I-TASSER results

I-TASSER results for job id Rv3096

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (379 residues)
MHRRTALKLPLLLAAGTVLGQAPRAAAEEPGRWSADRAHRWYQAHGWLVGANYITSNAIN
QLEMFQPGTYDPRRIDNELGLARFHGFNTVRVFLHDLLWAQDAPGFQTRLAQFVAIAARY
HIKPLFVLFDSCWDPLPRPGRQRAPRAGVHNSGWVQSPGAERLDDRRYASTLYNYVTGVL
GQFRNDDRVLGWDLWNEPDNPARVYRKVERKDKLERVAELLPQVFRWARTVDPVQPLTSG
VWQGNWGDPGRRSTISAIQLDNADVITFHSYAAPAEFEGRIAELAPLQRPILCTEYLARS
QGSTVEGILPIAKRHNVGAFNWGLVAGKTQTYLPWDSWDHPYRAPPKVWFHDLLHPNGRP
YRDGEVQTIRKLNGMPSQD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHRRTALKLPLLLAAGTVLGQAPRAAAEEPGRWSADRAHRWYQAHGWLVGANYITSNAINQLEMFQPGTYDPRRIDNELGLARFHGFNTVRVFLHDLLWAQDAPGFQTRLAQFVAIAARYHIKPLFVLFDSCWDPLPRPGRQRAPRAGVHNSGWVQSPGAERLDDRRYASTLYNYVTGVLGQFRNDDRVLGWDLWNEPDNPARVYRKVERKDKLERVAELLPQVFRWARTVDPVQPLTSGVWQGNWGDPGRRSTISAIQLDNADVITFHSYAAPAEFEGRIAELAPLQRPILCTEYLARSQGSTVEGILPIAKRHNVGAFNWGLVAGKTQTYLPWDSWDHPYRAPPKVWFHDLLHPNGRPYRDGEVQTIRKLNGMPSQD
Prediction	CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEHCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCHHHHHHCCCCCEEEEHCCCCHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
Conf.Score	9854668899999999987656666667777777788887765688668865578988766676656789999999999999998998999976776766685789999999999999999989999867888888878887777777667766667775546899999999999999999988999689998467888998888877888758999999999999999989999789865678888876666567765678988999689998899999999998899899986589998868999999999989847877664676666678776667788888654445557899888999999999997688889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MHRRTALKLPLLLAAGTVLGQAPRAAAEEPGRWSADRAHRWYQAHGWLVGANYITSNAINQLEMFQPGTYDPRRIDNELGLARFHGFNTVRVFLHDLLWAQDAPGFQTRLAQFVAIAARYHIKPLFVLFDSCWDPLPRPGRQRAPRAGVHNSGWVQSPGAERLDDRRYASTLYNYVTGVLGQFRNDDRVLGWDLWNEPDNPARVYRKVERKDKLERVAELLPQVFRWARTVDPVQPLTSGVWQGNWGDPGRRSTISAIQLDNADVITFHSYAAPAEFEGRIAELAPLQRPILCTEYLARSQGSTVEGILPIAKRHNVGAFNWGLVAGKTQTYLPWDSWDHPYRAPPKVWFHDLLHPNGRPYRDGEVQTIRKLNGMPSQD
Prediction	6522000000010000101131344245544413463045105732000000000231110000022431236203500420261000000000022214523530151033004105624010000000000112232142323242222222223233421425412520250033005303633000000000002031432342445431410240043005102612451000000022212343234203520040000000000231630340052037140000000001134322043003103624000000000103221201142044435541320001002641311365005103502534678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEHCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCHHHHHHCCCCCEEEEHCCCCHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
MHRRTALKLPLLLAAGTVLGQAPRAAAEEPGRWSADRAHRWYQAHGWLVGANYITSNAINQLEMFQPGTYDPRRIDNELGLARFHGFNTVRVFLHDLLWAQDAPGFQTRLAQFVAIAARYHIKPLFVLFDSCWDPLPRPGRQRAPRAGVHNSGWVQSPGAERLDDRRYASTLYNYVTGVLGQFRNDDRVLGWDLWNEPDNPARVYRKVERKDKLERVAELLPQVFRWARTVDPVQPLTSGVWQGNWGDPGRRSTISAIQLDNADVITFHSYAAPAEFEGRIAELAPLQRPILCTEYLARSQGSTVEGILPIAKRHNVGAFNWGLVAGKTQTYLPWDSWDHPYRAPPKVWFHDLLHPNGRPYRDGEVQTIRKLNGMPSQD

