I-TASSER results

I-TASSER results for job id Rv3094c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (376 residues)
MNQSETEIEILAEKIARWARARSAEIERDRRLPDELVTRLREAGLLRATMPREVAAPELA
PGRALRCAEAVARGDASAGWCVSIAITSALLVAYLPARSREEMFGGGRGVAAGVWAPRGT
ARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDRQVPSVVALNKDELQVLDTWHTLGLR
GTGSHDCVADDVFVPADRVFSVFDGPIVDRPLYRFPVFGFFALSIGAAALGNARAAIDDL
VELAGGKKGLGSTRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHDAEAVPVT
MRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYDNAPLQRRFRDAFTATAHFQVNEASRE
LPGRVLLDQPADVSML

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNQSETEIEILAEKIARWARARSAEIERDRRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAGWCVSIAITSALLVAYLPARSREEMFGGGRGVAAGVWAPRGTARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDRQVPSVVALNKDELQVLDTWHTLGLRGTGSHDCVADDVFVPADRVFSVFDGPIVDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGGKKGLGSTRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHDAEAVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYDNAPLQRRFRDAFTATAHFQVNEASRELPGRVLLDQPADVSML
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHCCHHHHHCCHCCCCCCCCCCCCCCEEEEEHCCEEEEHCEHCCCCCCCCCEEEEEEEEHCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCEEEEHCEEHCHHHHCCCCCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
Conf.Score	9887999999999999999999999998789999999999998987788776659999999999999999998576899999976669999998798765544457888877765575799996998999756656478987759999999789988579986899958846655567778898689995777567773457888888874566356887555677899999999999999998545457898877875999999999999999999999999999998666788899899999999999999999999999999988765677886889999999876478877999999999998988998899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNQSETEIEILAEKIARWARARSAEIERDRRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAGWCVSIAITSALLVAYLPARSREEMFGGGRGVAAGVWAPRGTARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDRQVPSVVALNKDELQVLDTWHTLGLRGTGSHDCVADDVFVPADRVFSVFDGPIVDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGGKKGLGSTRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHDAEAVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYDNAPLQRRFRDAFTATAHFQVNEASRELPGRVLLDQPADVSML
Prediction	8565263034005401620362055126644004400520370301000003412135020210010000002100000000000000010141026402542023423000102204030344674200213334014031000000000035752100000417504126514101020141020203002001110033463642510100021112110000010000000002101610551342446431152130031002011101000200240042015316645513351010011000100400040022003002010012221001000100001021101300010002100623364435
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHCCHHHHHCCHCCCCCCCCCCCCCCEEEEEHCCEEEEHCEHCCCCCCCCCEEEEEEEEHCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCEEEEHCEEHCHHHHCCCCCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCC
MNQSETEIEILAEKIARWARARSAEIERDRRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAGWCVSIAITSALLVAYLPARSREEMFGGGRGVAAGVWAPRGTARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDRQVPSVVALNKDELQVLDTWHTLGLRGTGSHDCVADDVFVPADRVFSVFDGPIVDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGGKKGLGSTRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHDAEAVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYDNAPLQRRFRDAFTATAHFQVNEASRELPGRVLLDQPADVSML

4l1fA

0.18

0.17

0.94

3.66

MUSTER

LTEDQQMIKDMAAEFAEKFLPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGGMGLDVLSYILAVEELSKVDDGTGITLSANVTEEQKQKYLAPIAEGTHVGAEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKSQGAFILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLL----GKEGEGFKIAMETLDGGRIGVAAQALGIAEGALAAAVKYSKEREQFG--RSISKFQALQFMMADMATKIEAARYLVYHAAMLKNEGKP--------YSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQIYEGTNQVMRIVTSRALLRD-------

