I-TASSER results

I-TASSER results for job id Rv3163c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (423 residues)
MIQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVP
VIQVHGDPDSQRCFENEHVRVTVWVTTESVDAAVELTVSALAGMQFEALESVSRRTTTVS
AVAQRWGRYPIRARVAVVARGGLLMGAGTVDAAEIVVFPLTPPQSTPLPQTELLDRLGAH
LTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTRRLTDRAADVVVLIDMYRQP
AGPATEATERVVRGAAQVVQTALRNGDRAGIVALGGNRPRWLGADIGQRQFYRVLDTVLG
AGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDSCPL
QDQLDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRRRGRGRASRA
RLP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MIQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVPVIQVHGDPDSQRCFENEHVRVTVWVTTESVDAAVELTVSALAGMQFEALESVSRRTTTVSAVAQRWGRYPIRARVAVVARGGLLMGAGTVDAAEIVVFPLTPPQSTPLPQTELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTRRLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGIVALGGNRPRWLGADIGQRQFYRVLDTVLGAGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDSCPLQDQLDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRRRGRGRASRARLP
Prediction	CCCCCCCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCEEEEEEEEEEHCCCCCEEEEEEHCCCCCCEEEHCCCCEEEEEEEEHCCCEEEEEHCEEEEEHCCCCCEEEEEEEHCCEEEEHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEHCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHCCCCCHHHHHHHHHHHHHCCEEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
Conf.Score	998876545665458999999999999999999999999999999999999999867887589999977766689867999999998898764667886578764577579877999999966755789984699996688858999998565899967866545544455555567865456788988878855789999864477544444798689988746788599999799988888855999999999999999999899689999769868987799899999999999997888888885888998858998599998799995999999999997996999997799866765789999999999999999999989959986999889999999999998755455677899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MIQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVPVIQVHGDPDSQRCFENEHVRVTVWVTTESVDAAVELTVSALAGMQFEALESVSRRTTTVSAVAQRWGRYPIRARVAVVARGGLLMGAGTVDAAEIVVFPLTPPQSTPLPQTELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTRRLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGIVALGGNRPRWLGADIGQRQFYRVLDTVLGAGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDSCPLQDQLDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRRRGRGRASRARLP
Prediction	734536240101002201000001021221123333321111111211221000001322303030405563034536040201020533110020214343524153044454230304030531031403020101000000113240535201001213423321432413533143324341422304211313421431301021001342010112134441200000000110223435101100000000010014341100000014523320305313400220041015144636422222222320343000000010114600400240143602100000013332445034001300333143015303713041030437320140033015214423233453738
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCEEEEEEEEEEHCCCCCEEEEEEHCCCCCCEEEHCCCCEEEEEEEEHCCCEEEEEHCEEEEEHCCCCCEEEEEEEHCCEEEEHCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEHCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEHCCCCCHHHHHHHHHHHHHCCEEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
MIQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVPVIQVHGDPDSQRCFENEHVRVTVWVTTESVDAAVELTVSALAGMQFEALESVSRRTTTVSAVAQRWGRYPIRARVAVVARGGLLMGAGTVDAAEIVVFPLTPPQSTPLPQTELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTRRLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGIVALGGNRPRWLGADIGQRQFYRVLDTVLGAGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDSCPLQDQLDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRRRGRGRASRARLP

4fx5A1

0.10

0.04

0.39

2.20

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SENVEVIIIDCSGSDYPRTK-----AAKEATKVAIDTLTDGAFFAVVAGTEGARVVYPTGGDYQSRAAAKEAVGRLHANGGTAGRWLAQAGRISAIKHAILLTDSETPADLARAIQSSIGNFTADCRGIGEDWE----------------PKELRKIADALLGTVGIIRDPATLAEDFRETAKS--------------

3ibsA

0.11

0.05

0.43

1.85

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGVEVIIALDISNSLAQDQPSRLEKAKRLISRLVDEL--DNDKVGIVFAGD-AFTQLPITSDYISAKFLESISPSLISKQGTAEAINLATRSFTPQRAIIVITDNHEGGAVEAAKAAAEKGIQVSVLGVGPEGTNDYRRDREGNVIVTRLNEGCQEIAKDGKGIYVRVDNSNSAQKAISQEISKAKS-----------

