I-TASSER results

I-TASSER results for job id Rv3169

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (374 residues)
MPQMLGPLDEYPLHQLPQPIAWPGSSDRNFYDRSYFNAHDRTGNIFLITGIGYYPNLGVK
DAFVLIRRADIQTAVHLSDAIDSDRLHQHVNGYRVEVVEPLRKLRIVLDETEGVAADLTW
EGLFDVVQEQPHVLRSGNRVTLDAQRFAQLGTWSGRIVVDGERIAVDPATWLGSRDRSWG
IRPVGEPEPAGRPADPPFEGMWWLYVPLAFDDFAVVLIIQEEPDGFRSLNDCTRIWRDGH
VEQLGWPRVRIHYRSGTRIPTGATIEASTPDGAPVHFDVESKLAVPTHVGGGYGGDSDWS
HGMWKGEKFVERRTYDMTDPTIIARAGFGVIDHVGRALCRDGDGNPVQGWGLFEHGALGR
HDPSGFADWSTLAP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPQMLGPLDEYPLHQLPQPIAWPGSSDRNFYDRSYFNAHDRTGNIFLITGIGYYPNLGVKDAFVLIRRADIQTAVHLSDAIDSDRLHQHVNGYRVEVVEPLRKLRIVLDETEGVAADLTWEGLFDVVQEQPHVLRSGNRVTLDAQRFAQLGTWSGRIVVDGERIAVDPATWLGSRDRSWGIRPVGEPEPAGRPADPPFEGMWWLYVPLAFDDFAVVLIIQEEPDGFRSLNDCTRIWRDGHVEQLGWPRVRIHYRSGTRIPTGATIEASTPDGAPVHFDVESKLAVPTHVGGGYGGDSDWSHGMWKGEKFVERRTYDMTDPTIIARAGFGVIDHVGRALCRDGDGNPVQGWGLFEHGALGRHDPSGFADWSTLAP
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEEEHCCCCCCEEEEEEEEHCCEEEEEHCCCCCCCCCCCCCCCCEEEEEHCCCCEEEEEHCCCCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEHCCEEEEHCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCEEEEEEHCCCCCCEEEEEEEEHCCCCEEEEEHCEEEEEEEHCCCCEEEEEEEEEEHCCCCEEEEEEEEEHCCCCHCCCCCCCCCCCCCCEEHCCCEHCCEEEHCCCCCCCCCCCCCCCEEEEEEEEHCCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCCCC
Conf.Score	99988887777666787765568999998656899999858998899999774788886569999998998899866887888876666566899998599589999959998799999985778644676545678766666655566689999999999999995885688756888778888888888777787766578887546898579999967899975677899987998588876558999995898757689999995999889999999646654445677888986576774665454467656787554555677545568999875789875788987655547888888666678899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPQMLGPLDEYPLHQLPQPIAWPGSSDRNFYDRSYFNAHDRTGNIFLITGIGYYPNLGVKDAFVLIRRADIQTAVHLSDAIDSDRLHQHVNGYRVEVVEPLRKLRIVLDETEGVAADLTWEGLFDVVQEQPHVLRSGNRVTLDAQRFAQLGTWSGRIVVDGERIAVDPATWLGSRDRSWGIRPVGEPEPAGRPADPPFEGMWWLYVPLAFDDFAVVLIIQEEPDGFRSLNDCTRIWRDGHVEQLGWPRVRIHYRSGTRIPTGATIEASTPDGAPVHFDVESKLAVPTHVGGGYGGDSDWSHGMWKGEKFVERRTYDMTDPTIIARAGFGVIDHVGRALCRDGDGNPVQGWGLFEHGALGRHDPSGFADWSTLAP
Prediction	73520332111011122222422456123010000000002311000000002001221000000001342200000223143413524134020301110440202035543010001020102012224313454330223221010102010101044441404354020110000011324434443344442120000000000032100000002245132112200102551424405414230403553330330302031763441303030203111100011112321110223244204233031332442253321111000202042463432100000000000212121033235638
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCEEEEEEEEHCCCCCCEEEEEEEEHCCEEEEEHCCCCCCCCCCCCCCCCEEEEEHCCCCEEEEEHCCCCCEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEHCCEEEEHCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCEEEEEEHCCCCCCEEEEEEEEHCCCCEEEEEHCEEEEEEEHCCCCEEEEEEEEEEHCCCCEEEEEEEEEHCCCCHCCCCCCCCCCCCCCEEHCCCEHCCEEEHCCCCCCCCCCCCCCCEEEEEEEEHCCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCCCC
MPQMLGPLDEYPLHQLPQPIAWPGSSDRNFYDRSYFNAHDRTGNIFLITGIGYYPNLGVKDAFVLIRRADIQTAVHLSDAIDSDRLHQHVNGYRVEVVEPLRKLRIVLDETEGVAADLTWEGLFDVVQEQPHVLRSGNRVTLDAQRFAQLGTWSGRIVVDGERIAVDPATWLGSRDRSWGIRPVGEPEPAGRPADPPFEGMWWLYVPLAFDDFAVVLIIQEEPDGFRSLNDCTRIWRDGHVEQLGWPRVRIHYRSGTRIPTGATIEASTPDGAPVHFDVESKLAVPTHVGGGYGGDSDWSHGMWKGEKFVERRTYDMTDPTIIARAGFGVIDHVGRALCRDGDGNPVQGWGLFEHGALGRHDPSGFADWSTLAP

