I-TASSER results

I-TASSER results for job id Rv3075c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (307 residues)
MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADIVVLDIEDAVA
PKDKHAARDNAVRWFGDGNADWVRINGFGTPWWADDLAMLADSPVGGVMLAMVESVDHVT
ETAKRLPNVPIVALVETARGLERINEIAAAKGTFRLAFGIGDFRRDTGFGEDPATLAYAR
SRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVSAEFGMTGKICLSPDQCPVVNEGLSP
SQDEIVWAKEFFAEFARDGGEIRNGSDLPRIARATKILDLARAYGIEVSDFEDEPVHMPA
PTDTYHY

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADIVVLDIEDAVAPKDKHAARDNAVRWFGDGNADWVRINGFGTPWWADDLAMLADSPVGGVMLAMVESVDHVTETAKRLPNVPIVALVETARGLERINEIAAAKGTFRLAFGIGDFRRDTGFGEDPATLAYARSRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVSAEFGMTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLPRIARATKILDLARAYGIEVSDFEDEPVHMPAPTDTYHY
Prediction	CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHCCCCEEEHCCCCCHHHHHHHHHHHCCCEEEEEHCCHHHHHHHHHHHHCCCEEEEEHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEHCCHCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCC
Conf.Score	9888888888888888888888655566543899999999999875998999968988997889999999999998599579998699985899999999966999999789999899999999857885898866999999999999888947899788899999899999689999999999999998998654677676666899999999788789668977988999999984999999999999999999869777667458999999999999999999866654567778998888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADIVVLDIEDAVAPKDKHAARDNAVRWFGDGNADWVRINGFGTPWWADDLAMLADSPVGGVMLAMVESVDHVTETAKRLPNVPIVALVETARGLERINEIAAAKGTFRLAFGIGDFRRDTGFGEDPATLAYARSRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVSAEFGMTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLPRIARATKILDLARAYGIEVSDFEDEPVHMPAPTDTYHY
Prediction	6443356264444443454624220100000011434510540470400000001310124732440141014004534311020011335202200110171402000000010031013014204402000000003003203300401200000000200021023223422011000100000200010000012233242341132023224131201000105104203401304661052035005203753421240313001520440052042140447514551463513465347
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHCCCCEEEHCCCCCHHHHHHHHHHHCCCEEEEEHCCHHHHHHHHHHHHCCCEEEEEHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEHCCHCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCC
MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADIVVLDIEDAVAPKDKHAARDNAVRWFGDGNADWVRINGFGTPWWADDLAMLADSPVGGVMLAMVESVDHVTETAKRLPNVPIVALVETARGLERINEIAAAKGTFRLAFGIGDFRRDTGFGEDPATLAYARSRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVSAEFGMTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLPRIARATKILDLARAYGIEVSDFEDEPVHMPAPTDTYHY

4l7zA

0.22

0.21

0.96

2.05

MUSTER

AHNFYKPLAIGAPEPI--RELPVRPERVVHFFPPHVEKIRARIPEVQVDVLCGNLEDAIPMDAKEAARNGFIEVVKADTALWVRVNALNSPWVLDDIAEIVAAKLDVIMIPKVEGPWDIHFVDQYLAPILIHALLETAQGMVNLEEIAGAPRMHGFSLGPADLAASRGMKTTRVLWHYTIARMVDVAVAHGLRAFYGPFGDIKDEAACEAQFRNAFLLGCTGAWSLAPNQIPIAKRVFSPDVNEVLFAKRILEAMPDSGVAMIDMQDDATWKQAKVIVDLARMIAKKDPDLAQAYGL----------

