I-TASSER results

I-TASSER results for job id Rv3195

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (472 residues)
MSTGEVMGDLPFGFSSGDDPPEDPSGRDKRGKDGADSGSGANPLGAFGIGGEFNMADLGQ
IFTRLGEMFGGVGTAMAAGKTSGPVNYDLARQVASSSIGFIAPIPAATNSAIADAVHLAD
TWLDGATSLPAGATKAVGWSPTDWVDNTLATWKRLCDPMAQQISTVWASSLPEEAKSMAG
PLLSIMSQMGGIAFGSQLGQALGRLSREVLTSTDIGLPLGPKGVAAILPGAVESFAAGLE
QPRSEILTFLATREAAHHRLFSHVPWLASQLLGAVEAYAMGMKIDMTGIEELARDINPTS
LADPAAMEQLLSQGVFEPKATPAQTQALERLETLLALIEGWVQTVVTAALGERIPGEAAL
SETLRRRRASGGPAEQTFATLVGLELRPRKLREAGALWERLTRAVGMDARDAVWQHPDLL
PATDDLDDPAAFIDRVIGGDTSGIDEAIAELERDQQARGADDSGHDGGPVDN

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTGEVMGDLPFGFSSGDDPPEDPSGRDKRGKDGADSGSGANPLGAFGIGGEFNMADLGQIFTRLGEMFGGVGTAMAAGKTSGPVNYDLARQVASSSIGFIAPIPAATNSAIADAVHLADTWLDGATSLPAGATKAVGWSPTDWVDNTLATWKRLCDPMAQQISTVWASSLPEEAKSMAGPLLSIMSQMGGIAFGSQLGQALGRLSREVLTSTDIGLPLGPKGVAAILPGAVESFAAGLEQPRSEILTFLATREAAHHRLFSHVPWLASQLLGAVEAYAMGMKIDMTGIEELARDINPTSLADPAAMEQLLSQGVFEPKATPAQTQALERLETLLALIEGWVQTVVTAALGERIPGEAALSETLRRRRASGGPAEQTFATLVGLELRPRKLREAGALWERLTRAVGMDARDAVWQHPDLLPATDDLDDPAAFIDRVIGGDTSGIDEAIAELERDQQARGADDSGHDGGPVDN
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
Conf.Score	9988888889999999999987755556667788888888887666778889998899999999999999865667788888998999999999998588999999999999999998577777755789899866886889999999999999999999999999987577889987586899999987788999999999999866457667777889998589865899999999799989999999999999999998685799999999999999755778999999998564556887889887556874547999999999999999999998789998876556799899999999999985999999999998976568999999999999999977776666657876799988875789999999778987557899999975667888888888898889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSTGEVMGDLPFGFSSGDDPPEDPSGRDKRGKDGADSGSGANPLGAFGIGGEFNMADLGQIFTRLGEMFGGVGTAMAAGKTSGPVNYDLARQVASSSIGFIAPIPAATNSAIADAVHLADTWLDGATSLPAGATKAVGWSPTDWVDNTLATWKRLCDPMAQQISTVWASSLPEEAKSMAGPLLSIMSQMGGIAFGSQLGQALGRLSREVLTSTDIGLPLGPKGVAAILPGAVESFAAGLEQPRSEILTFLATREAAHHRLFSHVPWLASQLLGAVEAYAMGMKIDMTGIEELARDINPTSLADPAAMEQLLSQGVFEPKATPAQTQALERLETLLALIEGWVQTVVTAALGERIPGEAALSETLRRRRASGGPAEQTFATLVGLELRPRKLREAGALWERLTRAVGMDARDAVWQHPDLLPATDDLDDPAAFIDRVIGGDTSGIDEAIAELERDQQARGADDSGHDGGPVDN
Prediction	6543441232000112344555556544555454545443422242233344243530340052034114323442443544210004003400443245644246531520250053042204410403545431300224300320150044004201530352145302530462433233004302220001000100030042010000000012651100000300230066171435000000000000021002001001520251034005404231520341044034543533531462244120413434703400410310000000100000110036202105302510440277421003001200201012520430350042005412251032006104302346106405300420354555523530450364465555566566656668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MSTGEVMGDLPFGFSSGDDPPEDPSGRDKRGKDGADSGSGANPLGAFGIGGEFNMADLGQIFTRLGEMFGGVGTAMAAGKTSGPVNYDLARQVASSSIGFIAPIPAATNSAIADAVHLADTWLDGATSLPAGATKAVGWSPTDWVDNTLATWKRLCDPMAQQISTVWASSLPEEAKSMAGPLLSIMSQMGGIAFGSQLGQALGRLSREVLTSTDIGLPLGPKGVAAILPGAVESFAAGLEQPRSEILTFLATREAAHHRLFSHVPWLASQLLGAVEAYAMGMKIDMTGIEELARDINPTSLADPAAMEQLLSQGVFEPKATPAQTQALERLETLLALIEGWVQTVVTAALGERIPGEAALSETLRRRRASGGPAEQTFATLVGLELRPRKLREAGALWERLTRAVGMDARDAVWQHPDLLPATDDLDDPAAFIDRVIGGDTSGIDEAIAELERDQQARGADDSGHDGGPVDN

