I-TASSER results

I-TASSER results for job id Rv3104c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (308 residues)
MTTSGTVLATSIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVLAARFVTWLANRVTRRL
DLGFTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEVIDVLPVPVGALVGPAAVL
GAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRS
SEGEVFTVPNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLLGE
LLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALTRAGIVTAADARA
AVAESPEQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTSGTVLATSIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLLGELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALTRAGIVTAADARAAVAESPEQ
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCEEEEEEEEEEEEEEEHCCCCEEEEHCCCCEEEEEHCCCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEHCCCEEEEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHCCCCC
Conf.Score	98657799999999999999999999999999999999999999999999999999999998776555545567889999999999999999999999999999989966899999999999999999999999999999998656678879998677788885899999999999999599959999598578999857998699999967888779999999999999987665455545689857878765798689999999788844479999999999999998999999857999778889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTSGTVLATSIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLLGELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALTRAGIVTAADARAAVAESPEQ
Prediction	64332230132024203401344013201422021011322332233213200320042025424545444454454135101400232122202320333221334043012111311201020022132032331221023031160000020133344541202044030110202037432000002312301020343110303030327431630250045006514746514740275031120230233000010100043552040033004301511573726120021103254388
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCEEEEEEEEEEEEEEEHCCCCEEEEHCCCCEEEEEHCCCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEHCCCEEEEEEEEEHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHCCCCC
MTTSGTVLATSIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLLGELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALTRAGIVTAADARAAVAESPEQ

3t9nA

0.26

0.23

0.86

3.28

MUSTER

-----------------------YDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLP-------QRKIDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTIN------GISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRD------EGPTVLGITDMQDSKLVIMVYAKTQPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKT

3t9nA

0.26

0.23

0.86

3.48

dPPAS

-----------------------YDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLP-------QRKIDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTIN------GISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRD------EGPTVLGITDMQDSKLVIMVYAKTQPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKT

3t9nA

0.26

0.23

0.86

6.76

wdPPAS

-----------------------YDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLP-------QRKIDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTIN------GISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKS------RDEGPTVLGITDMQDSKLVIMVYAKTQPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKT

3t9nA

0.27

0.23

0.86

4.37

wMUSTER

-------------------------IKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLP-------QRKIDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTIN------GISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRD------EGPTVLGITDMQDSKLVIMVYAKTQPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKT

3t9nA

0.26

0.23

0.86

6.29

wPPAS

-----------------------YDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLP-------QRKIDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTIN------GISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKS------RDEGPTVLGITDMQDSKLVIMVYAKTQPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKT

3t9nA

0.26

0.23

0.86

6.59

dPPAS2

-----------------------YDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLP-------QRKIDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTIN------GISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKSRD------EGPTVLGITDMQDSKLVIMVYAKTQPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKT

3t9nA

0.26

0.23

0.86

5.29

PPAS

-----------------------YDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLP-------QRKIDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTIN------GISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKS------RDEGPTVLGITDMQDSKLVIMVYAKTQPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKT

3t9nA

0.26

0.23

0.86

6.08

Env-PPAS

-----------------------YDIKAVKFLLDVLKILIIAFIGIKFADFLIYRFYKLYSKSKIQLP-------QRKIDTLTSLTKNAVRYIIYFLAGASILKLFNIDMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGDYVTIN------GISGTVEEIGLRVTKIRGFSDGLHIIPNGEIKMVTNLTKDSMMAVVNIAFPIDEDVDKIIEGLQEICEEVKKS------RDEGPTVLGITDMQDSKLVIMVYAKTQPMQKWAVERDIRYRVKKMFDQKNISFPYPRTTVILSEKKT

2vv5A

0.19

0.16

0.82

2.72

MUSTER

----------------------------LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISR--------------IDATVADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLG------GVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAIINFSRPVRRNEFIIGVAYDSDIDQVKQILTNIIQSE---DR---ILKDREMTVRLNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--

2vv5A

0.19

0.16

0.82

2.83

dPPAS

----------------------------LSYAVNIVAALAIIIVGLIIARMISNAVNRLMISRK-------------IDATVADFLSALVRYGIIAFTLIAALGRVGVQTASVIAVLGAAGLVVGLALQGSLSNLAAGVLLVMFRPFRAGEYVDLG------GVAGTVLSVQIFSTTMRTADGKIIVIPNGKIIAIINFSREPRRNEFIIGVAYDSDIDQVKQILTNIIQSEDR------ILKDREMTVRLNELGASSINFVVRVWSNSGDLQNVYWDVLERIKREFDAAGISFPYPQMDVNFKRV--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.10