4l1fA

0.18

0.17

0.94

3.62

dPPAS

LTEDQQMIKDMAAEFAEKFLPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGGMGLDVLSYILAVEELSKVDDGTGITLSANVTEEQKQKYLAPIAEGTHVGTEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKSQGAFILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLL----GKEGEGFKIAMETLDGGRIGVAAQALGIAEGALAAAVKYSKEREQFG--RSISKFQALQFMMADMATKIEAARYLVYHAAMLKNEGKP--------YSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQIYEGTNQVMRIVTSRALLRD-------

4l1fA

0.18

0.17

0.94

3.77

wdPPAS

LTEDQQMIKDMAAEFAEKFLPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGGMGLDVLSYILAVEELSKVDDGTGITLSAN-TEEQKQKYLAPIAEGTHVGAEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKGISAFILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLL----GKEGEGFKIAMETLDGGRIGVAAQALGIAEGALAAAVKYSKEREQFG--RSISKFQALQFMMADMATKIEAARYLVYHAAMLKNEGK--------PYSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQIYEGTNQVMRIVTSRALLRD-------

4l1fA

0.18

0.17

0.94

4.40

wMUSTER

LTEDQQMIKDMAAEFAEKFLPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGGMGLDVLSYILAVEELSKVDDGTGITLSAN-TEEQKQKYLAPIAEGTHVGAEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKSQGAFILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLL----GKEGEGFKIAMETLDGGRIGVAAQALGIAEGALAAAVKYSKEREQFG--RSISKFQALQFMMADMATKIEAARYLVYHAAMLKNEGKP--------YSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQIYEGTNQVMRIVTSRALLRD-------

4l1fA

0.18

0.17

0.94

3.81

wPPAS

LTEDQQMIKDMAAEFAEKFLPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGGMGLDVLSYILAVEELSKVDDGTGITLSAN-TEEQKQKYLAPIAEGTHVGAEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKSQGAFILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLL----GKEGEGFKIAMETLDGGRIGVAAQALGIAEGALAAAVKYSKEREQFG--RSISKFQALQFMMADMATKIEAARYLVYHAAMLKNEGK--------PYSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQIYEGTNQVMRIVTSRALLRD-------

4l1fA

0.18

0.17

0.94

3.44

dPPAS2

LTEDQQMIKDMAAEFAEKFLPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGGMGLDVLSYILAVEELSKVDDGTGITLSANVTEEQKQKYLAPIAEGTHVGAEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKSQGAFILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLL----GKEGEGFKIAMETLDGGRIGVAAQALGIAEGALAAAVKYSKEREQFG--RSISKFQALQFMMADMATKIEAARYLVYHAAMLKNEGKP--------YSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQIYEGTNQVMRIVTSRALLRD-------

4l1fA

0.18

0.17

0.94

3.91

PPAS

LTEDQQMIKDMAAEFAEKFLPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGGMGLDVLSYILAVEELSKVDDGTGITLSAN-TEEQKQKYLAPIAEGTHVGAEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKSQGVFILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLL----GKEGEGFKIAMETLDGGRIGVAAQALGIAEGALAAAVKYSKEREQFG--RSISKFQALQFMMADMATKIEAARYLVYHAAMLKNEGK--------PYSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQIYEGTNQVMRIVTSRALLRD-------

4l1fA

0.18

0.17

0.94

4.38

Env-PPAS

LTEDQQMIKDMAAEFAEKFLPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGGMGLDVLSYILAVEELSKVDDGTGITLSANVTEEQKQKYLAPIAEGTHVGAEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKSQGVFILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLL----GKEGEGFKIAMETLDGGRIGVAAQALGIAEGALAAAVKYSKEREQFG--RSISKFQALQFMMADMATKIEAARYLVYHAAMLKNEGK--------PYSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQIYEGTNQVMRIVTSRALLRD-------

