I-TASSER results

I-TASSER results for job id Rv3074

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (424 residues)
MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAAAVDAARRAAEGAAGVPAARR
GRGLASEIALARRDSPARGSRHLGFAKALVYEMPHTLAALDCGALSEWRATLIVRESACL
DVADRRALDAELCGDPGDLEGMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRP
APDTMTYLTALLPVAQGVSVYAALTRAADTRCDGRSRGQVMADTLVERVTGRDAAVPTPI
AVNLVMSDETLLGAANTPAQLCGYGPIPAAVARTMVASAVTDQRSRATLRRLYAHPQAGA
LVSMESRARLFPRGLAAFIELRDQRCRTPYCDAPIRHRDHAHPWADGGPTSAHNGLGTCE
RCNYAKQAPGWRVSTSVDENHTHTAEFITPTGSRHRSGAPPHLPAVTVSELEVRIGIALA
RYAA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAAAVDAARRAAEGAAGVPAARRGRGLASEIALARRDSPARGSRHLGFAKALVYEMPHTLAALDCGALSEWRATLIVRESACLDVADRRALDAELCGDPGDLEGMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRPAPDTMTYLTALLPVAQGVSVYAALTRAADTRCDGRSRGQVMADTLVERVTGRDAAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAAVARTMVASAVTDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAAFIELRDQRCRTPYCDAPIRHRDHAHPWADGGPTSAHNGLGTCERCNYAKQAPGWRVSTSVDENHTHTAEFITPTGSRHRSGAPPHLPAVTVSELEVRIGIALARYAA
Prediction	CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEHCCCCEEEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHCCCCCCCEHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEHCCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9875445788899899999999999999999999999999999975554556676644556788999999989999999999999988777659999999989999999999999986699999999999999877656778858999999999998788778886788775686899857996899999986999999999999987588999998887777777777566677777765678863455546678764657876689999999887654555554454445656899987777876789999999999995886799999998565664555456899996775555466644545799768885899998568997899988889999889887766777788865444579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAAAVDAARRAAEGAAGVPAARRGRGLASEIALARRDSPARGSRHLGFAKALVYEMPHTLAALDCGALSEWRATLIVRESACLDVADRRALDAELCGDPGDLEGMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRPAPDTMTYLTALLPVAQGVSVYAALTRAADTRCDGRSRGQVMADTLVERVTGRDAAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAAVARTMVASAVTDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAAFIELRDQRCRTPYCDAPIRHRDHAHPWADGGPTSAHNGLGTCERCNYAKQAPGWRVSTSVDENHTHTAEFITPTGSRHRSGAPPHLPAVTVSELEVRIGIALARYAA
Prediction	5323035134524233013003301301000201101000201433235544442332420210011002014112420221033034104300201300320301231011013001203451133003200430350431224202420441034124533554465146503020243310001010202020021014004421434446123110222122222322334333422210120110012112212212222101010001000002212012201220012244131241432211014200100000140001010310010000121135312000300110032002112445142332425545010101014224143421123252323516351314104258
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEHCCCCEEEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHCCCCCCCEHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEHCCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAAAVDAARRAAEGAAGVPAARRGRGLASEIALARRDSPARGSRHLGFAKALVYEMPHTLAALDCGALSEWRATLIVRESACLDVADRRALDAELCGDPGDLEGMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRPAPDTMTYLTALLPVAQGVSVYAALTRAADTRCDGRSRGQVMADTLVERVTGRDAAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAAVARTMVASAVTDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAAFIELRDQRCRTPYCDAPIRHRDHAHPWADGGPTSAHNGLGTCERCNYAKQAPGWRVSTSVDENHTHTAEFITPTGSRHRSGAPPHLPAVTVSELEVRIGIALARYAA

4ke2A

0.19

0.09

0.46

1.20

dPPAS2

-------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSD--------AAATAA------------------TAAAVAAATLEAAAAKAAATA-----VSAAAAAAAAAIAFAAAP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.21

0.17

0.79

1.10

PPAS

-----------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK------------------------------------------------------

