I-TASSER results

I-TASSER results for job id Rv3120

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (200 residues)
MSPSPSALLADHPDRIRWNAKYECADPTEAVFAPISWLGDVLQFGVPEGPVLELACGRSG
TALGLAAAGRCVTAIDVSDTALVQLELEATRRELADRLTLVHADLCSWQSGDGRFALVLC
RLFWHPPTFRQACEAVAPGGVVAWEAWRRPIDVARDTRRAEWCLKPGQPESELPAGFTVI
RVVDTDGSEPSRRIIAQRSL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MSPSPSALLADHPDRIRWNAKYECADPTEAVFAPISWLGDVLQFGVPEGPVLELACGRSGTALGLAAAGRCVTAIDVSDTALVQLELEATRRELADRLTLVHADLCSWQSGDGRFALVLCRLFWHPPTFRQACEAVAPGGVVAWEAWRRPIDVARDTRRAEWCLKPGQPESELPAGFTVIRVVDTDGSEPSRRIIAQRSL
Prediction	CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCEEEEEEHCCCCHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCEEEEEEHCCCCCCCCEEEEEHCC
Conf.Score	99988877788758999999998688877777875999999997899986899779998789999998997999978999999999999998998885899957767999998766999956668899999999859997999997688877778999846668975899986557678999875677775568887669
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MSPSPSALLADHPDRIRWNAKYECADPTEAVFAPISWLGDVLQFGVPEGPVLELACGRSGTALGLAAAGRCVTAIDVSDTALVQLELEATRRELADRLTLVHADLCSWQSGDGRFALVLCRLFWHPPTFRQACEAVAPGGVVAWEAWRRPIDVARDTRRAEWCLKPGQPESELPAGFTVIRVVDTDGSEPSRRIIAQRSL
Prediction	84454443345462354345215644344424401420240074235604110101121320022053304220450145005302630674725540311100045152474220000000011140043014012341110000004445444635424111435203520473042022244446434231224257
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCEEEEEEHCCCCHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCHHHCCCHHHHHHHHCCCCEEEEEEHCCCCCCCCEEEEEHCC
MSPSPSALLADHPDRIRWNAKYECADPTEAVFAPISWLGDVLQFGVPEGPVLELACGRSGTALGLAAAGRCVTAIDVSDTALVQLELEATRRELADRLTLVHADLCSWQSGDGRFALVLCRLFWHPPTFRQACEAVAPGGVVAWEAWRRPIDVARDTRRAEWCLKPGQPESELPAGFTVIRVVDTDGSEPSRRIIAQRSL

3merA

0.20

0.17

0.82

2.33

MUSTER

--------------------------------EPNDFLVSVANQI-PQGKILCLAEGEGRNACFLASLGYEVTAVDQSSVGLAKAKQLAQEKGV--KITTVQSNLADFDIVADAWEGIVSIFCHRQQLYPKVYQGLKPGGVFILEGFAPLQYNTGGPKDLDLLPKLETLQSEL-PSLNWLIANNLERNKAAIQLLGQKLE

3merA

0.21

0.17

0.82

3.42

dPPAS

--------------------------------EPNDFLVSVANQI-PQGKILCLAEGEGRNACFLASLGYEVTAVDQSSVGLAKAKQLAQEKGVKIT--TVQSNLADFDIVADAWEGIVSIFCHLQQLYPKVYQGLKPGGVFILEGFAPEQYNTGGPKDLDLLPKLETLQSELPSLNWLIANNLERNKAALIQLLGQKLE

3merA

0.21

0.17

0.81

2.76

wdPPAS

--------------------------------EPNDFLVSVANQI-PQGKILCLAEGEGRNACFLASLGYEVTAVDQSSVGLAKAKQLAQEKGV--KITTVQSNLADFDIVADAWEGIVSIFCHLQQLYPKVYQGLKPGGVFILEGFAPEQYNTGGPKDLDLLPKLETLQSELPSNWLIANNLERNKAA---QLLGQKLE

3merA

0.20

0.17

0.81

2.55

wMUSTER

---------------------------------PNDFLVSVANQI-PQGKILCLAEGEGRNACFLASLGYEVTAVDQSSVGLAKAKQLAQEKGV--KITTVQSNLADFDIVADAWEGIVSIFCHRQQLYPKVYQGLKPGGVFILEGFAPEQYNTGGPKDLDLLPKLETLQSEL-PSLNWLIANNLERNKAAIQLLGQKLE