5gjvF

0.13

0.11

0.87

0.81

MUSTER

FPSAVTIK-SWVDQEDLVTLAKTAVHQLVDIYEKYQRQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWR------------EDFASVVYYNAKDQRIKPVFIDDANFRRQVSYQ-------------HAAVHIPTDIYEGSTIV-LNELNW---TSALDDVFKKNREEDPSLLWQVFGSATGL----ARYY-PASPWVKID-LYDVRRRPWYIQG--AASPKDMLILVDVSGSV---SGLTLKLIRTSVSEMLET-LSDDDFVNVASFNSNAQDVSCFQHNVRNKKVLKDAVNNITAKGIKKGFSFAFEQLLNYNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYD---------------RGPIQWMACENGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQ

5gjvF1

0.10

0.08

0.79

0.96

dPPAS

----------------NARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASVVYYNAKDQRIKPVFIDDANFRRQVSYQHAAVHIPTDIYEGSTIVLNELNWTSALDDVFK------------KNREEDPSLLWQVFGSATGLARYYPASPWVKIDLYDVRRRPWYIQGAA-------------------------------------------SPKDMLILVDVSGSV---SGLTLKLIRTSVSEMLET-LSDDDFVNVASFNSNAQDVSCFQHNVRNKKVLKDAVNNITAKGIKKGFSFAFEQLLNYNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACEN--------------KGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQ

3ibsA

0.11

0.05

0.43

0.97

wdPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGVEVIIALDISNSLAQDQPSRLEKAKRLISRLVDEL--DNDKVGIVFAGD-AFTQLPITSDYISAKFLESISPSLISKQGTAEAINLATRSFTPQRAIIVITDGENHGAVEAAKAAAEKGIQVSVLGVGPEGTNDYRRDREGNVIVTRLNEGCQEIAKDGKGIYVRVDNSNSAQKAISQEISKAKS-----------

5gjvF1

0.12

0.09

0.77

0.78

wMUSTER

-------------------------RQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAH-------WREDFA------------SVVYYNAK----DQRIKPVFIDDANFR-----RQVSYQH-------AAVHI--PTDIYEG----STIVLNELNWTSALDDVFKKNEDPSLLWQVFGSATGLARYYPA-SPWVKIDDVRRRPWYIQGAA-----------SPKDMLILVDVSGSV---SGLTLKLIRTSVSEMLET-LSDDDFVNVASFNSNAQDVSCFQHNVRNKKVLKDAVNNITAKGIKKGFSFAFEQLLNYNKIIMLFTDGGEERAQEIFAKYNKKKVRVFTFSVGQHNYD----------------RGPIQWMACEN-YYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQ

4fx5A1

0.11

0.04

0.38

0.84

wPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SENVEVIIIDCSGSDY----PRTK-AAKEATKVAIDTLTDGAFFAVVAGTEGARVVYPTGGQYQSRAAAKEAVGRLHANGGTARWLAQAGRIFDTAKHAILLTD--TPADLARAIQSSIGNFTADCRGIGEDWE-----------------PKELRKIADAL-TVGIIRDPATLAEDFRETAKS--------------

4rckA

0.13

0.05

0.43

1.71

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EHRDLVVDLSGSAEGDFVDRLTAVKQVVSDFIDQR--KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLVGQRTALATKTFIESNAPQRTIILLSDAGVLEPLEAAQLAKDNHAKIYTVGIGAGEQVRGFFGKQTVNTARDLDEDTLTKIATTGGQYFRARNADELAEIYQTIDAL--------------

5gjvF1

0.11

0.09

0.78

0.87

PPAS

------------------RQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASVVYYNAKDQRIKPVFIDDANFRRQVSYQHAAVHI------PTDI----YEGSTIVLNELNWTSALDDVFKKNRE--EDPSLLWQVFGSATGLARYYP----------------------------ASPWVKIDLY----DVRRRPWYIQGAA-----------SPKDMLILVDVSGSV---SGLTLKLIRTSVSEMLET-LSDDDFVNVASFNSNAQDVSCFQHNVRNKKVLKDAVNNITAKGIKKGFSFAFEQLLNYNKIIMLFTDGGEERAQEIFAKYNKKKVRVFTFSVGQHNYD----------------RGPIQWMACEN-YYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQ

