I-TASSER results

I-TASSER results for job id Rv3205c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (292 residues)
MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGEVVLSMVADNARAAWSA
RVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPRHDEVVSAAVRLHEATGKL
ERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGVPTAPPAADPQRSIDLINQLA
GLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYWRPASWAAGVAVVDALSWGAADD
GLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAEAFPGLAHTAALVRLVL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGEVVLSMVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPRHDEVVSAAVRLHEATGKLERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGVPTAPPAADPQRSIDLINQLAGLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYWRPASWAAGVAVVDALSWGAADDGLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAEAFPGLAHTAALVRLVL
Prediction	CCCCCCCCCCCCCCCHHHHHHHCCCCCCCEHCCCCCCCEEEHCEEEEEHCCCCHHHHHHHHHHHHCCCCCCEHCCCCCCCCCCEEHCCEEHCEHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEHCCCCCEEEHCCCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
Conf.Score	9987777788899999999987999898678688778779986699996898568889999998767888566587667887589856775555689888888999999999999998699987556788887666665787777765677755655545667777647899999999999858777899667544554476579999879999755568546889999999887589889999875688568999999999999997688988556557999999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGEVVLSMVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPRHDEVVSAAVRLHEATGKLERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGVPTAPPAADPQRSIDLINQLAGLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYWRPASWAAGVAVVDALSWGAADDGLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAEAFPGLAHTAALVRLVL
Prediction	8555435514564126201411416634144035423200100200042064463031104125504266020032141340210000030322142445331320030032015104716315204544533444311002022101344435315423444433443440240044025225416333000000000000014741000000000011240000000000000240243005204414502000000000000000021634653252031004103415
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCHHHHHHHCCCCCCCEHCCCCCCCEEEHCEEEEEHCCCCHHHHHHHHHHHHCCCCCCEHCCCCCCCCCCEEHCCEEHCEHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEHCCCCCEEEHCCCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGEVVLSMVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPRHDEVVSAAVRLHEATGKLERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGVPTAPPAADPQRSIDLINQLAGLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYWRPASWAAGVAVVDALSWGAADDGLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAEAFPGLAHTAALVRLVL

3jr1A

0.10

0.09

0.93

1.17

MUSTER

-----NLYFQGKSISQVLAEQFGYFIKHKEKLYSGENEIWLINTVFVKINERSYRFRAEADQLALLATNSINVPLVYGIGNSQ---HSFLLLEALNKSKNKQFTIFAEKIAQLHQI-QGPDKYGLDFDTWLGPIYQPNDWQTSWAKFFSENRIGWQLQICKEKGLIF--GNIDLIVQIVADTLSKHNPKPSILHGNLWENCIQVDDK-IFVCNPACYWGDRECDIAFSSL----FEPFPTNFYQRYNEIEGYLERKLIYQLYYLLNFSYR---YNKKQSYVSLTQKLINQIL

3tdvA

0.13

0.94

1.09

dPPAS

--------QNKLHYTTMIMTQFDISIQSVESLGEGFRNAILVNDWVFRFPKSQQGADELNKEIQLLPCVKVNIPQYVKRSDGNPFVGGQILGE--DGMAVFPDDAKDRLALQLAEFMNELSA---FPVETAISAGVPVTNLKNKILLL----SEAVEDQVFPLLDESLRDYLTLRFQSYMTHPVYTRYTPRLIHGDLSDHFLTNLNSRQTPLTGIIDFGDAAIPDYDYVYLLEDCGELFTRQVMAYRGEVDKVSLFVTFDQVSYLLEGLRARDQDWISEGLELLEEDKANNF

2ppqA

0.15

0.13

0.89

1.37

wdPPAS

------TDITEDE--RNFLTQYDVGSLT-SYKGIAENSNFLL-PLILTLY-EKKNDLPFFLGLQHLAAKGLSCPLPLPRKDGEGELSGRPAASFLEGWLKPEAKHCREVGKALAAHLA-------SEGFEIKRPNALSVDGWKVLWD---KSEERADEVEKG-----LREEIRPEIDYLAAHW-PKDLPAGVIHADLQDNVFFLGDELSGLIDF-----LLAYDVSICLNAWCFEKDGAKALLEGYQSVRPSRGSALRFFLTRLYDWLTTPAGVKKDPLEYLRKLRFHRTIA

