I-TASSER results

I-TASSER results for job id Rv3218

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (321 residues)
MRAVLIVNPTATATTPAGRDLLAHALESRLQLTVEHTNHRGHGTELGQAAVADGVDLVVV
HGGDGTVSAVVNGMLGRPGTTPVRPVPAVAVVPGGSANVLARALGISADPIAATNQLIQL
LDDYGRHQQWRRIGLIDCGERWAVFNAGMGVDAEVVAAVEAERDKGGKVTAWRYIRAAVR
AVLACTRREPALTLQLPNRDPITGVHFVFVSNSSPWTYANNRPVWTNPDCRFESGLGVFA
TTSMKVVPTLRVVRQMFAKQPKFEFNHVINNDDVACLRVTSMGPPIASQFDGDYLGVRET
MTFRAVPDALAVVAPPARKRI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRAVLIVNPTATATTPAGRDLLAHALESRLQLTVEHTNHRGHGTELGQAAVADGVDLVVVHGGDGTVSAVVNGMLGRPGTTPVRPVPAVAVVPGGSANVLARALGISADPIAATNQLIQLLDDYGRHQQWRRIGLIDCGERWAVFNAGMGVDAEVVAAVEAERDKGGKVTAWRYIRAAVRAVLACTRREPALTLQLPNRDPITGVHFVFVSNSSPWTYANNRPVWTNPDCRFESGLGVFATTSMKVVPTLRVVRQMFAKQPKFEFNHVINNDDVACLRVTSMGPPIASQFDGDYLGVRETMTFRAVPDALAVVAPPARKRI
Prediction	CEEEEEHCCCCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEHCCEEEEEEEEHCCHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHCCEEEEEEEEEEEEEHCCCCCCCCCCCEEHCCCCCCCCCCEEEEEHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEEHCCCCEEEEHCCCCCCCCCCEEEEEHCCEEEEEHCCCCCCC
Conf.Score	979999869999987579999999999899799998589877999999999989989999869766999999999788876666788689987998679999989999999999999999755566767899899998998899999985478999865777877687557889999999999678888689999899689998999999858998888887656689998888977999977889999999999998678888886699989869999988998689976754688886899999685899968875689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRAVLIVNPTATATTPAGRDLLAHALESRLQLTVEHTNHRGHGTELGQAAVADGVDLVVVHGGDGTVSAVVNGMLGRPGTTPVRPVPAVAVVPGGSANVLARALGISADPIAATNQLIQLLDDYGRHQQWRRIGLIDCGERWAVFNAGMGVDAEVVAAVEAERDKGGKVTAWRYIRAAVRAVLACTRREPALTLQLPNRDPITGVHFVFVSNSSPWTYANNRPVWTNPDCRFESGLGVFATTSMKVVPTLRVVRQMFAKQPKFEFNHVINNDDVACLRVTSMGPPIASQFDGDYLGVRETMTFRAVPDALAVVAPPARKRI
Prediction	430142130321544541250043037470502022054552024004402755020000000100010001001435453444530000000011000001002124303400410151154344514223011020453000000000000200540453453433112200121002100424545040303056543333010000000122111132302001404132000000024242040030012002434615634303244044030315746020000112034334032302440165551466668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

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Sec.Str
Seq

CEEEEEHCCCCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEHCCEEEEEEEEHCCHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEHCCEEEEEEEEEEEEEHCCCCCCCCCCCEEHCCCCCCCCCCEEEEEHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEEEEEEHCCCCEEEEHCCCCCCCCCCEEEEEHCCEEEEEHCCCCCCC
MRAVLIVNPTATATTPAGRDLLAHALESRLQLTVEHTNHRGHGTELGQAAVADGVDLVVVHGGDGTVSAVVNGMLGRPGTTPVRPVPAVAVVPGGSANVLARALGISADPIAATNQLIQLLDDYGRHQQWRRIGLIDCGERWAVFNAGMGVDAEVVAAVEAERDKGGKVTAWRYIRAAVRAVLACTRREPALTLQLPNRDPITGVHFVFVSNSSPWTYANNRPVWTNPDCRFESGLGVFATTSMKVVPTLRVVRQMFAKQPKFEFNHVINNDDVACLRVTSMGPPIASQFDGDYLGVRETMTFRAVPDALAVVAPPARKRI