3sbtB

0.10

0.07

0.68

0.86

Env-PPAS

----------------------------------------------------------MNTVPFT------SAPIE----VTIGIDQ------YSFNVKENQPFHIKDIPIGHVHVIHFQHADNSRYGYWFDCR------MGNFYIQYDPKDGLYKMMEERDGAKFENIVHNFKERQMMVSYPKIDEDDTWYNLTEFVQMDKIRKIDENQFSYVDSSMTTVQENELLDPAHSLINFKSREAIRPGHEMEDFLDKSYYLNTVMLQG--------IFKNSSNYF----GELQFAFLNAMFFGN------YGSSLQWHAMIE----LICSSATVPKHMLDKLDEILYYQIKTLPEQYSDILLNERVWNICLYSSFQKNSHNTEKIMENKYPELL--------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.43

Estimated TM-score = 0.34±0.11

Estimated RMSD = 15.5±3.3Å

Download Model 2

C-score=-3.99

Download Model 3

C-score=-4.18

Download Model 4

C-score=-4.03

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5gjvF	0.728	2.77	0.099	0.794
2	3jbrF	0.717	2.94	0.092	0.794
3	3efoB	0.417	5.33	0.081	0.579
4	3eh2A	0.416	6.14	0.076	0.617
5	3o8oA	0.410	6.22	0.045	0.612
6	3opyA	0.409	5.84	0.042	0.577
7	3o8oB	0.408	6.30	0.063	0.624
8	3k71G	0.407	4.30	0.088	0.508
9	1pcxA	0.404	5.15	0.047	0.539
10	3txaA	0.403	4.51	0.069	0.503

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.16	9	3bqmB	BQM	Rep, Mult	230,254,258,267,325,348,350,351,352,389,390,391,403
2	0.07	4	3ehtA	III	Rep, Mult	270,271,323,324,326
3	0.05	3	1g42A	CP2	Rep, Mult	200,201
4	0.04	2	3kifD	GDL	Rep, Mult	207,208
5	0.02	1	3o8oB	F6P	Rep, Mult	233,234,235,272,352
6	0.02	1	1w1iH	UUU	Rep, Mult	213,214,215
7	0.02	1	1ytvA	III	Rep, Mult	248,255,294,295,296,297
8	0.02	1	1ytv0	III	Rep, Mult	207,400,404,407,408
9	0.02	1	2vxaA	RBF	Rep, Mult	197,208
10	0.02	1	3eg9B	III	Rep, Mult	226,227,228,406,410
11	0.02	1	3eobJ	ZN	Rep, Mult	235,237,239,329
12	0.02	1	1i8nA	ROP	Rep, Mult	201,204
13	0.02	1	3k6sC	CA	Rep, Mult	136,137,193
14	0.02	1	3ehuA	III	Rep, Mult	231,232,298,349,350,352

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2vdcF	0.377	7.21	0.050	0.641	1.4.1.13	325
2	0.060	3k2wB	0.375	6.93	0.073	0.605	1.2.1.8	NA
3	0.060	2opxA	0.383	6.68	0.063	0.605	1.2.1.21,1.2.1.22	380,405
4	0.060	1zumI	0.370	6.31	0.061	0.565	1.2.1.3	NA
5	0.060	1o01C	0.379	6.74	0.064	0.598	1.2.1.3	NA
6	0.060	2vdcA	0.388	7.04	0.050	0.648	1.4.1.13	NA
7	0.060	2ve5A	0.371	6.83	0.039	0.593	1.2.1.8	NA
8	0.060	2vroB	0.391	6.54	0.068	0.610	1.2.1.3	NA
9	0.060	2j6lB	0.380	6.92	0.055	0.617	1.2.1.31,1.2.1.3	NA
10	0.060	1rtkA	0.240	7.41	0.042	0.418	3.4.21.47	285
11	0.060	3ifgA	0.375	6.79	0.077	0.601	1.2.1.16	NA
12	0.060	3jz4A	0.378	6.74	0.083	0.601	1.2.1.16	NA
13	0.060	2ok5A	0.370	5.37	0.052	0.499	3.4.21.47	NA
14	0.060	3fg0C	0.379	6.84	0.085	0.605	1.2.1.8	NA
15	0.060	1t90A	0.376	6.91	0.057	0.608	1.2.1.18,1.2.1.27	NA
16	0.060	1o20A	0.374	6.47	0.033	0.579	1.2.1.41	NA
17	0.060	1o0sA	0.374	6.96	0.052	0.612	1.1.1.38	NA
18	0.060	1wnbA	0.378	6.73	0.088	0.603	1.2.1.19,1.2.1.8	NA
19	0.060	2pffD	0.371	6.03	0.044	0.541	2.3.1.86	256,258,260,325,327

