I-TASSER results

I-TASSER results for job id Rv3194c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (340 residues)
MNRRILTLMVALVPIVVFGVLLAVVTVPFVALGPGPTFDTLGEIDGKQVVQIVGTQTYPT
SGHLNMTTVSQRDGLTLGEALALWLSGQEQLMPRDLVYPPGKSREEIENDNAADFKRSEA
AAEYAALGYLKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGTPVGNLDQFTALLKNTKP
GQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPWAPFAVDFHLANVGGPSAG
LMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGGITHKMAAARAAGATVFLVPAK
NCYEASSDSPPGLKLVKVETLSQAVDALHAMTSGSPTPSC

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNRRILTLMVALVPIVVFGVLLAVVTVPFVALGPGPTFDTLGEIDGKQVVQIVGTQTYPTSGHLNMTTVSQRDGLTLGEALALWLSGQEQLMPRDLVYPPGKSREEIENDNAADFKRSEAAAEYAALGYLKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGTPVGNLDQFTALLKNTKPGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPWAPFAVDFHLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGGITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALHAMTSGSPTPSC
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCEEEEEEEEHCCCCCHHHHHHHHCCCCCEEHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCCCEEEEHCCCHCCCHHHHHHHHHHCCCCCEEEEEEEHCCEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHCCCCCEEHCCCHHHHHHHHHHHCCCEEEHCCHHHHHHHHHCCCCCEEEHCCCHHHHHHHHHHHHCCCCCCCC
Conf.Score	9857999999999999999999996476477489975334556788648999688788888769999998579988999999977998646657764689999999999999999999999999999997986579999876998755777788578875785557989999999977999579999998988877766666544566555567644555566655655789999865899999999999859999899857877887789977757887899999999899699978668999999767998899958999999999997558999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNRRILTLMVALVPIVVFGVLLAVVTVPFVALGPGPTFDTLGEIDGKQVVQIVGTQTYPTSGHLNMTTVSQRDGLTLGEALALWLSGQEQLMPRDLVYPPGKSREEIENDNAADFKRSEAAAEYAALGYLKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGTPVGNLDQFTALLKNTKPGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPWAPFAVDFHLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGGITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALHAMTSGSPTPSC
Prediction	5532220100122222222222331101000211130232235454431040544653555130100001024422002001100344330232442247743473045314420550153023201532724331203302573334431442330333424414325202410473547440201032674445234322433444433234242244424325040415723000000000000011027460466330000010225040110030430020035230410000350164027503750300205304200400451576664378
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCEEEEEEEEHCCCCCHHHHHHHHCCCCCEEHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCCCEEEEHCCCHCCCHHHHHHHHHHCCCCCEEEEEEEHCCEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHCCCCCEEHCCCHHHHHHHHHHHCCCEEEHCCHHHHHHHHHCCCCCEEEHCCCHHHHHHHHHHHHCCCCCCCC
MNRRILTLMVALVPIVVFGVLLAVVTVPFVALGPGPTFDTLGEIDGKQVVQIVGTQTYPTSGHLNMTTVSQRDGLTLGEALALWLSGQEQLMPRDLVYPPGKSREEIENDNAADFKRSEAAAEYAALGYLKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGTPVGNLDQFTALLKNTKPGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPWAPFAVDFHLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGGITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALHAMTSGSPTPSC

4yplA

0.15

0.14

0.96

1.36

MUSTER

MSSDWRGDPASAMLEVLDPEQNNTFTDHYL-DVPYDLSKVFNTLQTIPVIEIPGYTNMEK--------QAIARQYLWPKQVRESGMEGRIEVTDAAIL-SEYTREGVRGLERELGKIARKGAKFWLEGAWEGLRTIDIPTYLGIPRYPDKAETEPQVGTAQGLAWTPVGGTLLTIAAVPGSGKLSLTGQLGEVMKESAQAALTYRAHTQDYGLPEDFYNKVDLHVHVPDGATPKDGPSAGITMATAIASALSRRPARMD--IAMTGEVSLRGKVMPIGGVKEKLLAAHQAGIHKIVLPKDNEAQLPKEVLEGLEIKLVEDVGEVLEYL--LPEPTMPPVV