4iv6A

0.20

0.19

0.96

3.62

MUSTER

LTAEEETIVKTVHDFVEKQVPVVRELEHANTYPEELIETMKEIGIFGLAIPEPYGFGAVSMPCYVQVAEELARGWMSLAGAMGGHTTEEQKQKYLPRMATGELRATEPGGGSDLQAMRTVARRDGDDYVINGSKTWISNARRSDLVALMCKTDPDAQILLVEK-VPGFDVSRDLPKLGYKGVESCELNFTDARVPVSSLLG---DDEGRGFAQMMKGLEVGRLQVAARATGVARAAFEDALRYSQERESFG--KPIWQHQSVGNMLADMGTKLYAARSLLLSAAEKFDAGQR--------CDMEAGMAKLFASETAMQIALDAVRVHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAKQLVARGG-LDI-

4iv6A

0.20

0.19

0.96

3.56

dPPAS

LTAEEETIVKTVHDFVEKQVPVVRELEHANTYPEELIETMKEIGIFGLAIPEPYGFGAVSMPCYVQVAEELARGWMSLAGAMGGHTTEEQKQKYLPRMATGELRATEPGGGSDLQAMRTVARRDGDDYVINGSKTWISNARRSDLVALMCKTDPDAQPLLVEK-VPGFDVSRDLPKLGYKGVESCELNFTDARVPVSSLLG---DDEGRGFAQMMKGLEVGRLQVAARATGVARAAFEDALRYSQERESFG--KPIWQHQSVGNMLADMGTKLYAARSLLLSAAEKFDAGQRC--------DMEAGMAKLFASETAMQIALDAVRVHGGYGYSTEYDVERYFRDAPLMIVGEGTNEIQRNVIAKQLVARGGLDI--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.24

Estimated TM-score = 0.89±0.07

Estimated RMSD = 4.1±2.8Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4l1fA	0.921	1.25	0.175	0.944
2	4iv6A	0.918	1.61	0.191	0.960
3	1jqiA	0.913	1.54	0.185	0.950
4	3mpiA	0.912	1.89	0.174	0.957
5	1bucA	0.911	1.40	0.178	0.942
6	2jifA	0.906	1.53	0.189	0.944
7	2d29A	0.905	1.64	0.216	0.947
8	1udyA	0.905	1.71	0.179	0.950
9	2z1qB	0.901	2.49	0.185	0.979
10	1ivhA	0.901	1.65	0.166	0.944

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.43	189	4iv6B	FDA	Rep, Mult	107,109,110,111,112,113,136,137,138,176,179,184,347,350,351,353,354,356,357,360
2	0.17	91	1egcB	FAD	Rep, Mult	247,249,256,259,261,262,325,326,329,332
3	0.16	72	1udyD	CS8	Rep, Mult	80,83,84,107,112,114,211,215,218,219,222,293,302,351,352,353,357,361,364
4	0.08	40	3d9fD	N6C	Rep, Mult	83,87,218,221,225,351,352
5	0.02	9	3d9fA	N6C	Rep, Mult	87,218,351,352
6	0.02	9	2vigC	COS	Rep, Mult	106,109,112,218,222,352,353,357
7	0.01	8	3x0yA	FMN	Rep, Mult	80,84,107,109,110,136,138,179,184,348,350,351
8	0.01	3	2rfqC	1PS	Rep, Mult	165,168,169,170
9	0.01	4	2ix5B	CAA	Rep, Mult	111,112,114,115,211,218,222,352,353,357,361,364,370,372,373
10	0.01	7	3pfdC	IOD	Rep, Mult	61,86,220,223,284,287
11	0.01	7	2c12C	SPM	Rep, Mult	48,61,64,83,86,87,88,218,221,224,352
12	0.00	1	3oibA	IOD	Rep, Mult	53,54,91
13	0.00	2	2rfqC	1PS	Rep, Mult	124,125,193
14	0.00	1	3oibB	IOD	Rep, Mult	27,28,180
15	0.00	2	3pfdA	IOD	Rep, Mult	257,258,263
16	0.00	2	3pfdB	IOD	Rep, Mult	127,193,194,195
17	0.00	1	3oibA	IOD	Rep, Mult	172,175
18	0.00	1	2a1tC	FAD	Rep, Mult	133,135,136,174
19	0.00	1	3oibA	IOD	Rep, Mult	107,118,119,132,133
20	0.00	2	3pfdD	IOD	Rep, Mult	120,122,131

