I-TASSER results

I-TASSER results for job id Rv3071

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (369 residues)
MNEQCLKLTAYFGERQRAVGGAGRFLADAMLDLFGSHNVATSVMLRGTTSFGPKHEFRCD
QSLSLSEDPPVTVAAVDIESKIRSLVDDVTAMTDRGLVTLERARLVTRHSGAEEFGDIDS
RNGDAAKLTIYAGRQVRVAGAPAYYTICELLHRHGFAGATVLLGVDGTAHGRRRRARFFG
RNVNVPLMIIAVGTPAQVAVAAMELTAALPNPLLTIERVRLCKRDGELFARPQQLPQTDD
QGRTLWQKLMVHTAEATHHEGLPIHRALVHRLMQSETARGATALRGIWGFYGDHKPHGDK
LFQLVRRVPVTTIIVDTPQAIARSFDIVDELTNWHGLVTSEMVPAAVSLTGSRDGTQKTG
ETPLARYDY

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNEQCLKLTAYFGERQRAVGGAGRFLADAMLDLFGSHNVATSVMLRGTTSFGPKHEFRCDQSLSLSEDPPVTVAAVDIESKIRSLVDDVTAMTDRGLVTLERARLVTRHSGAEEFGDIDSRNGDAAKLTIYAGRQVRVAGAPAYYTICELLHRHGFAGATVLLGVDGTAHGRRRRARFFGRNVNVPLMIIAVGTPAQVAVAAMELTAALPNPLLTIERVRLCKRDGELFARPQQLPQTDDQGRTLWQKLMVHTAEATHHEGLPIHRALVHRLMQSETARGATALRGIWGFYGDHKPHGDKLFQLVRRVPVTTIIVDTPQAIARSFDIVDELTNWHGLVTSEMVPAAVSLTGSRDGTQKTGETPLARYDY
Prediction	CCCCEEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCEEHCCHHHHHCCCCCEEEEEHCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHCCCCCCCCCCCCCCCCEEEEEEEHCCCCCHCCCHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCEEEEHCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCC
Conf.Score	998768999998577654467886589999999999899846654566657889856555565546899879999869999999999999984678799998999985788877777777788758999997787654785699999999999899855654444577887566543433678987799998799999999999999847886999988999867877778766787766787644689999767655388469999999999989987634556666458998656654554368998799999599999999999999847886799986679998668888887778766566789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNEQCLKLTAYFGERQRAVGGAGRFLADAMLDLFGSHNVATSVMLRGTTSFGPKHEFRCDQSLSLSEDPPVTVAAVDIESKIRSLVDDVTAMTDRGLVTLERARLVTRHSGAEEFGDIDSRNGDAAKLTIYAGRQVRVAGAPAYYTICELLHRHGFAGATVLLGVDGTAHGRRRRARFFGRNVNVPLMIIAVGTPAQVAVAAMELTAALPNPLLTIERVRLCKRDGELFARPQQLPQTDDQGRTLWQKLMVHTAEATHHEGLPIHRALVHRLMQSETARGATALRGIWGFYGDHKPHGDKLFQLVRRVPVTTIIVDTPQAIARSFDIVDELTNWHGLVTSEMVPAAVSLTGSRDGTQKTGETPLARYDY
Prediction	765502200000105332443642100310042037360110000000000145240224302401720100000003463045005304600650000013030021334546356456354301100000125342532200310042037360110000100001144322323014035300000000046620450053037007500000130300213363354245144545434411110100012134254220032004202736103100000000001451402232004005501000000035630450052036005750000014030010122567445644554146366
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCEEHCCHHHHHCCCCCEEEEEHCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEHCCCCCCCCCCCCCCCCEEEEEEEHCCCCCHCCCHHHHHHHHHHHHHCCCCEEEEHHHCCCCCCCEEEEHCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEHCCCCCCCCCCCCCCCCCCCC
MNEQCLKLTAYFGERQRAVGGAGRFLADAMLDLFGSHNVATSVMLRGTTSFGPKHEFRCDQSLSLSEDPPVTVAAVDIESKIRSLVDDVTAMTDRGLVTLERARLVTRHSGAEEFGDIDSRNGDAAKLTIYAGRQVRVAGAPAYYTICELLHRHGFAGATVLLGVDGTAHGRRRRARFFGRNVNVPLMIIAVGTPAQVAVAAMELTAALPNPLLTIERVRLCKRDGELFARPQQLPQTDDQGRTLWQKLMVHTAEATHHEGLPIHRALVHRLMQSETARGATALRGIWGFYGDHKPHGDKLFQLVRRVPVTTIIVDTPQAIARSFDIVDELTNWHGLVTSEMVPAAVSLTGSRDGTQKTGETPLARYDY