3cmnA

0.20

0.12

0.62

1.98

MUSTER

-----------------------------------------------------------------------------------LIDWEQARQAALRLSQWEQAPVAFRREQYARMVALSEPLIADYLGVPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLG-VQIGGLLGYLAQ-----------------------RVLGQYDLSL-LSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFA----------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMDREG--------------------------------

3cmnA

0.19

0.12

0.62

2.73

dPPAS

-----------------------------------------------------------------------------------LIDWEQARQAALRLSQAPVDNRAFRREQYARMVALSEPLIADYLGVPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLG-VQIGGLLGYLAQ-----------------------RVLGQYDLSL-LSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL---------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMDREG--------------------------------

3cmnA

0.19

0.12

0.62

3.96

wdPPAS

-----------------------------------------------------------------------------------LIDWEQARQAALRLSQWEQDNRAFRREQYARMVALSEPLIADYLGVPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKL-LGVQIGGLLGYLAQ-----------------------RVLGQYDLSLLS-AGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL---------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMDREG--------------------------------

3cmnA

0.19

0.12

0.62

2.43

wMUSTER

------------------------------------------------------------------------------------IDWEQARQAALRLSQWEQAPVAFRREQYARMVALSEPLIADYLGVPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLL--VQIGGLLGYLAQ-----------------------RVLGQYDLSLLS-AGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL---------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMDREG--------------------------------

3cmnA

0.19

0.12

0.62

3.69

wPPAS

-----------------------------------------------------------------------------------LIDWEQARQAALRLSQWEQAPVAFRREQYARMVALSEPLIADYLGVPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKL---VQIGGLLGYLAQ-----------------------RVLGQYDLSLLS-AGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL---------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMDREG--------------------------------

3cmnA

0.19

0.12

0.62

7.52

dPPAS2

-----------------------------------------------------------------------------------LIDWEQARQAALRLSQWEQAPVAFRREQYARMVALSEPLIADYLGVPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKLLG-VQIGGLLGYLAQ-----------------------RVLGQYDLSL-LSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL---------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMDREG--------------------------------

3cmnA

0.20

0.12

0.62

3.17

PPAS

-----------------------------------------------------------------------------------LIDWEQARQAALRLSQWEQAPVAFRREQYARMVALSEPLIADYLGVPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKL-LGVQIGGLLGYLAQ-----------------------RVLGQYDLSLL-SAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFA----------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMDREG--------------------------------

3cmnA

0.20

0.12

0.62

7.62

Env-PPAS

-----------------------------------------------------------------------------------LIDWEQARQAALRLSQWEQAPVAFRREQYARMVALSEPLIADYLGVPEPVSRIFVFDRREWLEANIVSFSQLFRPIEEMYEKSSKL-LGVQIGGLLGYLAQ-----------------------RVLGQYDLSL-LSAGGSLYFVEPNIARVQQQLGLSDEDFRLWITLHEMTHAFEFEAYPWVRTYFRELLEQNFAL---------------------------------------TPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMDREG--------------------------------

5ic0A

0.13

0.12

0.91

0.83

MUSTER

LRQLETVREL---LENPVQPINDMSYFGLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAA------YLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGE-----PGCTQAQVLSAATIVAKHTSALCNSCRLASARTNPTAKRQFVQSAKEVANSTANLVKGDFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPI-VISAKTMLESAGGLIQTARALAVNP--DPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLTAIAALNSCLRSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARA----EASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALLYTAKEAGGNPKQAATQEALEEAVQMMTEAVE----DLTTTLNEAAS-------------------