4cg4A

0.06

0.05

0.84

1.10

Env-PPAS

HKKKIQKQ-----LEHLKKLRKSGEEQRSYGEEKAVSFLKQTEALKQRV--------QRKLEQVYYFLEQQE---HFFVASLEDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKECQSEWELLQDIGDILHRAKTVPVPEKWTTPQEIKQKIQLL--------HQKSEF------------------VEKSTKYFSETLRSEMEMFNVPELIGAQAHAVNVILDAETAYPNLIFSDDLKSVRLGN-KWERLPDGPQRFDSCIIVLGSPSFLSGRRYWEVEVGDKTAWILGACKTS--ISRKGNMTLSPENGYWVVIMMKENEYQA--SSVPPTRLLIKEPPKRVGSYNVTARSHIYTFASCSFSGPIFSPGTRDGGKNTAPLTICPVGGQGPDALEVLFQ---------------------

5cwqA

0.06

0.04

0.55

1.19

dPPAS2

------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGN-SEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAR----EQGDDEVLAL---------------------ALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEA--------------RKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH-------------------------------------------------------------------------------------------------------------------------------------

5cwiA

0.11

0.06

0.55

1.14

dPPAS2

----------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQ---AAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASK--------AAELAQR-------HPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEAS--------------KAAEEAQRHPDSQKA-------RDEIKEASQKAEEVKERCER----------------------------------------------------------------------------------------------------------------------------------------

5cwmA

0.12

0.06

0.53

1.12

dPPAS2

---------------DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEK-ALRTAEEAAREAKKVLEQAEKEGD-----PEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRV--------------------AEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAEL----------------LERIARESGSEEAKER------AERVREEARELQERVKELRER---------------------------------------------------------------------------------------------------------------------------------------

5cwoA

0.11

0.05

0.52

1.07

dPPAS2

---------------------PELEEWIRRAKEVAKEVEKVAQRAEEEGNPDLRDSAKELRRAVEEAIEEAKKQGNPELVEWVARAAKVAAEVIKVAIQAEKEGNRDLFRAALELVRAVIEAIEEAVKQGNPELVEWVARAAKVAAEVIKVAIQAEKE----GNRDLFRAAL---------------------ELVRAVIEAIEEAVKQGNPELVERVARLAKKAAELIK----------------RAIRAEKEGNRDERR------EALERVREVIERIEELVRQG-----------------------------------------------------------------------------------------------------------------------------------------

5j65A

0.08

0.07

0.89

0.71

MUSTER

KLNSNKKYGPGDNGNQFIISKQEWATIGAYIQTGLGVNEQQLRTHVNLSQDISIPSDFSQLYDVYCSDKTSAEWWNKNLYPLIIKSANDIASYGFKVAGDPSIDGYFKKLQDELDNIVDSDDDAIAKAIKDFKARCGILIK-EAKQYEEAAKNIVTSL--------DQFLHGDQK-----KLEGVINI-----QKRLKEVQTALNQAHGESSPAHKELLEKVKNLKTTLERTIKAEQDLEKKVEYSF----LLGPLLGFVVYEILENTAVQHIKNQIDEIKKQLDSAQHDLDRDVKIIGMLNSI-------NTDIDNLYSQGQE----------IKVFQKLQIWAT-----GAQIENLRTTSLQEVQDSDDADEIQIE--EDASDAWLV-TLNAYSTSNLEYKCPENNFMIYWYNNSDWYNNSD

5cwqA

0.12

0.06

0.55

0.68

dPPAS

------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAV--LALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALI---------------------AIALAVLALAEVACCRGNKEEAERAYEDARRVEEEAR-----------------KVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH-------------------------------------------------------------------------------------------------------------------------------------

