I-TASSER results

I-TASSER results for job id Rv3144c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (409 residues)
MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQSFASVTAGLAGQAWQGP
AALAMAAAAAPYAGWLTAAAAQSAGAAGQARAVASIFEAAQAATVLPAAVAANRDAFVQL
VMTNLFGQNAPLIAAAEGVYEEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPGLGA
GATGATGGESVGTGATGGESVGTGGGESVGTGGATASGGGVGYVGGGVASAGLAAGDPAH
GSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFIGAPLALAALGQMARGGTNSAPGTA
TESARAPEPAASAPPEAVVEVPELEVPAMGVLPTVDPKVAAKAAPLSTTRVGQSAGSGIP
ESTLRTAQGQQASETSAAEETAPSLRPEAAAGQLRPRVRKDPKIQMRGG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQSFASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAAGQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVYEEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVGTGGATASGGGVGYVGGGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFIGAPLALAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPTVDPKVAAKAAPLSTTRVGQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAGQLRPRVRKDPKIQMRGG
Prediction	CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9866688656665545799958999999999999999999999999999877557788869999999999999999999999999999999999999999987899899999999999999985467757899999999999989999999887766555555578888888777887766666666655666777766655666666666677888887788888887777777788777777667777777766666667776777777666667777777787777777777777778888888887777777666778888888888887777777777888888888888888887778888888877777777888876788888888887777876444679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQSFASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAAGQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVYEEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVGTGGATASGGGVGYVGGGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFIGAPLALAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPTVDPKVAAKAAPLSTTRVGQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAGQLRPRVRKDPKIQMRGG
Prediction	5421010000000102001100001000100220032012003102110111213312110000002002300300120022033203204000001210110113223032013200100000010000000030232044232210000010121121223333323332332333433344443332212222332212233323233222333332222123233232222312223112321311111021222221112223122110222242222322432222321221211333312112121322221302402011221221333333132131331323343131112331333334434444346563443445455353425345414334558
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQSFASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAAGQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVYEEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVGTGGATASGGGVGYVGGGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFIGAPLALAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPTVDPKVAAKAAPLSTTRVGQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAGQLRPRVRKDPKIQMRGG

2g38B

0.30

0.13

0.42

1.59

MUSTER

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.24

0.20

0.83

1.77

PPAS

-------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--

2g38B

0.30

0.13

0.42

1.91

dPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.30

0.13

0.42

3.03

wdPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.30

0.13

0.42

2.18

wMUSTER

--FEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.30

0.13

0.42

4.51

wPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.30

0.13

0.42

4.10

dPPAS2

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.30

0.13

0.42

3.51

PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.30

0.13

0.42

3.65

Env-PPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4j3pA

0.09

0.08

0.87

0.81

MUSTER

----TLPT-------TASSS--------------TAVASSQLDQLANFAYNVTTDSVAGCTLQNLR-------DWRA--------SKTQKKDYINSVLCLQKSRTPAHLAPGARTRYDDFVATHI--NQTQIIHYT------GTFLAWHRYFIYEFEQALRDECSYTGDYPYWNWGADADNMEKSQVFDGSETSMSGNGEYIPNQGDIKLLLGNYPAIDLPPGSGGGCVTSGPFKDYKLNLGPAALSLPGGNMTAAANPLTYNPRCMKRSLTTEILQRYNTFPKIVELILDSDDIWDFQMTMQGVPGSGSIGVHGGGHYSMGGDPGRDVYVSPGDTAFWLHHGMIDRVWWIWQNLDLRKRQNAISGTGTFMNNPASPNTTLDTVIDLGYANGGPIA-----MRDLMTAG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.58

Estimated TM-score = 0.52±0.15

Estimated RMSD = 10.5±4.6Å

Download Model 2

C-score=-2.03

Download Model 3

C-score=-3.06

Download Model 4

C-score=-2.62

Download Model 5

C-score=-1.92

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3p1uA	0.857	3.23	0.080	0.976
2	3ehnA	0.742	4.12	0.070	0.907
3	4f7aA	0.741	3.79	0.066	0.887
4	3gzsA	0.727	3.89	0.081	0.878
5	4pucA	0.721	3.84	0.087	0.868
6	3cghA	0.715	3.96	0.087	0.870
7	3sghA	0.692	3.96	0.081	0.846
8	4mruA	0.688	3.84	0.059	0.834
9	4f53A	0.683	3.94	0.094	0.829
10	3ck9B	0.657	5.08	0.065	0.885

