I-TASSER results

I-TASSER results for job id Rv3037c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (358 residues)
MRARFGDRAPWLVETTLLRRRAAGKLGELCPNVGVSQWLFTDEALQQATAAPVARHRARR
LAGRVVHDATCSIGTELAALRELAVRAVGSDIDPVRLAMARHNLAALGMEADLCRADVLH
PVTRDAVVVIDPARRSNGRRRFHLADYQPGLGPLLDRYRGRDVVVKCAPGIDFEEVGRLG
FEGEIEVISYRGGVREACLWSAGLAGSGIRRRASILDSGEQIGDDEPDDCGVRPAGKWIV
DPDGAVVRAGLVRNYGARHGLWQLDPQIAYLSGDRLPPALRGFEVLEQLAFDERRLRQVL
SALDCGAAEILVRGVAIDPDALRRRLRLRGSRPLAVVITRIGAGSLSHVTAYVCRPSR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRARFGDRAPWLVETTLLRRRAAGKLGELCPNVGVSQWLFTDEALQQATAAPVARHRARRLAGRVVHDATCSIGTELAALRELAVRAVGSDIDPVRLAMARHNLAALGMEADLCRADVLHPVTRDAVVVIDPARRSNGRRRFHLADYQPGLGPLLDRYRGRDVVVKCAPGIDFEEVGRLGFEGEIEVISYRGGVREACLWSAGLAGSGIRRRASILDSGEQIGDDEPDDCGVRPAGKWIVDPDGAVVRAGLVRNYGARHGLWQLDPQIAYLSGDRLPPALRGFEVLEQLAFDERRLRQVLSALDCGAAEILVRGVAIDPDALRRRLRLRGSRPLAVVITRIGAGSLSHVTAYVCRPSR
Prediction	CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCEEEHCCCCCCCCCEEHCHHHCCCCHHHHHHHHCCCCEEEHCCCCCCHHHHHHCCCCEEEEEEEHCCEEEEEEEEHCCCCCCCCEEEEEHCCCCEEHCCCCCCCCCCCCCCCEEEHCCHHHHHHCHHHHHHHHHCCEEHCCCEEEEHCCCCCCCCCEEEEEEEHCCCHHHHHHHHHHHCCCEEEEEEHCCCCCHHHHHHHHCCCCCCCEEEEEEEHCCCCEEEEEEEEEHCCC
Conf.Score	9887766569999999999999998666665566545788976544389999999999975999899969998699999999899799998899999999999999899679996886677788979998899999987577688879999999998578859998699999989886898668999997996789999976888899769999869985765788878887654557885668888875699999998986757875899768888988668999998599999999999979987999985999999999988567899968999999789975789999998589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRARFGDRAPWLVETTLLRRRAAGKLGELCPNVGVSQWLFTDEALQQATAAPVARHRARRLAGRVVHDATCSIGTELAALRELAVRAVGSDIDPVRLAMARHNLAALGMEADLCRADVLHPVTRDAVVVIDPARRSNGRRRFHLADYQPGLGPLLDRYRGRDVVVKCAPGIDFEEVGRLGFEGEIEVISYRGGVREACLWSAGLAGSGIRRRASILDSGEQIGDDEPDDCGVRPAGKWIVDPDGAVVRAGLVRNYGARHGLWQLDPQIAYLSGDRLPPALRGFEVLEQLAFDERRLRQVLSALDCGAAEILVRGVAIDPDALRRRLRLRGSRPLAVVITRIGAGSLSHVTAYVCRPSR
Prediction	6254237203100300300420263045125434143000243001000133004200530544100000000000001004203400002113400400230064160503011010243245100000000243744221204313220430151042330000001202252056044502011112543010000000323555221100003454414456455152540130000020000002003200641404301531000003422751300202321404363025104737043020323616150640154051556441000000026443210000003258
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCEEEHCCCCCCCCCEEHCHHHCCCCHHHHHHHHCCCCEEEHCCCCCCHHHHHHCCCCEEEEEEEHCCEEEEEEEEHCCCCCCCCEEEEEHCCCCEEHCCCCCCCCCCCCCCCEEEHCCHHHHHHCHHHHHHHHHCCEEHCCCEEEEHCCCCCCCCCEEEEEEEHCCCHHHHHHHHHHHCCCEEEEEEHCCCCCHHHHHHHHCCCCCCCEEEEEEEHCCCCEEEEEEEEEHCCC
MRARFGDRAPWLVETTLLRRRAAGKLGELCPNVGVSQWLFTDEALQQATAAPVARHRARRLAGRVVHDATCSIGTELAALRELAVRAVGSDIDPVRLAMARHNLAALGMEADLCRADVLHPVTRDAVVVIDPARRSNGRRRFHLADYQPGLGPLLDRYRGRDVVVKCAPGIDFEEVGRLGFEGEIEVISYRGGVREACLWSAGLAGSGIRRRASILDSGEQIGDDEPDDCGVRPAGKWIVDPDGAVVRAGLVRNYGARHGLWQLDPQIAYLSGDRLPPALRGFEVLEQLAFDERRLRQVLSALDCGAAEILVRGVAIDPDALRRRLRLRGSRPLAVVITRIGAGSLSHVTAYVCRPSR