4cgkA

0.12

0.08

0.72

0.61

wdPPAS

--SNLTA-----QQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEG--LSKNIVSRNQSLEKQAR-TNGAVTSYINTIVNAISRVAAMSEIVSA---NNKMLEQQKADKKAI-SEKQVANNDAINTVIANQQKLALTTKQAELKAAELSLAAEKATAEGEKASL---------------------LEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLANGAQWATSAAAAGFRTGSTPQVGAIACWNDGGY--------------------G---------HVA---AGNRT-IGN--------HR-----GWFN---PTTTSEGFVTYIYAD---------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.21

Estimated TM-score = 0.45±0.15

Estimated RMSD = 12.2±4.4Å

Download Model 2

C-score=-3.80

Download Model 3

C-score=-3.51

Download Model 4

C-score=-4.93

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5fvmA	0.932	1.93	0.050	0.984
2	4jspB	0.878	2.72	0.072	0.976
3	3hizA	0.524	4.22	0.061	0.656
4	5dfzC	0.519	4.49	0.061	0.663
5	2x6fA	0.519	4.49	0.041	0.660
6	2y3aA	0.517	4.54	0.063	0.667
7	2a5uA	0.515	4.66	0.065	0.674
8	3ihyC	0.509	4.57	0.047	0.658
9	2x38A	0.506	4.81	0.043	0.667
10	1vsy4	0.464	6.03	0.037	0.679

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.19	9	3h0gI	ZN	Rep, Mult	326,331,359,362
2	0.06	3	2wy2A	PO3	Rep, Mult	42,95
3	0.04	2	4x23F	III	Rep, Mult	302,305,306,309
4	0.04	2	4ag5C	MG	Rep, Mult	223,227
5	0.04	2	4drjB	RAP	Rep, Mult	225,226,229,233,295,298,299,302,305
6	0.02	1	2bptA	III	Rep, Mult	90,91,94,95,129,130,131,162,165,166
7	0.02	1	1o6pA	III	Rep, Mult	31,34,35,89,92,95,96
8	0.02	1	4wakB	BCT	Rep, Mult	70,73
9	0.02	1	4qjsU	MG	Rep, Mult	269,273
10	0.02	1	3pjlB	CO	Rep, Mult	323,340
11	0.02	1	3gl6A	ZN	Rep, Mult	326,331

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1f1sA	0.398	7.10	0.039	0.660	4.2.2.1	327
2	0.060	2x38A	0.506	4.81	0.043	0.667	2.7.1.153	189,197
3	0.060	1b0pA	0.365	6.69	0.030	0.580	1.2.7.1	NA
4	0.060	1ojnA	0.386	7.10	0.039	0.641	4.2.2.1	NA
5	0.060	2pffB	0.399	7.16	0.041	0.670	2.3.1.86	34,79
6	0.060	1kc7A	0.362	6.63	0.056	0.576	2.7.9.1	NA
7	0.060	1slyA	0.373	6.19	0.059	0.564	4.2.2.-	170
8	0.060	3c5wA	0.329	4.81	0.099	0.443	3.1.3.16	135
9	0.060	3c46B	0.411	7.26	0.045	0.705	2.7.7.6	23,72,99
10	0.060	2z8yP	0.393	6.87	0.069	0.630	2.3.1.169	100,104
11	0.060	1lnsA	0.359	7.37	0.045	0.620	3.4.14.11	323
12	0.060	1bglA	0.357	7.31	0.033	0.604	3.2.1.23	NA
13	0.060	1l5jA	0.363	6.14	0.070	0.547	4.2.1.3	162,170
14	0.060	2dqmA	0.388	7.56	0.051	0.689	3.4.11.2	NA
15	0.060	1hn0A	0.377	6.98	0.036	0.627	4.2.2.20	NA
16	0.060	3ihyC	0.509	4.57	0.047	0.658	2.7.1.137	159,165
17	0.060	2pdaA	0.357	7.54	0.043	0.625	1.2.7.1	NA
18	0.060	1dceA	0.392	6.82	0.059	0.625	2.5.1.60	NA
19	0.060	2vkzG	0.370	7.34	0.058	0.627	2.3.1.38,3.1.2.14	171