2vunA

0.12

0.11

0.91

0.64

MUSTER

--SKTIIKKIVSGDIKSPVLQADTIVVELIAAIGGEELAAGSTVTPGLVHVSGGDYAPRQKTMDFISSA-TMISAGSPAAGTKALAITLSKSYYAGVKVHGGAVILEKGLTEEDFIEMKKE--GVWIVGEV---LGTIKNPEDAAPMVEWAHKHGFKVQMHTGGTSIPGSSTVTADDVIKTKPD--VVSHINGGPTAIS--VQEVDRIMDETDFAMEIVQ----CGNPKIADYVARRAAEKGQLGRVIFGNDAPSGTGLIPLGILRNMCQIASMSDI-DPEVAVCMA--------GNSTAVYVIAPGKEADLIIMDTPLVAEDAMGAIAA---DIPGISVVLIDEAVVTKSRNTPPAKRAAKIL-----

2dclA

0.22

0.06

0.27

2.58

dPPAS

---------------------------------------------------------------------------------------------------------------------VEVEHWNTLRLRIYIGENDKWEGRPLYKVIVEKLREMGIAGATVYRGIYGFG-------------TDLPIIVEVVDRGHNIEKVVNVIKPMIKDGMITVEPTIVLWVGTQEE--------------------------------------------------------------------------------------------------------------------------------------------

2dclA

0.22

0.06

0.27

1.81

wdPPAS

---------------------------------------------------------------------------------------------------------------------VEVEHWNTLRLRIYIGENDKWEGRPLYKVIVEKLREMGIAGATVYRGIYGFG-------------TDLPIIVEVVDRGHNIEKVVNVIKPMIKDGMITVEPTIVLWVGTQEE--------------------------------------------------------------------------------------------------------------------------------------------

3rj8A

0.12

0.10

0.88

0.68

wMUSTER

GENGH--LMVQLDRMIDVISYKTGILGHLATVLNDKYGRAGPGV--GISGHGGFGFS--SHMHGLAVDSVVGVTVVLADGRI----ADLFWGIK-GIVAVWKLATFPA-------------PKVLTRFGVTLNWKNKTSALKGIEAVEDYARWVAPREVNFRIGDYGAGN--------------PGIEGLYYGTPEQWRAAFQPLLDTLPAGYVVNPTTSLNWIESLSYSNFDHVDFITPQPVENFYAKSLTLKSIKGDAVKNFVDYYFDVSNKVKDRFWFYQLDVHGGKNSQTKVTNAETAYPHRDKLWLIQFYDSFKFLDGWVNSVTKALPKSDWGMY-----INYADPRMDRDYATGEARLQKAKF

2dclA

0.26

0.07

0.26

1.19

wPPAS

VEWNTLRLRIYIGENDKW---EGRPLYKVIVEKLREMGIAGATVYRGIYGFGT--------------DLPIIVEVVDRGHNIEKVVNVIKPMIKDGMITVEPTIVLWVGTQEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2dclA

0.22

0.06

0.27

8.80

dPPAS2

---------------------------------------------------------------------------------------------------------------------VEVEHWNTLRLRIYIGENDKWEGRPLYKVIVEKLREMGIAGATVYRGIYGFG-------------TDLPIIVEVVDRGHNIEKVVNVIKPMIKDGMITVEPTIVLWVGTQEE--------------------------------------------------------------------------------------------------------------------------------------------

2dclA

0.22

0.06

0.27

1.17

PPAS

---------------------------------------------------------------------------------------------------------------------VEVEHWNTLRLRIYIGENDKWEGRPLYKVIVEKLREMGIAGATVYRGIYGFG-------------TDLPIIVEVVDRGHNIEKVVNVIKPMIKDGMITVEPTIVLWVGTQEE--------------------------------------------------------------------------------------------------------------------------------------------

2dclA

0.22

0.06

0.27

2.48

Env-PPAS

---------------------------------------------------------------------------------------------------------------------VEVEHWNTLRLRIYIGENDKWEGRPLYKVIVEKLREMGIAGATVYRGIYGFG-------------TDLPIIVEVVDRGHNIEKVVNVIKPMIKDGMITVEPTIVLWVGTQEE--------------------------------------------------------------------------------------------------------------------------------------------

