I-TASSER results

I-TASSER results for job id Rv3213c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (266 residues)
MTDTRVLAVANQKGGVAKTTTVASLGAAMVEKGRRVLLVDLDPQGCLTFSLGQDPDKLPV
SVHEVLLGEVEPNAVLVTTMEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKFSDRF
DVVIIDCPPSLGVLTLNGLTAADKAIVPLQCEMLAHRGVGQFLRTVADVQQITNPNLRLL
GALPTLYDSRTTHTRDVLLDVADRYDLQVLAPPIPRTVRFAEASASGSSVMAGRKNKGAV
AYRELAQALLKHWKTGRPLPTFTVDL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MTDTRVLAVANQKGGVAKTTTVASLGAAMVEKGRRVLLVDLDPQGCLTFSLGQDPDKLPVSVHEVLLGEVEPNAVLVTTMEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKFSDRFDVVIIDCPPSLGVLTLNGLTAADKAIVPLQCEMLAHRGVGQFLRTVADVQQITNPNLRLLGALPTLYDSRTTHTRDVLLDVADRYDLQVLAPPIPRTVRFAEASASGSSVMAGRKNKGAVAYRELAQALLKHWKTGRPLPTFTVDL
Prediction	CCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCHHHCCCCHHHHHHCCCCHHHHHCCCCCCEEEHCCCHHHHHHHHHHHCCHCHHHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHHHHHHCCEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHCCCCCCCCCCEEHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
Conf.Score	99976999987999997689999999999998998899988998666655898745577878899878998888444789997897688668899999865565999999999998757999999599999868899999888568975775899999999999999999997999889999874778875789999999999979544567888864445575669977876999799999999999999998656788888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MTDTRVLAVANQKGGVAKTTTVASLGAAMVEKGRRVLLVDLDPQGCLTFSLGQDPDKLPVSVHEVLLGEVEPNAVLVTTMEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKFSDRFDVVIIDCPPSLGVLTLNGLTAADKAIVPLQCEMLAHRGVGQFLRTVADVQQITNPNLRLLGALPTLYDSRTTHTRDVLLDVADRYDLQVLAPPIPRTVRFAEASASGSSVMAGRKNKGAVAYRELAQALLKHWKTGRPLPTFTVDL
Prediction	87412000000133211110000040000043421000010202000000011347624300010025624164024462520000001340140044016375024203500560475000000000221331110000002200000101310040033015105302742357040100000121532421440152037306741061403431214303434220221371500510240052016316754534544576
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCHHHCCCCHHHHHHCCCCHHHHHCCCCCCEEEHCCCHHHHHHHHHHHCCHCHHHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHHHHHHCCEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHCCCCCCCCCCEEHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MTDTRVLAVANQKGGVAKTTTVASLGAAMVEKGRRVLLVDLDPQGCLTFSLGQDPDKLPVSVHEVLLGEVEPNAVLVTTMEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKFSDRFDVVIIDCPPSLGVLTLNGLTAADKAIVPLQCEMLAHRGVGQFLRTVADVQQITNPNLRLLGALPTLYDSRTTHTRDVLLDVADRYDLQVLAPPIPRTVRFAEASASGSSVMAGRKNKGAVAYRELAQALLKHWKTGRPLPTFTVDL

4pfsA

0.84

0.77

0.92

4.02

MUSTER

--MTRVLAVANQKGA--KTTTVASIGAALTEQGRRVLLVDLDPQGCLTFSLGHDPDKLPVSVHEVLLGDVEPSAALVRTDEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKLDGDFDVVIIDCPPSLGVLTLNGLTAAHDVIVPLQCETLAHRGVGQFLRTISDVQQITNPDLKLLGALPTLYDSRTTHSRDVLLDVADRYELPVLAPPIPRTRK----------------SKGAIAYREFADALLRHWKSGRKMPTFTPE-

4pfsA

0.84

0.78

0.92

8.40

dPPAS

--MTRVLAVANQKG--AKTTTVASIGAALTEQGRRVLLVDLDPQGCLTFSLGHDPDKLPVSVHEVLLGDVEPSAALVRTDEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKLDGDFDVVIIDCPPSLGVLTLNGLTAAHDVIVPLQCETLAHRGVGQFLRTISDVQQITNPDLKLLGALPTLYDSRTTHSRDVLLDVADRYELPVLAPPIPRTRK----------------SKGAIAYREFADALLRHWKSGRKMPTFTPE-