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.11	0.711	2.71	0.09	0.78	3jbrF	GO:0005244 GO:0005262 GO:0006810 GO:0006811 GO:0006816 GO:0016020 GO:0016021 GO:0034765 GO:0046872 GO:0070588
1	0.06	0.418	5.41	0.04	0.57	1m2vB	GO:0000139 GO:0005048 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0016236 GO:0030127 GO:0031410 GO:0046872 GO:0090110
2	0.06	0.416	6.14	0.08	0.62	3eh2A	GO:0000139 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0048208 GO:0048471
3	0.06	0.417	5.33	0.08	0.58	3efoB	GO:0000139 GO:0001701 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0048208 GO:0048471
4	0.06	0.401	5.00	0.04	0.53	3eh1A	GO:0000139 GO:0001843 GO:0002093 GO:0002474 GO:0003151 GO:0005215 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0021747 GO:0030127 GO:0030134 GO:0035909 GO:0048208 GO:0048471 GO:0060088 GO:0060425 GO:0060463 GO:0060982 GO:0061156 GO:0072358 GO:0090178 GO:1901301
5	0.06	0.397	4.63	0.07	0.50	2ww8A	GO:0016020 GO:0016021
6	0.06	0.404	5.15	0.05	0.54	1pcxA	GO:0000139 GO:0005048 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0016236 GO:0030127 GO:0031410 GO:0046872 GO:0090110
7	0.06	0.400	5.04	0.05	0.53	3egdB	GO:0000139 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0045714 GO:0048208 GO:0048471 GO:0050714 GO:2000189
8	0.06	0.325	7.28	0.04	0.55	4bziA	GO:0000139 GO:0003400 GO:0005096 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0016236 GO:0030127 GO:0031410 GO:0043547 GO:0046872
9	0.06	0.391	4.78	0.05	0.51	3eg9A	GO:0000139 GO:0002474 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0030134 GO:0030868 GO:0048208 GO:0048471
10	0.06	0.365	2.63	0.10	0.40	4f1jA	GO:0046872
11	0.06	0.351	2.81	0.09	0.39	1n9zA	GO:0001948 GO:0005615 GO:0005886 GO:0007155 GO:0007229 GO:0008305 GO:0009986 GO:0010668 GO:0016020 GO:0016021 GO:0030198 GO:0034142 GO:0046872 GO:0050900 GO:0070062
12	0.06	0.346	3.03	0.09	0.39	3qa3I	GO:0001948 GO:0005615 GO:0005886 GO:0007155 GO:0007229 GO:0008305 GO:0009986 GO:0010668 GO:0016020 GO:0016021 GO:0030198 GO:0034142 GO:0046872 GO:0050900 GO:0070062
13	0.06	0.304	6.00	0.08	0.45	2h6eA	GO:0004022 GO:0008270 GO:0016491 GO:0046872 GO:0055114
14	0.06	0.352	5.69	0.07	0.50	4l4xA	GO:0000166 GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0048037
15	0.06	0.271	7.89	0.02	0.49	1k1xA	GO:0003824 GO:0004134 GO:0005975 GO:0005977 GO:0016740 GO:0016757 GO:0030246
16	0.06	0.302	7.82	0.05	0.54	2bklB	GO:0004252 GO:0006508 GO:0008236 GO:0070008
17	0.06	0.278	4.95	0.07	0.36	2k5uA	GO:0000166 GO:0003924 GO:0005525 GO:0005622 GO:0005794 GO:0006810 GO:0006888 GO:0006893 GO:0007264 GO:0015031 GO:0016192 GO:0016236
18	0.06	0.241	6.94	0.06	0.40	1n1eA	GO:0004367 GO:0005777 GO:0005975 GO:0006072 GO:0009331 GO:0016491 GO:0016616 GO:0020015 GO:0046168 GO:0051287 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0046914
GO-Score	0.47
Biological Processes	GO:0034613	GO:0071702	GO:0045184	GO:0090114	GO:0006461	GO:0006901	GO:0048207	GO:0002495	GO:0002478
GO-Score	0.47	0.47	0.47	0.36	0.36	0.36	0.36	0.36	0.36
Cellular Component	GO:0030658	GO:0044432	GO:0044431	GO:0042175	GO:0030134	GO:0030120
GO-Score	0.47	0.47	0.47	0.47	0.47	0.47

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.