3d2dA2

0.12

0.10

0.89

0.62

MUSTER

LNR------VSIDLESETAWVESGSTLGELYYAITESS-SKLGFTAGTGGHGGFGMMSRKY---LAADNVVDAILIDANGARQAMGEDVFWAIRGGAIYAWKIKLLPV-------------PEKVTVFRVTKNVAID-EATSLLHKWQFVAEELE-EDFTLS--VLGGADEKQVWLT---------MLGFHFGLKTVAKSTFDLLFPELGEDYLEMSWGESFAYLAGLETVSQLNNRFLKFDERAFKTKVDLTKEPLP---SKAFYGLLERLSKEP--NGFIALNGFGGQMSKIS-SDFTPFPHRSGTRLMVEYIVEQKKKTEFLDWLEKVYEFKPFVSKNPRLGYVNHIDLDLGGIDWGNKTVVNNAI

1o51A

0.22

0.05

0.23

2.12

dPPAS

---------------------------------------------------------------------------------------------------------------------------HHKLLKIYLGEKDKHSGKPLFEYLVKRAYELG-KGVTVYRGI-GFGH------------PDLPIVLEIVDEEERINLFLKEIDNIDFDGLVFTADVNVVK--------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.24

Estimated TM-score = 0.56±0.15

Estimated RMSD = 9.5±4.6Å

Download Model 2

C-score=-4.18

Download Model 3

C-score=-4.02

Download Model 4

C-score=-3.88

Download Model 5

C-score=-4.48

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5d79A	0.708	4.07	0.084	0.900
2	3vteA	0.699	4.28	0.054	0.900
3	4ud8A	0.693	4.25	0.069	0.894
4	3rj8A	0.692	4.44	0.075	0.900
5	3tshA	0.689	4.12	0.052	0.883
6	3d2dA	0.689	4.33	0.082	0.892
7	5k8eA	0.680	4.52	0.082	0.894
8	1zr6A	0.680	4.44	0.067	0.889
9	2wdwA	0.678	4.59	0.083	0.902
10	3popA	0.677	4.82	0.098	0.916

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	4	2dclA	AMP	Rep, Mult	11,50,51,52,70,96,97
2	0.06	4	3fw9A	SLX	Rep, Mult	58,161,163,243,247,281,283,286,313
3	0.06	4	1w1sA	EMU	Rep, Mult	250,283,313,315,347
4	0.03	2	2y3rA	TIR	Rep, Mult	243,244,247,249,283,314,316
5	0.03	2	2dclA	AMP	Rep, Mult	40,41,42,43,74,76
6	0.03	2	2y3rA	TIR	Rep, Mult	127,130,163,190,192
7	0.03	2	3fw8A	UUU	Rep, Mult	128,147,191
8	0.03	2	3d2dA	REN	Rep, Mult	163,189,243,245,247,281,283,313,317
9	0.02	1	1cq1B	CA	Rep, Mult	193,210
10	0.02	1	3d2hA	UUU	Rep, Mult	146,147,150
11	0.02	1	2dyo1	III	Rep, Mult	23,27,29,30,31,33,34,37,38,39,40
12	0.02	1	2dclB	AMP	Rep, Mult	41,42,43,74,75,76
13	0.02	1	1vaoA	ACT	Rep, Mult	249,313,345
14	0.02	1	5l6fA	BXP	Rep, Mult	2,358,368
15	0.02	1	1w1kA	EUG	Rep, Mult	127,190,214,215
16	0.02	1	4e5tF	MG	Rep, Mult	217,255
17	0.02	1	2q0yA	ZN	Rep, Mult	217,259

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1i19A	0.580	5.39	0.098	0.835	1.1.3.6	NA
2	0.060	1f20A	0.257	6.15	0.027	0.398	1.14.13.39	NA
3	0.060	3dq0A	0.651	4.70	0.092	0.881	1.5.99.12	NA
4	0.060	1rm6A	0.365	6.49	0.059	0.591	1.3.99.20	NA
5	0.060	1g72A	0.368	6.81	0.040	0.626	1.1.99.8	NA
6	0.060	2d0vA	0.373	6.65	0.036	0.621	1.1.99.8	NA
7	0.060	1lrwC	0.370	6.71	0.054	0.618	1.1.99.8	282
8	0.060	2ywfA	0.374	6.98	0.033	0.640	3.6.5.-	NA
9	0.060	1yq2A	0.364	6.40	0.037	0.580	3.2.1.23	NA
10	0.060	3i99A	0.423	5.14	0.067	0.596	1.1.1.158	NA
11	0.060	1diiA	0.624	4.68	0.082	0.832	1.17.99.1	220
12	0.060	2b3xA	0.381	7.00	0.051	0.653	4.2.1.3	NA
13	0.060	1ea0A	0.341	7.24	0.030	0.596	1.4.1.13	NA
14	0.060	1t3qB	0.359	6.74	0.070	0.602	1.3.99.17	NA
15	0.060	1hskA	0.387	5.09	0.054	0.537	1.1.1.158	NA
16	0.060	1w18B	0.362	6.45	0.052	0.583	2.4.1.10	NA
17	0.060	1tllA	0.369	6.90	0.060	0.637	1.14.13.39	NA
18	0.060	2q85A	0.426	5.28	0.056	0.602	1.1.1.158	NA
19	0.060	3epsA	0.360	7.09	0.058	0.631	2.7.11.5	142,272,286