4pfsA

0.84

0.78

0.92

6.71

wdPPAS

--MTRVLAVANQKG--AKTTTVASIGAALTEQGRRVLLVDLDPQGCLTFSLGHDPDKLPVSVHEVLLGDVEPSAALVRTDEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKLDGDFDVVIIDCPPSLGVLTLNGLTAAHDVIVPLQCETLAHRGVGQFLRTISDVQQITNPDLKLLGALPTLYDSRTTHSRDVLLDVADRYELPVLAPPIPRTRK----------------SKGAIAYREFADALLRHWKSGRKMPTFTPE-

4pfsA

0.84

0.77

0.92

4.33

wMUSTER

---TRVLAVANQKGA--KTTTVASIGAALTEQGRRVLLVDLDPQGCLTFSLGHDPDKLPVSVHEVLLGDVEPSAALVRTDEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKLDGDFDVVIIDCPPSLGVLTLNGLTAAHDVIVPLQCETLAHRGVGQFLRTISDVQQITNPDLKLLGALPTLYDSRTTHSRDVLLDVADRYELPVLAPPIPRTRK----------------SKGAIAYREFADALLRHWKSGRKMPTFTPE-

4pfsA

0.84

0.77

0.92

4.69

wPPAS

--MTRVLAVANQKGA--KTTTVASIGAALTEQGRRVLLVDLDPQGCLTFSLGHDPDKLPVSVHEVLLGDVEPSAALVRTDEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKLDGDFDVVIIDCPPSLGVLTLNGLTAAHDVIVPLQCETLAHRGVGQFLRTISDVQQITNPDLKLLGALPTLYDSRTTHSRDVLLDVADRYELPVLAPPIPRTRK----------------SKGAIAYREFADALLRHWKSGRKMPTFTPE-

4pfsA

0.84

0.78

0.92

8.27

dPPAS2

--MTRVLAVANQKG--AKTTTVASIGAALTEQGRRVLLVDLDPQGCLTFSLGHDPDKLPVSVHEVLLGDVEPSAALVRTDEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKLDGDFDVVIIDCPPSLGVLTLNGLTAAHDVIVPLQCETLAHRGVGQFLRTISDVQQITNPDLKLLGALPTLYDSRTTHSRDVLLDVADRYELPVLAPPIPRTRK----------------SKGAIAYREFADALLRHWKSGRKMPTFTPE-

4pfsA

0.84

0.77

0.92

4.49

PPAS

--MTRVLAVANQKGA--KTTTVASIGAALTEQGRRVLLVDLDPQGCLTFSLGHDPDKLPVSVHEVLLGDVEPSAALVRTDEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKLDGDFDVVIIDCPPSLGVLTLNGLTAAHDVIVPLQCETLAHRGVGQFLRTISDVQQITNPDLKLLGALPTLYDSRTTHSRDVLLDVADRYELPVLAPPIPRTRK----------------SKGAIAYREFADALLRHWKSGRKMPTFTPE-

4pfsA

0.84

0.77

0.92

6.58

Env-PPAS

--MTRVLAVANQKGA--KTTTVASIGAALTEQGRRVLLVDLDPQGCLTFSLGHDPDKLPVSVHEVLLGDVEPSAALVRTDEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKLDGDFDVVIIDCPPSLGVLTLNGLTAAHDVIVPLQCETLAHRGVGQFLRTISDVQQITNPDLKLLGALPTLYDSRTTHSRDVLLDVADRYELPVLAPPIPRTRK----------------SKGAIAYREFADALLRHWKSGRKMPTFTPE-

2bejA

0.43

0.39

0.92

3.71

MUSTER

-KV-RRIALANQKGGVGKTTTAINLAAYLARLGKRVLLVDLDPQGNATSGLGVR---AERGVYHLLQGE-PLEGLV-HPVDGFHLLPATPDLVGATVELA---GAPTALREALRD--EGYDLVLLDAPPSLSPLTLNALAAAEGVVVPVQAEYYALEGVAGLLATLEEVRAGLNPRLRLLGILVTMYDGRTLLAQQVEAQLRAHFGEKVFWTVIPRNVRLAEAPSFGKTIAHAPTSPGAHAYRRLAEEVMARVQEA----------

2bejA

0.43

0.40

0.92

7.44

dPPAS

--KVRRIALANQKGGVGKTTTAINLAAYLARLGKRVLLVDLDPQGNATSGLGVR---AERGVYHLLQGEPLEG--LVHPVDGFHLLPATPDLVGATVELA---GAPTALREALRD--EGYDLVLLDAPPSLSPLTLNALAAAEGVVVPVQAEYYALEGVAGLLATLEEVRAGLNPRLRLLGILVTMYDGRTLLAQQVEAQLRAHFGEKVFWTVIPRNVRLAEAPSFGKTIAHAPTSPGAHAYRRLAEEVMARVQEA----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.86