3cmnA2

0.24

0.07

0.29

1.33

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YPWVRTYFRELLEQNFA---LTPEQRAVFDRIQALMSLIEGYGNHVMNAVGRRLLPSFNQIEQQIAQRQRQRTMLDQMVFRLTGLDLKLAQYQQGEAFVNAVVAARGIQFASRVWERPENLPSMDEIRNPGQWIVRMDREG--------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.24

Estimated TM-score = 0.45±0.15

Estimated RMSD = 12.6±4.3Å

Download Model 2

C-score=-2.76

Download Model 3

C-score=-3.02

Download Model 4

C-score=-2.96

Download Model 5

C-score=-3.31

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3cmnA	0.605	1.42	0.191	0.621
2	4ka7A	0.406	5.67	0.046	0.561
3	3o0yA	0.401	5.48	0.100	0.544
4	3ebgA	0.400	5.97	0.058	0.549
5	4wz9A	0.399	5.63	0.111	0.538
6	1y791	0.399	6.11	0.046	0.561
7	3se6A	0.398	5.64	0.063	0.534
8	1r4lA	0.397	6.05	0.051	0.566
9	2xdtA	0.396	5.63	0.069	0.532
10	3sksA	0.394	5.57	0.038	0.538

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	1mkdC	MG	Rep, Mult	214,254
2	0.08	4	4fgmA	ZN	Rep, Mult	253,257,339
3	0.04	2	3fymA	ZN	Rep, Mult	254,258
4	0.04	2	2y02A	2CV	Rep, Mult	360,365
5	0.02	1	2voyH	III	Rep, Mult	246,249
6	0.02	1	5ezmA	MPG	Rep, Mult	337,340
7	0.02	1	3ak1B	EDO	Rep, Mult	327,330
8	0.02	1	2yazA	UMP	Rep, Mult	398,414
9	0.02	1	2bkoA	CA	Rep, Mult	345,348
10	0.02	1	3fu3A	IMD	Rep, Mult	327,328,333,336,385,388
11	0.02	1	2dysN	DCW	Rep, Mult	337,421
12	0.02	1	3nteA	FE	Rep, Mult	355,362
13	0.02	1	3fueA	11S	Rep, Mult	398,421,426,430
14	0.02	1	1h19A	IMD	Rep, Mult	120,123,124,127,257
15	0.02	1	3zprB	2CV	Rep, Mult	346,350,360,365
16	0.02	1	1gw6A	IMD	Rep, Mult	217,218,375,378,379,382
17	0.02	1	1hs6A	IMD	Rep, Mult	117,248,251,255

