I-TASSER results

I-TASSER results for job id Rv3210c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (231 residues)
MPSPSSADQVADSPRPRLPADHPGVNELFALLAYGEVAAFYRLTDEARMAPDLRGRISMA
SMAAAEMGHYELLRNALERRGVDVVSAMSKYTSALENYHRLTTPSTWLEALVKTYVADAL
AADLYLEIADGLPDEVADVVRAALSETGHSQFVVAEVRAAVTASGKQRSRLALWSRRLLG
EAITQAQLVLADHDELVDLVVSGSGGLSQLGAFFDRLQQTHDQRMRELGLS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MPSPSSADQVADSPRPRLPADHPGVNELFALLAYGEVAAFYRLTDEARMAPDLRGRISMASMAAAEMGHYELLRNALERRGVDVVSAMSKYTSALENYHRLTTPSTWLEALVKTYVADALAADLYLEIADGLPDEVADVVRAALSETGHSQFVVAEVRAAVTASGKQRSRLALWSRRLLGEAITQAQLVLADHDELVDLVVSGSGGLSQLGAFFDRLQQTHDQRMRELGLS
Prediction	CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
Conf.Score	998888877788888888865569999999999999999999999999899999999999999999999999999999989999999999999999999868999958999999999999999999999869957899999987556657999999999999766776677889999999999999999986889999998578898899999999999999999998899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MPSPSSADQVADSPRPRLPADHPGVNELFALLAYGEVAAFYRLTDEARMAPDLRGRISMASMAAAEMGHYELLRNALERRGVDVVSAMSKYTSALENYHRLTTPSTWLEALVKTYVADALAADLYLEIADGLPDEVADVVRAALSETGHSQFVVAEVRAAVTASGKQRSRLALWSRRLLGEAITQAQLVLADHDELVDLVVSGSGGLSQLGAFFDRLQQTHDQRMRELGLS
Prediction	765355565665545454363341013000000101200022105205404505323300410240253154025204724241350044035305514631424423221031100300032003200731466025203500464421410142036105525614320000012000100320231034274025214545243640350043027412520562658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
MPSPSSADQVADSPRPRLPADHPGVNELFALLAYGEVAAFYRLTDEARMAPDLRGRISMASMAAAEMGHYELLRNALERRGVDVVSAMSKYTSALENYHRLTTPSTWLEALVKTYVADALAADLYLEIADGLPDEVADVVRAALSETGHSQFVVAEVRAAVTASGKQRSRLALWSRRLLGEAITQAQLVLADHDELVDLVVSGSGGLSQLGAFFDRLQQTHDQRMRELGLS

3ez0A

0.30

0.27

0.90

1.97

MUSTER

------------TSPADTAR--YNRFVADLFGAYGELSAFERFSADARYSPTLHDRAVLGRIAVVEFRHYELVSARLEA--IDAEDAL-PFQAAVDYFHSRTRPAD-WYESLKAYVIDTVSADFYRAISRYVDAGTRDVIEQIQASDETTEVLRERLRSALADDPRLASRLALWGRRLLGEALTQAQRVSYEHAFLGSLIAAA---KELVSGLIAGLAEKHSKRTQL--LT

3ez0A

0.30

0.27

0.91

2.41

dPPAS

--------------TSPADTARYNRFVADLFGAYGELSAFERFSADARYSPTLHDRAVLGRIAVVEFRHYELVSARLEAG-IDAEDAL-PFQAAVDYFHSRTRPAD-WYESLKAYVIDTVSADFYRAISRYVDAGTRDVIEQIQASDETTEVLRERLRSALADDPRLASRLALWGRRLLGEALTQAQRVSYEHAFLGSLIAAA---KELVSGLIAGLAEKHSKRTQLG-LT

3ez0A

0.30

0.27

0.90

3.44

wdPPAS

------------TSPADTAR--YNRFVADLFGAYGELSAFERFSADARYSPTLHDRAVLGRIAVVEFRHYELVSARLEA--IDAEDAL-PFQAAVDYFHSRTRPAD-WYESLKAYVIDTVSADFYRAISRYVDAGTRDVIEQIQASDETTEVLRERLRSALADDPRLASRLALWGRRLLGEALTQAQRVSYEHAFLGSLIAA---AKELVSGLIAGLAEKHSKRTQL--LT

3ez0A

0.30

0.27

0.90

2.38

wMUSTER

-------------SPADTAR--YNRFVADLFGAYGELSAFERFSADARYSPTLHDRAVLGRIAVVEFRHYELVSARLEA--IDAEDAL-PFQAAVDYFHSRTRPAD-WYESLKAYVIDTVSADFYRAISRYVDAGTRDVIEQIQASDETTEVLRERLRSALADDPRLASRLALWGRRLLGEALTQAQRVSYEHAFLGSLIAAA---KELVSGLIAGLAEKHSKRTQL--LT