3m6aA2

0.19

0.10

0.53

1.71

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------YGQAETEDQVGVVTGLAYTTVGGDTLSIEVSPGKGKLILTGKLGDVMRESAQAAFSYVRSKTEEGIEPDFHEKYDIHIHVPEGAVPKDGPAAGITMATALVSALTGRAVSRE--VGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEKDIPESVREGLTFILASHLDEVLEHALV----------

3m6aA

0.18

0.15

0.85

1.83

wMUSTER

LSK-----------------VLFIATANNLATIPGPLRDRM------EIINIAGYTEIE---------LEIVKDHLLPKQIKEHLKKSNLQLRDQAIL----TRE-VRSLERQLAAICRKAAKAIVAEE-RKRITVTEKNLGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSPGKGKLILTGKLGDVMRESAQAAFSYVRSKTELGIEPDFHEKYDIHIHVPEGAVPKDGPAAGITMATALVSALTGRAVSRE--VGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEKDIPESVREGLTFILASHLDEVLEHALV----------

3m6aA2

0.19

0.10

0.53

3.69

wdPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------YGQAETEDQVGVVTGLAYTTVGGDTLSIEVSPGKGKLILTGKLGDVMRESAQAAFSYVRSKTEEGIEPDFHEKYDIHIHVPEGAVPKDGPAAGITMATALVSALTGRAVSRE--VGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEKDIPESVREGLTFILASHLDEVLEHALV----------

4yplA

0.17

0.16

0.94

1.80

wMUSTER

MPGKLIHAMKQV-PASAMLEVL-TFTDHYL-DVPYDLSKVFNTLQTIPVIEIPGYTNMEK--------QAIARQYLWPKQVRESGMEGRIEVTDAAIL----TRE-VRGLERELGKIARKGAKFWLEGAWEGLRTIDASDIGIPRYRPDKAETEPQVGTAQGLAWTPVGGTLLTIEVVPGSGKLSLTGQLGEVMKESAQAALTYLRAHTQYGLPEDFYNKVDLHVHVPDGATPKDGPSAGITMATAIASALSRRPARMD--IAMTGEVSLRGKVMPIGGVKEKLLAAHQAGIHKIVLPKDNEAQLPKEVLEGLEIKLVEDVGEVLEYL--LPEPTMPPVV

4yplA2

0.20

0.11

0.56

3.08

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------RPDKAETEPQVGTAQGLAWTPVGGTLLTIEVVPGSGKLSLTGQLGEVMKESAQAALTYLRAHTQDGLPEDFYNKVDLHVHVPDGATPKDGPSAGITMATAIASALSRRPARMD--IAMTGEVSLRGKVMPIGGVKEKLLAAHQAGIHKIVLPKDNEAQLPKEVLEGLEIKLVEDVGEVLEYL--LPEPTMPPVV

3m6aA2

0.19

0.10

0.52

3.98

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------YGQAETEDQVGVVTGLAYTTVGGDTLSIEVSPGKGKLILTGKLGDVMRESAQAAFSYVRSKTEE---LGIEPDFHEKYDIHIHVPEKDGPAAGITMATALVSALTGRAVSRE--VGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEKDIPESVREGLTFILASHLDEVLEHALV----------

3m6aA2

0.19

0.10

0.52

2.03

PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------YGQAETEDQVGVVTGLAYTTVGGDTLSIEVSPGKGKLILTGKLGDVMRESAQAAFSYVRSKTE---ELGIEPDFHEKYDIHIHVPPKDGPAAGITMATALVSALTGRAVSRE--VGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEKDIPESVREGLTFILASHLDEVLEHA--V---------