1uz4A

0.13

0.12

0.88

1.48

MUSTER

-----------------------------EHFVRVNGGHFELQGKPVITGVNMWYA----AYLGAPNEVGDRDRLAKELDNLKAIGVNNLRVLAVSNGFGNYDETLLQGLDYLLVELAKRDMTVVLYFNNFWQWSGGIEGEPVQDPNVTNEWEAFMAKSASFYRSEKAQQEYRKTLEKIITRYVDDATIMSWQLANEPRPGNSQTT----AEEKQIYIDWVHAAAAYIKTLDAHHLVSSGSEGEMGSVNDMQVFIDAHATPDIDYLTYHMWIRQNYMRAHIDVAKQLNKPLVLEEFGLDRDMGYFRGVFELMLASLAGYNIWAWNGYGRTTRYWWQEGDDFMGDPPQEEMYGVFDTD-----TSTIAIMKEFNAQP---

1qnqA

0.15

0.12

0.80

1.78

dPPAS

----------------------------ASSFVTISGTQFNIDGKGYFAGTNC----------YWCSFLTNHADVDSTFSHISSSGLKVVRVWGFNGSTINTGADGLQTLDYVVQSAEQHNLKLIIPFVNNWSD----YGGINAYVNAFGGNA------TTWYTNTAAQTQYRKYVQAVVSRYANSTAIFAWELGNEPRCNGCS---------TDVIVQWATSVSQYVKSLDSNHLVTLGDEGLGLSTGEGTDFAKNVQIKSLDFGTFHLYPDNGWIQTHAAACLAAGKPCVFEEYGAQQNPCTNEAPWQTTSLTTRGDMFWQWGDTFANGAQSNSDPYTVWYNSSN-------------WQCLVKNHVDAIN------

4aweA

0.18

0.15

0.83

2.39

wdPPAS

------------------------------GFVTTEGDHFKLDGKDFFAGSNAY-----------YFPFNDQPDIEKGMTAARAAGLTVFRTWGFNDKNRTEADGTVSPFDKVVDSATKTGIKLIVALTNNWAD----YGGMDVYTVNLGG-----KYHDDFYTVPKIKEAFKRYVKAMVTRYRDSEAILAWELANEARCGADGTRNSEKGCTTETVTGWIEEMSAYVKSLDGNHLVTWGGEGGFNRGEDGGDFDRELGLRNVDFGTMHLYPDNQWIHDHAASGRAANKPVVLEEYGWMTDKGVVGGWQKIAIQEKLGDMYWQFGYGGYSYGRNHDDS------------FTIYLEDDEAKEYKHAKKVQKLNER----

1uz4A

0.13

0.12

0.88

1.90

wMUSTER

------------------------------HFVRVNGGHFELQGKPVITGVNMWY----AAYLGAPNEVGDRDRLAKELDNLKAIGVNNLRVLAVKPAVTNGFETLLQGLDYLLVELAKRDMTVVLYFNNFWQWSGGIEGEPVQDPNVTNEWEAFMAKSASFYRSEKAQQEYRKTLEKIITRYVDDATIMSWQLANEPRPGNSQTT----AEEKQIYIDWVHAAAAYIKTLDAHHLVSSGSEGEMGSVNDMQVFIDAHATPDIDYLTYHMWIRQNYMRAHIDVAKQLNKPLVLEEFGLDRDMGYFRGVFELMLASLAGYNIWAWNGYGRTTRYWWQEGDDFMGDPPQEEMYGVFDTD-----TSTIAIMKEFNARQP--

1qnqA

0.15

0.12

0.80

2.61

wPPAS

----------------------------ASSFVTISGTQFNIDGKVYFAGTNC----------YWCSFLTNHADVDSTFSHISSSGLKVVRVWGFNDVNTQPSADGLQTLDYVVQSAEQHNLKLIIPFVNNWSD----YGGINAYVNAFGGN------ATTWYTNTAAQTQYRKYVQAVVSRYANSTAIFAWELGNEPRCN---------GCSTDVIVQWATSVSQYVKSLDSNHLVTLGDEGLGLSTGEGTDFAKNVQIKSLDFGTFHLYPDNGWIQTHAAACLAAGKPCVFEEYGAQQNPCTNEAPWQTTSLTTGGDMFWQWGDTFANGAQSNSDP------------YTVWYNS-SNWQCLVKNHVDAIN------