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.21	0.879	2.71	0.07	0.98	4jsnB	GO:0000139 GO:0000166 GO:0001030 GO:0001031 GO:0001032 GO:0001156 GO:0001933 GO:0001934 GO:0001938 GO:0003007 GO:0003179 GO:0004672 GO:0004674 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005741 GO:0005764 GO:0005765 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0005942 GO:0005979 GO:0006109 GO:0006112 GO:0006207 GO:0006281 GO:0006468 GO:0006950 GO:0007050 GO:0007165 GO:0007281 GO:0007420 GO:0007569 GO:0007584 GO:0007616 GO:0008542 GO:0009791 GO:0010507 GO:0010592 GO:0010628 GO:0010831 GO:0010942 GO:0010976 GO:0012505 GO:0014042 GO:0014736 GO:0016020 GO:0016049 GO:0016236 GO:0016242 GO:0016301 GO:0016310 GO:0016605 GO:0016740 GO:0018105 GO:0018107 GO:0019901 GO:0019904 GO:0021510 GO:0030030 GO:0030163 GO:0030425 GO:0030838 GO:0031090 GO:0031295 GO:0031397 GO:0031529 GO:0031641 GO:0031669 GO:0031929 GO:0031931 GO:0031932 GO:0031998 GO:0032095 GO:0032868 GO:0032956 GO:0032991 GO:0035176 GO:0035264 GO:0040007 GO:0042060 GO:0042220 GO:0043022 GO:0043025 GO:0043087 GO:0043200 GO:0043231 GO:0043278 GO:0043610 GO:0044877 GO:0045429 GO:0045670 GO:0045727 GO:0045792 GO:0045859 GO:0045945 GO:0046777 GO:0046889 GO:0048015 GO:0048255 GO:0048661 GO:0048714 GO:0048738 GO:0050731 GO:0050769 GO:0050882 GO:0051219 GO:0051496 GO:0051534 GO:0051896 GO:0051897 GO:0055006 GO:0055013 GO:0060048 GO:0060135 GO:0060252 GO:0060999 GO:0061051 GO:0071456 GO:0090335 GO:0090559 GO:1900034 GO:1901216 GO:1901838 GO:1904000 GO:1904056 GO:1904058 GO:1904193 GO:1904197 GO:1904206 GO:1904213
1	0.07	0.527	4.49	0.05	0.68	5dxhA	GO:0000166 GO:0001525 GO:0001889 GO:0001944 GO:0004674 GO:0005524 GO:0005622 GO:0005829 GO:0005886 GO:0005942 GO:0005943 GO:0006006 GO:0006468 GO:0006661 GO:0006909 GO:0007173 GO:0010468 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030027 GO:0030168 GO:0030295 GO:0031295 GO:0032147 GO:0033138 GO:0035004 GO:0035005 GO:0036092 GO:0038028 GO:0038095 GO:0038096 GO:0038128 GO:0040014 GO:0043457 GO:0043491 GO:0043524 GO:0043542 GO:0043560 GO:0044029 GO:0046854 GO:0046934 GO:0048010 GO:0048015 GO:0050852 GO:0050900 GO:0060048 GO:0060612 GO:0071333 GO:0097009 GO:0098779 GO:2000270 GO:2000653 GO:2000811
2	0.07	0.518	4.33	0.06	0.66	4ovuA	GO:0000166 GO:0001525 GO:0001889 GO:0001944 GO:0004674 GO:0005524 GO:0005622 GO:0005829 GO:0005886 GO:0005942 GO:0005943 GO:0006006 GO:0006468 GO:0006661 GO:0006909 GO:0007173 GO:0010468 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030027 GO:0030168 GO:0030295 GO:0031295 GO:0032147 GO:0033138 GO:0035004 GO:0035005 GO:0036092 GO:0038028 GO:0038095 GO:0038096 GO:0038128 GO:0040014 GO:0043457 GO:0043491 GO:0043524 GO:0043542 GO:0043560 GO:0044029 GO:0046854 GO:0046934 GO:0048010 GO:0048015 GO:0050852 GO:0050900 GO:0060048 GO:0060612 GO:0071333 GO:0097009 GO:0098779 GO:2000270 GO:2000653 GO:2000811
3	0.07	0.517	4.96	0.06	0.69	1e8wA	GO:0000166 GO:0001525 GO:0002376 GO:0004674 GO:0005524 GO:0005737 GO:0005886 GO:0005942 GO:0006468 GO:0006897 GO:0006935 GO:0006954 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0035005 GO:0036092 GO:0046854 GO:0046934 GO:0048015