3merA

0.21

0.17

0.81

2.75

wPPAS

--------------------------------EPNDFLVSVANQI-PQGKILCLAEGEGRNACFLASLGYEVTAVDQSSVGLAKAKQLAQEKGV--KITTVQSNLADFDIVADAWEGIVSIFCHRQQLYPKVYQGLKPGGVFILEGFAPEQYNTGGPKDLDLLPKLETLQSELPSNWLIANNLERNKAA---QLLGQKLE

3merA

0.20

0.17

0.82

4.50

dPPAS2

--------------------------------EPNDFLVSVANQI-PQGKILCLAEGEGRNACFLASLGYEVTAVDQSSVGLAKAKQLAQEKGV--KITTVQSNLADFDIVADAWEGIVSIFCHRQQLYPKVYQGLKPGGVFILEGFAPEQYNTGGPKDLDLLPKLETLQSEL-PSLNWLIANNLERNKAAIQLLGQKLE

3merA

0.21

0.17

0.81

2.59

PPAS

--------------------------------EPNDFLVSVANQI-PQGKILCLAEGEGRNACFLASLGYEVTAVDQSSVGLAKAKQLAQEKGV--KITTVQSNLADFDIVADAWEGIVSIFCHRQQLYPKVYQGLKPGGVFILEGFAPEQYNTGGPKDLDLLPKLETLQSELPSNWLIANNLERNKAA---QLLGQKLE

3merA

0.21

0.17

0.82

2.81

Env-PPAS

--------------------------------EPNDFLVSVANQ-IPQGKILCLAEGEGRNACFLASLGYEVTAVDQSSVGLAKAKQLAQEKGV--KITTVQSNLADFDIVADAWEGIVSIFCHRQQLYPKVYQGLKPGGVFILEGFAPEQYNTGGPKDLDLLPKLETLQSELPSNWLIANNLERNKAA-LIQLLGQKLE

3lccA

0.18

0.17

0.97

2.21

MUSTER

VIPTPEEFLHKTVEEGGWEKCWEEEITPWDQGRATPLIVHLVDTSSPLGRALVPGCGGGHDVVAMASPERFVVGLDISESALAKANETYGSSPKAEYFSFVKEDVFTWR-PTELFDLIFDYVFFCPAWAKSMYELLKPDGELITLMYPITDHVGGPP----YKVDVSTFEEVLVPGFKAVSVEENPHAIPKEKLGRWKKI

3lccA

0.17

0.97

3.11

dPPAS

TPEEVATFLHKTVEEGGWEKCWEEEITPWDQGRATPLIVHLVDTSSPLGRALVPGCGGGHDVVAMASPERFVVGLDISESALAKANETYGSSPKAEYFSFVKEDVFTWR-PTELFDLIFDYVFFCPAWAKSMYELLKPDGELITLMYPITDHVGGPPY----KVDVSTFEEVLVPGFKAVSVEENPHAIPKEKLGRWKKI

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.64

Estimated TM-score = 0.80±0.09

Estimated RMSD = 4.1±2.7Å

Download Model 2

C-score=-4.85

Download Model 3

C-score=-5.00

Download Model 4

C-score=-4.93

Download Model 5

C-score=-4.86

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3lccA	0.816	2.77	0.159	0.975
2	5f8cA	0.780	3.21	0.179	0.975
3	4necA	0.768	2.88	0.199	0.920
4	3vc1A	0.767	3.17	0.105	0.935
5	4ineA	0.765	3.23	0.157	0.935
6	5egpA	0.764	2.78	0.136	0.915
7	4pneA	0.764	3.13	0.165	0.925
8	3f4kA	0.763	3.25	0.126	0.950
9	1tw2B	0.761	3.33	0.112	0.975
10	5thyA	0.757	3.67	0.143	0.980

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.59	37	4necA	SAH	Rep, Mult	18,22,29,55,56,57,76,77,78,103,104,105,121,122,123
2	0.03	2	4er6A	AW2	Rep, Mult	41,53,55,56,57,61,76,77,78,103,104,105,119,121,124,143,144,194
3	0.01	1	2xvaB	ZN	Rep, Mult	35,36