3r4iA

0.20

0.18

0.89

2.25

dPPAS

----------------------ALTPAEVLFDPAVLKSLALQQQLGPVFDITLDCEDGAQVGREAQHAELVASLLGSFGRVGVRIHDFDHAHWRDDVRLILRAAPAYITLPKIRHVHDAAEVAFIEAPVPVQLLVETHGALTRVFDLAALPGVEALSFGLDFVSAHDGAIPDHPLVRRAKLEISAACHAYGKVPSHNVSTEVRDSVVANDAARARNEFGY-TRWSIHPAQIEAIVAAFAPRDEEITTATEILLAAQSAQWTRYHLHDRASYRYYWSVLRRAQATGRAVPQDAAPLF-----------

4l7zA

0.22

0.21

0.96

3.17

wdPPAS

AHNFYKPLAIGAPEPI--RELPVRPERVVHFFPPHVEKIRARIPEVQVDVLCGNLEDAIPMDAKEAARNGFIEVVKADTALWVRVNALNSPWVLDDIAEIVAAKLDVIMIPKVEGPWDIHFVDQYLAPILIHALLETAQGMVNLEEIAGAPRMHGFSLGPADLAASRGMKTTRVLWHYTIARMVDVAVAHGLRAFYGPFGDIKDEAACEAQFRNAFLLGCTGAWSLAPNQIPIAKRVFSPDVNEVLFAKRILEAMDGSGVAMIDMQDDATWKQAKVIVDLARMIAKKDPDLAQAYGL----------

4l7zA

0.22

0.21

0.96

2.62

wMUSTER

AHNFYKPLAIGAPEPI--RELPVRPERVVHFFPPHVEKIRARIPEVQVDVLCGNLEDAIPMDAKEAARNGFIEVVKADTALWVRVNALNSPWVLDDIAEIVAAKLDVIMIPKVEGPWDIHFVDQYLAPILIHALLETAQGMVNLEEIAGAPRMHGFSLGPADLAASRGMKTTRDLWHYTIARMVDVAVAHGLRAFYGPFGDIKDEAACEAQFRNAFLLGCTGAWSLAPNQIPIAKRVFSPDVNEVLFAKRILEAMPDSGVAMIDMQDDATWKQAKVIVDLARMIAKKDPDLAQAYGL----------

3r4iA

0.21

0.18

0.89

3.69

wPPAS

----------------------ALTPAEVLFDPAVLKSLALQQQLGPVFDITLDCEDGAQVGREAQHAELVASLLGSFGRVGVRIHDFDHAHWRDDVRLILRAAPAYITLPKIRHVHDAAEVAFIEAPVPVQLLVETHGALTRVFDLAALPGVEALSFGLDFVSAHDGAIPDHPLVRRAKLEISAACHAYGKVPSHNVSTEVRDSVVANDAARARNEFGY-TRWSIHPAQIEAIVAAFAPRDEEITTATEILLAAQSAGPTRYHLHDRASYRYYWSVLRRAQATGRAVPQDAAPL-----------F

3r4iA

0.20

0.18

0.89

4.10

dPPAS2

----------------------ALTPAEVLFDPAVLKSLALQQQLGPVFDITLDCEDGAQVGREAQHAELVASLLGSFGRVGVRIHDFDHAHWRDDVRLILRAAPAYITLPKIRHVHDAAEVAFIEAPVPVQLLVETHGALTRVFDLAALPGVEALSFGLDFVSAHDGAIPDHPLVRRAKLEISAACHAYGKVPSHNVSTEVRDSVVANDAARARNEFGY-TRWSIHPAQIEAIVAAFAPRDEEITTATEILLAAQSAQWTRYHLHDRASYRYYWSVLRRAQATGRAVPQDAAPLF-----------

3r4iA

0.21

0.18

0.89

3.23

PPAS

----------------------ALTPAEVLFDPAVLKSLALQQQLGPVFDITLDCEDGAQVGREAQHAELVASLLGSFGRVGVRIHDFDHAHWRDDVRLILRAAPAYITLPKIRHVHDAAEVAFIEAPVPVQLLVETHGALTRVFDLAALPGVEALSFGLDFVSAHDGAIPDHPLVRRAKLEISAACHAYGKVPSHNVSTEVRDSVVANDAARARNEFGY-TRWSIHPAQIEAIVAAFAPRDEEITTATEILLAAQSAGPTRYHLHDRASYRYYWSVLRRAQATGRAVPQDAAPLF-----------