2ichB

0.16

0.12

0.78

1.03

MUSTER

----LAPVV--PGKALEFPQDFGAHNDFR-IEWWYVTGW-PTGKPLGFQITFFRAPDQLIIAHVALSDPAIGKLQHDQKRAGFDLAYARTGNTDVKLDDTDGRYRTRIEA-EDFTLTFILTPSQPLLQGENGFSRKGPGAPQASYYSEPHLQVSGIINRQGEDIPV---TGTAWLDREWSSEYLDP------------NAAGWDWISANLDDGSALAFQIRGKDDSKIWAYAALRDASGHTRLFTPDQVSFHPIRRTQAVYPVATRVLTGE---TEWQITPLDDQELDSGAVYWEGA-----TFTRDGQPAGRGYELTGYVR----------------------------------------------------

2ichB

0.14

0.11

0.79

1.05

dPPAS

----LAPVV--PGKALEFPQDFGAHNDFR-IEWWYVTGWLPTGKPLGFQITFFRTANPLIIAHVALSDPADQKIARAGFDLAYGNTDVKLDDWIFVRETDGR-YRTRIE-AEDFTLTFILTPSQPLLQGENGFSRKGPGAPQASYYSEPHLQVSGIINRQGEDIPVTGTAWLDRE---WS------------SEYLDPNAAGWDWISANLDDGSALAFQIRGKDDSKIWAYAALRDASGHTRLFTPHPIRTWRSARTQAVYPVATRVLTGE---TEWQITPLDDQELDSRASAGAVYWEGAVTFTRDGQPAGRGYELTGYVR----------------------------------------------------

2ichB

0.16

0.12

0.76

2.18

wdPPAS

----LAPVV--PGKALEFPQDFGAHNDFR-IEWWYVTGW-PTGKPLGFQITFFRTANPLIIAHVALSDPAIGKLQHDQK--GFDLAYARTGNTDVKLDDTDGRYRTRIEA-EDFTLTFILTPSQPLLQGENGFSRKGPGAPQAS--SEPHLQVSGIINRQGEDIPVT---GTAWLDREWSSEYLDP------------NAAGWDWISANLDDGSALAFQIRGKDDSKIWAYAALRDASGHTRLFTPDQVSFHPIRRTQAVYPVATRVLTGE---TEWQITPLDDQRASAGAVYWEGA-----TFTRDGQPAGRGYELTGYVR----------------------------------------------------

2ichB

0.16

0.12

0.75

1.28

wMUSTER

VPKALEPQDFGA-H-------------NDFIEWWYVTGW-PTGKPLGFQITFFRAPDQLIIAHVALSDPAIGKLQHDQKRAGFDLAYARTGNTDVKLDDTDGRYRTRIEA-EDFTLTFILTPSQPLLQGENGFSRKGPGAPQASYYSEPHLQVSGIINRQGEDIPV---TGTAWLDREWSSEYLDP------------NAAGWDWISANLDDGSALAFQIRGKDDSKIWAYAALRDASGHTRLFTPDQVSFHPIRQAVYPVATRVLTG-----ETEWQITPLDDQELSAGAVYWEGAV----TFTRDGQPAGRGYELTGYVR----------------------------------------------------

2ichB

0.16

0.12

0.74

1.76

wPPAS

VPKALEPQDFGA-H-----------ND---IEWWYVTGW-PTGKQITFFRTANPSPDQLIIAHVALSDPAIGKLQHDQK--GFDLAYARTGNTDVKLDDTDGRYRTRIEA-EDFTLTFILTPSQPLLQGENGFSRKGPGAPQAS-YSEPHLQVSGIINRQGEDIPVT---GTAWLDREWSSEYLDP------------NAAGWDWISANLDDGSALAFQIRGKDDSKIWAYAALRDASGHTRLFTPDQVSFHPIRQAVYPVATRVLT----ETEWQITPELDSRAS--AGAVYWE----------GA-----------------------------VTFT---RDGQAGRGYELT-----YVR-----------