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.422	1t9gC	0.907	1.67	0.184	0.950	1.3.99.3	270
2	0.414	1udyA	0.905	1.71	0.179	0.950	1.3.99.3	270
3	0.331	3mddA	0.905	1.69	0.182	0.950	1.3.99.3	111,114,218,359
4	0.320	2ix6A	0.881	1.95	0.142	0.939	1.3.3.6	224
5	0.245	2ix6E	0.881	1.95	0.142	0.939	1.3.3.6	116
6	0.239	1bucA	0.911	1.40	0.178	0.942	1.3.99.2	NA
7	0.236	1ukwA	0.901	1.66	0.177	0.944	1.3.99.3	NA
8	0.217	1rx0A	0.898	1.73	0.185	0.947	1.3.99.-	NA
9	0.214	1siqA	0.889	1.82	0.148	0.939	1.3.99.7	NA
10	0.060	1bucB	0.912	1.38	0.181	0.942	1.3.99.2	136,356
11	0.060	2pg0A	0.881	1.95	0.161	0.942	1.3.99.3	NA
12	0.060	2ebaA	0.881	1.78	0.179	0.928	1.3.99.7	228,233
13	0.060	3djlA	0.865	2.63	0.113	0.960	1.3.99.-	NA
14	0.060	1y2mB	0.458	5.97	0.079	0.689	4.3.1.24	NA
15	0.060	2z1qB	0.901	2.49	0.185	0.979	1.3.99.3	NA
16	0.060	3e04D	0.411	5.65	0.072	0.596	4.2.1.2	275
17	0.060	2fonB	0.798	3.64	0.116	0.955	1.3.3.6	NA
18	0.060	3d9dA	0.897	2.24	0.150	0.973	1.7.3.1	224
19	0.060	2jifA	0.906	1.53	0.189	0.944	1.3.99.-	270
20	0.060	1j3uA	0.410	5.52	0.047	0.588	4.3.1.1	NA
21	0.060	1ivhA	0.901	1.65	0.166	0.944	1.3.99.10	348
22	0.060	1w07B	0.799	3.63	0.119	0.955	1.3.3.6	NA
23	0.060	2r0nA	0.890	1.80	0.148	0.939	1.3.99.7	113
24	0.060	1h2aL	0.405	5.28	0.091	0.558	1.12.2.1	9,67
25	0.060	2o6yA	0.453	5.79	0.081	0.652	4.3.1.-	NA
26	0.060	2wbiB	0.848	2.79	0.136	0.952	1.3.99.-	NA
27	0.060	1jqiA	0.913	1.54	0.185	0.950	1.3.99.2	NA
28	0.060	1jswB	0.408	5.49	0.043	0.582	4.3.1.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.47	0.864	1.68	0.19	0.91	4o5mC	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
1	0.46	0.868	2.12	0.18	0.93	4u83A	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
2	0.44	0.889	1.97	0.19	0.95	3oibA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
3	0.43	0.881	1.78	0.18	0.93	2ebaA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
4	0.43	0.891	2.05	0.16	0.95	5af7B	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
5	0.39	0.797	3.02	0.21	0.91	3mxlB	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
6	0.39	0.905	1.64	0.22	0.95	2d29A	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
7	0.39	0.896	1.73	0.20	0.94	4ktoA	GO:0000166 GO:0003995 GO:0008152 GO:0008470 GO:0016491 GO:0016627 GO:0050660 GO:0055114
8	0.39	0.890	1.56	0.19	0.93	3pfdC	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
9	0.39	0.836	3.01	0.21	0.95	3mxlA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
10	0.38	0.880	1.99	0.14	0.94	4irnA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
11	0.37	0.896	1.61	0.22	0.94	4n5fA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
12	0.37	0.917	1.62	0.19	0.96	4iv6B	GO:0003995 GO:0004085 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
13	0.37	0.833	3.02	0.21	0.95	4kcfA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
14	0.37	0.895	1.63	0.19	0.94	4m9aB	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