3ez0A

0.30

0.27

0.90

3.79

wPPAS

------------TSPADTAR--YNRFVADLFGAYGELSAFERFSADARYSPTLHDRAVLGRIAVVEFRHYELVSARLEA--IDAEDAL-PFQAAVDYFHSRTRPAD-WYESLKAYVIDTVSADFYRAISRYVDAGTRDVIEQIQASDETTEVLRERLRSALADDPRLASRLALWGRRLLGEALTQAQRVSYEHAFLGSLIAAA---KELVSGLIAGLAEKHSKRTQL--LT

3ez0A

0.30

0.27

0.91

5.81

dPPAS2

--------------TSPADTARYNRFVADLFGAYGELSAFERFSADARYSPTLHDRAVLGRIAVVEFRHYELVSARLEAG-IDAEDAL-PFQAAVDYFHSRTRPAD-WYESLKAYVIDTVSADFYRAISRYVDAGTRDVIEQIQASDETTEVLRERLRSALADDPRLASRLALWGRRLLGEALTQAQRVSYEHAFLGSLIAAA---KELVSGLIAGLAEKHSKRTQLG-LT

3ez0A

0.32

0.29

0.89

2.99

PPAS

----------------TSPADTYNRFVADLFGAYGELSAFERFSADARYSPTLHDRAVLGRIAVVEFRHYELVSARLEA--IDAEDAL-PFQAAVDYFHSRTRPAD-WYESLKAYVIDTVSADFYRAISRYVDAGTRDVIEQIQASDETTEVLRERLRSALADDPRLASRLALWGRRLLGEALTQAQRVSYEHAFLGSLIAAA---KELVSGLIAGLAEKHSKRTQL--LT

3ez0A

0.30

0.27

0.91

6.09

Env-PPAS

------------TSPADTAR--YNRFVADLFGAYGELSAFERFSADARYSPTLHDRAVLGRIAVVEFRHYELVSARLEAG-IDAEDAL-PFQAAVDYFHSRTRPAD-WYESLKAYVIDTVSADFYRAISRYVDAGTRDVIEQIQASDETTEVLRERLRSALADDPRLASRLALWGRRLLGEALTQAQRVSYEHAFLGSLIAAA---KELVSGLIAGLAEKHSKRTQLG-LT

4mudA

0.15

0.14

0.90

1.19

MUSTER

--------QKLRSVKEVPQDLTNTLVNIIELRADFELAV-EQYSPWLVNAPTVDSRLFVAKLVSDELNHGWQLVRLLEEFKV--KDVIERISNARLGIHKLEPLFNWEDVIAFTFLVDGAGLYQLKILKDCSFEPLSTLASSIKEEESHIFFSQNELRNY--QNKNRQGAINFWFPRAVE-----------TWSLNETHLRDLNISDLTKNDLINGYIKTTNEELKKCGYN

4ke2A

0.14

0.12

0.85

0.92

dPPAS

-------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP----------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.88

Estimated TM-score = 0.83±0.08

Estimated RMSD = 3.9±2.6Å

Download Model 2

C-score=-2.11

Download Model 3

C-score=-3.44

Download Model 4

C-score=0.86

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ez0A	0.855	1.61	0.343	0.905
2	3pvrA	0.815	3.00	0.146	0.978
3	1mhyB	0.794	2.79	0.101	0.939
4	3perA	0.789	2.97	0.121	0.944
5	1xmgC	0.784	2.71	0.120	0.931
6	2inpD	0.770	2.48	0.117	0.883
7	4hr0A	0.764	3.28	0.088	0.948
8	3dhiA	0.762	3.04	0.128	0.935
9	3ee4A	0.760	3.08	0.115	0.931
10	1mhzD	0.759	2.91	0.094	0.922

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.38	90	1nf4A	FE2	Rep, Mult	36,66,69
2	0.20	20	4pgkA	Y69	Rep, Mult	31,35,36,39,66,114,117,118,120,121,124,125,182,186,189,213,217
3	0.07	18	3qb9C	FE	Rep, Mult	43,62,66,118,149
4	0.06	15	4kvsA	6NA	Rep, Mult	35,36,39,66,114,117,118,121
5	0.05	6	3ez0A	UNL	Rep, Mult	31,32,36,66,69,117,121,125,143
6	0.02	6	1xvgA	BRJ	Rep, Mult	28,31,32,95,124,195
7	0.01	4	1nf4B	FEC	Rep, Mult	33,40,41,44,48,60,67,71
8	0.01	2	1xvbB	BHL	Rep, Mult	28,95,121,124,182,185,186,195
9	0.00	1	1xvgC	BRJ	Rep, Mult	64,67,71
10	0.00	1	1xvgA	BRJ	Rep, Mult	39,43,59,63,114
11	0.00	1	1xvgA	BRJ	Rep, Mult	112,113,116,171,174,175
12	0.00	1	3u52A	XE	Rep, Mult	28,73,76,77,136,139