2ichB

0.15

0.10

0.72

2.32

dPPAS2

----LAPVV--PGKALEFPQDFGAHNDFR-IEWWYVTGWLPTGKQITFFRTANPSHFAPIIAHVALSDPADQKIARAGFDLAYGNTDVKLDDWIFVRE-TDGRYRTRIE-AEDFTLTFILTPSQPLLQGENGFSRKGPGAPQASYYSEPHLQVSGIINRQGEDIPVTGTAWLDRE---WS------------SEYLDPNAAGWDWISANLDDGSALAFQIRGKDDSKIWAYAALRDASGHTRLFTPHPIRTWRSARTQAVYPVATRVLTGE---TEWQITPLDDQELRDGTGYVR-------------------------------------------------------------------------------

4lgnA1

0.10

0.09

0.98

1.30

PPAS

AIGGFNEGAPGILYGRWIPLLDWVGWNNWGYNGVVSIAADPINTNKVWAAVGMYTNSWDPNDGAILRSSDQQITPLPFKLGGNMPGRGMGERLAVDPNND-NILYFGAPSGKGLWRSATWSQMTNFPDVGTYIANPTDTTGYQSDIQGVVWVAFD--KSSSSLGQASKTIFVGVADPNNPVFWSRDGGATWQAVPGAPTGFIPHKGVFDPVNHVLYIATSNTGGPYDGSSGDVWKFSVGTWTRISPVP---STDTANDYFGYSGLTIDRQHPNTIMVATQISWWPDTIIFRSTDGGATWTR-IWDWTSYPNRSLRYVLDISAEPWLTFGVQPNPPVPSPKLGWMDEATGATLYATNDLTKWDSGGQIHIAPMVK

2ichB

0.16

0.13

0.78

1.71

Env-PPAS

----LAPVV--PGKALEFPQDFGAHNDFR-IEWWYVTGWLETPTLGFQITFFRTAPDQLIIAHVALSDPAIGKLQHDQKRAGFDLAYARTGNTDVKLDDTDGRYRTRIEA-EDFTLTFILTPSQPLLQGENGFSRKGPGAPQASYYSEPHLQVSGIINRQGEDIPV---TGTAWLDREWSSEYLDP------------NAAGWDWISANLDDGSALAFQIRGKDDSKIWAYAALRDASGHTRLFTPDQVSFHPIRRTQAVYPVATRVLTGE---TEWQITPLDDSRASAGAVY-----W-EGTFTRDGQPAGRGYELTGYVR----------------------------------------------------

4lgnA1

0.10

0.97

MUSTER

VAIGFNEGAPGILYVRTDILDWVGWNNWGYN-GVVSIAADPINTNKVWAAVGMYTNSWDPNDGAILRSSDQQITPLPFKLGGNMPGRGMGERLAVDPNND-NILYFGAPSGKGLWRSATWSQMTNFPDVGTYIANPTDTTGYQSD-----IQGVVWVAFDKSSSSLGQASFVGVADPNNPVFWSRDGGATWQAVPGAPTGFIPHKGVFDPVNHVLYIATSNTGGPYDGSSGDVWKFSVGTWTRISPVPST---DTANDYFGYSGLTIDRQHPNTIMVATQISWWPDTIIFRSTDGGATWTR-IWDWTSYPNRSLRYVLDISAEPWLTFGVQPNPPVPSPKLGWMDEATGATLYATNDLTKWDSGGQIHIAPMVK

4g1eA1

0.09

0.94

1.03

dPPAS

FFVPSASSRMFPKANTTQPGIVEGGQDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQ--DGTKTVEYAPCR----------SQDIDADGQGFCQGGFSIDFTKAD-RVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNTRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTG--------EQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQASGDFQTTKLNGFEVFARFGSLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.41

Estimated TM-score = 0.43±0.14

Estimated RMSD = 12.4±4.3Å

Download Model 2

C-score=-2.71

Download Model 3

C-score=-2.98

Download Model 4

C-score=-3.74

Download Model 5

C-score=-3.59

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2ichB	0.687	2.74	0.152	0.773
2	3elqB	0.389	6.42	0.040	0.620
3	1kekA	0.389	6.94	0.046	0.663
4	4hizA	0.386	6.87	0.047	0.652
5	4clfA	0.386	7.06	0.045	0.666
6	2jkbA	0.385	6.69	0.042	0.628
7	3pigA	0.384	6.95	0.042	0.650
8	2ebsB	0.383	6.64	0.053	0.623
9	2sliA	0.382	6.82	0.074	0.639
10	4k3bA	0.381	6.50	0.029	0.615