Estimated TM-score = 0.98±0.05

Estimated RMSD = 2.3±1.8Å

Download Model 2

C-score=-0.24

Download Model 3

C-score=-2.88

Download Model 4

C-score=-4.54

Download Model 5

C-score=-2.87

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4pfsA	0.909	0.71	0.853	0.921
2	2bejA	0.856	1.77	0.407	0.913
3	3ez2B1	0.847	2.64	0.206	0.962
4	2ozeA	0.828	3.00	0.218	0.955
5	4ru8A	0.817	2.45	0.207	0.925
6	3q9lA	0.807	2.66	0.214	0.917
7	4v02A	0.773	2.60	0.203	0.876
8	3fwyA	0.766	3.11	0.212	0.895
9	4rz2A	0.763	2.85	0.160	0.891
10	1hyqA	0.762	2.43	0.236	0.861

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.79	179	4wopD	CTP	Rep, Mult	14,15,16,17,18,19,20,185,186,214,215,217,220,221
2	0.13	32	3la6I	CA	Rep, Mult	18,19,42,126
3	0.07	18	2bekA	ATP	Rep, Mult	13,14,153,155
4	0.02	6	1g5pB	SF4	Rep, Mult	154,155,156,199,201,202
5	0.02	8	3ibgC	ADP	Rep, Mult	15,16,17,18,19,20,46,260,261,262,265,266
6	0.02	10	2ynmA	AF3	Rep, Mult	14,15,18,42,44,129
7	0.02	6	3r9iB	III	Rep, Mult	49,54,222,224,225,226,227
8	0.01	5	3qxcA	ATP	Rep, Mult	14,15,16,17,18,19,20,40,47,126,185,215
9	0.01	3	2wojA	UUU	Rep, Mult	13,14,189,191
10	0.01	3	3zq6A	UUU	Rep, Mult	13,14,216,218
11	0.01	4	1m34O	ALF	Rep, Mult	13,14,130
12	0.01	2	3k9gA	IOD	Rep, Mult	12,147,158
13	0.00	2	3r9iA	III	Rep, Mult	156,157,160,200,203,204
14	0.00	1	2xj9A	MG	Rep, Mult	19,45,47
15	0.00	1	3kjhA	ZN	Rep, Mult	101,103
16	0.00	1	3ez9A	MG	Rep, Mult	106,173,174
17	0.00	1	3k9gA	IOD	Rep, Mult	178,180,204
18	0.00	2	3ez2A	ADP	Rep, Mult	49,52,53,54,227
19	0.00	2	3fwyB	SF4	Rep, Mult	61,62,63,93,94,96
20	0.00	1	3k9gA	IOD	Rep, Mult	151,186,193,195,196