3jr1A

0.13

0.12

0.91

1.27

wMUSTER

LYFQGWKSIS-----QVLAEQFGYFIKHKEKLYSGENEIWLINTVFVKINERSYRFRAEADQLALLKTNSINVPLVYGNSQG----HSFLLLEALNKSKNKQFTIFAEKIAQLHQIQGPLDFDTWLGPIYQPNDWQTSKFFSENRIGWQ---LQICKEKGLIFGN------IDLIVQIVADTLSKHNPKPSILHGNLWENCIQVDDK-IFVCNPACYWGDRECDIAFSSL----FEPFPTNFYQRYNEIEGYLERKLIYQLYYLLNFSYR---YNKKQSYVSLTQKLINQIL

2ppqA

0.18

0.16

0.89

1.27

wPPAS

------TDITEDE--RNFLTQYDV--GSLTSYGIAENSNFLL-PLILTLYEKKNDLPFFLGLQHLAA-KGLSCPLPLPRKDGEGELSGRPAASFLEGWPEAKHCREVGKALAAHLASEGFEIKR---------PNALS--VDGWKVLWDKS-EERADEVEKG-----LREEIRPEIDYLAAHW-PKDLPAGVIHADLFDNVFFLGDELSGLIDFCNDLL---YDVSICLNAWCFEKDGAKALLEGYQSVPEALPLLSRGSALRFFLTRLYTPAGALEYLRKLRFHRTIANVA

2ppqA

0.14

0.13

0.91

2.27

dPPAS2

------TDITEDEL-RNFLTQYDVGSLTSYK-GIAENSNFLLHTLILTLYEKKNDLPFFLGLQHLAA-KGLSCPLPLPRKDGEGELSGRPAASFLEGWLKPEAKHCREVGKALAAHLA-------SEGFEIKRPNALSVDGWKVLWD---KSEERADEVEKG-----LREEIRPEIDYLAAHW-PKDLPAGVIHADLQDNVFFLGDELSGLIDFCNDLL--AYDVSICLNAWCFEKDGAKALLEGYQSVRPSRGSALRFFLTRLYDWLTTPAGVKKDPLEYLRKLRFHRTIA

2ppqA

0.15

0.14

0.90

1.20

PPAS

------TDITEDE--RNFLTQYDV-GSLTSYKGIAENSNFLL-PLILTLYEKKNDLPFFLGLQHLAA-KGLSCPLPLPRKDGEGELSGRPAASFLEGWLKPEAKHCREVGKALAAHLASEGFEI-------KRPNALSVDGWKVLWDKSEERADEV--------EKGLREEIRPEIDYLAAHW-PKDLPAGVIHADLFDNVFFLGDELSGLIDFCNDLL--AYDVSICLNAWCFEKDGAKALLEGYQSVRPSRGSALRFFLTRLYDWLTTPAGVKKDPLEYLRKLRFHRTIA

4pdyA

0.15

0.98

1.61

Env-PPAS

LGSRS----QAPLIPQAVVSKYDLAIQQRHADGNIE--VWTDRRYAAKRSSIAPAHCRIVQCLRHAQEQGFKFARFVTTSSNAPYVRDYYVTEWVSGQANFGVAQTAYTLAQFHEATRSFRTDWKDDVFGLFQARWRDLRQWLGADRREKDAFDQLLLSRDELHRDAAESLALFEDRDVIAYLEAERSSGGWCHLDVISNCLYTPQHQVVLIDFE-LARPAPRALAHLLRRSLERGNWDGHLAYACFLIPKEAILRFPYLPWRIAHARYHFAADPSQLDALQQYAVQAEKRQ

3tdvA

0.12

0.11

0.91

1.14

MUSTER

--------QNKLHYTTMIMTQFDISIQSVESLGEGFRYAILVNDWVFRFPKSQDELNKEIQLLPLLVCVKVNIPQYVKRSDGNPFVGGQILGEGMAVFPDDAKDRLALQLAEFMNELSAFP-VETAISAGVPVTNLKNKILLLSEAV-----EDQVFPLLDES----LRDYLTLRFQSYMTHPVYTRYTPRLIHGDLSDHFLTNLNSRQGIIDFGDAISDPDYDYVYLLEDC----LFTRQVMAYRGEVD--LDTHIRKVSLFVTFDQVSY---LEGLRAISEGLELLEEDK

