I-TASSER results

I-TASSER results for job id Rv3081

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (412 residues)
MTPHYRQAAASRLDTHRTQKLRSQTNGGKDRHQLTYEQFARMLTLMGPSDLWTVERAARH
WGVSASRARAILSSRHIHRVSGYPAQAIKAVTLRQGARTDLKTANHLVPAAQAFTMAETG
AAIGETEDERARLRIFFEFLRGADETGTSALDLIVDEPALIGEHRFDALLAAAAEYISAR
WGRPGPLWSVSIERFLDTAWWVSDLPSARAFAAVWTPAPFRRRGIYLDRHDLTSDGVCVM
PEPVFNRTELQRAFTALAAKLERRGVVGQVHVVGGAAMLLAYNSRVTTRDIDALFSTDGP
MLEAIREVADEMGWPRTWLNNQASGYVSRTPGEGAPVFDHPFLHVVATPAQHLLAMKVVA
ARGVRDGEDIRLLLDRLRITSAAGVWEIVARYFPAETITDRSRLLVEDLLNQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTPHYRQAAASRLDTHRTQKLRSQTNGGKDRHQLTYEQFARMLTLMGPSDLWTVERAARHWGVSASRARAILSSRHIHRVSGYPAQAIKAVTLRQGARTDLKTANHLVPAAQAFTMAETGAAIGETEDERARLRIFFEFLRGADETGTSALDLIVDEPALIGEHRFDALLAAAAEYISARWGRPGPLWSVSIERFLDTAWWVSDLPSARAFAAVWTPAPFRRRGIYLDRHDLTSDGVCVMPEPVFNRTELQRAFTALAAKLERRGVVGQVHVVGGAAMLLAYNSRVTTRDIDALFSTDGPMLEAIREVADEMGWPRTWLNNQASGYVSRTPGEGAPVFDHPFLHVVATPAQHLLAMKVVAARGVRDGEDIRLLLDRLRITSAAGVWEIVARYFPAETITDRSRLLVEDLLNQ
Prediction	CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEHCCCCCHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHCHHHHHHHHCCCCCCCCEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEEEHCCCEEEEHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
Conf.Score	9875456677766566777777655677765434489999999856876554677777764677677788886577555578875666778776554455545555566555666999999999688756789999999998657858899999867888887589999999999999997999998777876567898667898579999999787888774855687766667875566678899999999999999999989958999985589999977777688589998797899999999999989996546645555467887777678984997999879999999998765665569999999999899999999999999878877648999999999969
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTPHYRQAAASRLDTHRTQKLRSQTNGGKDRHQLTYEQFARMLTLMGPSDLWTVERAARHWGVSASRARAILSSRHIHRVSGYPAQAIKAVTLRQGARTDLKTANHLVPAAQAFTMAETGAAIGETEDERARLRIFFEFLRGADETGTSALDLIVDEPALIGEHRFDALLAAAAEYISARWGRPGPLWSVSIERFLDTAWWVSDLPSARAFAAVWTPAPFRRRGIYLDRHDLTSDGVCVMPEPVFNRTELQRAFTALAAKLERRGVVGQVHVVGGAAMLLAYNSRVTTRDIDALFSTDGPMLEAIREVADEMGWPRTWLNNQASGYVSRTPGEGAPVFDHPFLHVVATPAQHLLAMKVVAARGVRDGEDIRLLLDRLRITSAAGVWEIVARYFPAETITDRSRLLVEDLLNQ
Prediction	7434245202541444325504653543544230215200200100215211203300431213343031104442023024122410400323431422142233104322230024004202746533210230121012136426312410364155373310000000000100542705104002464230430001042540232024322430442312135430445314324554043730350053005105747140200000000000003215002000000436630350034006637146510152013204444641221152540100001230000000212155200400130052061532630140036102663023102200320178
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEHCCCCCHHHHHHHHHHHCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHCHHHHHHHHCCCCCCCCEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCEEEEHCCCEEEEHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
MTPHYRQAAASRLDTHRTQKLRSQTNGGKDRHQLTYEQFARMLTLMGPSDLWTVERAARHWGVSASRARAILSSRHIHRVSGYPAQAIKAVTLRQGARTDLKTANHLVPAAQAFTMAETGAAIGETEDERARLRIFFEFLRGADETGTSALDLIVDEPALIGEHRFDALLAAAAEYISARWGRPGPLWSVSIERFLDTAWWVSDLPSARAFAAVWTPAPFRRRGIYLDRHDLTSDGVCVMPEPVFNRTELQRAFTALAAKLERRGVVGQVHVVGGAAMLLAYNSRVTTRDIDALFSTDGPMLEAIREVADEMGWPRTWLNNQASGYVSRTPGEGAPVFDHPFLHVVATPAQHLLAMKVVAARGVRDGEDIRLLLDRLRITSAAGVWEIVARYFPAETITDRSRLLVEDLLNQ