3ll7A

0.22

0.21

0.96

2.57

MUSTER

LGSNPPEYRAAVATQIELWPRLRNKLPQWAGISSL--YIPSRLSLEQSSGAVTSSYKSRFIRGTKVVDLTGGLGIDFIALSKAS-QGIYIERNDETAVAARHNIPLLGKDVNILTGDFKEYLPHPDYIYVDPARR----RVYAIADCEPDLIPLATELLCSSILAKLSPIDLWDTLQSLLHVQELHVVAAHGEVKELLVRSLNEATIPVPIHAINLLLETVIPERSISIPYTDSIDKYVYEPHTALLKAGAFKTVAYRLGLRKLHPNSHLYTSEAYESAFRTFVLEEIIPFSTSVLKQLRKV--VPQASISCRNFPLSPIELRQRSKADGG-EKTLGTTADGKK-----VLLLLRKAE

3ll7A

0.21

0.20

0.96

4.95

dPPAS

SNDIPPEYRAAVATQIELWPRLRNKLPQWAGISSL--YIPSRLSLEQSSGAVTSSYKSRFIRGTKVVDLTGGLGIDFIALSKAS-QGIYIERNDETAVAARHNIPLLLNEVNILTGDFKEYLPHPDYIYVDPARRRV----YAIADCEPDLIPLATELLCSSILAKLSPIDLWDTLQSLLHVQELHVVAAHGEVKELLVRSLNEATIPVPIHAINLLLETVIPERSISIPYTDSIDKYVYEPHTALLKAGAFKTVAYRLGLRKLHPNSHLYTSEAYESAFRTFVLEEIIPFSTSVLKQLRKV--VPQASISCRNFPLSPIELRQRSKAD-GGEKTLGTTADGKK-----VLLLLRKAE

3ll7A

0.22

0.21

0.96

5.04

wdPPAS

LGSNPPEYRAAVATQIELWPRLRNKLPQWAGISSL--YIPSRLSLEQSSGAVTSSYKSRFIRGTKVVDLTGGLGIDFIALSKAS-QGIYIERNDETAVAARHNIPLLLNEVNILTGDFKEYLPHPDYIYVDPARRRVY----AIADCEPDLIPLATELLCSSILAKLSPIDLWDTLQSLLHVQELHVVAAHGEVKELLVRSLNEATIPVPIHAINLLLETVIPERSISIPYTDSIDKYVYEPHTALLKAGAFKTVAYRLGLRKLHPNSHLYTSEAYESAFRTFVLEEIIPFSTSVLKQLRKV--VPQASISCRNFPLSPIELRQRSKADGG-EKTLGTTADGKK-----VLLLLRKAE