15	0.37	0.913	1.54	0.18	0.95	1jqiA	GO:0000062 GO:0003995 GO:0004085 GO:0005739 GO:0005759 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0016491 GO:0016627 GO:0031966 GO:0033539 GO:0042594 GO:0046359 GO:0050660 GO:0051289 GO:0051384 GO:0055088 GO:0055114
16	0.36	0.890	2.37	0.17	0.97	3mkhA	GO:0000166 GO:0008152 GO:0016627 GO:0050660 GO:0055114
17	0.36	0.881	1.95	0.14	0.94	2ix6A	GO:0000062 GO:0003995 GO:0003997 GO:0005777 GO:0005829 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0009514 GO:0009793 GO:0016491 GO:0016627 GO:0033539 GO:0046459 GO:0050660 GO:0052890 GO:0055088 GO:0055114
18	0.36	0.881	1.95	0.16	0.94	2pg0A	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
19	0.36	0.848	2.79	0.14	0.95	2wbiB	GO:0000062 GO:0003995 GO:0004466 GO:0005634 GO:0005739 GO:0005743 GO:0005777 GO:0006635 GO:0008152 GO:0009055 GO:0016491 GO:0016627 GO:0017099 GO:0031966 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114 GO:0070991
20	0.36	0.889	1.82	0.15	0.94	2r0mA	GO:0000062 GO:0003995 GO:0004361 GO:0005739 GO:0005759 GO:0006554 GO:0006568 GO:0006637 GO:0008152 GO:0009055 GO:0016491 GO:0016627 GO:0019395 GO:0033539 GO:0046949 GO:0050660 GO:0052890 GO:0055088 GO:0055114
21	0.36	0.874	2.02	0.20	0.94	3r7kA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
22	0.35	0.831	2.46	0.18	0.91	4w9uB	GO:0003995 GO:0004361 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
23	0.35	0.921	1.25	0.17	0.94	4l1fA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
24	0.35	0.901	2.49	0.18	0.98	2z1qB	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
25	0.34	0.906	1.53	0.19	0.94	2jifA	GO:0000062 GO:0003995 GO:0005739 GO:0005759 GO:0006629 GO:0006631 GO:0008152 GO:0009055 GO:0009083 GO:0016491 GO:0016627 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114 GO:0070062
26	0.34	0.831	2.57	0.18	0.92	4xvxB	GO:0000062 GO:0003995 GO:0008152 GO:0009055 GO:0016491 GO:0016627 GO:0016631 GO:0019540 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114
27	0.34	0.906	1.68	0.18	0.95	2a1tC	GO:0000062 GO:0003995 GO:0005634 GO:0005739 GO:0005759 GO:0005777 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0016491 GO:0016627 GO:0019254 GO:0030424 GO:0033539 GO:0042802 GO:0045329 GO:0050660 GO:0051791 GO:0051793 GO:0052890 GO:0055088 GO:0055114 GO:0070062 GO:0070991
28	0.34	0.905	1.69	0.18	0.95	3mddA	GO:0000062 GO:0001889 GO:0003995 GO:0005739 GO:0005759 GO:0005777 GO:0005978 GO:0006082 GO:0006111 GO:0006629 GO:0006631 GO:0006635 GO:0007507 GO:0008152 GO:0009055 GO:0009409 GO:0009437 GO:0009791 GO:0016491 GO:0016627 GO:0019254 GO:0033539 GO:0042594 GO:0050660 GO:0051791 GO:0052890 GO:0055007 GO:0055088 GO:0055114 GO:0070991
29	0.34	0.874	1.68	0.23	0.92	3nf4A	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
30	0.33	0.911	1.40	0.18	0.94	1bucA	GO:0003995 GO:0004085 GO:0006629 GO:0006631 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