3r4iA

0.21

0.18

0.89

5.04

Env-PPAS

----------------------ALTPAEVLFDPAVLKSLALQQQLGPVFDITLDCEDGAQVGREAQHAELVASLLGSFGRVGVRIHDFDHAHWRDDVRLILRAAPAYITLPKIRHVHDAAEVAFIEAPVPVQLLVETHGALTRVFDLAALPGVEALSFGLDFVSAHDGAIPDHPLVRRAKLEISAACHAYGKVPSHNVSTEVRDSVVANDAARARNEFGY-TRWSIHPAQIEAIVAAFAPRDEEITTATEILLAAQSAGPTRYHLHDRASYRYYWSVLRRAQATGRAVPQDAAPLF-----------

4l9yA

0.26

0.23

0.88

2.02

MUSTER

---------SFRLQPAP----PARPNRCQLFGPGSRPALFEKMAASAADVINLDLEDSVAPDDKAQARANIIEAINGLKYLSVRINGLDTPFWYRDVVDLLEQRLDQIMIPKVGCAADVYAVDALVTPLSFEVIIESAAGIAHVEEIAASSRLQAMSLGAADFAASMGMQTTSDPWHWAQAAIVAACRTHGILPVDGPFGDFSDDEGFRAQARRSATLGMVGKWAIHPKQVALANEVFTPSETAVTEAREILAAMDAAKATVYKLVDIASIKQAEVIVRQAEM------------------------

4l9yA

0.26

0.23

0.88

2.20

dPPAS

-------------SFRLQPAPPARPNRCQLFGPGSRPALFEKMAASAADVINLDLEDSVAPDDKAQARANIIEAINGRKYLSVRINGLDTPFWYRDVVDLLEQRLDQIMIPKVGCAADVYAVDALVTPLSFEVIIESAAGIAHVEEIAASPRLQAMSLGAADFAASMGMQTTGDPWHWAQAAIVAACRTHGILPVDGPFGDFSDDEGFRAQARRSATLGMVGKWAIHPKQVALANEVFTPSETAVTEAREILAAMDAAKATVYKLVDIASIKQAEVIVRQAEM------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.32

Estimated TM-score = 0.76±0.10

Estimated RMSD = 5.6±3.5Å

Download Model 2

C-score=-1.17

Download Model 3

C-score=-1.91

Download Model 4

C-score=-3.77

Download Model 5

C-score=-0.50

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4l7zA	0.924	1.39	0.224	0.961
2	4roqA	0.827	1.68	0.264	0.876
3	4l9yA	0.749	2.98	0.246	0.853
4	3r4iA	0.730	3.13	0.165	0.850
5	3qqwA	0.728	2.12	0.184	0.798
6	3gr4A	0.676	4.16	0.101	0.840
7	1a3wA	0.675	3.95	0.100	0.827
8	3cv1A	0.671	2.68	0.110	0.756
9	3hqqX	0.671	3.91	0.103	0.818
10	3ma8A	0.670	3.91	0.097	0.818

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.44	45	4l80B	OXL	Rep, Mult	84,134,136,159,160,161,162,198,224
2	0.13	12	1pknA	MN	Rep, Mult	112,136,162
3	0.12	10	3r4iA	CA	Rep, Mult	84,136,162
4	0.06	8	4l80E	1VU	Rep, Mult	30,31,38,39,42,57,58,84,161,198,224,226,228
5	0.03	4	1sgjA	OAA	Rep, Mult	84,157,198,224,226
6	0.02	2	1z6kA	OAA	Rep, Mult	56,84,136
7	0.01	1	1sgjB	MG	Rep, Mult	84,136,157
8	0.01	1	1u5vA	ATP	Rep, Mult	177
9	0.01	1	2g50F	NA	Rep, Mult	113,114,115,117,118
10	0.01	1	3oyzA	UUU	Rep, Mult	26,27,28,39,42,43,54,57,58,136,159,160,161,162,198,202,203,224,226,227,228,260,265,267
11	0.01	1	3oyxA	GLV	Rep, Mult	267
12	0.01	1	3n25B	PRO	Rep, Mult	148,150,153,154,155