3m6aA2

0.19

0.10

0.52

3.24

Env-PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------YGQAETEDQVGVVTGLAYTTVGGDTLSIEVSPGKGKLILTGKLGDVMRESAQAAFSYVRSKTE---ELGIEPDFHEKYDIHIHVPPKDGPAAGITMATALVSALTGRAVS--REVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEKDIPESVREGLTFILASHLDEVLEHALV----------

3m6aA2

0.19

0.10

0.53

1.00

MUSTER

---------------------------------------------------------------------------------------------------------------------------------------------------YGQAETEDQVGVVTGLAYTTVGGDTLSIELSPGKGKLILTGKLGDVMRESAQAAFSYVRSKTELGIEPDFHEKYDIHIHVPEGAVPKDGPAAGITMATALVSALTGRAVSRE--VGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEKDIPESVREGLTFILASHLDEVLEHALV----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.23

Estimated TM-score = 0.56±0.15

Estimated RMSD = 9.2±4.6Å

Download Model 2

C-score=-2.41

Download Model 3

C-score=-3.92

Download Model 4

C-score=-2.73

Download Model 5

C-score=-4.61

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4yplA	0.871	2.60	0.158	0.968
2	3m6aA	0.746	3.61	0.141	0.885
3	3k1jA	0.584	4.92	0.127	0.759
4	4fw9A	0.553	5.08	0.123	0.744
5	2x36A	0.490	2.16	0.191	0.532
6	1z0bA	0.483	2.38	0.171	0.532
7	1xhkB	0.473	2.20	0.177	0.515
8	1rreE	0.467	2.02	0.202	0.503
9	3zyvA	0.457	6.63	0.054	0.773
10	4uhwA	0.448	6.72	0.058	0.771

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	4	2ckjC	FES	Rep, Mult	240,242,265,266,267,277
2	0.09	4	3fofC	NUC	Rep, Mult	236,238
3	0.07	3	2ckjC	FES	Rep, Mult	262,263,264,288,291,293,312,314
4	0.05	2	1fiqA	FES	Rep, Mult	284,288,289,290,291,293,313
5	0.03	1	4ypmA	MG	Rep, Mult	163,238,265,283
6	0.02	1	2ckjD	FES	Rep, Mult	265,266,267,268,274,275,276,299,320
7	0.02	1	1rrgA	GDP	Rep, Mult	268,272
8	0.02	1	3f1fP	MG	Rep, Mult	283,286
9	0.02	1	3d5bY	MG	Rep, Mult	279,283
10	0.02	1	1z0bA	CA	Rep, Mult	314,315
11	0.02	1	1vdvA	CA	Rep, Mult	249,253,254
12	0.02	1	2ckjD	FES	Rep, Mult	235,237,277,278,279

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3fvyA	0.415	5.80	0.036	0.632	3.4.14.4	178,236
2	0.060	1qf6A	0.360	6.66	0.036	0.621	6.1.1.3	NA
3	0.060	1k32A	0.276	7.08	0.047	0.485	3.4.21.-	NA
4	0.060	1yguB	0.365	6.63	0.089	0.618	3.1.3.48	NA
5	0.060	1fo4A	0.449	6.69	0.035	0.776	1.17.1.4	NA
6	0.060	2pdaA	0.353	7.06	0.042	0.644	1.2.7.1	213,243
7	0.060	1vlbA	0.367	6.98	0.049	0.653	1.2.99.7	NA
8	0.060	1z1wA	0.315	7.05	0.039	0.547	3.4.11.-	NA
9	0.060	2dqmA	0.378	6.90	0.043	0.668	3.4.11.2	NA
10	0.060	2vumA	0.360	6.09	0.045	0.571	2.7.7.6	205
11	0.060	1pj6A	0.360	6.76	0.036	0.624	1.5.3.10	NA
12	0.060	1llwA	0.429	6.55	0.053	0.712	1.4.7.1	NA
13	0.060	2vdcA	0.423	6.80	0.058	0.732	1.4.1.13	NA
14	0.060	1kogH	0.260	6.84	0.031	0.462	6.1.1.3	245
15	0.060	2e1qA	0.458	6.68	0.056	0.779	1.17.3.2,1.17.1.4	NA
16	0.060	2je8B	0.405	6.85	0.047	0.694	3.2.1.25	NA
17	0.060	2ckjA	0.450	6.75	0.056	0.773	1.17.1.4,1.17.3.2	NA
18	0.060	3b9jJ	0.219	7.15	0.021	0.394	1.17.1.4,1.17.3.2	239
19	0.060	2zxqA	0.363	7.42	0.032	0.671	3.2.1.97	325