3ll7A

0.21

0.20

0.96

3.22

wMUSTER

LGSNPPEYRAAVATQIELWPRLRNKLPQWAGISSL--YIPSRLSLEQSSGAVTSSYKSRFIRGTKVVDLTGGLGIDFIALSKAS-QGIYIERNDETAVAARHNIPLLLNDVNILTGDFKEYLPHPDYIYVDPARR----RVYAIADCEPDLIPLATELLCSSILAKLSPIDLWDTLQSLLHVQELHVVAAHGEVKELLVRSLNEATIPVPIHAINLLLEFIFTEESISIPYTDSIDKYVYEPHTALLKAGAFKTVAYRLGLRKLHPNSHLYTSEAYESAFRTFVLEEIIPFSTSVLKQLRKV--VPQASISCRNFPLSPIELRQRSKADGG-EKTLGTTADGKK-----VLLLLRKAE

3ll7A

0.22

0.21

0.96

4.71

wPPAS

LGSNPPEYRAAVATQIELWPRLRNKLPQWAGISSL--YIPSRLSLEQSSGAVTSSYKSRFIRGTKVVDLTGGLGIDFIALSKAS-QGIYIERNDETAVAARHNIPLLLNDVNILTGDFKEYLPHPDYIYVDPARR----RVYAIADCEPDLIPLATELLCSSILAKLSPIDLWDTLQSLLHVQELHVVAAHGEVKELLVRSLNEATIPVPIHAINLLLETVIPERSISIPYTDSIDKYVYEPHTALLKAGAFKTVAYRLGLRKLHPNSHLYTSEAYESAFRTFVLEEIIPFSTSVLKQLRKV--VPQASISCRNFPLSPIELRQRSKADGG-EKTLGTTADGKK-----VLLLLRKAE

3ll7A

0.22

0.21

0.96

10.75

dPPAS2

LGSNPPEYRAAVATQIELWPRLRNKLPQWAGISSL--YIPSRLSLEQSSGAVTSSYKSRFIRGTKVVDLTGGLGIDFIALSKAS-QGIYIERNDETAVAARHNIPLLLNEVNILTGDFKEYLPHPDYIYVDPARR----RVYAIADCEPDLIPLATELLCSSILAKLSPIDLWDTLQSLLHVQELHVVAAHGEVKELLVRSLNEATIPVPIHAINLLLETVIPERSISIPYTDSIDKYVYEPHTALLKAGAFKTVAYRLGLRKLHPNSHLYTSEAYESAFRTFVLEEIIPFSTSVLKQLRKV--VPQASISCRNFPLSPIELRQRSKAD-GGEKTLGTTADGKK-----VLLLLRKAE

3ll7A

0.22

0.21

0.96

4.26

PPAS

LGSNPPEYRAAVATQIELWPRLRNKLPQWAGISSL--YIPSRLSLEQSSGAVTSSYKSRFIRGTKVVDLTGGLGIDFIALSKAS-QGIYIERNDETAVAARHNIPLLLNEVNILTGDFKEYLFHPDYIYVDPARR----RVYAIADCEPDLIPLATELLCSSILAKLSPIDLWDTLQSLLHVQELHVVAAHGEVKELLVRSLNEATIPVPIHAINLLLETVIPERSISIPYTDSIDKYVYEPHTALLKAGAFKTVAYRLGLRKLHPNSHLYTSEAYESPGRTFVLEEIIPFSTSVLKQLRKV--VPQASISCRNFPLSPIELRQRSKADGG-EKTLGTTADGKK-----VLLLLRKAE

3ll7A

0.22

0.21

0.96

5.95

Env-PPAS

LGSNPPEYRAAVATQIELWPRLRNKLPQWAGISSL--YIPSRLSLEQSSGAVTSSYKSRFIRGTKVVDLTGGLGIDFIALSKAS-QGIYIERNDETAVAARHNIPLLLNEVNILTGDFKEYLPHPDYIYVDPARR----RVYAIADCEPDLIPLATELLCSSILAKLSPIDLWDTLQSLLHVQELHVVAAHGEVKELLVRSLNEATIPVPIHAINLLLETVIPERSISIPYTDSIDKYVYEPHTALLKAGAFKTVAYRLGLRKLHPNSHLYTSEAYESPGRTFVLEEIIPFSTSVLKQLRKV--VPQASISCRNFPLSPIELRQRSKADGGE-KTLGTTADGKK-----VLLLLRKAE