Estimated TM-score = 0.70±0.12

Estimated RMSD = 6.5±3.9Å

Download Model 2

C-score=-1.96

Download Model 3

C-score=-0.99

Download Model 4

C-score=-1.81

Download Model 5

C-score=-0.39

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3t9nA	0.844	1.07	0.263	0.864
2	4hw9A	0.699	2.75	0.141	0.805
3	2vv5A	0.587	4.06	0.162	0.744
4	4zhjA	0.402	6.10	0.052	0.653
5	3h0gA	0.395	6.25	0.051	0.643
6	3k71G	0.395	6.27	0.053	0.659
7	5flmA	0.394	6.28	0.058	0.662
8	5a22A	0.386	6.72	0.031	0.679
9	4qjty	0.385	5.77	0.047	0.591
10	1vw1A	0.385	6.54	0.042	0.649

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	6	2wieB	CVM	Rep, Mult	125,126,129
2	0.04	2	2jhrA	PBQ	Rep, Mult	134,137,138,141,176,177,188
3	0.04	2	4zzcA	XE	Rep, Mult	46,49,91,94
4	0.04	2	1wdc2	III	Rep, Mult	109,112,114,115,116,117,118,119,120,121,122,123,124,125,126,127,129,130,132,133,135,136,139,140
5	0.04	2	4zzbA	XE	Rep, Mult	128,129,132
6	0.04	2	1mneA	POP	Rep, Mult	146,147,148,149,150,200,201
7	0.04	2	3k71E	UUU	Rep, Mult	153,176,178,180
8	0.02	1	1bpyA	MG	Rep, Mult	202,209
9	0.02	1	1wdc0	III	Rep, Mult	81,82,85,88,89,90,91,92,93,94,95,96,97,99,102,103,108,109
10	0.02	1	2wieC	CVM	Rep, Mult	132,135,139
11	0.02	1	1xmeC	HAS	Rep, Mult	40,44
12	0.02	1	2o011	CLA	Rep, Mult	150,151
13	0.02	1	1o5qA	MG	Rep, Mult	151,266
14	0.02	1	3c9iC	XE	Rep, Mult	43,46
15	0.02	1	1w0nA	MG	Rep, Mult	147,217

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1pn0C	0.339	5.61	0.048	0.513	1.14.13.7	NA
2	0.060	1g87B	0.363	5.95	0.040	0.568	3.2.1.4	NA
3	0.060	3gqbA	0.285	6.77	0.032	0.513	3.6.3.14	NA
4	0.060	1i1qA	0.321	5.66	0.059	0.487	2.4.2.18,4.1.3.27	NA
5	0.060	2cjbB	0.345	5.34	0.048	0.500	6.1.1.11	NA
6	0.060	1l8aA	0.359	6.15	0.027	0.584	1.2.4.1	NA
7	0.060	3h0gA	0.395	6.25	0.051	0.643	2.7.7.6	NA
8	0.060	2jfdA	0.217	6.06	0.028	0.354	2.3.1.85	141
9	0.060	1kc7A	0.344	6.71	0.032	0.607	2.7.9.1	NA
10	0.060	2vz9B	0.281	6.67	0.050	0.497	2.3.1.85	NA
11	0.060	2qtcB	0.288	6.44	0.022	0.477	1.2.4.1	166,179
12	0.060	2g8eA	0.255	6.13	0.044	0.425	3.4.22.52	NA
13	0.060	1ofdA	0.259	4.35	0.035	0.341	1.4.7.1	NA
14	0.060	1llwA	0.340	6.75	0.017	0.601	1.4.7.1	NA
15	0.060	1yq2A	0.341	6.60	0.052	0.594	3.2.1.23	101
16	0.060	1bglA	0.337	6.70	0.054	0.591	3.2.1.23	NA
17	0.060	2nqaB	0.232	6.13	0.054	0.373	3.4.22.53,3.4.22.52	NA
18	0.060	2qf7B	0.365	6.64	0.027	0.630	6.4.1.1	NA
19	0.060	2vuaA	0.258	6.81	0.025	0.471	3.4.24.69	274,282