31	0.33	0.864	2.75	0.13	0.96	5ez3B	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
32	0.33	0.885	2.05	0.20	0.94	5iduC	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
33	0.32	0.910	2.30	0.15	0.98	3owaC	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
34	0.32	0.898	1.73	0.18	0.95	1rx0A	GO:0000062 GO:0003995 GO:0005739 GO:0005759 GO:0006351 GO:0006355 GO:0006574 GO:0006629 GO:0008152 GO:0009055 GO:0009083 GO:0016491 GO:0016627 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114
35	0.31	0.901	1.66	0.18	0.94	1ukwA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
36	0.31	0.912	1.89	0.17	0.96	3mpiC	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0019439 GO:0050660 GO:0055114
37	0.31	0.901	1.65	0.17	0.94	1ivhA	GO:0000062 GO:0003995 GO:0005739 GO:0005759 GO:0006552 GO:0008152 GO:0008470 GO:0009055 GO:0009083 GO:0016491 GO:0016627 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114
38	0.30	0.801	3.30	0.24	0.93	2or0B	GO:0008152 GO:0016627 GO:0050660 GO:0055114
39	0.30	0.880	1.93	0.16	0.94	3sf6A	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
40	0.30	0.874	2.14	0.18	0.94	3ii9C	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
41	0.30	0.878	2.06	0.19	0.93	5jscA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
42	0.30	0.896	1.66	0.22	0.94	2dvlA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
43	0.29	0.882	1.91	0.16	0.94	3swoA	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
44	0.28	0.839	2.38	0.15	0.92	4x28C	GO:0000062 GO:0003995 GO:0008152 GO:0009055 GO:0016627 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114
45	0.28	0.897	2.24	0.15	0.97	3d9dA	GO:0000166 GO:0003995 GO:0006807 GO:0008152 GO:0016491 GO:0016627 GO:0050141 GO:0050660 GO:0052664 GO:0055114 GO:0071949
46	0.28	0.840	2.04	0.20	0.90	1r2jA	GO:0000166 GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
47	0.27	0.819	3.14	0.13	0.94	4rm7A	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
48	0.25	0.864	2.85	0.12	0.96	4y9jB	GO:0000062 GO:0000166 GO:0003995 GO:0005739 GO:0006629 GO:0006631 GO:0008152 GO:0009055 GO:0016491 GO:0016627 GO:0033539 GO:0050660 GO:0052890 GO:0055088 GO:0055114
49	0.22	0.866	2.62	0.11	0.96	3u33A	GO:0000062 GO:0003677 GO:0003995 GO:0005737 GO:0006974 GO:0008152 GO:0008470 GO:0009055 GO:0016491 GO:0016627 GO:0033539 GO:0043565 GO:0045892 GO:0050660 GO:0052890 GO:0055088 GO:0055114
50	0.19	0.887	2.33	0.15	0.96	2uxwA	GO:0000062 GO:0001659 GO:0003995 GO:0004466 GO:0005634 GO:0005730 GO:0005737 GO:0005739 GO:0005743 GO:0005759 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0015980 GO:0016020 GO:0016491 GO:0016627 GO:0017099 GO:0030855 GO:0033539 GO:0036498 GO:0042645 GO:0042760 GO:0045717 GO:0046322 GO:0050660 GO:0052890 GO:0055088 GO:0055114 GO:0090181

Consensus prediction of GO terms

Molecular Function	GO:0050660	GO:0003995
GO-Score	0.95	0.95
Biological Processes	GO:0055114
GO-Score	0.95
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.