2ppqA

0.13

0.12

0.91

1.04

dPPAS

------TDITEDEL-RNFLTQYDVGSLTSYK-GIAENSNFLLHTLILTLYEKKNDLPFFLGLQHLAA-KGLSCPLPLPRKDGEGELSGRPAALILEGWLKPEAKHCREVGKALAAHLA-------SEGFEIKRPNALSVDGWKVLWD---KSEERADEVEKG------LREEIRPEIDYLAAHWPKDLPAGVIHADLQDNVFFLGDELSGLIDFYFACNLLAYDVSICLNAWCFEKDGAKALLEGYQSVRPSRGSALRFFLTRLYDWLTTPAGVKKDPLEYLRKLRFHRTIA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.74

Estimated TM-score = 0.62±0.14

Estimated RMSD = 7.8±4.4Å

Download Model 2

C-score=-3.29

Download Model 3

C-score=-3.55

Download Model 4

C-score=-3.19

Download Model 5

C-score=-3.88

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3i0oA	0.788	3.13	0.101	0.945
2	2ppqA	0.774	2.97	0.135	0.911
3	4ocjA	0.766	3.44	0.120	0.945
4	3tdvA	0.766	3.00	0.098	0.907
5	2qg7D	0.746	3.94	0.093	0.959
6	3mesA	0.739	3.34	0.077	0.894
7	3g15A	0.739	3.69	0.077	0.921
8	3atsA	0.732	3.80	0.094	0.907
9	2pywA	0.729	4.22	0.099	0.952
10	3c5iD	0.728	3.56	0.068	0.904

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.28	24	4dcaA	ADP	Rep, Mult	33,46,48,92,93,94,95,200,202,212,213
2	0.14	11	4dtaB	ADN	Rep, Mult	46,74,93,94,95,202,212,213
3	0.06	5	3atsA	MG	Rep, Mult	196,198,200,213
4	0.02	2	3c5iB	CHT	Rep, Mult	196,198,231,263,266,279,283
5	0.01	1	4r7bA	CHT	Rep, Mult	35,196,231,264,267,276
6	0.01	1	1l8tA	MG	Rep, Mult	37,213

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.273	1nd4A	0.615	4.02	0.111	0.784	2.7.1.95	196
2	0.232	2ppqA	0.774	2.97	0.135	0.911	2.7.1.39	97,196,203
3	0.141	1l8tA	0.617	4.22	0.063	0.798	2.7.1.95	196
4	0.060	3f2sA	0.738	3.71	0.081	0.921	2.7.1.32	196
5	0.060	2ckpA	0.698	3.51	0.091	0.863	2.7.1.32	196
6	0.060	2pywA	0.729	4.22	0.099	0.952	2.7.1.100	196
7	0.060	3fegA	0.716	3.82	0.106	0.901	2.7.1.82	199,202
8	0.060	1tkiA	0.463	3.92	0.047	0.586	2.7.11.1	196
9	0.060	2b9iA	0.465	4.06	0.074	0.596	2.7.11.24,2.7.1.37	196
10	0.060	2pulA	0.718	4.18	0.083	0.931	2.7.1.100	196
11	0.060	2excX	0.445	4.00	0.080	0.572	2.7.11.24,2.7.1.37	196
12	0.060	2qr8A	0.463	4.24	0.118	0.610	2.7.11.1	202,221
13	0.060	3c0gB	0.465	4.09	0.086	0.596	2.7.11.1	NA
14	0.060	2wb8A	0.462	3.69	0.077	0.575	2.7.11.1	33,35,94,196,202,213,215
15	0.060	2zoqA	0.465	4.09	0.098	0.603	2.7.11.24	196,215
16	0.060	3fbvD	0.463	3.84	0.094	0.582	2.7.11.1,	196
17	0.060	1j7lA	0.621	4.02	0.072	0.791	2.7.1.95	196
18	0.060	3kn5A	0.460	4.58	0.103	0.616	2.7.11.1	33,35,97,202,213
19	0.060	3e7oA	0.449	4.20	0.094	0.596	2.7.11.24	196
20	0.060	2ckpB	0.624	3.35	0.098	0.767	2.7.1.32	196
21	0.060	2wntB	0.459	4.19	0.097	0.603	2.7.11.1	196
22	0.060	2jiiB	0.466	4.12	0.083	0.620	2.7.11.1	203

