I-TASSER results

I-TASSER results for job id Rv3179

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (429 residues)
MVHDEAGHELIERHMLEQLREVAEYTRVVLINGPRQAGKTTLLQQLHAELGGWLRSLDVD
VERASARADPEGYIMSAPRPTFLDEVQCAGDPLILAIKTATDRDRRPRQFFLSGSTRFLT
VPTLSESLAGRVAILDLWPLSVAERSGVRPEIIAQLFTEPQVVLGTEPAPVTRHEYLQLA
CAGGFPEVVQRPAGRARSRWFSDYLRTVTQRDVRELKRIEQTDRLPRFMRYLAAITAQEL
NVAEAARVIGVDAGTIRSDLALFETVYLVHRLPAWSRNLTAKIKKRSKIHVVDSGFAAWL
RGQSADSLARPTAEGAGPIMETFVINELMKLRAATELEVDLYHFRDRDGREIDCILQTPD
SRVVGVEVKASATVNVHDFRHLSFARDRLGDEFITGVLFYTGARALPFGDRLMALPINLL
WNGQSVSSL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVHDEAGHELIERHMLEQLREVAEYTRVVLINGPRQAGKTTLLQQLHAELGGWLRSLDVDVERASARADPEGYIMSAPRPTFLDEVQCAGDPLILAIKTATDRDRRPRQFFLSGSTRFLTVPTLSESLAGRVAILDLWPLSVAERSGVRPEIIAQLFTEPQVVLGTEPAPVTRHEYLQLACAGGFPEVVQRPAGRARSRWFSDYLRTVTQRDVRELKRIEQTDRLPRFMRYLAAITAQELNVAEAARVIGVDAGTIRSDLALFETVYLVHRLPAWSRNLTAKIKKRSKIHVVDSGFAAWLRGQSADSLARPTAEGAGPIMETFVINELMKLRAATELEVDLYHFRDRDGREIDCILQTPDSRVVGVEVKASATVNVHDFRHLSFARDRLGDEFITGVLFYTGARALPFGDRLMALPINLLWNGQSVSSL
Prediction	CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHHCCCEEHCCCCHHHHHHHCCHHHHHHHCCCEEEEHCHHHCCCHHHHHHHHHHHCCCCCEEEEEHCCCCHHHHHCCCCCCCCEEEEEEHCCCCHHHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEHCCCCCCCHHHHHCCCCCEEEHCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCEEEEEEEEHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCEEEHCCCEEEEEHHHHHCCCCCCCC
Conf.Score	988888876434579999999985799799995898878999999999757758875787688999859899998799669975466587556778888865688885999976765777655655668868999857888899984666646788756655556665566689999999987976776568778999999999999999999998758899999999999998667888899999998998999999999999986556657788865666546776466576899999899878877555554789999999999999876557886677898589958999999789679999998599999899999999999759744458998599856887797899877788758886569
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVHDEAGHELIERHMLEQLREVAEYTRVVLINGPRQAGKTTLLQQLHAELGGWLRSLDVDVERASARADPEGYIMSAPRPTFLDEVQCAGDPLILAIKTATDRDRRPRQFFLSGSTRFLTVPTLSESLAGRVAILDLWPLSVAERSGVRPEIIAQLFTEPQVVLGTEPAPVTRHEYLQLACAGGFPEVVQRPAGRARSRWFSDYLRTVTQRDVRELKRIEQTDRLPRFMRYLAAITAQELNVAEAARVIGVDAGTIRSDLALFETVYLVHRLPAWSRNLTAKIKKRSKIHVVDSGFAAWLRGQSADSLARPTAEGAGPIMETFVINELMKLRAATELEVDLYHFRDRDGREIDCILQTPDSRVVGVEVKASATVNVHDFRHLSFARDRLGDEFITGVLFYTGARALPFGDRLMALPINLLWNGQSVSSL
Prediction	635554325104440263036107622000000001000122033005624310000204223330341033003336310000000303302120000000433411000001101212244234202110221202000010013232420241034442225443352235202302214210100223234223420330032023310231231442520210020002222431224302531413350033002001200101422202441343232342201000000000121235302342342001000000000012222234240100011345322120003267330000000115514561041034017405540120000022644041642000000000143632567
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHHCCCEEHCCCCHHHHHHHCCHHHHHHHCCCEEEEHCHHHCCCHHHHHHHHHHHCCCCCEEEEEHCCCCHHHHHCCCCCCCCEEEEEEHCCCCHHHHHCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCEEHCCCCCCCHHHHHCCCCCEEEHCHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCEEEEEEEEHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCEEEHCCCEEEEEHHHHHCCCCCCCC
MVHDEAGHELIERHMLEQLREVAEYTRVVLINGPRQAGKTTLLQQLHAELGGWLRSLDVDVERASARADPEGYIMSAPRPTFLDEVQCAGDPLILAIKTATDRDRRPRQFFLSGSTRFLTVPTLSESLAGRVAILDLWPLSVAERSGVRPEIIAQLFTEPQVVLGTEPAPVTRHEYLQLACAGGFPEVVQRPAGRARSRWFSDYLRTVTQRDVRELKRIEQTDRLPRFMRYLAAITAQELNVAEAARVIGVDAGTIRSDLALFETVYLVHRLPAWSRNLTAKIKKRSKIHVVDSGFAAWLRGQSADSLARPTAEGAGPIMETFVINELMKLRAATELEVDLYHFRDRDGREIDCILQTPDSRVVGVEVKASATVNVHDFRHLSFARDRLGDEFITGVLFYTGARALPFGDRLMALPINLLWNGQSVSSL