1qnqA

0.15

0.12

0.80

3.10

dPPAS2

----------------------------ASSFVTISGTQFNIDGKGYFAGTNC----------YWCSFLTNHADVDSTFSHISSSGLKVVRVWGFNGSTINTGADGLQTLDYVVQSAEQHNLKLIIPFVNNWSD----YGGINAYVNAFGGNA------TTWYTNTAAQTQYRKYVQAVVSRYANSTAIFAWELGNEPRCNGCS---------TDVIVQWATSVSQYVKSLDSNHLVTLGDEGLGLSTGEGTDFAKNVQIKSLDFGTFHLYPDNGWIQTHAAACLAAGKPCVFEEYGAQQNPCTNEAPWQTTSLTTGGDMFWQWGDTFANGAQSNSDPYTVWYNSSN-------------WQCLVKNHVDAIN------

1qnqA

0.15

0.12

0.80

2.23

PPAS

----------------------------ASSFVTISGTQFNIDGKVYFAGTNC----------YWCSFLTNHADVDSTFSHISSSGLKVVRVWGFNGSTINTGADGLQTLDYVVQSAEQHNLKLIIPFVNNWSD----YGGINAYVN------AFGGNATTWYTNTAAQTQYRKYVQAVVSRYANSTAIFAWELGNEPRCNGCS---------TDVIVQWATSVSQYVKSLDSNHLVTLGDEGLGLSTGEGTDFAKNVQIKSLDFGTFHLYPDNGWIQTHAAACLAAGKPCVFEEYGAQQNPCTNEAPWQTTSLTTGGDMFWQWGDTFANGAQSNSDP------------YTVWY-NSSNWQCLVKNHVDAIN------

3vupA

0.19

0.15

0.80

2.46

Env-PPAS

-------------------------------RLHIQNGHFVLNGQRFLSGGNLPW-MSYAYDFGDGQWQRNKNRIEPEFKKLHDAGGNSMRLWIHIQGETTKQGTMLDDMKDLLDTAKKYNILVFPCLWNAAVN-----------------QDSHNRLDGLIKDQHKLQSYIDKALKPIVNHVKGHVALGGWDLMNEPEGKNSGAGWAGNKYLYQDILRFLNWQADAIKTTDPGALVTMGVWNNNHYSDHCLRLAGGKQKGVFDFYQFHSYSDEVAPFTHQASDYGLHKPIVVGEFWEQGGGMTITQMFNYVYNHGYGAWSWHLVQRGDNQRKGITNIKD-KTSNGKIPI-SL--------------------------

3wh9A

0.17

0.13

0.80

1.48

MUSTER

------------------------------SFASTSGLQFTIDGETYFAGTNSY--------WIGFLT--DNADVDLVMGHLKSSGLKILRVWGFNDVTSQPGADGLQRLDYVVSSAEQHDIKLIINFVNYWTD----YGGMSAYVSAYGGSG-----ETDFYTSDTMQSAYQTYIKTVVERYSNSSAVFAWELANEPRCPSCD---------TSVLYNWIEKTSKFIKGLDADRMVCIGDEGFGLQFSEGLNFTMNLDIDTIDFGTLHLYPDNGWITAHGAACKAAGKPCLLEEYGVTSNHCVEGAWQKTALSTTGADLFWQYGDDLSTGKSPDDG-------------NTIYYGT-SDYQCLVTDHVAAIGSA----

3wh9A

0.18

0.15

0.80

1.76

dPPAS

------------------------------SFASTSGLQFTIDGETYFAGTNSY----------WIGFLTDNADVDLVMGHLKSSGLKILRVWGFNDVTSQPSSGTLQRLDYVVSSAEQHDIKLIINFVNYWTD----YGGMSAYVSAYGGSG-----ETDFYTSDTMQSAYQTYIKTVVERYSNSSAVFAWELANEPRCPSCD---------TSVLYNWIEKTSKFIKGLDADRMVCIGDEGFGLNFSEGLNFTMNLDIDTIDFGTLHLYPDNGWITAHGAACKAAGKPCLLEEYGVTSNHCSVEGAWQKTALSTTGDLFWQYGDDLSTGKSPDDGNTIYYGTSD--------------YQCLVTDHVAAIGSA----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.16

Estimated TM-score = 0.57±0.15

Estimated RMSD = 9.3±4.6Å

Download Model 2

C-score=-2.04

Download Model 3

C-score=-1.50

Download Model 4

C-score=-3.18

Download Model 5

C-score=-1.85

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1uz4A	0.773	2.84	0.125	0.855
2	4aweA	0.760	2.42	0.167	0.823
3	1qnqA	0.755	1.80	0.135	0.799
4	3wh9A	0.754	1.81	0.165	0.799
5	3zizA	0.753	1.86	0.175	0.799
6	4lypA	0.752	2.76	0.139	0.831
7	1rh9A	0.746	2.40	0.146	0.815
8	4l3mA	0.746	2.21	0.128	0.802
9	3wflA	0.744	1.84	0.164	0.789
10	5ccuA	0.712	3.57	0.163	0.839