4werA

0.19

0.16

0.86

2.52

MUSTER

KKAVLIVNPSSGGEKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFD-SVFVGGDGTVNEGISGLAEQA------YRPKFGFFPLGTVNDLARALNLP-DPEEAIQQL--------DLEKTSALDVGKINDDYFN-VVAIG---------------TIKLGKLAYFISGAKHLANAQT--YPFHLSLDQKEQTIESSTVLVGLTNSIGGF----ETLLPEAQVDDGLHLVYLKDQSLWDAVKAVPDLLKGV--DQSTDNLVYLTFKEGTISLEQEELTTNVDGDEGA-ALPITLKILPKHLTVYCGEE----

4werA

0.19

0.17

0.86

4.28

dPPAS

KKAVLIVNPSSGGEKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFD-SVFVGGDGTVNEGISGLAEQA------YRPKFGFFPLGTVNDLARALNLP-DPEEAIQQL--------DLEKTSALDVGKINDDYFNVVAIG----------------TIKLGKLAYFISGAKHLANAQT--YPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLL----PEAQVDDGLHLVYLKDQSLWDAVKAVPDLLKGVDQSTDNLVYLTFKEGTISLE-NQEELTTNVDGDEGA-ALPITLKILPKHLTVYCGEE----

4werA

0.19

0.17

0.86

4.52

wdPPAS

KKAVLIVNPSSGGEKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFD-SVFVGGDGTVNEGISGLAEQA------YRPKFGFFPLGTVNDLARALNLP-DPEEAIQQLDL--------EKTSALDVGKINDDYFN-VVAIG---------------TIKLGKLAYFISGAKHLANAQT--YPFHLSLDQKEQTIESSTVLVGLTNSIGGF----ETLLPEAQVDDGLHLVYLKDQSLWDAVKAVPDLLKGVDQSTDNLVYLTFKEGTISLEN-QEELTTNVDGDEGA-ALPITLKILPKHLTVYCGEE----

4werA

0.19

0.16

0.86

3.28

wMUSTER

KKAVLIVNPSSGGEKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFD-SVFVGGDGTVNEGISGLAEQA------YRPKFGFFPLGTVNDLARALNLP-DPEEAIQQL--------DLEKTSALDVGKINDDYFN-VVAIG---------------TIKLGKLAYFISGAKHLANAQT--YPFHLSLDQKEQTIESSTVLVGLTNSIGGF----ETLLPEAQVDDGLHLVYLKDQSLWDAVKAVPDLLKGV--DQSTDNLVYLTFKEGTISLEQEELTTNVDGDEGA-ALPITLKILPKHLTVYCGEE----

4werA

0.19

0.17

0.86

4.51

wPPAS

KKAVLIVNPSSGGEKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFD-SVFVGGDGTVNEGISGLAEQA------YRPKFGFFPLGTVNDLARALNLP-DPEEAIQQLDL--------EKTSALDVGKINDDYFN-VVAIG---------------TIKLGKLAYFISGAKHLANAQ--TYPFHLSLDQKEQTIESSTVLVGLTNSIGGF----ETLLPEAQVDDGLHLVYLKDQSLWDAVKAVPDLLKGVDQSTDNLVYLTFKEGTISLEN-QEELTTNVDGDEGA-ALPITLKILPKHLTVYCGEE----

4werA

0.19

0.17

0.86

8.33

dPPAS2

KKAVLIVNPSSGGEKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFD-SVFVGGDGTVNEGISGLAEQA------YRPKFGFFPLGTVNDLARALNLP-DPEEAIQQL--------DLEKTSALDVGKINDDYFN-VVAIG---------------TIKLGKLAYFISGAKHLANAQT--YPFHLSLDQKEQTIESSTVLVGLTNSIGGFETLL----PEAQVDDGLHLVYLKDQSLWDAVKAVPDLLKGVDQSTDNLVYLTFKEGTISLE-NQEELTTNVDGDEGA-ALPITLKILPKHLTVYCGEE----