2qenA

0.18

0.11

0.64

1.16

wdPPAS

MLFDLRPKT--REEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRKLSLREVFRELNDLGEELGEFIVAFDEAQYLGKELLALFAYAYDSL-PNLKIILTGSEVGLLHD-YESPLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP------ENEIEEAVELLDGIPGWLVVGDFGRAMKRTLEVAKGLIMGELEELRRRS--PRYVDILRAIALGYNRWSLIRDYLAVKGIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI-------------------------------------------------------------------------------------------------------------------------------

2qenA

0.18

0.11

0.65

0.78

MUSTER

MLFDLRPKTIF-EEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCNLKFLTLEPRKLLNDLGEELGEIVAFDEAQYLRFELLALFAYAYDSL-PNLKIILTGSEVGLLHDFLKIPLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP------ENEIEEAVELLDGIPGWLVVFGVEYLRNFGRAMKRTLEVAKGLIMGELEELRRRPRYVDILRAIALGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI-------------------------------------------------------------------------------------------------------------------------------

2qenA

0.17

0.11

0.66

0.73

dPPAS

MLFDLRPKTFDREEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRKLSLREVFRELNDLGEELGEFIVAFDEAQYLGGKELLALFAYAYDSLPNLKIILTGSEVGLLHDFYESPLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVPENEIEEAVELLIPGWLVVFGVEYLRNGDFGRAMKRTLEVAKGLIMGELEELRRRS--PRYVDILRAIALGYNRWSLIRDYLAVKGIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI-------------------------------------------------------------------------------------------------------------------------------

2qenA

0.16

0.10

0.64

1.03

wMUSTER

LFDLRPKTRIFREEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCNLKFLTLEPRKLLNDLGEELGEIVAFDEAQYLRFELLALFAYAYDSL-PNLKIILTGSEVGLLHDFLKSPLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP------ENEIEEAVELLDGIPGWLVVGDFGRAMKRTLEVAKGLIMGELEELRR--RSPRYVDILRAIALGYNR---WSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI-------------------------------------------------------------------------------------------------------------------------------

2qenA

0.16

0.10

0.63

1.44

wPPAS

MLFDTRREDIFREEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCNLKFLTLPRKLSLREVFRE-EFIVAFDEAQYLRFELLALFAYAYDSL-PNLKIILTGSEVGLLHD-YESPLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP------ENEIEEAVELLDGIPGWLVVGDFGRAMKRTLEVAKGLIMGELEELRRRS--PRYVDILRAIALGYN---RWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLR-I------------------------------------------------------------------------------------------------------------------------------

2qenA

0.18

0.11

0.62

1.31

dPPAS2

IFDR--------EEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCELIKELQSTISPFQKFQSKFKIIVAFDEAQYLRFELLALFAYAYDSL-PNLKIILTGSEVGLLHDFLKITLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP------ENEIEEAVELLDGIPGWLVVGDFGRAMKRTLEVAKGLIMGELEELRRRS--PRYVDILRAIALGYNRWSLIRDYLAVKGIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI-------------------------------------------------------------------------------------------------------------------------------