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.296	3lccA	0.816	2.77	0.159	0.975	2.1.1.-	33,82,101
2	0.171	3e05D	0.651	3.04	0.117	0.800	2.1.1.132	82,100
3	0.154	2iftA	0.635	2.52	0.122	0.740	2.1.1.52	NA
4	0.143	3bgdA	0.755	3.32	0.087	0.930	2.1.1.67	121
5	0.101	2ex4A	0.731	3.39	0.123	0.915	2.1.1.-	NA
6	0.098	1f38A	0.648	2.87	0.179	0.795	2.1.1.-	NA
7	0.097	2pxxA	0.698	3.22	0.154	0.865	3.4.24.71	60
8	0.087	1xcjA	0.709	3.39	0.122	0.905	2.1.1.2	18
9	0.087	3e05B	0.649	3.01	0.122	0.795	2.1.1.132	NA
10	0.083	3hnrA	0.663	3.15	0.145	0.815	2.1.1.-	NA
11	0.076	3gdhA	0.649	3.00	0.117	0.800	2.1.1.-	NA
12	0.074	3cbgA	0.676	3.20	0.115	0.835	2.1.1.-	NA
13	0.074	3bwmA	0.667	3.21	0.113	0.830	2.1.1.6	NA
14	0.073	3grzB	0.649	2.78	0.129	0.770	2.1.1.-	NA
15	0.073	2cl5A	0.664	3.24	0.101	0.830	2.1.1.6	NA
16	0.060	1xxlA	0.710	2.62	0.120	0.830	2.1.1.-	NA
17	0.060	1wznA	0.729	3.23	0.187	0.895	2.1.1.-	NA
18	0.060	2vdwG	0.718	3.35	0.103	0.890	2.7.7.50	NA
19	0.060	2h11B	0.751	3.21	0.094	0.920	2.1.1.67	28,54,62
20	0.060	1ri5A	0.693	3.04	0.120	0.845	2.1.1.56	56,60,104
21	0.060	2aovA	0.697	3.60	0.065	0.910	2.1.1.8	102
22	0.060	1tpyA	0.730	3.38	0.122	0.915	2.1.1.79	NA
23	0.060	1ri1A	0.694	3.02	0.120	0.845	2.1.1.56	76
24	0.060	2opbB	0.719	3.37	0.105	0.910	2.1.1.28	57,76
25	0.060	2ytzA	0.690	3.21	0.104	0.850	2.1.1.32	76,123
26	0.060	3g5tA	0.697	3.58	0.105	0.895	2.1.1.145	56,63,86
27	0.060	3c3yA	0.691	3.37	0.109	0.865	2.1.1.104	8
28	0.060	1jq3A	0.698	3.57	0.105	0.905	2.5.1.16	77
29	0.060	2i62C	0.728	3.50	0.134	0.930	2.1.1.1	57,79,82,85,104
30	0.060	1kpiA	0.726	3.30	0.113	0.910	2.1.1.79	NA
31	0.060	1l1eA	0.712	3.12	0.114	0.880	2.1.1.79	NA
32	0.060	2iipA	0.742	3.50	0.161	0.950	2.1.1.1	57,79,82,104
33	0.060	3duwA	0.692	3.24	0.142	0.860	2.1.1.-	NA
34	0.060	2fk8A	0.734	3.18	0.094	0.905	2.1.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.35	0.816	2.77	0.16	0.97	3lccA	GO:0005886 GO:0006952 GO:0008168 GO:0008757 GO:0016740 GO:0018708 GO:0019762 GO:0032259
1	0.31	0.766	3.34	0.12	0.97	4kifB	GO:0008168 GO:0016740 GO:0017000 GO:0032259
2	0.30	0.773	2.91	0.20	0.93	4necB	GO:0008168 GO:0016740 GO:0032259
3	0.28	0.672	2.76	0.18	0.80	2i6gB	GO:0005737 GO:0008168 GO:0008757 GO:0016740 GO:0032259 GO:0046690
4	0.27	0.752	3.21	0.09	0.92	2bzgA	GO:0005737 GO:0005829 GO:0006139 GO:0008119 GO:0008168 GO:0008757 GO:0016740 GO:0032259 GO:0070062
5	0.26	0.736	2.92	0.20	0.89	3busA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
6	0.25	0.763	3.25	0.13	0.95	3f4kA	GO:0005737 GO:0008168 GO:0008757 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
7	0.25	0.755	3.32	0.09	0.93	3bgdA	GO:0005737 GO:0006139 GO:0008119 GO:0008168 GO:0008757 GO:0016740 GO:0032259 GO:0070062
8	0.25	0.665	2.83	0.19	0.81	2kw5A	GO:0005737 GO:0008757 GO:0032259
9	0.24	0.699	2.82	0.18	0.82	3sm3A	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872
10	0.24	0.701	2.68	0.17	0.82	2xvaA	GO:0005737 GO:0005829 GO:0008168 GO:0008757 GO:0009636 GO:0016740 GO:0032259 GO:0046677 GO:0046690
11	0.24	0.767	3.14	0.16	0.93	4krhA	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
12	0.24	0.698	3.33	0.18	0.87	3ou7A	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
13	0.24	0.683	3.46	0.19	0.88	3g2pA	GO:0046872 GO:0051536 GO:0051539