1vw1A

0.11

0.10

0.94

0.81

MUSTER

TGDWRKTILKRAFDDVSLFRLLKITDHDNKDGKIKNN--LKNLSN-----LYIGKLLADIHQLTIDELDLLLIAVGEGNLSAISDKQLATLIRKLNTITSWLHTQKWSVFQLFIMTSTSYNK-TLTPEIKNLLDTVYHGLQGFDKDLHVMAPYIAATLQLSSENVAHSVLLWADKLQPGDGAMTAEKFWDWLNTKYTP--GSSEAVETQEHIVQYC-QALAQLEMVYHSTGINENGAATGAAPAHD-ALSLIMLTRFADWVNALGEK-------ASSVLAAFEANSLTAEQLAAMNLDANLLLQASIQAQNHQHLPPVTPENAFSCWTSINTILQWVNVAQQLNVAPQGVSALVGLDYIQSMKETPYAQWENAAGVLTAGLNSQQANTLHAFLDE----SRSAALSTYYIRQ

4k6jA

0.10

0.09

0.97

0.56

dPPAS

TLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRASLDLMIRLLELEQLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDEDEEKLVASLWGAERCLRVHNPENQSYLIA----YKDSQLIVSSAKALQHCEELIQQYN---RAEDSICLADSKPLPHQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGTALNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMETSCQAVQALVQLFLERERAAQL--AESKTDELIKDNKALQHAGKHMEDCIVASYTALLLGCLCQES-----PINVTTVREYLPEGDFSIMTEMLKKFLAVGTTGQKSISRVIEYLEH

4hh0A

0.23

0.16

0.68

0.58

wdPPAS

LV--YRSLAAPDLTLRDLLDIVETSNQG-----LFYSQFFQWL---GRPAMTHIQRDRRHWHMSEADMRSLGLSRQIVTVGRSLRIAAVRRFLSDVCAARTLAPDTPVEADTFALYALTEAQAGR--SGRAKAVARLSDLLSTDPLGTEVEELLRA--HAPTAADFARLFEACAERLTRAL-------LQMALRRIHHL--PDPQKSVGAVLVAGVPEMLRAVGSVVHPESLKTSRTPSLLEGTEQEADTLRFVSALRARTDLPGL---SILVGGRLAQLPPSKLKDSG-ADAGFAHLALLPAALARVA-------------------------------------------------------------------------------------------------------

2ynsA

0.13

0.12

0.90

0.67

wMUSTER

L-PAMIGGVYNNLQLEATTQFRKLLSIERSPPIIQSGVVPRFVQFLTREDFPQLQFEAAW-SGTSENTKVVIDHGAVPIFSSSDEQAVWALGNVAGCRDLVLANGALTKLSMLRNATWTLSNFCRGKPQFEQTRPALPALARLIHSNTDACWALSY---DGTNDKIQAVIEAVCPRLVELLLHPSPSVLI---------------PALRTVGNIVTGDDAQTQCI-IDHQALPC--LLSLLTQNLKKSIKKEACWTISNITAGNKDQIQAVINAGIIGPLVNLLQTAEFDI------KKEAAWAISNATSGGS------HDQIKYLVSEGIKPLCDLLICPDIRIVTVCLEGLENILKVGETAAGDVNVFSQMIDEAEG--LEKIENLQSH--DNNEIYEKAVKILEAYWM-

4hh0A

0.22

0.16

0.73

0.64

wPPAS

LV--Y----RSLLTLRDLLDIVETSN----RAQLTYSQFFQWL---GRPAVTHIQRDRRHWHMSEADMRSLGLSRQIVTVGRSLRIAAVRRFLSDVCAARTLAPDTPVEADTFALYALTEAQAGR--SGRAKAVARLSDLLSTDPLGTEVEELLRAHAPT------AADFARLFEACAERLTR---ALAEDR----------------------------------ISRMQVT-----------LAYSALQMALRRIHHLPDPQKSVGAVLVAGEAALAAEM--RAV--STSVVHESVAALAARLKTS-STLVVALEGTEQDTLRFVSALRART----DLPGLSILVAQLPPSKLKDSGADAGFAHLALLPAALARVA----------------------------------