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.693	4.25	0.07	0.89	4ud8A	GO:0000166 GO:0003824 GO:0005618 GO:0009506 GO:0009793 GO:0010197 GO:0016491 GO:0016614 GO:0045551 GO:0050660 GO:0055114
1	0.11	0.693	4.27	0.08	0.89	3d2jA	GO:0003824 GO:0009820 GO:0016023 GO:0016491 GO:0016614 GO:0031410 GO:0050468 GO:0050660 GO:0055114
2	0.11	0.708	4.07	0.08	0.90	5d79A	GO:0003824 GO:0016491 GO:0016614 GO:0050660 GO:0055114
3	0.11	0.699	4.28	0.05	0.90	3vteA	GO:0003824 GO:0005576 GO:0016491 GO:0016614 GO:0048046 GO:0050660 GO:0055114
4	0.11	0.692	4.44	0.07	0.90	3rj8A	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0046562 GO:0046872 GO:0050660 GO:0055114
5	0.11	0.680	4.45	0.07	0.89	2axrA	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0046872 GO:0050660 GO:0055114
6	0.11	0.690	4.12	0.05	0.88	4pveA	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0050660 GO:0055114
7	0.10	0.689	4.12	0.05	0.88	4dnsA	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0050660 GO:0055114
8	0.10	0.677	4.59	0.08	0.90	5awvA	GO:0003824 GO:0004497 GO:0016491 GO:0016614 GO:0016746 GO:0016757 GO:0050660 GO:0055114
9	0.10	0.665	4.85	0.09	0.90	2y08B	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0050660 GO:0055114
10	0.10	0.667	4.50	0.08	0.88	3w8wB	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0050660 GO:0055114
11	0.10	0.677	4.82	0.10	0.92	3popA	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0050660 GO:0055114
12	0.09	0.661	4.75	0.09	0.89	2ipiA	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0017000 GO:0050660 GO:0055114
13	0.09	0.646	4.70	0.06	0.87	2bvfA	GO:0000166 GO:0003824 GO:0016491 GO:0016614 GO:0018530 GO:0050660 GO:0055114
14	0.08	0.635	4.92	0.08	0.87	4ml8A	GO:0000166 GO:0003824 GO:0009690 GO:0016491 GO:0016614 GO:0019139 GO:0050660 GO:0055114
15	0.08	0.637	4.85	0.07	0.88	2exrA	GO:0003824 GO:0009690 GO:0009823 GO:0016491 GO:0016614 GO:0019139 GO:0050660 GO:0055114
16	0.07	0.621	4.70	0.08	0.84	4mlaB	GO:0000166 GO:0003824 GO:0009690 GO:0016491 GO:0016614 GO:0019139 GO:0050660 GO:0055114
17	0.07	0.594	4.92	0.08	0.81	5adzA	GO:0003824 GO:0005730 GO:0005739 GO:0005777 GO:0005778 GO:0006629 GO:0008609 GO:0008610 GO:0008611 GO:0016020 GO:0016491 GO:0016614 GO:0016740 GO:0043231 GO:0050660 GO:0055114 GO:0071949
18	0.07	0.596	4.89	0.07	0.81	5adzC	GO:0003824 GO:0005730 GO:0005739 GO:0005777 GO:0005778 GO:0006629 GO:0008609 GO:0008610 GO:0008611 GO:0016020 GO:0016491 GO:0016614 GO:0016740 GO:0043231 GO:0050660 GO:0055114 GO:0071949

Consensus prediction of GO terms

Molecular Function	GO:0050660	GO:0016614
GO-Score	0.45	0.45
Biological Processes	GO:0055114
GO-Score	0.45
Cellular Component	GO:0009506	GO:0005618	GO:0016023	GO:0048046
GO-Score	0.12	0.12	0.11	0.11

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.