I-TASSER results

I-TASSER results for job id Rv3196

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (299 residues)
MSARSVAPSQVMRRAASALYSLNPAMPVLLRPDGAVQVGWDPRRAVLVRPPRGLTATGLA
ALLRSMRSPIPITELQRQAAERGLVDGDAMANLVAQLVGAGVATPLANPGNLDSRRRAAS
IRVHGRGPLSDLLVQALRCSGARIRHSSQPHAAVTPAGVDLVVLSDYLVADPHMVRDLHT
ERVPHLPVRVRDGTGMVGPLVVPGVTSCLGCADLHRSDRDAAWPAIAAQLRDTVGVADRA
TLLATAALALSQVNRVIAAVRGQEATPEPPSALNTTLEFDLNAGSIVARQWTRHPRCFC

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSARSVAPSQVMRRAASALYSLNPAMPVLLRPDGAVQVGWDPRRAVLVRPPRGLTATGLAALLRSMRSPIPITELQRQAAERGLVDGDAMANLVAQLVGAGVATPLANPGNLDSRRRAASIRVHGRGPLSDLLVQALRCSGARIRHSSQPHAAVTPAGVDLVVLSDYLVADPHMVRDLHTERVPHLPVRVRDGTGMVGPLVVPGVTSCLGCADLHRSDRDAAWPAIAAQLRDTVGVADRATLLATAALALSQVNRVIAAVRGQEATPEPPSALNTTLEFDLNAGSIVARQWTRHPRCFC
Prediction	CCCCCCCCCCCCCCCCCCCEEHCCCCEEEEHCCCEEEEEHCCCCEEEHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEHCCCCCCCCCCCCCCCEEEEEHCCCHHHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHHHHCCCEEEEEEHCCEEEHCCEHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHCCCCEEEEEEHCCCCCCCC
Conf.Score	98877887655677888866767887689977997999966897699757899888999999998689989999999999989886578999999999989755677887655556776799995885789999999987996775888777778888858999589888979999999989978999998988998566668999789999998998586658999987578888875567889999999999999987545577888877887999988999589998579999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSARSVAPSQVMRRAASALYSLNPAMPVLLRPDGAVQVGWDPRRAVLVRPPRGLTATGLAALLRSMRSPIPITELQRQAAERGLVDGDAMANLVAQLVGAGVATPLANPGNLDSRRRAASIRVHGRGPLSDLLVQALRCSGARIRHSSQPHAAVTPAGVDLVVLSDYLVADPHMVRDLHTERVPHLPVRVRDGTGMVGPLVVPGVTSCLGCADLHRSDRDAAWPAIAAQLRDTVGVADRATLLATAALALSQVNRVIAAVRGQEATPEPPSALNTTLEFDLNAGSIVARQWTRHPRCFC
Prediction	75355244554354543330203310100203732000001141001032266142520140042035624264024204733244362034004202421102333544434443441201011322104201510462313133444354435543010000012221214104402744100000003433010000000441002100111125335314301320453444243202220011002101100222444435543151241201030541413423032327574
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCEEHCCCCEEEEHCCCEEEEEHCCCCEEEHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCEHCCCCCCCCCCCCCCCEEEEEHCCCHHHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHHHHCCCEEEEEEHCCEEEHCCEHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHCCCCEEEEEEHCCCCCCCC
MSARSVAPSQVMRRAASALYSLNPAMPVLLRPDGAVQVGWDPRRAVLVRPPRGLTATGLAALLRSMRSPIPITELQRQAAERGLVDGDAMANLVAQLVGAGVATPLANPGNLDSRRRAASIRVHGRGPLSDLLVQALRCSGARIRHSSQPHAAVTPAGVDLVVLSDYLVADPHMVRDLHTERVPHLPVRVRDGTGMVGPLVVPGVTSCLGCADLHRSDRDAAWPAIAAQLRDTVGVADRATLLATAALALSQVNRVIAAVRGQEATPEPPSALNTTLEFDLNAGSIVARQWTRHPRCFC

4bs9A

0.18

0.16

0.89

1.45

MUSTER

----------------PTALQIKPHFHVEIIEPKQVYLLG-EQGNHALTG------QLYCQILPFLNGEYTREQIVEKLD--GQVPEEYIDFVLSRLVEKGYLTEVAPELSAEGLKQPVTVTTAGKGIIVANLAAALEEAGIQVSDPT--------AQLQVVLTDDYLQPLAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLQGNREVEASVLQQKRATARATLPSTLQTGLQWAATEIAKWMVKRHLAPGTARFPTLAGKIFTFNQTTLELKAHPLSRRPQCPC