4werA

0.19

0.17

0.86

4.06

PPAS

KKAVLIVNPSSGGEKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFD-SVFVGGDGTVNEGISGLAEQA------YRPKFGFFPLGTVNDLARALNLP-DPEEAIQQLD--------LEKTSALDVGKINDDYFN-VVAIG---------------TIKLGKLAYFISGAKHLANAQ--TYPFHLSLDQKEQTIESSTVLVGLTNSIGGF----ETLLPEAQVDDGLHLVYLKDQSLWDAVKAVPDLLKGVDQSTDNLVYLTFKEGTISLEN-QEELTTNVDGDEGA-ALPITLKILPKHLTVYCGEE----

4werA

0.19

0.17

0.86

5.34

Env-PPAS

KKAVLIVNPSSGGEKEFETLAEEKLKQLFDEVVVKQTEKGGDAEQFAREAAESHFD-SVFVGGDGTVNEGISGLAEQA------YRPKFGFFPLGTVNDLARALNLP-DPEEAIQQLD--------LEKTSALDVGKINDDYFN-VVAIG---------------TIKLGKLAYFISGAKHLANAQ--TYPFHLSLDQKEQTIESSTVLVGLTNSIGGF----ETLLPEAQVDDGLHLVYLKDQSLWDAVKAVPDLLKGVDQSTDNLVYLTFKEGTISLEN-QEELTTNVDGDEGA-ALPITLKILPKHLTVYCGEE----

3s40A

0.17

0.14

0.82

2.43

MUSTER

FKVLLIVNPKAGQGDTNLTKIVPPLAAAFPDLHILHTKEQGDATKYCQEFAS-KVDLIIVFGGDGTVFECTNGLAPLE------IRPTLAIIPGGTCNDFSRTLGVPQNIAEAAKLITK--------EHVKPVDVAKANGQHFLNFWGI--------------------GKIGYYLSTI--------ETFPVKITYDG-QVYEDEAVLVVGNGEYLGGI----PSFIPNVKCDDGLDIFVVKSTGIQAFKDYIGKKL---FEDSNENDIFHVKAKSIHIET-EEEKEVDTDSSL---HTPCQIELLQGHFTIYNPAVV---

3s40A

0.17

0.14

0.82

3.90

dPPAS

EKVLLIVNPKAGQGDTNLTKIVPPLAAAFPDLHILHTKEQGDATKYCQEFAS-KVDLIIVFGGDGTVFECTNGLAPLE------IRPTLAIIPGGTCNDFSRTLGVPQNIAEAAKLITK--------EHVKPVDVAKANGQHFLNFWGI--------------------GKIGYYLSTI--------ETFPVKITYDG-QVYEDEAVLVVGNGEYLGGI----PSFIPNVKCDDGTDIFVVKSTGIQAFKDYIGKKL---FEDSNENDIFHVKAKSIHIET-EEEKEVDTDS---SLHTPCQIELLQGHFTIYNPAVV---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.98

Estimated TM-score = 0.85±0.08

Estimated RMSD = 4.3±2.9Å

Download Model 2

C-score=-3.52

Download Model 3

C-score=-3.20

Download Model 4

C-score=-3.61

Download Model 5

C-score=-3.49

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4werA	0.826	1.37	0.192	0.860
2	2qv7A	0.765	2.61	0.190	0.851
3	3s40A	0.733	2.48	0.183	0.819
4	3vzdA	0.731	3.73	0.190	0.900
5	2p1rA	0.722	3.17	0.180	0.847
6	3afoA	0.633	3.37	0.144	0.763
7	2an1B	0.622	3.30	0.128	0.738
8	1yt5A	0.614	3.19	0.123	0.729
9	1u0rD	0.612	3.48	0.139	0.748
10	1suwA	0.606	3.10	0.121	0.717