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.194	3ee4A	0.760	3.08	0.115	0.931	1.17.4.1	NA
2	0.183	1krqA	0.502	2.71	0.097	0.593	1.16.3.1	145
3	0.176	3e6sF	0.501	2.48	0.081	0.584	1.16.3.1	69,126,129,144
4	0.142	1eumE	0.504	2.49	0.126	0.584	1.16.3.1	129,146
5	0.139	2vuxB	0.671	3.29	0.088	0.836	1.17.4.1	NA
6	0.136	1h0nA	0.716	3.08	0.105	0.892	1.17.4.1	NA
7	0.135	2wlaA	0.524	2.99	0.096	0.615	1.16.3.1	143
8	0.121	3es3A	0.516	2.81	0.108	0.610	1.16.3.1	41,71
9	0.088	3bvlF	0.508	2.83	0.092	0.602	1.16.3.1	64
10	0.084	1uzrB	0.746	3.06	0.095	0.918	1.17.4.1	70
11	0.075	2qcxB	0.627	3.28	0.087	0.775	3.5.99.2	65,69
12	0.074	2rd3D	0.618	3.21	0.065	0.766	3.5.99.2	94
13	0.060	2htnG	0.537	2.08	0.141	0.593	1.16.3.1	149
14	0.060	1jk0A	0.724	3.12	0.091	0.900	1.17.4.1	NA
15	0.060	1mfrW	0.517	2.73	0.096	0.610	1.16.3.1	41,71
16	0.060	2j2fA	0.699	3.62	0.102	0.887	1.14.19.2,1.14.99.6	NA
17	0.060	1we1A	0.563	3.93	0.045	0.745	1.14.99.3	118
18	0.060	1mhyB	0.794	2.79	0.101	0.939	1.14.13.25	32,40
19	0.060	1rsrB	0.749	3.28	0.075	0.939	1.17.4.1	NA
20	0.060	1jkuA	0.557	3.20	0.097	0.667	1.11.1.6	NA
21	0.060	1xvgC	0.781	2.75	0.120	0.931	1.14.13.25	32,40
22	0.060	3hf1B	0.730	3.02	0.091	0.896	1.17.4.1	NA
23	0.060	1we1C	0.547	4.27	0.047	0.762	1.14.99.3	115,118,142
24	0.060	1iw1A	0.546	3.93	0.073	0.740	1.14.99.3	NA
25	0.060	1bg7A	0.446	3.18	0.034	0.558	1.16.3.1	41,71
26	0.060	2bq1I	0.734	3.13	0.095	0.913	1.17.4.1	NA
27	0.060	1otwA	0.623	2.82	0.114	0.749	1.3.3.11	71,121,144
28	0.060	1r03A	0.520	2.72	0.127	0.610	1.16.3.1	126
29	0.060	1smsA	0.711	3.18	0.087	0.896	1.17.4.1	NA
30	0.060	1wowA	0.592	3.98	0.050	0.792	1.14.99.3	NA
31	0.060	2v8tA	0.530	2.86	0.090	0.623	1.11.1.6	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.48	0.762	3.04	0.13	0.94	3dhiA	GO:0004497 GO:0006725 GO:0016491 GO:0019439 GO:0042203 GO:0046872 GO:0055114
1	0.35	0.782	2.74	0.12	0.93	1fyzC	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0015050 GO:0015947 GO:0016491 GO:0016709 GO:0055114
2	0.33	0.531	2.40	0.15	0.60	3fvbA	GO:0004322 GO:0005623 GO:0006826 GO:0006879 GO:0008199 GO:0046872 GO:0055114
3	0.33	0.529	2.19	0.14	0.59	3gvyB	GO:0004322 GO:0005623 GO:0006826 GO:0006879 GO:0008199 GO:0046872 GO:0055114
4	0.32	0.816	3.03	0.14	0.98	4ii4A	GO:0005829 GO:0010124 GO:0016491 GO:0055114 GO:0097266
5	0.30	0.533	2.15	0.10	0.59	3bknA	GO:0004322 GO:0005623 GO:0006826 GO:0006879 GO:0008199 GO:0046872 GO:0055114
6	0.30	0.552	2.08	0.10	0.61	1nf6F	GO:0004322 GO:0005623 GO:0006826 GO:0006879 GO:0006880 GO:0008199 GO:0016491 GO:0046872 GO:0055114
7	0.30	0.789	2.97	0.12	0.94	3perA	GO:0016491 GO:0019439 GO:0046872 GO:0051213 GO:0055114