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.557	4.95	0.14	0.75	4fwhA	GO:0004176 GO:0004252 GO:0005524 GO:0006508 GO:0030163
1	0.21	0.554	5.07	0.12	0.74	4fw9A	GO:0004176 GO:0004252 GO:0005524 GO:0006508 GO:0030163
2	0.21	0.478	2.23	0.17	0.52	1xhkB	GO:0000166 GO:0004176 GO:0004252 GO:0005524 GO:0005886 GO:0006508 GO:0008233 GO:0008236 GO:0016020 GO:0016021 GO:0016787 GO:0030163
3	0.19	0.862	2.71	0.15	0.97	4yplC	GO:0000166 GO:0004176 GO:0004252 GO:0005524 GO:0005737 GO:0006508 GO:0006515 GO:0008233 GO:0008236 GO:0016787 GO:0016887 GO:0030163 GO:0033554 GO:0043565
4	0.14	0.492	2.20	0.19	0.54	2x36C	GO:0000002 GO:0000166 GO:0001666 GO:0003677 GO:0003697 GO:0003727 GO:0004176 GO:0004252 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005759 GO:0006508 GO:0006515 GO:0007005 GO:0007568 GO:0008233 GO:0008236 GO:0009725 GO:0010044 GO:0016020 GO:0016787 GO:0016887 GO:0030163 GO:0032042 GO:0034599 GO:0042645 GO:0043531 GO:0043565 GO:0043623 GO:0051131 GO:0051260 GO:0051603 GO:0051880 GO:0070182 GO:0070361 GO:0070362 GO:0070363 GO:0070364 GO:0070407 GO:0090296
5	0.13	0.746	3.61	0.14	0.89	3m6aA	GO:0000166 GO:0004176 GO:0004252 GO:0005524 GO:0005737 GO:0006508 GO:0006515 GO:0008233 GO:0008236 GO:0016787 GO:0016887 GO:0030163 GO:0033554 GO:0043565
6	0.12	0.478	2.10	0.19	0.52	3wu6E	GO:0000166 GO:0003677 GO:0004176 GO:0004252 GO:0005524 GO:0005737 GO:0006508 GO:0006515 GO:0008233 GO:0008236 GO:0016787 GO:0016887 GO:0030163 GO:0033554 GO:0043565
7	0.12	0.483	2.38	0.17	0.53	1z0bA	GO:0000166 GO:0004176 GO:0004252 GO:0005524 GO:0005886 GO:0006355 GO:0006508 GO:0008134 GO:0008233 GO:0008236 GO:0016020 GO:0016021 GO:0016787 GO:0030163
8	0.07	0.584	4.92	0.13	0.76	3k1jA	GO:0000166 GO:0004176 GO:0004252 GO:0005524 GO:0006355 GO:0006508 GO:0008134 GO:0008233 GO:0016020 GO:0016021 GO:0030163
9	0.06	0.396	5.33	0.04	0.57	2ce7D	GO:0000166 GO:0004176 GO:0004222 GO:0005524 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0030163 GO:0046872
10	0.06	0.398	5.80	0.06	0.60	5c18E	GO:0000166 GO:0000502 GO:0005102 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005783 GO:0005789 GO:0005811 GO:0005829 GO:0006281 GO:0006302 GO:0006511 GO:0006734 GO:0006810 GO:0006888 GO:0006919 GO:0006974 GO:0008289 GO:0010918 GO:0016567 GO:0016787 GO:0016887 GO:0018279 GO:0019079 GO:0019903 GO:0019904 GO:0019985 GO:0030433 GO:0030968 GO:0030970 GO:0031334 GO:0031593 GO:0031625 GO:0032403 GO:0032436 GO:0034098 GO:0034214 GO:0035800 GO:0035861 GO:0036435 GO:0036503 GO:0036513 GO:0042288 GO:0042802 GO:0042981 GO:0043161 GO:0043209 GO:0043231 GO:0043234 GO:0043531 GO:0044389 GO:0044822 GO:0045184 GO:0045732 GO:0046034 GO:0048471 GO:0051260 GO:0070062 GO:0070842 GO:0070987 GO:0071712 GO:0072389 GO:1903006 GO:1903007 GO:1903715 GO:1903862 GO:1904288 GO:1990381 GO:1990730 GO:2001171