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.209	1tqxA	0.540	3.46	0.132	0.645	5.1.3.1	NA
2	0.185	1rpxA	0.537	3.84	0.071	0.661	5.1.3.1	54,197
3	0.179	3inpA	0.529	3.53	0.096	0.635	5.1.3.1	54,197
4	0.166	3exrA	0.520	3.48	0.045	0.638	4.1.1.85	119
5	0.132	1xi3B	0.510	3.05	0.137	0.596	2.5.1.3	198
6	0.122	1xi3A	0.510	3.06	0.114	0.603	2.5.1.3	NA
7	0.101	2yw3E	0.504	2.94	0.115	0.593	4.1.2.14	NA
8	0.095	1h1yB	0.535	3.49	0.132	0.645	5.1.3.1	197,227
9	0.085	1mxsA	0.517	3.22	0.089	0.622	4.1.2.14	NA
10	0.075	1h1yA	0.536	3.49	0.123	0.645	5.1.3.1	54,197
11	0.075	1xbzB	0.539	3.37	0.065	0.651	4.1.1.85	NA
12	0.071	3f4wA	0.532	3.27	0.097	0.638	4.1.2.-	198,224
13	0.068	2fliC	0.531	3.36	0.090	0.635	5.1.3.1	NA
14	0.067	1tqjC	0.526	3.52	0.085	0.635	5.1.3.1	54,197
15	0.067	1g69B	0.541	3.42	0.093	0.655	2.5.1.3	NA
16	0.067	3ct7A	0.520	3.62	0.101	0.632	5.1.3.-	54
17	0.067	1nsjA	0.497	3.35	0.114	0.599	5.3.1.24	NA
18	0.067	1v5xA	0.483	3.86	0.085	0.609	5.3.1.24	NA
19	0.066	2cz5A	0.506	3.19	0.108	0.606	4.1.1.23	NA
20	0.060	2g50D	0.675	4.08	0.105	0.837	2.7.1.40	NA
21	0.060	3h6oC	0.675	4.16	0.101	0.840	2.7.1.40	NA
22	0.060	1rh9A	0.586	3.87	0.060	0.749	3.2.1.78	NA
23	0.060	2oykB	0.595	4.78	0.086	0.811	3.2.1.123	NA
24	0.060	1jqoA	0.577	3.62	0.049	0.717	4.1.1.31	NA
25	0.060	3cuxA	0.645	2.75	0.125	0.726	2.3.3.9	54,56,84
26	0.060	2bmbA	0.599	3.91	0.068	0.756	2.5.1.15,2.7.6.3,4.1.2.25	NA
27	0.060	2qezF	0.580	4.12	0.090	0.746	4.3.1.7	179
28	0.060	1pkyA	0.663	3.66	0.108	0.785	2.7.1.40	NA
29	0.060	2x0sA	0.578	3.57	0.126	0.700	2.7.9.1	118
30	0.060	1b90A	0.595	4.19	0.065	0.778	3.2.1.2	38
31	0.060	1aqfE	0.674	4.01	0.105	0.834	2.7.1.40	NA
32	0.060	2wqdA	0.582	3.30	0.096	0.691	2.7.3.9	NA
33	0.060	2osxA	0.598	4.65	0.092	0.805	3.2.1.123	219
34	0.060	3ma8A	0.670	3.91	0.097	0.818	2.7.1.40	63
35	0.060	1vr6A	0.579	3.61	0.105	0.713	2.5.1.54	NA
36	0.060	1dioA	0.591	4.13	0.066	0.775	4.2.1.28	197
37	0.060	1wkyA	0.595	4.56	0.055	0.791	3.2.1.78	NA
38	0.060	3lrkA	0.607	4.40	0.063	0.801	3.2.1.22	202