3e7qB

0.17

0.08

0.50

0.66

dPPAS2

MNQ---EVRFSRLE---PEQRKAL----------LIEATLACLKRHGFQGA-SVRKICAEAGVS----VGLINH---H----YDAEAYLAVTGRVMRLLRGAID-TAPGGARPRLSAFFEASFSAELLDPQLLDAWLAFWGAVGSIEAIGRVHDHS------YGEYRALLVGVLRQLAEEGGWAD------------------FDAELAAISLSALLDGLWLESG-LNPATFTPRQG---------VQICEAWVDGLEAGAHRRFRR-------------------------------------------------------------------------------------------------------------------------------------------------

3qxyA

0.13

0.12

0.90

0.69

PPAS

------------LDPVACFLSWCRRVGLELSPKV---AVSRQGTVAGQAGLFVVPRAA--LSQHTCSIGGLLERERVQSQSGWVPLLLALLHELQAWRPYFALWPELGRLEHPMFWEEERRCLLQGTGVPEAVEKDLANIRSEYQ--SIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEKEPNSPLNHLANHNANLEYSANCLRMVATQPIPKG-IFNTYGQMANWGVEPYPDNTDDTADI-QMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREEVLTEEELTTTLKVLCMPAE----EFRELKDQKREEGS----------LTITNIPKLKASWRQL-----QNSVLLTLQTYA-TDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQ

3mveA

0.14

0.12

0.88

0.64

Env-PPAS

--------ATSALYMPTSQSLLDEIKE--KNGFSWY----RNLRRL----QWVWQGVPIEQ---EQVLARIASSKHSRTDEQW-----------------LDTVMGYHSGNWAYEWTRLGMEHQKRAGEMTNEAASEALFSASLCYSIAGYPHLKSDN-----LAIQAQVLANSAYLEAAKKSKYILHLTNTDKPHPVVIVSAGLDSLQTDMWRLFRDHLAKHDIAM----LTVDMPSVYSSKYPLTEDYSRLHQAVLNELFSIPYHHRVGLIGGGNAMVRLSFLEQEK-IKACVILGAPIHDIFASPQKLQQMPKMYLDVLASRLGKSVVDIYSLSGQMAAWSLKVQGFLSSRKTKILAMSLEGDYSDNQMVAFFSTYGKAKKISKTITQGYE-QSLDLAIKWLEDELLR-

5svdA

0.09

0.08

0.90

0.76

MUSTER

FNGVFFGLSCHKYASHVLETLFVRSERELLTYVTMENMFLFMLNELKP----HLKTMMNHYASHVLRLLILILSSKTLPVYQTPESFKSELRDIITTLYKGFTNGAESRSDISQSTITKFREYSVDKVASPVIQLIIQVEGIFDRDR-SFWRLVFNTADEKDPKEESFLEYLLSDPVGSHF----------LENVIG----SARLKYVERLYRLYMKDRIVKL----AKRDTTGAFVVRALLEHLKEKDVKQILDAVVPELSML---LNSNMDFGTAIINTSNKQGGYL--------RDDVIAQLIQKYYPEKSDAKNILESCLLLSASTLGNTRDDWPTAE-----ERRRSVFLEQLIDY----DDKFLNITIDSMLALPEERLIQMCYHGVTTRVDIIKRKMLLNILSKE

2amxA

0.09

0.08

0.82

0.53

dPPAS

----------------------GLVPRGSEIKFLKKEDVQNILNGM-----------------SKKERYEIWRRIHCHLDLTFSAEFFLKWARKYNILDHYLFTKEGKSLAEFIRKAISVSDL--YRDYDFIEDLAKWAVIEKYKEGRYSPTFVSSSYGLDVELIHKAFIKGIKNATELLNNKIHVALICISDTGHA------------AASIKHSGDFAIKHKHDFVGFDHGGREIDL------------KDHKDVYHSVRDHGLHLTVHALPNLNTLYTAINILNVERIGHGIRVSESDELIELVKKKDILLEVCPISNLLLNNVKSMDTHPIRKLYDAGVKVSVNSDD--------PGMFLSNINDNYEKLYIHLNFTLEEFMIMNNWAFEKSFVSDDVKSELKALYF-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.78