14	0.24	0.705	2.71	0.14	0.83	2p8jB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
15	0.23	0.764	3.11	0.14	0.94	3ofkA	GO:0008168 GO:0008757 GO:0009312 GO:0009877 GO:0016740 GO:0032259
16	0.23	0.729	3.23	0.19	0.90	1wznA
17	0.23	0.724	3.57	0.14	0.92	1bhjA	GO:0001887 GO:0005542 GO:0005634 GO:0005737 GO:0005829 GO:0006544 GO:0008168 GO:0008757 GO:0016594 GO:0016740 GO:0017174 GO:0032259 GO:0046498 GO:0046500 GO:0046655 GO:0051262 GO:0051289 GO:0098603 GO:1901052
18	0.23	0.677	3.26	0.14	0.85	3mggB	GO:0008168 GO:0016740 GO:0032259
19	0.23	0.748	3.43	0.12	0.94	3kkzA	GO:0046872 GO:0051536 GO:0051539
20	0.23	0.677	3.29	0.11	0.83	3dtnA	GO:0046872
21	0.22	0.710	2.93	0.15	0.84	4htfB	GO:0008033 GO:0008168 GO:0016740 GO:0032259
22	0.22	0.698	2.80	0.14	0.83	3l8dA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
23	0.20	0.633	3.24	0.11	0.78	3cggA	GO:0008168 GO:0016740 GO:0032259
24	0.18	0.727	3.15	0.11	0.89	4iv8A	GO:0000234 GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
25	0.17	0.669	3.71	0.18	0.89	2yqzA	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
26	0.15	0.763	3.04	0.17	0.92	4pneB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
27	0.14	0.707	3.38	0.15	0.89	3h2bB	GO:0008168 GO:0016740 GO:0032259
28	0.14	0.761	2.90	0.11	0.92	3uj7A	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
29	0.13	0.724	3.09	0.13	0.88	3e23A	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
30	0.13	0.738	3.28	0.18	0.91	4qdkA	GO:0005737 GO:0008168 GO:0008757 GO:0015979 GO:0015995 GO:0016740 GO:0032259 GO:0036068 GO:0046406
31	0.13	0.730	3.16	0.15	0.90	2avnA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
32	0.12	0.712	3.28	0.16	0.88	1y8cA	GO:0008168 GO:0016740 GO:0032259
33	0.12	0.720	3.00	0.15	0.89	1ve3B	GO:0046872 GO:0051536 GO:0051539
34	0.12	0.711	3.24	0.17	0.89	4oqdC	GO:0008168 GO:0008757 GO:0016740 GO:0017000 GO:0032259 GO:0042803
35	0.12	0.746	3.31	0.14	0.93	3ggdA
36	0.12	0.713	3.17	0.14	0.89	5bszA	GO:0008168 GO:0016740 GO:0032259
37	0.12	0.733	3.08	0.13	0.90	5je1A	GO:0008168 GO:0016740 GO:0032259
38	0.11	0.753	3.32	0.17	0.94	4hh4C	GO:0008170 GO:0032259
39	0.11	0.751	2.81	0.12	0.90	4gekG	GO:0002098 GO:0008168 GO:0016300 GO:0016740 GO:0016743 GO:0030488 GO:0032259 GO:1904047
40	0.10	0.739	2.75	0.12	0.88	1im8A	GO:0002098 GO:0005737 GO:0008757 GO:0016300 GO:0016740 GO:0016743 GO:0030488 GO:0032259 GO:1904047
41	0.10	0.641	3.17	0.14	0.79	3mtiB	GO:0008168 GO:0016740 GO:0032259
42	0.09	0.708	2.64	0.12	0.83	2gluA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
43	0.08	0.756	3.06	0.12	0.93	4mwzB	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
44	0.07	0.678	3.28	0.13	0.85	5bp9A	GO:0008168 GO:0016740 GO:0032259
45	0.07	0.649	2.60	0.15	0.76	3cjtA	GO:0005737 GO:0006479 GO:0008168 GO:0008276 GO:0016740 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0018708
GO-Score	0.35
Biological Processes	GO:0032259	GO:0010035	GO:0046483	GO:0034641	GO:1901360	GO:0006725	GO:0044238	GO:0006952	GO:0019762	GO:0017000
GO-Score	0.83	0.56	0.53	0.53	0.53	0.53	0.46	0.35	0.35	0.31
Cellular Component	GO:0031988	GO:0044444	GO:1903561	GO:0005886
GO-Score	0.53	0.53	0.53	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.