4bs9A4

0.19

0.11

0.59

1.30

dPPAS

------------------------------------------------------------------------------------------------------------APSVVAEGLKQPVTVTTAGKIVANLAAALEEAGIQVSDPT--------AQLQVVLTDDYLQPEAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLQGNREVEASVLQQKRALQERPTAQTGLQWAATEIAKWMVKRHLNAIAPGTARFPTLAGKIFTFNQTTLELKAHPLSR------

4bs9A

0.18

0.16

0.89

1.82

wMUSTER

-----------------TALQIKPHFHVEIIEPKQVYLLGEQG-NHALTG------QLYCQILPFLNGEYTREQIVEKLD--GQVPEEYIDFVLSRLVEKGYLTEVAPELSAEGLKQPVTVTTAGKGIIVANLAAALEEAGIQVSDPT--------AQLQVVLTDDYLQPEAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLQGNREVEASVLQQKRATARATLPSTLQTGLQWAATEIAKWMVKRHLAPGTARFPTLAGKIFTFNQTTLELKAHPLSRRPQCPC

4bs9A4

0.19

0.11

0.59

2.07

wdPPAS

------------------------------------------------------------------------------------------------------------APSVVAEGLKQPVTVTTAGKIVANLAAALEEAGIQVSDPT--------AQLQVVLTDDYLQPEAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLQGNREVEASVLQQKRALQERPTASTLQTGLQWAATEIAKWMVKRHLAPGTARFPTLAGKIFTFNQTTLELKAHPLSR------

4bs9A

0.18

0.16

0.89

1.86

dPPAS2

----------------PTALQIKPHFHVEIIEPKQVYLLGEQGNHALTG-------QLYCQILPFLNGEYTREQIVEKLD--GQVPEEYIDFVLSRLVEKGYLTEVAPELSVVAEGLKQPVTVTTAGKIVANLAAALEEAGIQVSDPT--------AQLQVVLTDDYLQPLAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLQGNREVEASVLQQKRALQERPTASTLQTGLQWAATEIAKWMVKRHLAPGTARFPTLAGKIFTFNQTTLELKAHPLSRRPQCPT

4bs9A4

0.19

0.11

0.60

2.60

wPPAS

-----------------------------------------------------------------------------------------------------------APSVVAEGLKQPTVTTAGKGIIVANLAAALEEAGIQVSDPT--------AQLQVVLTDDYLQPEAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLQGNREVEASVLQQKRALQERPTASTLQTGLQWAATEIAKWMVKRHLAPGTARFPTLAGKIFTFNQTTLELKAHPLSR------

4bs9A

0.18

0.16

0.89

1.29

PPAS

----------------PTALQIKPHFHVEIIEPKQVYLLGEQGNHALTG-------QLYCQILPFLNGEYTREQIVEKLD--GQVPEEYIDFVLSRLVEKGYLTEVAPELSLEVAKQPVTVTTAGKGIIVANLAAALEEAGIQVSDPT--------AQLQVVLTDDYLQPEAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLQGNREVEASVLQQKRALQERPTASTLQTGLQWAATEIAKWMVKRHLAPGTARFPTLAGKIFTFNQTTLELKAHPLSRRPQCPC

4bs9A4

0.19

0.11

0.59

3.00

dPPAS2

------------------------------------------------------------------------------------------------------------APSVVAEGLKQPVTVTTAGKIVANLAAALEEAGIQVSDPT--------AQLQVVLTDDYLQPEAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLQGNREVEASVLQQKRALQERPTASTLQTGLQWAATEIAKWMVKRHLAPGTARFPTLAGKIFTFNQTTLELKAHPLSR------

3h5aA

0.19

0.17

0.89

1.82

Env-PPAS

-----------------MDYILGRYVKIARYGSG-GLVGGGGKEQYVENLVL---WENIIKTAYCFITPSSYTAALETA----NIPEKDFSNCFRFLKENFFIIPGANPVLVQDKLKNAKVVILGCGGIGNHVSVILATSGISEIALNINDYTDLHPEADIWVVSHPFNLINWVNKYCVRANQPYINAGYVNDIAVFGPLYVPGKTGCYECQDLYGSEKENIDHKIKLINSRFKPATFAPVNNVAAALCAADVIKFIGKY-------SEPLSLNKRIGIWSDEIKIHSQNMGRSPVCSC