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.341	1de0A	0.755	3.05	0.179	0.898	1.18.6.1	13,18
2	0.322	1cp2A	0.746	3.26	0.191	0.898	1.18.6.1	13,18
3	0.305	1cp2B	0.743	3.22	0.192	0.895	1.18.6.1	14,43,132
4	0.212	3bfkB	0.460	3.50	0.092	0.560	3.6.5.2	45
5	0.066	2bmeA	0.452	3.27	0.071	0.549	3.6.5.2	45
6	0.060	2azdB	0.542	5.37	0.082	0.816	2.4.1.1	138
7	0.060	1s1mB	0.621	3.72	0.111	0.778	6.3.4.2	NA
8	0.060	2vo1B	0.566	3.28	0.081	0.692	6.3.4.2	149,164
9	0.060	1ha3B	0.507	3.65	0.133	0.628	3.1.5.1	NA
10	0.060	1a82A	0.598	3.64	0.102	0.752	6.3.3.3	18
11	0.060	1m7jA	0.514	5.36	0.061	0.808	3.5.1.81	126
12	0.060	1kgzB	0.519	4.85	0.063	0.752	2.4.2.18	14
13	0.060	1ii0B	0.619	3.81	0.142	0.778	3.6.3.16	15,18
14	0.060	1vcoA	0.623	3.91	0.111	0.789	6.3.4.2	45
15	0.060	1dj3A	0.520	4.53	0.077	0.711	6.3.4.4	NA
16	0.060	2elcD	0.512	4.91	0.113	0.748	2.4.2.18	14,138
17	0.060	2ad5B	0.616	3.80	0.116	0.782	6.3.4.2	43,45,92
18	0.060	3fgnA	0.636	3.17	0.146	0.771	6.3.3.3	16,19,163
19	0.060	3cioA	0.598	2.94	0.171	0.688	2.7.10.2	108
20	0.060	1p9bA	0.523	4.49	0.083	0.711	6.3.4.4	NA
21	0.060	2r4uA	0.523	5.36	0.072	0.793	2.4.1.21	NA
22	0.060	1vcnA	0.617	3.83	0.112	0.778	6.3.4.2	NA
23	0.060	1dj2A	0.523	4.51	0.082	0.714	6.3.4.4	NA
24	0.060	3do6A	0.618	3.90	0.115	0.808	6.3.4.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.56	0.856	1.77	0.41	0.91	2bejA	GO:0000166 GO:0003677 GO:0005524 GO:0007059 GO:0016787
1	0.49	0.847	2.64	0.21	0.96	3ez2B	GO:0030541 GO:0042802
2	0.46	0.603	3.35	0.19	0.71	3la6B	GO:0000166 GO:0000271 GO:0004713 GO:0005524 GO:0005886 GO:0005887 GO:0009103 GO:0009242 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016887 GO:0018108 GO:0038083 GO:0045226
3	0.42	0.762	2.81	0.23	0.88	3pg5C	GO:0005524 GO:0016491 GO:0055114
4	0.35	0.777	2.34	0.25	0.87	1g3qA	GO:0000166 GO:0005524 GO:0051301
5	0.32	0.674	3.41	0.17	0.82	3kb1A	GO:0000166 GO:0005524 GO:0016787 GO:0016887 GO:0046872 GO:0051536
6	0.31	0.631	3.14	0.18	0.74	3cwqA	GO:0000166
7	0.31	0.762	2.43	0.24	0.86	1hyqA	GO:0000166 GO:0005524 GO:0051301
8	0.28	0.773	2.60	0.20	0.88	4v02A	GO:0000166 GO:0005524 GO:0016887
9	0.28	0.752	3.10	0.18	0.90	2afhE	GO:0000166 GO:0005524 GO:0009399 GO:0016163 GO:0016491 GO:0016612 GO:0018697 GO:0046872 GO:0051536 GO:0051539 GO:0055114
10	0.28	0.770	2.79	0.16	0.88	2ynmB	GO:0000166 GO:0005524 GO:0015979 GO:0015995 GO:0016491 GO:0016636 GO:0016730 GO:0019685 GO:0036068 GO:0046148 GO:0046872 GO:0051536 GO:0051539 GO:0055114
11	0.28	0.697	2.29	0.20	0.77	4dzzA	GO:0000166
12	0.27	0.659	3.70	0.16	0.82	2ph1A	GO:0000166 GO:0005524 GO:0016787 GO:0016887 GO:0046872 GO:0051536
13	0.26	0.619	3.81	0.14	0.78	1ii0B	GO:0000166 GO:0005524 GO:0015446 GO:0016787 GO:0016887 GO:0046685 GO:0071722 GO:0098655 GO:0098656
14	0.16	0.595	3.18	0.14	0.69	2vedB	GO:0000166 GO:0004715 GO:0005576 GO:0006859 GO:0009103 GO:0015542 GO:0015992 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0045226
15	0.16	0.598	2.94	0.17	0.69	3cioA	GO:0000166 GO:0004713 GO:0005524 GO:0005886 GO:0009103 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0038083 GO:0042802 GO:0045226
16	0.15	0.776	2.40	0.24	0.87	1ionA	GO:0000166 GO:0005524 GO:0051301
17	0.14	0.746	3.26	0.19	0.90	1cp2A	GO:0000166 GO:0005524 GO:0009399 GO:0016163 GO:0016491 GO:0016612 GO:0018697 GO:0046872 GO:0051536 GO:0051539 GO:0055114
18	0.08	0.641	3.85	0.15	0.83	4iojA	GO:0000166 GO:0004329 GO:0005524 GO:0006730 GO:0009396 GO:0016874 GO:0035999
19	0.08	0.631	3.48	0.16	0.77	3ug7A	GO:0000166 GO:0005524 GO:0015446 GO:0016787 GO:0016887 GO:0042802 GO:0046685 GO:0098655 GO:0098656

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0003677	GO:0042802	GO:0016887	GO:0004713	GO:0016491
GO-Score	0.91	0.56	0.49	0.46	0.46	0.42
Biological Processes	GO:0007059	GO:0030541	GO:0038083	GO:0009103	GO:0009242	GO:0045226	GO:0055114	GO:0051301
GO-Score	0.56	0.49	0.46	0.46	0.46	0.46	0.42	0.35
Cellular Component	GO:0005887
GO-Score	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.