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	8	4w8bA	GLC	Rep, Mult	130,196,197,271,295,322
2	0.10	6	4u5iB	BXP	Rep, Mult	55,130,134,196,197,297,322,350
3	0.04	2	2oswB	NA	Rep, Mult	184,186,187,189,235
4	0.04	2	5fihA	BGC	Rep, Mult	56,93,196,322,323
5	0.03	2	1wdsA	UUU	Rep, Mult	52,93,95,127,130,240,269,294,322
6	0.03	2	2oykB	9MR	Rep, Mult	64,129,130,148,149,151,197,271,295,322
7	0.03	2	1qnrA	MAB	Rep, Mult	132,197,200,242
8	0.03	2	3pzmA	GOL	Rep, Mult	53,93,134,139,322
9	0.02	1	1qnqA	TPT	Rep, Mult	271,337,351
10	0.02	1	2zoxA	MG	Rep, Mult	91,196,240,269,294
11	0.02	1	2zunB	CBI	Rep, Mult	180,181,231,232,235
12	0.02	1	4ucfA	GLA	Rep, Mult	46,86,88,373

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.479	1qnoA	0.755	1.80	0.132	0.799	3.2.1.78	91,196,197,269,271,295
2	0.386	2whjA	0.613	3.25	0.114	0.707	3.2.1.78	196,197,269,271,295
3	0.382	1tvnA	0.597	3.42	0.146	0.705	3.2.1.4	196,197,269,271,295
4	0.375	1e5jA	0.612	3.31	0.147	0.718	3.2.1.4	196,197,269,271,295
5	0.364	2cksB	0.611	3.38	0.120	0.723	3.2.1.4	91,196,197,269,271,295
6	0.354	1bqcA	0.622	3.37	0.133	0.723	3.2.1.78	91,196,197,269,295
7	0.178	1v0nA	0.591	3.65	0.127	0.707	3.2.1.8	197,322
8	0.175	2g3iA	0.597	3.66	0.131	0.715	3.2.1.8	197,322
9	0.096	1egzA	0.600	3.16	0.135	0.699	3.2.1.4	196,197,269,271,295
10	0.083	1xasA	0.583	3.73	0.126	0.702	3.2.1.8	NA
11	0.079	1h1nA	0.597	3.34	0.142	0.691	3.2.1.4	196,197,269,271,295
12	0.063	1rh9A	0.746	2.40	0.146	0.815	3.2.1.78	196,197,269,271,295
13	0.060	3icgA	0.664	3.82	0.125	0.799	3.2.1.4	257
14	0.060	1xc6A	0.679	3.40	0.114	0.799	3.2.1.23	191
15	0.060	1gowA	0.656	3.91	0.099	0.789	3.2.1.23	NA
16	0.060	1myrA	0.645	3.69	0.086	0.765	3.2.1.147	NA
17	0.060	2e9lA	0.646	3.65	0.108	0.768	3.2.1.21	NA
18	0.060	1qoxA	0.648	3.66	0.124	0.768	3.2.1.21	NA
19	0.060	1bhgA	0.669	3.43	0.161	0.770	3.2.1.31	NA
20	0.060	1edgA	0.653	3.66	0.101	0.778	3.2.1.4	196,197,269,271,295
21	0.060	1np2A	0.648	3.65	0.151	0.765	3.2.1.21	NA
22	0.060	1wcgA	0.649	3.59	0.105	0.765	3.2.1.147	NA
23	0.060	2osxA	0.682	3.73	0.136	0.815	3.2.1.123	291,318
24	0.060	1b90A	0.669	3.54	0.078	0.794	3.2.1.2	248
25	0.060	3gnrA	0.645	3.67	0.128	0.765	3.2.1.21	182
26	0.060	1bglA	0.644	3.84	0.130	0.768	3.2.1.23	NA
27	0.060	1e1eB	0.647	3.71	0.096	0.770	3.2.1.21	91,197
28	0.060	2cerA	0.656	3.91	0.096	0.789	3.2.1.23	NA
29	0.060	1bgaA	0.646	3.69	0.140	0.768	3.2.1.21	NA
30	0.060	1b1yA	0.683	3.50	0.092	0.799	3.2.1.2	248