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.57	0.845	1.12	0.27	0.87	3udcA	GO:0005886 GO:0006810 GO:0006811 GO:0008381 GO:0009992 GO:0016020 GO:0016021 GO:0034220 GO:0055085
1	0.27	0.699	2.75	0.14	0.81	4hw9A	GO:0016020 GO:0016021 GO:0055085
2	0.23	0.598	4.11	0.16	0.76	5ajiA	GO:0005886 GO:0006810 GO:0006811 GO:0008381 GO:0009992 GO:0016020 GO:0016021 GO:0034220 GO:0055085
3	0.06	0.396	6.43	0.06	0.67	4zhjB	GO:0009058 GO:0015995 GO:0016851
4	0.06	0.341	6.21	0.03	0.57	4r0mA	GO:0003824 GO:0008152 GO:0016740 GO:0031177
5	0.06	0.347	6.68	0.05	0.62	4yuub1	GO:0009507 GO:0009521 GO:0009523 GO:0009535 GO:0009536 GO:0009579 GO:0009767 GO:0009772 GO:0015979 GO:0016020 GO:0016021 GO:0016168 GO:0018298 GO:0019684 GO:0045156
6	0.06	0.402	6.10	0.05	0.65	4zhjA	GO:0009058 GO:0015995 GO:0016851
7	0.06	0.311	5.26	0.05	0.45	3kz1A	GO:0000910 GO:0001558 GO:0001664 GO:0005085 GO:0005089 GO:0005096 GO:0005622 GO:0005737 GO:0005829 GO:0006928 GO:0006941 GO:0007186 GO:0007266 GO:0016020 GO:0030010 GO:0030036 GO:0035023 GO:0043065 GO:0043547 GO:0045893 GO:0051056
8	0.06	0.320	6.46	0.04	0.55	1izlB	GO:0009521 GO:0009523 GO:0009579 GO:0009767 GO:0009772 GO:0015979 GO:0016020 GO:0016021 GO:0016168 GO:0018298 GO:0019684 GO:0042651 GO:0045156
9	0.06	0.239	5.80	0.05	0.37	4rkcA	GO:0003824 GO:0006520 GO:0008483 GO:0008793 GO:0009058 GO:0016740 GO:0030170 GO:0080130
10	0.06	0.233	6.93	0.07	0.42	4nphA	GO:0000166 GO:0005524 GO:0005737 GO:0006754 GO:0006810 GO:0006811 GO:0009058 GO:0009405 GO:0015031 GO:0015992 GO:0016787 GO:0016887 GO:0030254 GO:0030257 GO:0030430 GO:0033644 GO:0043621 GO:0044128 GO:0046961 GO:0050714 GO:0051087 GO:1902600
11	0.06	0.228	4.72	0.03	0.32	1byeA	GO:0004364 GO:0016740
12	0.06	0.209	6.49	0.05	0.36	4itrA	GO:0000166 GO:0003824 GO:0004197 GO:0005524 GO:0005576 GO:0006464 GO:0006508 GO:0008152 GO:0008233 GO:0008234 GO:0009279 GO:0009405 GO:0016020 GO:0016740 GO:0016779 GO:0016787 GO:0018117 GO:0034260 GO:0070733
13	0.06	0.197	5.85	0.04	0.31	4yjdA	GO:0003884 GO:0005102 GO:0005741 GO:0005777 GO:0005778 GO:0005829 GO:0006562 GO:0016491 GO:0036088 GO:0042416 GO:0046416 GO:0046983 GO:0048037 GO:0055114 GO:0055130 GO:0070178 GO:0071949
14	0.06	0.241	6.97	0.02	0.43	2i3oD	GO:0003840 GO:0006749 GO:0016740
15	0.06	0.198	6.51	0.03	0.35	4hktB	GO:0008152 GO:0016491 GO:0050112 GO:0055114
16	0.06	0.230	6.95	0.03	0.40	1cvrA	GO:0004197 GO:0004198 GO:0005509 GO:0005576 GO:0006508 GO:0008233 GO:0008234 GO:0009405 GO:0016787
17	0.06	0.209	6.74	0.04	0.37	3h9uC	GO:0000166 GO:0004013 GO:0005829 GO:0006730 GO:0016787 GO:0033353
18	0.06	0.199	5.50	0.04	0.30	3esvF

Consensus prediction of GO terms

Molecular Function	GO:0008381
GO-Score	0.67
Biological Processes	GO:0009992	GO:0034220
GO-Score	0.67	0.67
Cellular Component	GO:0016021	GO:0005886
GO-Score	0.76	0.67

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.