	NA
18	0.060	1iexA	0.371	7.13	0.048	0.670	3.2.1.58	NA
19	0.060	3hmjA	0.391	6.81	0.050	0.664	2.3.1.86	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.48	0.762	1.80	0.25	0.81	2rcnA	GO:0000166 GO:0003924 GO:0005525 GO:0016787 GO:0046872
1	0.47	0.698	2.74	0.21	0.79	1t9hA	GO:0000166 GO:0003924 GO:0005525 GO:0016787 GO:0046872
2	0.44	0.705	2.83	0.24	0.80	2yv5A	GO:0000166 GO:0003924 GO:0005525 GO:0016787 GO:0046872
3	0.44	0.718	2.41	0.23	0.79	1u0lA	GO:0000166 GO:0003924 GO:0005525 GO:0016787 GO:0046872
4	0.09	0.348	3.61	0.10	0.42	3cnlA	GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0042254
5	0.06	0.330	6.42	0.04	0.55	1b23P	GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737 GO:0006412 GO:0006414
6	0.06	0.333	6.34	0.05	0.55	3qsyA	GO:0000166 GO:0001731 GO:0003743 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0006412 GO:0006413 GO:0006414
7	0.06	0.291	6.72	0.06	0.49	4v5pAZ	GO:0000166 GO:0003723 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737 GO:0006412 GO:0006414
8	0.06	0.234	6.36	0.04	0.39	4dcsA	GO:0000027 GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0042254 GO:0043022
9	0.06	0.323	6.42	0.06	0.54	3odmC	GO:0000287 GO:0003824 GO:0006099 GO:0006107 GO:0008964 GO:0015977 GO:0016829
10	0.06	0.249	7.36	0.05	0.46	3m6aA	GO:0000166 GO:0004176 GO:0004252 GO:0005524 GO:0005737 GO:0006508 GO:0006515 GO:0008233 GO:0008236 GO:0016787 GO:0016887 GO:0030163 GO:0033554 GO:0043565
11	0.06	0.281	6.00	0.06	0.45	4fzvA	GO:0003723 GO:0005739 GO:0005762 GO:0006364 GO:0008168 GO:0016740 GO:0019843 GO:0031167 GO:0032259 GO:0042254 GO:0042256 GO:0070131 GO:0070181
12	0.06	0.287	6.75	0.04	0.49	3ievA	GO:0000028 GO:0000166 GO:0003723 GO:0003924 GO:0005525 GO:0005622 GO:0005737 GO:0005829 GO:0005886 GO:0016020 GO:0019843 GO:0042254 GO:0042274 GO:0043024 GO:0070181
13	0.06	0.279	5.97	0.06	0.45	3k53D	GO:0005525 GO:0015093 GO:0015684 GO:0016020 GO:0016021 GO:1903874
14	0.06	0.281	5.76	0.06	0.43	1vpxE	GO:0003824 GO:0004801 GO:0005737 GO:0005975 GO:0006098 GO:0016740
15	0.06	0.291	4.25	0.03	0.37	2e87A	GO:0005525
16	0.06	0.297	6.45	0.07	0.47	3jcex	GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005829 GO:0005886 GO:0006412 GO:0006414 GO:0009268 GO:0009409 GO:0009651 GO:0016020 GO:0016787 GO:0043022 GO:0043023 GO:0043024 GO:0045727
17	0.06	0.272	5.12	0.03	0.38	3a1sA	GO:0003924 GO:0005525 GO:0005737 GO:0005886 GO:0006810 GO:0015093 GO:0015684 GO:0016020 GO:0016021 GO:0055072 GO:1903874
18	0.06	0.254	7.29	0.04	0.48	3qktB	GO:0000166 GO:0005524 GO:0006281 GO:0006302 GO:0006974 GO:0008270 GO:0016787 GO:0016887 GO:0042802 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0005525	GO:0003924	GO:0046872
GO-Score	0.92	0.92	0.91
Biological Processes	GO:0042254
GO-Score	0.09
Cellular Component	GO:0005737
GO-Score	0.09

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.