Estimated TM-score = 0.30±0.10

Estimated RMSD = 16.4±3.0Å

Download Model 2

C-score=-3.23

Download Model 3

C-score=-4.05

Download Model 4

C-score=-4.80

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1vw1A	0.866	2.71	0.087	0.954
2	3ffzA	0.427	7.18	0.032	0.726
3	4kmqA	0.426	6.95	0.044	0.706
4	3thwB	0.414	6.66	0.036	0.663
5	2o8fA	0.414	6.64	0.034	0.653
6	4bedA	0.410	6.58	0.034	0.646
7	4iglA	0.410	7.52	0.034	0.731
8	1ej6A	0.407	6.72	0.051	0.655
9	4knhA	0.401	6.97	0.057	0.660
10	3k1qA	0.401	7.17	0.038	0.680

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	5	1xsnA	MG	Rep, Mult	290,292
2	0.04	2	2jcgA	CA	Rep, Mult	307,311
3	0.04	2	1vd5A	GLY	Rep, Mult	353,370
4	0.02	1	5ezmA	MPG	Rep, Mult	93,96
5	0.02	1	4kl1A	PCG	Rep, Mult	343,344
6	0.02	1	4d2eC	78M	Rep, Mult	257,261
7	0.02	1	1oh6B	QNA	Rep, Mult	256,266,270
8	0.02	1	4il6R	HEM	Rep, Mult	97,101
9	0.02	1	1r3nF	BIB	Rep, Mult	194,275
10	0.02	1	4ej7A	CA	Rep, Mult	321,366
11	0.02	1	5ezmA	MPG	Rep, Mult	87,90
12	0.02	1	1r85A	ZN	Rep, Mult	4,366
13	0.02	1	3c46A	2HP	Rep, Mult	282,286,287,288,289
14	0.02	1	2o013	CLA	Rep, Mult	254,257
15	0.02	1	1y10C	CA	Rep, Mult	275,290
16	0.02	1	2ypaA	NUC	Rep, Mult	94,95,98
17	0.02	1	1bcpC	ATP	Rep, Mult	221,222