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3t24A	C8E	Rep, Mult	34,51,52,62
2	0.04	2	3ig8A	MG	Rep, Mult	32,177
3	0.04	2	2qc8D	MN	Rep, Mult	34,175,177
4	0.04	2	3lj7A	OHO	Rep, Mult	65,66,110,113,114,115
5	0.02	1	2oizA	TSR	Rep, Mult	147,150,185
6	0.02	1	2x56A	C8E	Rep, Mult	154,155,156,165
7	0.02	1	3akgA	AHR	Rep, Mult	53,54,79
8	0.02	1	1bosA	UUU	Rep, Mult	160,179
9	0.02	1	2i44A	CA	Rep, Mult	37,207,313
10	0.02	1	3i8gH	NUC	Rep, Mult	54,90
11	0.02	1	3okwB	UUU	Rep, Mult	340,342,345
12	0.02	1	3rj8A	ZN	Rep, Mult	121,125
13	0.02	1	1b0pA	SF4	Rep, Mult	49,76,77,78,79,93,109,110,111
14	0.02	1	3k83B	1DO	Rep, Mult	47,48,49,118
15	0.02	1	1vykA	ZN	Rep, Mult	76,112
16	0.02	1	3k6dA	ZN	Rep, Mult	99,176
17	0.02	1	2vk6A	MG	Rep, Mult	55,56
18	0.02	1	1z9yA	ZN	Rep, Mult	37,39
19	0.02	1	2gtfX	P1R	Rep, Mult	106,108,116,118
20	0.02	1	2ydtA	MN	Rep, Mult	354,362