11	0.06	0.336	5.17	0.04	0.47	3kdsE	GO:0000166 GO:0004176 GO:0004222 GO:0005524 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0030163 GO:0046872
12	0.06	0.325	6.54	0.05	0.54	4ww0B	GO:0000166 GO:0004176 GO:0004222 GO:0005524 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0030163 GO:0046872
13	0.06	0.376	6.63	0.06	0.64	1ksfX	GO:0000166 GO:0004176 GO:0005524 GO:0005829 GO:0006508 GO:0006979 GO:0016887 GO:0019538 GO:0043335
14	0.06	0.304	6.04	0.04	0.48	1sxjC	GO:0000166 GO:0003677 GO:0003689 GO:0005524 GO:0005634 GO:0005663 GO:0005829 GO:0006260 GO:0006272 GO:0006298 GO:0007049 GO:0007062 GO:0016887 GO:0031389 GO:0031390 GO:0031391
15	0.06	0.388	6.68	0.08	0.66	4d2qA	GO:0000166 GO:0005524 GO:0005737 GO:0005829 GO:0006986 GO:0009408 GO:0016020 GO:0016485 GO:0019538 GO:0042623 GO:0042802
16	0.06	0.406	5.72	0.06	0.61	5c1aK	GO:0000166 GO:0000502 GO:0005102 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005783 GO:0005789 GO:0005811 GO:0005829 GO:0006281 GO:0006302 GO:0006511 GO:0006734 GO:0006810 GO:0006888 GO:0006919 GO:0006974 GO:0008289 GO:0010918 GO:0016567 GO:0016787 GO:0016887 GO:0018279 GO:0019079 GO:0019903 GO:0019904 GO:0019985 GO:0030433 GO:0030968 GO:0030970 GO:0031334 GO:0031593 GO:0031625 GO:0032403 GO:0032436 GO:0034098 GO:0034214 GO:0035800 GO:0035861 GO:0036435 GO:0036503 GO:0036513 GO:0042288 GO:0042802 GO:0042981 GO:0043161 GO:0043209 GO:0043231 GO:0043234 GO:0043531 GO:0044389 GO:0044822 GO:0045184 GO:0045732 GO:0046034 GO:0048471 GO:0051260 GO:0070062 GO:0070842 GO:0070987 GO:0071712 GO:0072389 GO:1903006 GO:1903007 GO:1903715 GO:1903862 GO:1904288 GO:1990381 GO:1990730 GO:2001171
17	0.06	0.262	6.73	0.04	0.44	4r7yA	GO:0000166 GO:0003677 GO:0004386 GO:0004519 GO:0005524 GO:0006260 GO:0016539 GO:0016787 GO:0046872 GO:0051301 GO:0090305
18	0.06	0.304	6.02	0.05	0.48	2chqA	GO:0000166 GO:0003677 GO:0003689 GO:0005524 GO:0005663 GO:0006260

Consensus prediction of GO terms

Molecular Function	GO:0004176	GO:0004252	GO:0005524	GO:0003677
GO-Score	0.66	0.66	0.66	0.60
Biological Processes	GO:0051603	GO:0051716	GO:0006950
GO-Score	0.60	0.37	0.37
Cellular Component	GO:0044424	GO:0071944	GO:0031224
GO-Score	0.60	0.41	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.