4bs9A4

0.19

0.11

0.60

2.07

PPAS

----------------------------------------------------------------------------------------------------------APSVVAEGLKQPVTVTTAGKGIIVANLAAALEEAGIQVSDPT--------AQLQVVLTDDYLQPEAAINKEALERQQPWLLVKPVGSILWLGPLFVPGETGCWHCLAQRLQGNREVEASVLQQKRALQERPTASTLQTGLQWAATEIAKWMVKRHLAPGTARFPTLAGKIFTFNQTTLELKAHPLSR------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.67

Estimated TM-score = 0.63±0.14

Estimated RMSD = 7.7±4.3Å

Download Model 2

C-score=-1.85

Download Model 3

C-score=-1.26

Download Model 4

C-score=-4.44

Download Model 5

C-score=-2.91

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4bs9A	0.851	1.43	0.173	0.886
2	3h5aA	0.645	4.40	0.134	0.866
3	5ff5A	0.604	3.82	0.137	0.752
4	3cmmC	0.535	4.09	0.057	0.669
5	4ii2A	0.535	4.05	0.068	0.669
6	2nvuB	0.515	3.54	0.099	0.615
7	1jwbB	0.498	2.91	0.115	0.572
8	3vh1A	0.497	3.50	0.078	0.592
9	1zkmA	0.495	3.56	0.116	0.592
10	2nvuA1	0.493	3.49	0.096	0.585

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.46	18	4bs9A	ZN	Rep, Mult	208,211,297,299
2	0.05	2	3h9gC	III	Rep, Mult	187,188,189,196,198,276
3	0.02	1	1zud4	III	Rep, Mult	128,164,171,189,190,194,196,212,213,214,276,287,289,290,292,294,295,296
4	0.02	1	3h9jA	III	Rep, Mult	276,278,287