2qenA

0.16

0.10

0.65

1.33

PPAS

MLFDLRPKTFDREEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCNLKFLTLEPRKLNDLGEELGEFIVAFDEAQYLRFELLALFAYAYDSL-PNLKIILTGSEVGLLHDFLKITLYGRAGEVLVKPFDKDTSVEF----LKRGFREVNLDVP------ENEIEEAVELLDGIPGWLVVFGVEYLRNFGRAMKRTLEVAKGLIMGELEELRRRSPRYVDILRAIAGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI-------------------------------------------------------------------------------------------------------------------------------

1j7kA

0.20

0.13

0.64

1.24

Env-PPAS

-LRPKSLDEFIQENVKKKLSLALEAAKMVLLAGPPGLGKTTLAHIIASELQTNIHVTS--GPVLVKQGDMAAILTSLERVLFIDEIHRLNKAVEELLYSAIEDFQDIQPFTLVGATTR--SGLLSSPLRSRFIILELDFYTVKELKE----IIKRAASLMDVEIE----DAAAEMIAKRS--RGTGRIAIRLTKRVRDMLTVVRINTDIVLKTMEVLNIDDEEFDRKILKTIIEIYGGPVGLNALAASLGVEADTLSEVYEPYLLQAFLARTPRVTEKAYKHLKYEVP---------------------------------------------------------------------------------------------------------------------------------------------

2fnaA

0.17

0.11

0.63

0.72

MUSTER

LFDTSPKDNFFDR--EKEIEKLKGRAPITLVLGLRRTGKSSIIKIGINELNLPYIYLDLKDFLLELQKEINKLVKRLPSIIVLDEAQELGVNLLPALAYAYDNLKR--IKFISGSEGYLRVEDPESPLFGRFSTVELKPFSREEAIEF----LRRGFQEADIDFK--------DYEVVYEKIGGIPGWLTYKNLDFAINQTLEYAKKLILKEFENFLHGREIARKRYLNIRTLSKCGKWKRALELEEGIEISDSEIYNYLTQLTKHSWIIK-------------EGEKYCPSEPLISLAFS--------------------------------------------------------------------------------------------------------------------------------

2fnaA

0.15

0.10

0.65

dPPAS

LFDTSPKDN--RKDFEKEIEKLKGRAPITLVLGLRRTGKSSIIKIGINELNLPYIYLDLRKFEERNYISYKDFLLELNVIIVLDEAQELGVNLLPALAYAYDNLKR--IKFISGSEGYLRVEDPESPLFGRFSTVELKPFSREEAIEF----LRRGFQEADIDFKDYEVVYEKIGGIPGWLTYFGFIYLDNKNLDFAINQTLEYAKKLILKEFENFLHGREIARKRYLNIRTLSKCGKVKRALELEEGIEISDSEIYNYLTQLTKHSWIIK-------------EGEKYCPSEPLISLAFS--------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.44

Estimated TM-score = 0.33±0.11

Estimated RMSD = 15.6±3.3Å

Download Model 2

C-score=-3.65

Download Model 3

C-score=-3.87

Download Model 4

C-score=-4.00

Download Model 5

C-score=-4.29

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2qenA	0.628	1.86	0.152	0.660
2	2fnaA	0.598	2.32	0.138	0.643
3	1vt4I	0.569	4.32	0.086	0.702
4	2a5yB	0.547	4.38	0.077	0.688
5	3iytA	0.540	4.47	0.060	0.681
6	1w5tB	0.534	4.29	0.123	0.669
7	5irlA	0.526	5.18	0.096	0.706
8	4kxfK	0.493	6.08	0.070	0.709
9	1sxjA	0.479	5.00	0.083	0.634
10	2qbyA	0.473	4.78	0.099	0.618

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.26	21	2dhrB	ADP	Rep, Mult	10,11,35,36,37,38,39,40,41,152,182
2	0.12	10	1sxjB	MG	Rep, Mult	40,84,85
3	0.09	7	3glfC	BEF	Rep, Mult	35,36,39,40,85,179
4	0.01	1	3shfA	GBL	Rep, Mult	228,229,260,264
5	0.01	1	3sfzA	GBL	Rep, Mult	231,232,242,245,326