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.49	0.744	3.04	0.17	0.85	3r4iA	GO:0003824 GO:0008815 GO:0016829 GO:0046872
1	0.47	0.827	1.68	0.26	0.88	4roqA	GO:0003824 GO:0016829 GO:0046872 GO:0050083
2	0.43	0.669	2.21	0.16	0.73	3oyzA	GO:0003824 GO:0004474 GO:0005737 GO:0006097 GO:0006099 GO:0016740 GO:0046872
3	0.41	0.754	2.15	0.17	0.82	3qqwE	GO:0003824 GO:0016829 GO:0046872
4	0.39	0.657	1.90	0.30	0.71	1sgjA	GO:0003824 GO:0016829 GO:0046872
5	0.38	0.768	2.82	0.26	0.87	4l9yC	GO:0003824 GO:0016829 GO:0046872 GO:0047777 GO:0050083
6	0.38	0.648	1.59	0.29	0.68	3qllA	GO:0003824 GO:0016829 GO:0046872
7	0.37	0.845	2.61	0.22	0.94	4l80B	GO:0003824 GO:0015977 GO:0016829 GO:0043427 GO:0046872 GO:0047777 GO:0050083
8	0.34	0.647	2.19	0.33	0.70	1u5hA	GO:0000287 GO:0003824 GO:0006107 GO:0016829 GO:0046872
9	0.33	0.560	2.93	0.12	0.65	2v5jA	GO:0003824 GO:0010124 GO:0016829 GO:0016832 GO:0018802 GO:0019439 GO:0046872
10	0.30	0.561	2.86	0.13	0.65	2vwsA	GO:0000287 GO:0003824 GO:0005737 GO:0005975 GO:0006725 GO:0016151 GO:0016829 GO:0016832 GO:0046872
11	0.29	0.560	3.13	0.18	0.65	1izcA	GO:0003824
12	0.22	0.568	2.89	0.17	0.65	1dxeA	GO:0000287 GO:0003824 GO:0005737 GO:0008672 GO:0016829 GO:0016830 GO:0019394 GO:0042838 GO:0046392 GO:0046872
13	0.20	0.569	2.77	0.18	0.65	4mf4A	GO:0003824 GO:0016829 GO:0046872
14	0.20	0.556	3.14	0.14	0.65	3qz6A	GO:0003824 GO:0046872
15	0.09	0.671	2.44	0.15	0.74	3pugA	GO:0003824 GO:0004474 GO:0005737 GO:0006097 GO:0006099 GO:0016740 GO:0046872
16	0.07	0.490	4.78	0.08	0.69	2a3cA	GO:0000272 GO:0004553 GO:0004568 GO:0005576 GO:0005975 GO:0006032 GO:0008152 GO:0016787 GO:0016798
17	0.07	0.544	3.99	0.10	0.69	4lv4A	GO:0003824 GO:0004332 GO:0005576 GO:0005618 GO:0005829 GO:0005886 GO:0005975 GO:0006094 GO:0006096 GO:0008270 GO:0016829 GO:0016832 GO:0046872
18	0.06	0.338	6.41	0.05	0.56	4f6lA	GO:0003824 GO:0008152
19	0.06	0.282	5.89	0.04	0.46	1wzcB	GO:0005737 GO:0016311 GO:0016787 GO:0046872 GO:0050531 GO:0051479
20	0.06	0.287	6.74	0.04	0.50	4dsgA	GO:0000166 GO:0016491 GO:0055114
21	0.06	0.249	4.82	0.05	0.35	1c41A	GO:0000906 GO:0009231 GO:0009349 GO:0016740 GO:1902444

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0008815	GO:0050083	GO:0004474
GO-Score	0.94	0.49	0.47	0.43
Biological Processes	GO:0006099	GO:0006097
GO-Score	0.43	0.43
Cellular Component	GO:0005737
GO-Score	0.43

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.