4	0.07	0.519	4.94	0.06	0.69	1e7uA	GO:0000166 GO:0001525 GO:0002376 GO:0004674 GO:0005524 GO:0005737 GO:0005886 GO:0005942 GO:0006468 GO:0006897 GO:0006935 GO:0006954 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0035005 GO:0036092 GO:0046854 GO:0046934 GO:0048015
5	0.07	0.517	4.55	0.06	0.67	4bfrA	GO:0000166 GO:0001935 GO:0001952 GO:0005524 GO:0005634 GO:0005730 GO:0005737 GO:0005886 GO:0005942 GO:0006874 GO:0006897 GO:0006914 GO:0007155 GO:0007156 GO:0009611 GO:0010628 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030168 GO:0031526 GO:0035005 GO:0036092 GO:0040016 GO:0043560 GO:0045171 GO:0046854 GO:0046934 GO:0048015 GO:0060055
6	0.07	0.521	4.25	0.05	0.65	2x6kA	GO:0000166 GO:0000421 GO:0005524 GO:0005769 GO:0006897 GO:0006914 GO:0009267 GO:0010506 GO:0016301 GO:0016303 GO:0016310 GO:0016322 GO:0016740 GO:0033227 GO:0034271 GO:0035004 GO:0035005 GO:0035032 GO:0035096 GO:0036092 GO:0045850 GO:0046854 GO:0046934 GO:0048015
7	0.07	0.510	4.75	0.04	0.67	5ae9A	GO:0000166 GO:0001782 GO:0002250 GO:0002376 GO:0005524 GO:0005737 GO:0005886 GO:0005942 GO:0006935 GO:0006954 GO:0007166 GO:0010628 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030154 GO:0030335 GO:0035005 GO:0036092 GO:0042113 GO:0045087 GO:0046854 GO:0046934 GO:0048015 GO:0048872 GO:0050832
8	0.07	0.524	4.43	0.05	0.67	4yknA	GO:0000166 GO:0001525 GO:0001889 GO:0001944 GO:0004674 GO:0005524 GO:0005622 GO:0005829 GO:0005886 GO:0005942 GO:0005943 GO:0006006 GO:0006468 GO:0006661 GO:0006909 GO:0007173 GO:0010468 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030027 GO:0030168 GO:0030295 GO:0031295 GO:0032147 GO:0033138 GO:0035004 GO:0035005 GO:0036092 GO:0038028 GO:0038095 GO:0038096 GO:0038128 GO:0040014 GO:0043457 GO:0043491 GO:0043524 GO:0043542 GO:0043560 GO:0044029 GO:0046854 GO:0046934 GO:0048010 GO:0048015 GO:0050852 GO:0050900 GO:0060048 GO:0060612 GO:0071333 GO:0097009 GO:0098779 GO:2000270 GO:2000653 GO:2000811
9	0.07	0.517	4.54	0.06	0.67	2y3aA	GO:0000166 GO:0001935 GO:0001952 GO:0005524 GO:0005634 GO:0005730 GO:0005737 GO:0005886 GO:0005942 GO:0006874 GO:0006897 GO:0006914 GO:0007155 GO:0007156 GO:0009611 GO:0010628 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030168 GO:0031526 GO:0035005 GO:0036092 GO:0040016 GO:0043560 GO:0045171 GO:0046854 GO:0046934 GO:0048015 GO:0060055
10	0.07	0.509	4.57	0.05	0.66	3ihyC	GO:0000045 GO:0000166 GO:0000910 GO:0004672 GO:0005524 GO:0005768 GO:0005770 GO:0005776 GO:0005829 GO:0005930 GO:0005942 GO:0006468 GO:0006661 GO:0006914 GO:0007032 GO:0007049 GO:0016020 GO:0016236 GO:0016301 GO:0016303 GO:0016310 GO:0016485 GO:0016740 GO:0030496 GO:0030670 GO:0031410 GO:0032465 GO:0034162 GO:0035004 GO:0035032 GO:0036092 GO:0042149 GO:0043201 GO:0045022 GO:0045335 GO:0046854 GO:0048015 GO:0050708 GO:0051301