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.788	3.13	0.10	0.95	3i0oA	GO:0000166 GO:0016740
1	0.28	0.781	2.96	0.13	0.92	2ppqA	GO:0000166 GO:0004413 GO:0005524 GO:0008652 GO:0009088 GO:0016301 GO:0016310 GO:0016740
2	0.28	0.744	3.46	0.10	0.92	3w0sA	GO:0000166 GO:0005524 GO:0016301 GO:0016310 GO:0016740 GO:0046677
3	0.27	0.732	3.80	0.09	0.91	3atsA	GO:0000166 GO:0005524 GO:0016301 GO:0016310 GO:0016740 GO:0046677 GO:0046872
4	0.26	0.720	4.09	0.08	0.93	3hamA	GO:0000166 GO:0005524 GO:0016740
5	0.25	0.742	3.42	0.08	0.90	3mesB	GO:0000166 GO:0016301 GO:0016310 GO:0046872
6	0.24	0.719	4.41	0.10	0.96	2q83A	GO:0030435 GO:0031160
7	0.23	0.748	3.37	0.11	0.91	3fi8A	GO:0000166 GO:0004103 GO:0005829 GO:0006656 GO:0006657 GO:0016301 GO:0016310 GO:0016740 GO:0033265
8	0.23	0.713	3.84	0.07	0.90	5iqcA	GO:0000166 GO:0003824 GO:0005524 GO:0005737 GO:0008080 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0016746 GO:0046677
9	0.22	0.736	3.72	0.08	0.92	5afvA	GO:0000166 GO:0004103 GO:0004104 GO:0004305 GO:0004871 GO:0005524 GO:0005737 GO:0005829 GO:0006580 GO:0006629 GO:0006646 GO:0006656 GO:0006657 GO:0006869 GO:0007165 GO:0008144 GO:0008654 GO:0009636 GO:0016301 GO:0016310 GO:0016740 GO:0019695 GO:0033265 GO:0042803 GO:1904681
10	0.22	0.655	3.63	0.12	0.81	4h05B	GO:0005524 GO:0016740 GO:0016773 GO:0046677
11	0.22	0.703	4.05	0.09	0.90	4dfbB	GO:0000166
12	0.21	0.704	4.21	0.14	0.94	4pdyA	GO:0016740
13	0.21	0.698	3.51	0.09	0.86	2ckpA	GO:0000166 GO:0004103 GO:0004104 GO:0004305 GO:0004871 GO:0005524 GO:0005737 GO:0005829 GO:0006580 GO:0006629 GO:0006646 GO:0006656 GO:0006657 GO:0006869 GO:0007165 GO:0008144 GO:0008654 GO:0009636 GO:0016301 GO:0016310 GO:0016740 GO:0019695 GO:0033265 GO:0042803 GO:1904681
14	0.21	0.718	4.18	0.08	0.93	2pulA	GO:0000166 GO:0005524 GO:0008652 GO:0009086 GO:0016301 GO:0016310 GO:0016740 GO:0019284 GO:0019509 GO:0046522
15	0.16	0.687	4.63	0.10	0.94	1nw1A	GO:0000166 GO:0004103 GO:0004305 GO:0005524 GO:0006629 GO:0006646 GO:0006656 GO:0006657 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046872
16	0.15	0.728	3.56	0.07	0.90	3c5iD	GO:0046872
17	0.15	0.783	3.20	0.14	0.94	4ocuA	GO:0000166 GO:0016740
18	0.14	0.745	3.94	0.09	0.96	2qg7E	GO:0016301 GO:0016310
19	0.13	0.702	3.33	0.14	0.86	3dxqA
20	0.11	0.709	3.99	0.10	0.91	2ig7B	GO:0000166 GO:0004103 GO:0004305 GO:0005524 GO:0005829 GO:0006629 GO:0006646 GO:0006656 GO:0006657 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046474
21	0.11	0.696	3.72	0.11	0.87	3csvA	GO:0016740 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0016773	GO:0019202	GO:0043169
GO-Score	0.72	0.55	0.55	0.55
Biological Processes	GO:0016310	GO:0046394	GO:0009067	GO:0006566	GO:0046677
GO-Score	0.62	0.55	0.55	0.55	0.47
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
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