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.42	19	3vzdC	ADP	Rep, Mult	8,10,37,38,39,62,63,65,66,69,95,96,97,293
2	0.11	7	2bonA	MG	Rep, Mult	231,234,236
3	0.08	3	2jgrA	POP	Rep, Mult	63,65,66,95,96,97
4	0.03	2	3afoA	NAI	Rep, Mult	64,65,68,99,100,145,146,215,216,217,291,292
5	0.03	2	2p1rA	CA	Rep, Mult	263,264,265,266,269
6	0.02	1	2p1rA	NA	Rep, Mult	63,64,67,98,99,100,101
7	0.02	1	3vzdB	MG	Rep, Mult	65,291,292,293
8	0.01	1	1z0sA	ATP	Rep, Mult	233,234,235,309
9	0.01	1	1suwB	NAP	Rep, Mult	188,189,204,206,242,244

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.366	2qv7A	0.765	2.61	0.190	0.851	2.7.1.107	8,63,65,72,93,103,106,292
2	0.098	1z0zC	0.608	3.07	0.121	0.717	2.7.1.23	63,65,146,218
3	0.088	2an1B	0.622	3.30	0.128	0.738	2.7.1.23	65,217
4	0.079	1y3iA	0.513	3.25	0.151	0.617	2.7.1.23	63,65,101,217,292,320
5	0.078	2q5fA	0.588	3.39	0.106	0.717	2.7.1.23	63,65,146
6	0.060	1yt5A	0.614	3.19	0.123	0.729	2.7.1.23	65,146,217
7	0.060	2d6fA	0.426	5.76	0.075	0.651	6.3.5.-	NA
8	0.060	2vdcF	0.407	6.31	0.059	0.667	1.4.1.13	NA
9	0.060	3ecaA	0.424	5.23	0.074	0.604	3.5.1.1	64
10	0.060	3eifA	0.406	5.74	0.049	0.629	3.4.21.110	NA
11	0.060	1l7qA	0.407	5.91	0.067	0.626	3.1.1.1	NA
12	0.060	3nxkA	0.422	5.11	0.085	0.589	3.5.1.1	62,64
13	0.060	2vdcA	0.410	6.37	0.059	0.673	1.4.1.13	NA
14	0.060	1wsaB	0.429	5.66	0.053	0.635	3.5.1.1	NA
15	0.060	1djoA	0.428	5.85	0.091	0.654	3.5.1.38	NA
16	0.060	1vljB	0.401	5.29	0.066	0.561	1.1.1.-	NA
17	0.060	1f20A	0.325	6.75	0.073	0.570	1.14.13.39	37
18	0.060	1tllA	0.412	5.83	0.069	0.639	1.14.13.39	NA
19	0.060	1r64A	0.406	5.36	0.054	0.583	3.4.21.61	24
20	0.060	1ea0A	0.394	6.48	0.049	0.651	1.4.1.13	NA
21	0.060	1p8jA	0.406	5.78	0.034	0.626	3.4.21.75	NA
22	0.060	2fr0A	0.455	5.94	0.055	0.707	2.3.1.94	NA
23	0.060	1zq1A	0.428	5.79	0.100	0.642	6.3.5.-	NA
24	0.060	2et6A	0.460	5.66	0.066	0.679	1.1.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.53	0.720	3.33	0.18	0.86	2bonA	GO:0000166 GO:0000287 GO:0001727 GO:0005524 GO:0005737 GO:0006629 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046834 GO:0046872
1	0.43	0.736	3.38	0.18	0.87	2p1rA	GO:0000166 GO:0000287 GO:0001727 GO:0005524 GO:0005737 GO:0006629 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046834 GO:0046872
2	0.41	0.835	1.37	0.19	0.87	4werA	GO:0000166 GO:0003951 GO:0008152 GO:0016301 GO:0016310
3	0.41	0.785	2.63	0.18	0.88	2qv7A	GO:0000166 GO:0003951 GO:0004143 GO:0005524 GO:0006629 GO:0008152 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046872
4	0.32	0.606	3.10	0.12	0.72	1suwA	GO:0000166 GO:0003951 GO:0005524 GO:0005737 GO:0006741 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0019674 GO:0046872 GO:0051287