11	0.07	0.515	4.65	0.05	0.67	4uwhA	GO:0000045 GO:0000166 GO:0000910 GO:0004672 GO:0005524 GO:0005768 GO:0005770 GO:0005776 GO:0005829 GO:0005930 GO:0005942 GO:0006468 GO:0006661 GO:0006914 GO:0007032 GO:0007049 GO:0016020 GO:0016236 GO:0016301 GO:0016303 GO:0016310 GO:0016485 GO:0016740 GO:0030496 GO:0030670 GO:0031410 GO:0032465 GO:0034162 GO:0035004 GO:0035032 GO:0036092 GO:0042149 GO:0043201 GO:0045022 GO:0045335 GO:0046854 GO:0048015 GO:0050708 GO:0051301
12	0.07	0.513	4.20	0.05	0.64	5dxtA	GO:0000166 GO:0001525 GO:0001889 GO:0001944 GO:0004674 GO:0005524 GO:0005622 GO:0005829 GO:0005886 GO:0005942 GO:0005943 GO:0006006 GO:0006468 GO:0006661 GO:0006909 GO:0007173 GO:0010468 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030027 GO:0030168 GO:0030295 GO:0031295 GO:0032147 GO:0033138 GO:0035004 GO:0035005 GO:0036092 GO:0038028 GO:0038095 GO:0038096 GO:0038128 GO:0040014 GO:0043457 GO:0043491 GO:0043524 GO:0043542 GO:0043560 GO:0044029 GO:0046854 GO:0046934 GO:0048010 GO:0048015 GO:0050852 GO:0050900 GO:0060048 GO:0060612 GO:0071333 GO:0097009 GO:0098779 GO:2000270 GO:2000653 GO:2000811
13	0.07	0.494	4.68	0.04	0.64	4ajwA	GO:0000166 GO:0001782 GO:0002250 GO:0002376 GO:0005524 GO:0005737 GO:0005886 GO:0005942 GO:0006935 GO:0006954 GO:0007166 GO:0010628 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030154 GO:0030335 GO:0035005 GO:0036092 GO:0042113 GO:0045087 GO:0046854 GO:0046934 GO:0048015 GO:0048872 GO:0050832
14	0.07	0.498	4.59	0.04	0.64	2wxiA	GO:0000166 GO:0001782 GO:0002250 GO:0002376 GO:0005524 GO:0005737 GO:0005886 GO:0005942 GO:0006935 GO:0006954 GO:0007166 GO:0010628 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030154 GO:0030335 GO:0035005 GO:0036092 GO:0042113 GO:0045087 GO:0046854 GO:0046934 GO:0048015 GO:0048872 GO:0050832
15	0.07	0.498	4.80	0.05	0.66	5dxuA	GO:0000166 GO:0001779 GO:0001816 GO:0002250 GO:0002376 GO:0002551 GO:0002679 GO:0005524 GO:0005737 GO:0005829 GO:0005886 GO:0005942 GO:0006468 GO:0006661 GO:0006935 GO:0006954 GO:0007165 GO:0010628 GO:0010818 GO:0014065 GO:0014066 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030101 GO:0030154 GO:0030217 GO:0030335 GO:0030593 GO:0035004 GO:0035005 GO:0035747 GO:0035754 GO:0036092 GO:0042110 GO:0042113 GO:0042629 GO:0043303 GO:0045087 GO:0046854 GO:0046934 GO:0048015 GO:0050852 GO:0050853 GO:0060374 GO:0072672
16	0.06	0.494	4.70	0.04	0.64	4ajwB	GO:0000166 GO:0001782 GO:0002250 GO:0002376 GO:0005524 GO:0005737 GO:0005886 GO:0005942 GO:0006935 GO:0006954 GO:0007166 GO:0010628 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030154 GO:0030335 GO:0035005 GO:0036092 GO:0042113 GO:0045087 GO:0046854 GO:0046934 GO:0048015 GO:0048872 GO:0050832
17	0.06	0.399	5.92	0.04	0.60	4jlqA	GO:0000059 GO:0000060 GO:0005634 GO:0005737 GO:0005829 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0016032 GO:0031965 GO:0034399 GO:0043488 GO:0044822 GO:0070062 GO:0072372
18	0.06	0.402	6.01	0.05	0.61	1qbkB	GO:0000059 GO:0000060 GO:0005634 GO:0005737 GO:0005829 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0016032 GO:0031965 GO:0034399 GO:0043488 GO:0044822 GO:0070062 GO:0072372