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.27	0.603	3.92	0.10	0.73	2fglA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0045493 GO:0046872
1	0.27	0.580	3.79	0.10	0.70	4xv0A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176
2	0.26	0.753	1.86	0.17	0.80	3zizA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0016985
3	0.25	0.591	3.95	0.12	0.73	3ms8A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0045493
4	0.25	0.716	2.23	0.17	0.77	3pznA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0016985
5	0.25	0.746	2.20	0.13	0.80	4qp0A	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0016985
6	0.25	0.682	3.73	0.14	0.82	2osxA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0047876
7	0.25	0.760	2.42	0.17	0.82	4aweA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0016985
8	0.24	0.600	3.16	0.14	0.70	1egzA	GO:0000272 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246
9	0.24	0.611	3.38	0.12	0.72	2cksB	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030247
10	0.24	0.754	1.81	0.17	0.80	3wh9A	GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0016985 GO:0046355
11	0.23	0.657	3.59	0.16	0.78	2c0hA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0016985 GO:0046355
12	0.22	0.614	3.57	0.14	0.72	4ee9A	GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798
13	0.20	0.746	2.40	0.15	0.82	1rh9A	GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0016985 GO:0046355
14	0.19	0.662	3.50	0.13	0.79	4oozA	GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0016985
15	0.14	0.773	2.84	0.12	0.85	1uuqA	GO:0005975
16	0.14	0.613	3.26	0.14	0.72	4xzwA	GO:0000272 GO:0003860 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016020 GO:0016021 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030248
17	0.13	0.755	1.80	0.13	0.80	1qnoA	GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030248
18	0.11	0.696	3.26	0.10	0.80	4uniA	GO:0004565 GO:0005975 GO:0006012 GO:0008152 GO:0009341 GO:0016787 GO:0016798
19	0.11	0.628	3.29	0.14	0.74	4xzbA	GO:0003860 GO:0004553 GO:0005975 GO:0008152 GO:0016020 GO:0016021 GO:0016787 GO:0016798
20	0.10	0.682	3.78	0.13	0.81	3lpfA	GO:0004553 GO:0004566 GO:0005829 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0019391 GO:0043231
21	0.10	0.597	3.42	0.15	0.70	1tvnA	GO:0004553 GO:0005509 GO:0005576 GO:0005975 GO:0007155 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030246
22	0.10	0.677	4.13	0.11	0.82	4jkmA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
23	0.09	0.688	3.43	0.11	0.81	5dfaA	GO:0004565 GO:0005975 GO:0006012 GO:0008152 GO:0009341 GO:0016787 GO:0016798 GO:0046872
24	0.09	0.651	4.08	0.14	0.79	1eceA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030247
25	0.09	0.638	4.06	0.14	0.77	4tufA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030247
26	0.07	0.668	3.96	0.12	0.80	4jkkA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
27	0.07	0.672	3.71	0.14	0.79	5c70A	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
28	0.06	0.337	7.06	0.05	0.59	2qgmA	GO:0046677
29	0.06	0.335	7.07	0.05	0.58	3o04A	GO:0003824 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
30	0.06	0.338	7.02	0.05	0.58	4ls8A	GO:0003824 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0016747 GO:0033817
31	0.06	0.286	7.10	0.03	0.50	4po7A	GO:0001503 GO:0005634 GO:0005764 GO:0005765 GO:0005768 GO:0005769 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0005886 GO:0005905 GO:0006810 GO:0006895 GO:0006897 GO:0007186 GO:0007218 GO:0007275 GO:0008333 GO:0008625 GO:0009986 GO:0010008 GO:0010465 GO:0010468 GO:0014902 GO:0016020 GO:0016021 GO:0016023 GO:0016050 GO:0019899 GO:0030136 GO:0030140 GO:0030154 GO:0030379 GO:0030425 GO:0031965 GO:0032509 GO:0032580 GO:0032868 GO:0038180 GO:0043025 GO:0043231 GO:0045599 GO:0046323 GO:0048011 GO:0048227 GO:0048406 GO:0048471 GO:0051005 GO:1904037
32	0.06	0.296	6.89	0.08	0.50	4i9eA	GO:0004721 GO:0006470 GO:0016787
33	0.06	0.235	5.98	0.03	0.36	3nxhA	GO:0005886 GO:0006351 GO:0006355 GO:0016020 GO:0016021

Consensus prediction of GO terms

Molecular Function	GO:0031176	GO:0043169	GO:0016985
GO-Score	0.60	0.54	0.44
Biological Processes	GO:0045493
GO-Score	0.46
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.