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.122	1jwbB	0.498	2.91	0.115	0.572	2.7.7.-	166
2	0.066	1zkmA	0.495	3.56	0.116	0.592	2.7.7.-	166
3	0.060	1p8jA	0.377	5.87	0.064	0.545	3.4.21.75	NA
4	0.060	1sy7A	0.400	6.06	0.039	0.632	1.11.1.6	185,254
5	0.060	3ga0A	0.377	4.37	0.071	0.502	1.1.1.-	NA
6	0.060	2jfdA	0.239	6.76	0.031	0.415	2.3.1.85	178
7	0.060	1gytJ	0.380	6.13	0.044	0.629	3.4.11.1	NA
8	0.060	2vz8B	0.426	5.55	0.077	0.619	2.3.1.85	NA
9	0.060	1v8bC	0.364	5.12	0.043	0.515	3.3.1.1	164
10	0.060	1vj5A	0.384	6.36	0.030	0.655	3.3.2.10,3.3.2.3	NA
11	0.060	1z7eD	0.423	5.75	0.064	0.639	2.1.2.-,1.1.1.-	NA
12	0.060	2fu3B	0.418	5.84	0.068	0.652	2.7.7.-	NA
13	0.060	2blnA	0.291	5.43	0.062	0.428	2.1.1.2	NA
14	0.060	2vz8A	0.414	5.97	0.093	0.666	2.3.1.85	NA
15	0.060	2ajtA	0.388	6.07	0.032	0.619	5.3.1.4	NA
16	0.060	1sy7B	0.396	6.75	0.042	0.709	1.11.1.6	165
17	0.060	2x58A	0.392	5.79	0.084	0.615	5.3.3.8,4.2.1.17,1.1.1.35	165
18	0.060	1lnsA	0.440	5.76	0.039	0.689	3.4.14.11	NA
19	0.060	2hxgA	0.382	5.65	0.035	0.585	5.3.1.4	207
20	0.060	1jqnA	0.381	6.24	0.051	0.625	4.1.1.31	255
21	0.060	2gsdA	0.381	4.65	0.056	0.522	1.2.1.43	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.40	0.645	4.40	0.14	0.87	3h5aC	GO:0000166 GO:0005524 GO:0008641 GO:0046872
1	0.33	0.495	3.61	0.11	0.59	1zfnA	GO:0000166 GO:0000287 GO:0005524 GO:0005829 GO:0006464 GO:0008270 GO:0008641 GO:0009228 GO:0009229 GO:0016740 GO:0016779 GO:0046872
2	0.28	0.499	2.89	0.12	0.57	1jw9B	GO:0000166 GO:0000287 GO:0005524 GO:0005829 GO:0006464 GO:0006777 GO:0008270 GO:0008641 GO:0016740 GO:0016779 GO:0046872 GO:0061605
3	0.19	0.851	1.43	0.17	0.89	4bs9A	GO:0046872
4	0.19	0.845	1.91	0.16	0.91	4v1tB	GO:0000166 GO:0046872
5	0.07	0.613	3.80	0.14	0.76	5ff5A	GO:0008641
6	0.07	0.531	4.17	0.07	0.67	4ii3A	GO:0000166 GO:0000287 GO:0004839 GO:0004842 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006464 GO:0008641 GO:0016567 GO:0016874 GO:0019941
7	0.07	0.535	4.09	0.06	0.67	3cmmC	GO:0000166 GO:0004839 GO:0004842 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006464 GO:0008641 GO:0016567 GO:0016874 GO:0019941
8	0.07	0.515	3.54	0.10	0.62	2nvuB	GO:0000166 GO:0000278 GO:0005524 GO:0005634 GO:0005829 GO:0006464 GO:0006508 GO:0007049 GO:0007113 GO:0008641 GO:0016874 GO:0016881 GO:0016922 GO:0019781 GO:0038061 GO:0045116 GO:0045892 GO:0046982 GO:0051726
9	0.07	0.493	3.49	0.10	0.59	2nvuA	GO:0005634 GO:0005737 GO:0005829 GO:0005886 GO:0006915 GO:0007049 GO:0007165 GO:0008641 GO:0016020 GO:0019781 GO:0031625 GO:0033314 GO:0042981 GO:0043523 GO:0045116 GO:0046982 GO:0051402
10	0.07	0.504	3.58	0.08	0.60	4gslA	GO:0000407 GO:0000422 GO:0005737 GO:0005829 GO:0006501 GO:0006810 GO:0006914 GO:0006995 GO:0008641 GO:0015031 GO:0016020 GO:0016236 GO:0019778 GO:0019779 GO:0030163 GO:0032258 GO:0032446 GO:0034727 GO:0044805 GO:0097632
11	0.07	0.486	3.38	0.10	0.57	4gskB	GO:0000407 GO:0000422 GO:0005737 GO:0005829 GO:0006501 GO:0006810 GO:0006914 GO:0006995 GO:0008641 GO:0015031 GO:0016020 GO:0016236 GO:0019778 GO:0019779 GO:0030163 GO:0032258 GO:0032446 GO:0034727 GO:0044805 GO:0097632
12	0.07	0.485	3.69	0.14	0.59	3kydB	GO:0000166 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0008047 GO:0008134 GO:0008641 GO:0016874 GO:0016925 GO:0019948 GO:0031510 GO:0043085 GO:0046872 GO:0046982
13	0.07	0.468	2.80	0.15	0.53	3gucA	GO:0000166 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0008641 GO:0033146 GO:0034976 GO:0043231 GO:0046872 GO:0061503 GO:0061504 GO:0071566 GO:0071569 GO:1990592
14	0.06	0.363	4.09	0.09	0.45	4yedD	GO:0000166 GO:0005524 GO:0005829 GO:0008641 GO:0016020 GO:0016021 GO:0016874 GO:0030955 GO:0031402 GO:0061503 GO:0061504
15	0.06	0.319	5.63	0.05	0.47	3k6jA	GO:0003857 GO:0006631 GO:0016491 GO:0046872 GO:0055114
16	0.06	0.331	4.55	0.08	0.44	3tl2A	GO:0003824 GO:0004470 GO:0005975 GO:0006099 GO:0016491 GO:0016616 GO:0019752 GO:0030060 GO:0055114
17	0.06	0.492	3.28	0.14	0.58	3kycB	GO:0000166 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0008047 GO:0008134 GO:0008641 GO:0016874 GO:0016925 GO:0019948 GO:0031510 GO:0043085 GO:0046872 GO:0046982
18	0.06	0.456	3.97	0.09	0.57	4p22B	GO:0000166 GO:0000792 GO:0004839 GO:0004842 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005765 GO:0005829 GO:0006464 GO:0006974 GO:0008641 GO:0010008 GO:0016567 GO:0016874 GO:0019941 GO:0030057 GO:0030867 GO:0044822 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0008641	GO:0005524	GO:0070566	GO:0008270	GO:0000287
GO-Score	0.71	0.71	0.56	0.51	0.51
Biological Processes	GO:0019720	GO:0006464	GO:0009228	GO:0009229
GO-Score	0.56	0.51	0.33	0.33
Cellular Component	GO:0005829
GO-Score	0.51

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.