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2wk5A	0.369	6.32	0.074	0.580	2.4.2.4	94
2	0.060	3h71B	0.367	6.85	0.051	0.623	3.2.1.18	NA
3	0.060	1y4wA	0.371	6.96	0.051	0.626	3.2.1.80	40
4	0.060	3fedA	0.314	6.86	0.042	0.529	3.4.17.21	NA
5	0.060	2ebsB	0.383	6.64	0.053	0.623	3.2.1.150	NA
6	0.060	2bixA	0.366	6.22	0.052	0.575	1.14.99.-	147
7	0.060	3fsnB	0.363	6.34	0.043	0.578	5.2.1.7	113,154,157
8	0.060	2ac1A	0.370	6.91	0.043	0.618	3.2.1.26	40
9	0.060	2w68C	0.210	6.10	0.065	0.324	3.2.1.18	117
10	0.060	1yiqA	0.361	7.02	0.055	0.620	1.1.99.-	NA
11	0.060	1kitA	0.362	6.97	0.050	0.607	3.2.1.18	NA
12	0.060	1sliA	0.381	6.83	0.070	0.639	4.2.2.15,3.2.1.18	NA
13	0.060	1lrwC	0.356	7.00	0.065	0.604	1.1.99.8	114
14	0.060	1oygA	0.363	7.08	0.034	0.620	2.4.1.10	NA
15	0.060	1lrwA	0.355	6.98	0.061	0.602	1.1.99.8	NA
16	0.060	1z4zA	0.360	6.63	0.034	0.586	3.2.1.18	NA
17	0.060	1oqzB	0.370	6.25	0.045	0.580	3.5.1.93	NA
18	0.060	1st8A	0.370	6.76	0.052	0.610	3.2.1.80	NA
19	0.060	3dt7A	0.363	6.87	0.042	0.604	4.1.1.32	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.311	6.98	0.05	0.54	1hfeL	GO:0005506 GO:0008901 GO:0016491 GO:0042597 GO:0046872 GO:0051536 GO:0051539 GO:0055114
1	0.09	0.687	2.74	0.15	0.77	2ichB
2	0.06	0.383	6.68	0.05	0.64	1b0pA	GO:0003824 GO:0005506 GO:0005737 GO:0006086 GO:0008152 GO:0016491 GO:0016903 GO:0019164 GO:0022900 GO:0030976 GO:0046872 GO:0051536 GO:0051539 GO:0055114
3	0.06	0.388	6.62	0.06	0.63	4p07A	GO:0004062 GO:0016740 GO:0042597 GO:0047686
4	0.06	0.320	6.52	0.03	0.52	4g56D	GO:0005634 GO:0005737 GO:0005829 GO:0034709 GO:0035097
5	0.06	0.299	7.28	0.03	0.53	5e7qA	GO:0003824 GO:0008152
6	0.06	0.320	5.71	0.04	0.47	5htrA	GO:0004856 GO:0005737 GO:0005975 GO:0009507 GO:0009536 GO:0016301 GO:0016310 GO:0016773
7	0.06	0.314	7.34	0.05	0.56	1a0eA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
8	0.06	0.313	7.32	0.05	0.56	3cf4A	GO:0003824 GO:0005506 GO:0006084 GO:0015948 GO:0016151 GO:0016491 GO:0018492 GO:0019385 GO:0043885 GO:0046872 GO:0051536 GO:0051539 GO:0055114
9	0.06	0.291	6.30	0.05	0.46	3or1B	GO:0006790 GO:0009055 GO:0016491 GO:0018551 GO:0020037 GO:0046872 GO:0051536 GO:0051539 GO:0055114
10	0.06	0.263	7.75	0.06	0.50	5c4iA	GO:0003824 GO:0008152 GO:0016491 GO:0016625 GO:0033611 GO:0055114
11	0.06	0.266	7.13	0.05	0.47	5exeC	GO:0003824 GO:0016491 GO:0016625 GO:0030976 GO:0033611 GO:0046872 GO:0051536 GO:0051539 GO:0055114
12	0.06	0.269	6.45	0.10	0.43	3rg0A	GO:0000122 GO:0001669 GO:0001948 GO:0002479 GO:0002502 GO:0003729 GO:0005178 GO:0005506 GO:0005509 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005783 GO:0005788 GO:0005790 GO:0005794 GO:0005829 GO:0005844 GO:0005925 GO:0006457 GO:0006611 GO:0006898 GO:0007050 GO:0007283 GO:0008284 GO:0009897 GO:0009986 GO:0010033 GO:0010628 GO:0016020 GO:0016529 GO:0017148 GO:0030246 GO:0030866 GO:0031012 GO:0031625 GO:0032355 GO:0033018 GO:0033144 GO:0033574 GO:0034504 GO:0040020 GO:0042277 GO:0042493 GO:0042562 GO:0042824 GO:0043231 GO:0043234 GO:0044822 GO:0045335 GO:0045665 GO:0045740 GO:0045787 GO:0045892 GO:0046872 GO:0048387 GO:0048471 GO:0050681 GO:0050766 GO:0050821 GO:0051082 GO:0055007 GO:0061077 GO:0070062 GO:0071285 GO:0071310 GO:0090398 GO:1900026 GO:1901224 GO:2000510
13	0.06	0.248	6.93	0.05	0.41	4ddgA	GO:0000151 GO:0000166 GO:0000209 GO:0002223 GO:0002250 GO:0002376 GO:0004842 GO:0004843 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006281 GO:0006464 GO:0006508 GO:0006511 GO:0006974 GO:0008233 GO:0008234 GO:0016567 GO:0016579 GO:0016740 GO:0016787 GO:0019784 GO:0031625 GO:0035666 GO:0036459 GO:0038095 GO:0043130 GO:0043234 GO:0050852 GO:0051865 GO:0061418 GO:0061631 GO:0070062 GO:0070936 GO:0071108 GO:0071347 GO:1901315 GO:2000780
14	0.06	0.201	6.53	0.04	0.32	3lecA	GO:0016429 GO:0030488 GO:0046872
15	0.06	0.214	5.74	0.02	0.32	3kr9A	GO:0008168 GO:0016429 GO:0016740 GO:0030488 GO:0032259
16	0.06	0.211	6.52	0.02	0.34	2b76B	GO:0000104 GO:0005829 GO:0006099 GO:0006113 GO:0008177 GO:0009055 GO:0009061 GO:0016020 GO:0016491 GO:0044780 GO:0045284 GO:0046872 GO:0051536 GO:0051537 GO:0051538 GO:0051539 GO:0055114 GO:0071973
17	0.06	0.210	6.23	0.04	0.33	1k3zD	GO:0005634 GO:0005737 GO:0005829 GO:0007165 GO:0007253 GO:0071222
18	0.06	0.206	6.59	0.05	0.34	2izpA	GO:0005576 GO:0009405

Consensus prediction of GO terms

Molecular Function	GO:0046914	GO:0051536
GO-Score	0.36	0.36
Biological Processes	GO:0044710
GO-Score	0.36
Cellular Component	GO:0005623
GO-Score	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.