8	0.29	0.775	2.96	0.14	0.93	4mudD	GO:0005829 GO:0010124
9	0.29	0.521	2.38	0.12	0.59	1b71A	GO:0005506 GO:0005737 GO:0016491 GO:0046872 GO:0055114
10	0.26	0.717	2.97	0.13	0.87	4iitC	GO:0010124
11	0.26	0.723	2.94	0.12	0.87	4ii4C	GO:0005829 GO:0010124
12	0.23	0.757	3.00	0.10	0.93	2innA	GO:0006725 GO:0016491 GO:0046872 GO:0055114
13	0.23	0.749	2.57	0.10	0.88	3n1xB	GO:0004497 GO:0006725 GO:0016491 GO:0016709 GO:0055114
14	0.21	0.529	2.21	0.13	0.59	1jgcA	GO:0004322 GO:0005623 GO:0006826 GO:0006879 GO:0008199 GO:0016491 GO:0046872 GO:0055114
15	0.21	0.512	2.40	0.16	0.58	3qhbA	GO:0009536 GO:0009842 GO:0016491 GO:0046872 GO:0055114
16	0.20	0.751	3.26	0.11	0.94	2incA	GO:0004497 GO:0006725 GO:0016491 GO:0046872 GO:0055114
17	0.15	0.794	2.79	0.10	0.94	1mhyB	GO:0004497 GO:0006725 GO:0006730 GO:0015049 GO:0016491 GO:0016709 GO:0055114
18	0.14	0.770	2.48	0.12	0.88	2inpD	GO:0006725 GO:0016491 GO:0016709 GO:0055114
19	0.13	0.568	3.27	0.09	0.68	1veiA	GO:0003677 GO:0005737 GO:0006879 GO:0006950 GO:0008199 GO:0009295 GO:0016491 GO:0016722 GO:0046872 GO:0055114
20	0.12	0.551	3.14	0.09	0.65	2vxxB	GO:0005623 GO:0006879 GO:0006950 GO:0008199 GO:0016722 GO:0046872 GO:0055114
21	0.12	0.530	2.58	0.11	0.61	1n1qA	GO:0003677 GO:0005737 GO:0006879 GO:0006950 GO:0008199 GO:0009295 GO:0016491 GO:0016722 GO:0030261 GO:0046872 GO:0055114
22	0.07	0.513	2.02	0.15	0.57	2qqyA	GO:0005623 GO:0006879 GO:0008199
23	0.06	0.364	6.03	0.07	0.63	4ntcA	GO:0000166 GO:0016491 GO:0055114
24	0.06	0.345	6.73	0.05	0.66	4xddA	GO:0005506 GO:0008901 GO:0009055 GO:0016491 GO:0046872 GO:0051536 GO:0051539 GO:0055114
25	0.06	0.364	5.89	0.05	0.61	3kkzA	GO:0046872 GO:0051536 GO:0051539
26	0.06	0.293	5.86	0.04	0.52	1r30B	GO:0003824 GO:0004076 GO:0005506 GO:0009102 GO:0016740 GO:0046872 GO:0051536 GO:0051537 GO:0051539
27	0.06	0.274	6.10	0.04	0.49	2rjqA	GO:0004222 GO:0005178 GO:0005576 GO:0005578 GO:0005615 GO:0005788 GO:0006508 GO:0008201 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0022617 GO:0031012 GO:0036066 GO:0042742 GO:0046872 GO:0050840
28	0.06	0.318	6.34	0.04	0.58	2wm4A	GO:0004497 GO:0005506 GO:0005886 GO:0006629 GO:0006631 GO:0006707 GO:0008395 GO:0010430 GO:0016491 GO:0016705 GO:0020037 GO:0036199 GO:0046872 GO:0055114 GO:0070402 GO:0097089

Consensus prediction of GO terms

Molecular Function	GO:0004322	GO:0008199	GO:0015049	GO:0097266
GO-Score	0.55	0.55	0.35	0.32
Biological Processes	GO:0055114	GO:0006879	GO:0006826	GO:0042203	GO:0006730	GO:0015947	GO:0010124
GO-Score	0.90	0.55	0.55	0.48	0.35	0.35	0.32
Cellular Component	GO:0015050	GO:0005829
GO-Score	0.35	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.