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1s46A	0.366	6.93	0.073	0.599	2.4.1.4	136
2	0.060	2w00B	0.372	6.02	0.059	0.538	3.1.21.3	41
3	0.060	1vpeA	0.367	6.04	0.057	0.545	2.7.2.3	NA
4	0.060	3gpbA	0.373	7.19	0.050	0.627	2.4.1.1	285
5	0.060	2qllA	0.343	7.11	0.045	0.573	2.4.1.1	NA
6	0.060	1oidA	0.364	6.57	0.059	0.573	3.6.1.45,3.1.3.5	351
7	0.060	1njgA	0.384	3.39	0.125	0.448	2.7.7.7	38,85,116
8	0.060	2b3xA	0.317	7.14	0.030	0.517	4.2.1.3	NA
9	0.060	1jqnA	0.362	6.81	0.056	0.576	4.1.1.31	NA
10	0.060	3glfG	0.461	4.80	0.094	0.592	2.7.7.7	NA
11	0.060	1oyyA	0.397	5.95	0.098	0.583	3.6.4.12	34,39,42,85
12	0.060	5acnA	0.371	7.12	0.049	0.615	4.2.1.3	NA
13	0.060	1ixsB	0.422	5.07	0.130	0.555	3.6.4.12	116
14	0.060	1xxiA	0.397	5.60	0.100	0.559	2.7.7.7	149,180
15	0.060	1ygpA	0.372	7.00	0.045	0.622	2.4.1.1	269
16	0.060	3gdeA	0.378	7.16	0.052	0.634	6.5.1.1	NA
17	0.060	1fa9A	0.373	7.14	0.039	0.632	2.4.1.1	285
18	0.060	2c4mC	0.371	6.98	0.037	0.622	2.4.1.1	NA
19	0.060	1llwA	0.400	6.92	0.055	0.655	1.4.7.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.569	4.16	0.09	0.70	4v4lA	GO:0002921 GO:0005524 GO:0006915 GO:0006919 GO:0007291 GO:0007423 GO:0008635 GO:0008656 GO:0010332 GO:0012501 GO:0021556 GO:0033353 GO:0034352 GO:0035006 GO:0035070 GO:0035071 GO:0042594 GO:0043065 GO:0043293 GO:0043531 GO:0046668 GO:0046672 GO:0048813 GO:0050700 GO:0051260 GO:0051291 GO:0070050 GO:0070328 GO:0097190 GO:0097199 GO:1901053
1	0.07	0.628	1.86	0.15	0.66	2qenA	GO:0000166 GO:0005524
2	0.07	0.605	2.30	0.14	0.65	2fnaA	GO:0000166 GO:0005524
3	0.07	0.546	4.40	0.08	0.69	4m9sB	GO:0000166 GO:0005524 GO:0005634 GO:0005739 GO:0005829 GO:0006915 GO:0008361 GO:0008635 GO:0008656 GO:0009792 GO:0010954 GO:0016020 GO:0016505 GO:0030155 GO:0042981 GO:0043065 GO:0043066 GO:0043281 GO:0043531 GO:0048471 GO:0048598 GO:0051432 GO:0051434 GO:0061133 GO:1902742 GO:2001056
4	0.07	0.532	4.97	0.07	0.71	3j2tA	GO:0000166 GO:0001666 GO:0001843 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0007275 GO:0007399 GO:0007420 GO:0007568 GO:0007584 GO:0008635 GO:0008656 GO:0010659 GO:0030154 GO:0030900 GO:0031072 GO:0034349 GO:0042802 GO:0042981 GO:0043065 GO:0043293 GO:0043531 GO:0051260 GO:0051402 GO:0070059 GO:0070062 GO:0071560 GO:0072432 GO:0097190 GO:0097193 GO:1902510 GO:2001235
5	0.07	0.473	4.78	0.10	0.62	2qbyA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
6	0.06	0.375	5.55	0.03	0.53	3sfzA	GO:0000166 GO:0001666 GO:0001843 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0007275 GO:0007420 GO:0007568 GO:0007584 GO:0008635 GO:0008656 GO:0010659 GO:0030154 GO:0030900 GO:0031072 GO:0034349 GO:0042802 GO:0042981 GO:0043293 GO:0043531 GO:0051260 GO:0051402 GO:0070059 GO:0070062 GO:0071560 GO:0097190 GO:1902510 GO:2001235
7	0.06	0.313	6.41	0.05	0.49	4ixmA	GO:0000166 GO:0003924 GO:0005525 GO:0005829 GO:0006974 GO:0042802 GO:0046914