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2ckjA	0.336	7.10	0.034	0.540	1.17.1.4,1.17.3.2	NA
2	0.060	1y791	0.399	6.11	0.046	0.561	3.4.15.5	NA
3	0.060	1dgjA	0.357	7.43	0.058	0.598	1.2.-.-	NA
4	0.060	3ebgA	0.400	5.97	0.058	0.549	3.4.11.-	254
5	0.060	1bxrA	0.352	7.39	0.038	0.589	6.3.5.5	NA
6	0.060	2jgdA	0.343	6.89	0.045	0.538	1.2.4.2	NA
7	0.060	1z8lA	0.357	7.01	0.042	0.578	3.4.17.21	NA
8	0.060	1i1iP	0.354	6.64	0.035	0.538	3.4.24.16	NA
9	0.060	1fo4A	0.338	7.45	0.044	0.568	1.17.1.4	NA
10	0.060	1z1wA	0.392	5.34	0.060	0.515	3.4.11.-	254
11	0.060	1wgzA	0.376	5.32	0.058	0.511	3.4.24.66	339
12	0.060	3dwbA	0.375	6.05	0.037	0.540	3.4.24.71	NA
13	0.060	1qo9A	0.350	6.97	0.060	0.557	3.1.1.7	NA
14	0.060	3fedA	0.358	7.08	0.053	0.587	3.4.17.21	NA
15	0.060	3b9jJ	0.255	6.35	0.070	0.388	1.17.1.4,1.17.3.2	231,251
16	0.060	1t3tA	0.347	7.69	0.063	0.589	6.3.5.3	NA
17	0.060	3en9A	0.343	6.62	0.028	0.508	3.4.24.57	NA
18	0.060	2h1nA	0.390	5.79	0.042	0.540	3.4.24.-	255
19	0.060	2e1qA	0.324	6.92	0.030	0.511	1.17.3.2,1.17.1.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.400	5.81	0.11	0.55	4wz9B	GO:0005737 GO:0005886 GO:0006508 GO:0008237 GO:0008270 GO:0042277 GO:0043171 GO:0070006
1	0.06	0.393	5.44	0.06	0.52	3q7jA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0046872
2	0.06	0.400	5.97	0.06	0.55	3ebgA	GO:0004177 GO:0005737 GO:0005829 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0046872
3	0.06	0.393	5.54	0.07	0.53	2xpyA	GO:0004177 GO:0004301 GO:0004463 GO:0005634 GO:0005737 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0030163 GO:0042277 GO:0043171 GO:0044255 GO:0046872 GO:0070006
4	0.06	0.399	6.11	0.05	0.56	1y791	GO:0004180 GO:0004222 GO:0005737 GO:0005829 GO:0006508 GO:0006518 GO:0008233 GO:0008237 GO:0016787 GO:0030288 GO:0046872
5	0.06	0.393	5.59	0.07	0.53	5c97A	GO:0000209 GO:0002480 GO:0004177 GO:0005576 GO:0005622 GO:0005765 GO:0005829 GO:0005886 GO:0005887 GO:0006508 GO:0007165 GO:0007267 GO:0007565 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0030163 GO:0030659 GO:0031905 GO:0042277 GO:0043171 GO:0046872 GO:0048471 GO:0060395 GO:0061024 GO:0070006
6	0.06	0.398	5.66	0.04	0.55	3ahmA	GO:0006508 GO:0008233 GO:0008237 GO:0016787 GO:0046872
7	0.06	0.397	5.62	0.07	0.54	4xo4A	GO:0004177 GO:0005737 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016787 GO:0042277 GO:0042802 GO:0043171 GO:0046872 GO:0070006
8	0.06	0.316	7.31	0.03	0.51	4fkeA	GO:0001525 GO:0001618 GO:0004177 GO:0005737 GO:0005886 GO:0006508 GO:0007275 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0030154 GO:0042277 GO:0043171 GO:0046718 GO:0046872 GO:0070006
9	0.06	0.327	7.22	0.05	0.53	4fyrA	GO:0001525 GO:0001618 GO:0004177 GO:0004872 GO:0005615 GO:0005737 GO:0005765 GO:0005793 GO:0005829 GO:0005886 GO:0005887 GO:0006508 GO:0006725 GO:0007275 GO:0008233 GO:0008237 GO:0008270 GO:0009897 GO:0012506 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0030154 GO:0031983 GO:0035814 GO:0042277 GO:0043171 GO:0046718 GO:0046872 GO:0070006 GO:0070062
10	0.06	0.310	6.69	0.04	0.49	4qpeA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787 GO:0046872
11	0.06	0.390	5.54	0.07	0.53	3b7rL	GO:0004177 GO:0004301 GO:0004463 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006508 GO:0006691 GO:0008233 GO:0008237 GO:0008270 GO:0010043 GO:0016787 GO:0019370 GO:0042277 GO:0043171 GO:0043434 GO:0044822 GO:0046872 GO:0060509 GO:0070006 GO:0070062
12	0.06	0.402	5.90	0.06	0.55	5ab0A	GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005783 GO:0005788 GO:0005789 GO:0005886 GO:0006508 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0046872 GO:0070006
13	0.06	0.394	5.57	0.04	0.54	3sksA	GO:0006508 GO:0008233 GO:0008237 GO:0016787 GO:0046872
14	0.06	0.337	5.99	0.07	0.48	3ciaA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787 GO:0046872
15	0.06	0.329	6.72	0.05	0.51	5dllA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787
16	0.06	0.390	5.56	0.06	0.53	4gaaA	GO:0004463 GO:0005737 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0019370 GO:0046872
17	0.06	0.396	5.66	0.07	0.53	2yd0A	GO:0001525 GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005138 GO:0005151 GO:0005164 GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005829 GO:0005886 GO:0006508 GO:0006509 GO:0008217 GO:0008233 GO:0008235 GO:0008237 GO:0008270 GO:0009617 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0043231 GO:0045088 GO:0045444 GO:0045766 GO:0046872 GO:0070006 GO:0070062
18	0.06	0.401	5.48	0.10	0.54	3o0yA

Consensus prediction of GO terms

Molecular Function	GO:0046914	GO:0008238
GO-Score	0.47	0.36
Biological Processes	GO:0019538
GO-Score	0.57
Cellular Component	GO:0044424
GO-Score	0.57

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.