Consensus prediction of GO terms

Molecular Function	GO:0016307	GO:0052742	GO:0035004	GO:0052813	GO:0001025	GO:0043021	GO:0001016	GO:0019900	GO:0080084	GO:0004674	GO:0005524
GO-Score	0.48	0.48	0.48	0.48	0.41	0.41	0.41	0.41	0.41	0.40	0.40
Biological Processes	GO:0048646	GO:0048514	GO:0046834	GO:0006661	GO:0046320	GO:0008306	GO:1904192	GO:0008361	GO:0022412	GO:0042552	GO:0030307	GO:0010591	GO:1904195	GO:2000253	GO:2000727	GO:1904212	GO:0042992	GO:1900006	GO:0048660	GO:0043549	GO:0046890	GO:0050730	GO:0002761	GO:0014745	GO:0009758	GO:0050679	GO:0009887	GO:1904202	GO:0006417	GO:0031668	GO:1901214	GO:0006259	GO:0007632	GO:0007565	GO:0031329	GO:0014072	GO:0031646	GO:0070873	GO:0060251	GO:0019856	GO:0007568	GO:0014744	GO:0060322	GO:0006359	GO:1904054	GO:1904036	GO:0014735	GO:0045943	GO:0010962	GO:0043434	GO:0001936	GO:0009611	GO:0051336	GO:1903998	GO:0045834	GO:0010830	GO:0080135	GO:0001666	GO:0007276	GO:0045786	GO:1903796	GO:0043488	GO:0051705	GO:0034605	GO:0018210	GO:0018209	GO:0030833	GO:0060998	GO:1902745	GO:0043489	GO:0034250	GO:0007613	GO:0010613	GO:0051930	GO:0003006	GO:0050873	GO:1903321	GO:1904204	GO:0032107	GO:0043491	GO:1903428	GO:0005978	GO:0048713	GO:0036294	GO:1903431	GO:0031401	GO:0050881	GO:0032273	GO:0014041	GO:0045598	GO:0022402	GO:1902533	GO:0032233	GO:0006974	GO:1904407	GO:0006635	GO:0061050	GO:1901836	GO:0032094	GO:0009057	GO:0051492	GO:0042327	GO:0055023	GO:0050994	GO:0016241	GO:0051703	GO:0001101	GO:0031396	GO:0042326	GO:0045687	GO:0030316	GO:0045428	GO:0003170	GO:0051532	GO:0048015	GO:0031295	GO:0060048
GO-Score	0.48	0.48	0.48	0.48	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.40	0.31	0.31
Cellular Component	GO:0071944	GO:0031968	GO:0044432	GO:0005764	GO:0043005	GO:0038201	GO:0044431	GO:0098852	GO:0036477	GO:0042175	GO:0044297	GO:0031966	GO:0016604	GO:0005942	GO:0005829
GO-Score	0.48	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.40	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.