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2j5wA	0.376	7.35	0.038	0.653	1.16.3.1	NA
2	0.060	2pffB	0.386	7.14	0.053	0.653	2.3.1.86	265
3	0.060	1l8aA	0.344	7.02	0.038	0.580	1.2.4.1	NA
4	0.060	3lxuX	0.357	7.40	0.052	0.631	3.4.14.10	258
5	0.060	3b8eC	0.360	7.01	0.039	0.597	3.6.3.9	NA
6	0.060	2qtcB	0.351	6.98	0.044	0.585	1.2.4.1	274
7	0.060	1eulA	0.304	6.81	0.038	0.490	3.6.3.8	NA
8	0.060	3ffzA	0.427	7.18	0.032	0.726	3.4.24.69	NA
9	0.060	1bxrA	0.375	6.80	0.050	0.607	6.3.5.5	NA
10	0.060	2x38A	0.366	6.74	0.037	0.587	2.7.1.153	257
11	0.060	2dqmA	0.353	6.70	0.044	0.563	3.4.11.2	NA
12	0.060	1mswD	0.340	7.51	0.054	0.607	2.7.7.6	NA
13	0.060	3ecqB	0.359	7.64	0.035	0.646	3.2.1.97	NA
14	0.060	3ixzA	0.362	6.85	0.050	0.592	3.6.3.10	NA
15	0.060	3hkzJ	0.375	6.81	0.047	0.609	2.7.7.6	226,254
16	0.060	2rd0A	0.365	6.74	0.046	0.587	2.7.1.153	NA
17	0.060	3c46B	0.381	7.07	0.051	0.641	2.7.7.6	312
18	0.060	2pdaA	0.297	7.78	0.056	0.556	1.2.7.1	274,295
19	0.060	1ej6A	0.407	6.72	0.051	0.655	2.7.7.50	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.427	7.18	0.03	0.73	3ffzA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
1	0.06	0.320	7.85	0.04	0.59	1m1cA	GO:0019012 GO:0019028
2	0.06	0.330	7.47	0.03	0.58	3wsyA	GO:0000042 GO:0001540 GO:0004888 GO:0005576 GO:0005615 GO:0005641 GO:0005768 GO:0005769 GO:0005783 GO:0005794 GO:0005802 GO:0005887 GO:0006605 GO:0006622 GO:0006629 GO:0006810 GO:0006869 GO:0006892 GO:0006897 GO:0006898 GO:0007165 GO:0008202 GO:0008203 GO:0014910 GO:0016020 GO:0016021 GO:0030169 GO:0030306 GO:0031985 GO:0032091 GO:0032460 GO:0034362 GO:0043407 GO:0045053 GO:0045732 GO:0050768 GO:0051604 GO:0055037 GO:0070062 GO:0070863 GO:1901215 GO:1902430 GO:1902771 GO:1902948 GO:1902953 GO:1902955 GO:1902960 GO:1902963 GO:1902966 GO:1902997 GO:2001137
3	0.06	0.329	6.88	0.03	0.54	3cfoA	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0039693 GO:0071897 GO:0090305
4	0.06	0.321	7.31	0.03	0.55	3v0aB	GO:0004222 GO:0005576 GO:0006508 GO:0009405 GO:0050827 GO:0051609
5	0.06	0.288	7.33	0.05	0.49	3v0aA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
6	0.06	0.317	7.13	0.03	0.54	3vuoA	GO:0004222 GO:0005576 GO:0006508 GO:0009405 GO:0050827 GO:0051609
7	0.06	0.327	7.12	0.03	0.55	5bqnA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
8	0.06	0.308	7.54	0.05	0.54	2np0A	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
9	0.06	0.295	7.25	0.04	0.50	5d0uA	GO:0000166 GO:0003676 GO:0004386 GO:0005524 GO:0008026 GO:0016787
10	0.06	0.259	7.69	0.04	0.47	1amuA	GO:0000166 GO:0003824 GO:0005524 GO:0008152 GO:0016853 GO:0016874 GO:0017000 GO:0047462
11	0.06	0.319	6.64	0.06	0.51	5dfaA	GO:0004565 GO:0005975 GO:0006012 GO:0008152 GO:0009341 GO:0016787 GO:0016798 GO:0046872
12	0.06	0.285	6.76	0.03	0.46	1z7hA	GO:0004222 GO:0005576 GO:0005829 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016787 GO:0030666 GO:0030669 GO:0046872 GO:0046929 GO:0050827 GO:0051609 GO:0071806
13	0.06	0.281	6.68	0.04	0.45	1zkxB	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
14	0.06	0.283	6.51	0.03	0.44	1zb7A	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016787 GO:0046872 GO:0050827 GO:0051609 GO:0071806
15	0.06	0.309	7.23	0.05	0.53	4zcfC	GO:0003677 GO:0004519 GO:0005524 GO:0016787 GO:0090305
16	0.06	0.268	6.85	0.04	0.44	3fieA	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
17	0.06	0.265	7.50	0.05	0.46	4bjpA	GO:0008658 GO:0008955 GO:0016020 GO:0016021 GO:0016740 GO:0016757
18	0.06	0.277	6.94	0.02	0.45	2imcB	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806

Consensus prediction of GO terms

Molecular Function	GO:0050827	GO:0004222	GO:0008320	GO:0000166	GO:0003677	GO:0004888	GO:0003887	GO:0030306	GO:0001540	GO:0030169	GO:0008408	GO:0008270
GO-Score	0.12	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0009405	GO:0051609	GO:0006869	GO:0006898	GO:0006622	GO:1902997	GO:0000042	GO:0045732	GO:0006892	GO:0045053	GO:1902955	GO:0051604	GO:1902963	GO:1902430	GO:0071806	GO:1902953	GO:0071897	GO:0032091	GO:0008203	GO:2001137	GO:1902960	GO:0043407	GO:1902771	GO:1901215	GO:1902966	GO:0070863	GO:0032460	GO:0050768	GO:0014910	GO:0039693	GO:1902948	GO:0090305
GO-Score	0.12	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0044231	GO:0005802	GO:0005887	GO:0070062	GO:0034362	GO:0019028	GO:0044164	GO:0044156	GO:0005783	GO:0031985	GO:0055037	GO:0005641	GO:0005769
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.