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	4oadA	CLM	Rep, Mult	66,69,70,73
2	0.04	2	1jb0M	CLA	Rep, Mult	62,66
3	0.04	2	1gfzA	CFF	Rep, Mult	231,235,244,245
4	0.04	2	1l7xA	700	Rep, Mult	100,150,155,313,314
5	0.02	1	2atiA	IHU	Rep, Mult	217,219,223,224
6	0.02	1	3cisB	MG	Rep, Mult	11,148
7	0.02	1	2jstA	HLT	Rep, Mult	31,69
8	0.02	1	2g38B	MN	Rep, Mult	149,152,153
9	0.02	1	2jstB	HLT	Rep, Mult	31,34,69
10	0.02	1	3cemA	AVD	Rep, Mult	204,205,206,209
11	0.02	1	2cj0A	MAN	Rep, Mult	200,201
12	0.02	1	2a68P	MG	Rep, Mult	147,150
13	0.02	1	2bkoA	CA	Rep, Mult	115,152,156
14	0.02	1	3dslB	CA	Rep, Mult	237,238,239,240,252,253
15	0.02	1	5tglA	HEE	Rep, Mult	208,272
16	0.02	1	1xoiB	288	Rep, Mult	96,147,151,311,312
17	0.02	1	2np5C	NDS	Rep, Mult	78,79,83,87
18	0.02	1	1izlM	CLA	Rep, Mult	154,157
19	0.02	1	2vn4A	MAN	Rep, Mult	357,358
20	0.02	1	3cejB	AVF	Rep, Mult	227,228,229,230,233

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2qllA	0.405	6.54	0.041	0.648	2.4.1.1	NA
2	0.060	1ahpA	0.406	6.76	0.031	0.670	2.4.1.1	NA
3	0.060	2vdcA	0.377	7.07	0.065	0.633	1.4.1.13	NA
4	0.060	1gaiA	0.382	6.53	0.060	0.602	3.2.1.3	NA
5	0.060	2eabA	0.369	6.88	0.044	0.597	3.2.1.63	NA
6	0.060	1nxcA	0.369	6.29	0.062	0.565	3.2.1.113	NA
7	0.060	1ygpA	0.400	6.38	0.029	0.626	2.4.1.1	NA
8	0.060	1obbA	0.364	6.64	0.072	0.580	3.2.1.20	NA
9	0.060	2vn4A	0.391	6.19	0.050	0.589	3.2.1.3	NA
10	0.060	1gw0A	0.358	6.85	0.039	0.582	1.10.3.2	NA
11	0.060	3epsA	0.365	6.87	0.039	0.609	2.7.11.5	259
12	0.060	1e1yA	0.403	6.68	0.041	0.648	2.4.1.1	NA
13	0.060	3bq5A	0.356	7.37	0.047	0.614	2.1.1.14	NA
14	0.060	1q16A	0.347	7.37	0.064	0.606	1.7.99.4	NA
15	0.060	1fp3A	0.372	6.36	0.062	0.565	5.1.3.8	NA
16	0.060	1hcuB	0.374	6.35	0.068	0.570	3.2.1.113	9,14
17	0.060	1t7lA	0.373	7.28	0.043	0.636	2.1.1.14	NA
18	0.060	1xmeA	0.369	6.29	0.050	0.555	1.9.3.1	NA
19	0.060	1hxgA	0.365	6.81	0.070	0.589	4.2.3.9,4.1.99.7	203

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.13	0.729	3.90	0.10	0.88	3cghA	GO:0046872
1	0.12	0.737	3.76	0.10	0.88	4pucB	GO:0046872
2	0.09	0.663	4.22	0.07	0.83	3mx3A	GO:0046872
3	0.06	0.308	7.56	0.06	0.55	4bjuA	GO:0000287 GO:0004610 GO:0005975 GO:0016868 GO:0046872 GO:0071704
4	0.06	0.260	7.06	0.07	0.44	4mpqA	GO:0003824 GO:0008152 GO:0016829
5	0.06	0.238	7.85	0.07	0.45	4p3mB	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008652 GO:0016740 GO:0019264 GO:0030170 GO:0035999
6	0.06	0.251	7.05	0.02	0.42	1p5hA	GO:0003824 GO:0005737 GO:0008152 GO:0008410 GO:0016740 GO:0033608 GO:0033611
7	0.06	0.179	5.64	0.03	0.26	1ou0B	GO:0009236 GO:0016993
8	0.06	0.150	5.77	0.05	0.22	4j8pA	GO:0000166 GO:0010181
9	0.06	0.136	4.97	0.03	0.19	4hhxA	GO:0005886 GO:0006810 GO:0009306 GO:0015031 GO:0016020 GO:0016021
10	0.06	0.107	4.32	0.04	0.13	3wztE	GO:0003980 GO:0006486 GO:0016740 GO:0097359
11	0.06	0.077	3.54	0.10	0.09	3adgA	GO:0003723 GO:0003725 GO:0004525 GO:0005634 GO:0009733 GO:0009735 GO:0009737 GO:0010267 GO:0010305 GO:0010445 GO:0010589 GO:0015030 GO:0031047 GO:0031053 GO:0031054 GO:0035196 GO:0035198 GO:0035279 GO:0090502
12	0.06	0.124	4.58	0.06	0.16	2qyaA
13	0.06	0.692	3.96	0.08	0.85	3sghA
14	0.06	0.741	3.79	0.07	0.89	4f7aA
15	0.06	0.640	4.70	0.08	0.84	3fdhA
16	0.06	0.633	4.13	0.07	0.79	3ejnA
17	0.06	0.133	4.59	0.04	0.17	3l7qA
18	0.06	0.688	3.84	0.06	0.83	4mruA

Consensus prediction of GO terms

Molecular Function	GO:0046872
GO-Score	0.35
Biological Processes	GO:0005975
GO-Score	0.06
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.