8	0.06	0.382	4.64	0.07	0.48	1z6tB	GO:0000166 GO:0001666 GO:0001843 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0007275 GO:0007399 GO:0007420 GO:0007568 GO:0007584 GO:0008635 GO:0008656 GO:0010659 GO:0030154 GO:0030900 GO:0031072 GO:0034349 GO:0042802 GO:0042981 GO:0043065 GO:0043293 GO:0043531 GO:0051260 GO:0051402 GO:0070059 GO:0070062 GO:0071560 GO:0072432 GO:0097190 GO:0097193 GO:1902510 GO:2001235
9	0.06	0.300	5.79	0.07	0.41	3gd7A	GO:0000166 GO:0005215 GO:0005224 GO:0005254 GO:0005260 GO:0005524 GO:0005737 GO:0005765 GO:0005768 GO:0005769 GO:0005829 GO:0005886 GO:0006695 GO:0006810 GO:0006811 GO:0006821 GO:0006904 GO:0007585 GO:0008643 GO:0009986 GO:0015106 GO:0015108 GO:0015423 GO:0015609 GO:0015701 GO:0015768 GO:0016020 GO:0016021 GO:0016323 GO:0016324 GO:0016787 GO:0016820 GO:0016887 GO:0017081 GO:0019869 GO:0019899 GO:0030165 GO:0030301 GO:0030660 GO:0031205 GO:0031234 GO:0031901 GO:0033613 GO:0034707 GO:0035774 GO:0042626 GO:0042956 GO:0043190 GO:0043225 GO:0043234 GO:0045921 GO:0048240 GO:0051454 GO:0055037 GO:0055085 GO:0060081 GO:0070062 GO:0071320 GO:1902161 GO:1902476 GO:1902943 GO:1990060
10	0.06	0.356	6.83	0.07	0.56	2esdA	GO:0008152 GO:0008886 GO:0016491 GO:0016620 GO:0047100 GO:0055114
11	0.06	0.252	6.67	0.05	0.39	4p4uA	GO:0000166 GO:0002376 GO:0003924 GO:0005525 GO:0005634 GO:0005737 GO:0005783 GO:0005789 GO:0005829 GO:0006915 GO:0006952 GO:0007165 GO:0009615 GO:0016020 GO:0031965 GO:0034340 GO:0045071 GO:0045087 GO:0048471 GO:0051607 GO:0060337
12	0.06	0.266	6.45	0.06	0.42	4arzB	GO:0000166 GO:0000329 GO:0000790 GO:0003924 GO:0005525 GO:0005634 GO:0005737 GO:0005764 GO:0005773 GO:0005774 GO:0006810 GO:0006914 GO:0009267 GO:0010507 GO:0015031 GO:0016020 GO:0016237 GO:0031902 GO:0034448 GO:0043547 GO:0045944 GO:0071230 GO:1903778 GO:1904263 GO:1990131
13	0.06	0.228	7.27	0.02	0.39	4k50A	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0051259 GO:0075509
14	0.06	0.237	7.56	0.03	0.41	3kq4B	GO:0001894 GO:0004872 GO:0005215 GO:0005509 GO:0005737 GO:0005764 GO:0005765 GO:0005768 GO:0005783 GO:0005794 GO:0005829 GO:0005886 GO:0005903 GO:0005905 GO:0006629 GO:0006810 GO:0006897 GO:0006898 GO:0008202 GO:0008203 GO:0009235 GO:0010008 GO:0015031 GO:0015889 GO:0016020 GO:0016324 GO:0030139 GO:0031232 GO:0031419 GO:0031526 GO:0042157 GO:0042359 GO:0042803 GO:0042953 GO:0043202 GO:0045177 GO:0046872 GO:0070062
15	0.06	0.253	6.12	0.03	0.38	4ofxA	GO:0004122 GO:0004124 GO:0005737 GO:0006535 GO:0016829 GO:0030170
16	0.06	0.225	6.94	0.03	0.37	3nvtA	GO:0003824 GO:0009058 GO:0009073 GO:0016740 GO:0016832 GO:0046417 GO:0046872
17	0.06	0.255	6.57	0.05	0.39	4jyzA	GO:0000166 GO:0003723 GO:0004812 GO:0004819 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006424 GO:0006425 GO:0016874 GO:0016876 GO:0043039
18	0.06	0.228	5.30	0.04	0.32	2xvnC	GO:0000272 GO:0004553 GO:0004568 GO:0005576 GO:0005618 GO:0005886 GO:0005975 GO:0006032 GO:0008061 GO:0008152 GO:0016020 GO:0016787 GO:0016798 GO:0031225

Consensus prediction of GO terms

Molecular Function	GO:0016505	GO:0043028	GO:0005524
GO-Score	0.47	0.47	0.33
Biological Processes	GO:0006919	GO:0007165	GO:0051259
GO-Score	0.47	0.36	0.36
Cellular Component	GO:0044445	GO:0043234
GO-Score	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.