5	0.31	0.741	2.61	0.17	0.82	3t5pF	GO:0003951 GO:0008152 GO:0016301 GO:0016310 GO:0046872
6	0.30	0.688	3.15	0.19	0.80	2bonB	GO:0000166 GO:0000287 GO:0001727 GO:0005524 GO:0005737 GO:0006629 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046834 GO:0046872
7	0.25	0.731	3.70	0.19	0.90	4l02A	GO:0000166 GO:0000287 GO:0001568 GO:0001934 GO:0001956 GO:0003376 GO:0003677 GO:0005516 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0006457 GO:0006670 GO:0006954 GO:0007165 GO:0007420 GO:0007565 GO:0008021 GO:0008284 GO:0008481 GO:0009267 GO:0010800 GO:0010803 GO:0010976 GO:0014070 GO:0014075 GO:0016020 GO:0016301 GO:0016740 GO:0017050 GO:0019371 GO:0019722 GO:0030148 GO:0030307 GO:0030335 GO:0030424 GO:0031398 GO:0032026 GO:0032570 GO:0032651 GO:0033198 GO:0035556 GO:0038036 GO:0042346 GO:0043005 GO:0043066 GO:0045766 GO:0045931 GO:0045987 GO:0046512 GO:0046521 GO:0046834 GO:0048146 GO:0051092 GO:0051721 GO:0070301 GO:0070555 GO:0071363
8	0.20	0.777	2.62	0.18	0.87	3t5pL	GO:0003951 GO:0008152 GO:0016301 GO:0016310 GO:0046872
9	0.09	0.630	3.33	0.12	0.75	4haoB	GO:0000166 GO:0003951 GO:0005524 GO:0005737 GO:0006741 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0019674 GO:0046872
10	0.07	0.633	3.37	0.14	0.76	3afoA	GO:0000166 GO:0003951 GO:0005524 GO:0005739 GO:0005759 GO:0006741 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0019674 GO:0034599 GO:0042736
11	0.06	0.405	6.37	0.05	0.68	5a63A	GO:0002262 GO:0004175 GO:0005765 GO:0005783 GO:0005794 GO:0005886 GO:0005887 GO:0005925 GO:0006508 GO:0006509 GO:0007219 GO:0007220 GO:0008233 GO:0016020 GO:0016021 GO:0016485 GO:0031293 GO:0042098 GO:0042470 GO:0042987 GO:0043065 GO:0043085 GO:0048013 GO:0050435 GO:0050673 GO:0070062
12	0.06	0.305	4.49	0.06	0.40	3loqA	GO:0000166 GO:0006950
13	0.06	0.308	5.70	0.06	0.47	3oc4A	GO:0000166 GO:0005623 GO:0016491 GO:0045454 GO:0050660 GO:0055114
14	0.06	0.322	6.86	0.05	0.58	5fa0A	GO:0000271 GO:0015774 GO:0016740
15	0.06	0.276	5.44	0.04	0.41	2v1uA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
16	0.06	0.247	4.31	0.07	0.33	3e05B	GO:0006479 GO:0008152 GO:0008168 GO:0008276 GO:0009236 GO:0016740 GO:0032259
17	0.06	0.212	5.64	0.02	0.32	1kk6A	GO:0016740 GO:0016746 GO:0046677
18	0.06	0.204	6.18	0.04	0.34	4husB	GO:0016740 GO:0016746 GO:0046677
19	0.06	0.201	6.47	0.05	0.33	4wd7B	GO:0016020 GO:0016021

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0003951	GO:0001727	GO:0000287	GO:0004143	GO:0051287
GO-Score	0.89	0.76	0.73	0.73	0.41	0.32
Biological Processes	GO:0008654	GO:0046834	GO:0019674	GO:0006741
GO-Score	0.84	0.73	0.32	0.32
Cellular Component	GO:0005737
GO-Score	0.82

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.