3gdhA

0.20

0.11

0.54

1.16

MUSTER

----LPPEIAAVPELAKYWAQRYRLFSRFDD-----GIKLDREGWFSVTPEKIAEHIAGRVKCDVVVDAFCGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIKIEFICGDFLLLALKADVVFLSPPWGGPDYATFDIRMMSPDGFEIFRLSKTNNIVYFLPRNADIDQVASLGGQVEIEQNFLNNKLKTITAYFGD-----------------------------------------------------------------------------------------------------------------------------------------------------------

3gdhA

0.20

0.11

0.54

2.32

dPPAS

----LPPEIAAVPELAKYWAQRYRLFSRFDD-----GIKLDREGWFSVTPEKIAEHIAGRVKCDVVVDAFCGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAEVYGIKIEFICGDFLLLALKADVVFLSPPWGGTAETFDIRTMMSPDGFEIFRLSKTNNIVYFLPRNADIDQVASLGGQVEIEQNFLNNKLKTITAYFGD-----------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.37

Estimated TM-score = 0.90±0.06

Estimated RMSD = 3.8±2.6Å

Download Model 2

C-score=-2.40

Download Model 3

C-score=-1.09

Download Model 4

C-score=-4.52

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ll7A	0.911	1.69	0.216	0.958
2	3s1sA	0.584	4.96	0.103	0.782
3	5hr4C	0.521	5.25	0.062	0.718
4	2zwaB	0.519	5.53	0.070	0.737
5	2ytzA	0.496	4.40	0.104	0.631
6	3axsA	0.493	4.68	0.055	0.651
7	4xqkA3	0.483	4.40	0.099	0.615
8	3ufbA	0.482	4.56	0.132	0.623
9	1ej6A	0.481	5.91	0.065	0.690
10	3khkA	0.480	4.66	0.098	0.623

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.26	17	3gdhA	SAH	Rep, Mult	43,47,48,49,69,70,71,72,73,75,76,91,92,96,116,117,118,131,132,133
2	0.16	9	1g38D	NEA	Rep, Mult	70,91,92,96,116,117,118,131,132,133,150
3	0.08	6	3gdhC	MGP	Rep, Mult	46,47,48,49,50,131,132,134,169,193,195,196
4	0.03	2	4pclB	MN	Rep, Mult	47,131,166,167
5	0.01	1	2bx2L	MG	Rep, Mult	68,117
6	0.01	1	4awyB	MG	Rep, Mult	48,103
7	0.01	1	3melA	MG	Rep, Mult	91,117,131,172

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.067	3gdhA	0.470	2.63	0.202	0.525	2.1.1.-	49
2	0.060	1xj5A	0.434	4.56	0.120	0.564	2.5.1.16	50,131
3	0.060	2jkvA	0.426	5.39	0.079	0.609	1.1.1.44	NA
4	0.060	1l5jA	0.426	6.53	0.045	0.701	4.2.1.3	NA
5	0.060	1ej6A	0.481	5.91	0.065	0.690	2.7.7.50	68,92,100
6	0.060	2p4qA	0.421	5.55	0.071	0.609	1.1.1.44	NA
7	0.060	2pxaB	0.415	4.51	0.097	0.536	2.7.7.48,3.4.21.91	131,166
8	0.060	2b2cA	0.414	4.34	0.129	0.525	2.5.1.16	NA
9	0.060	1qkiF	0.422	5.58	0.039	0.623	1.1.1.49	NA
10	0.060	2iz1B	0.427	5.47	0.059	0.606	1.1.1.44	NA
11	0.060	1jq3A	0.436	4.45	0.093	0.556	2.5.1.16	NA
12	0.060	2w90B	0.428	5.53	0.059	0.609	1.1.1.44	NA
13	0.060	2b3tA	0.435	3.77	0.108	0.522	2.1.1.-	NA
14	0.060	1u2zC	0.422	4.08	0.061	0.522	2.1.1.43	92
15	0.060	3fwnA	0.426	5.73	0.079	0.617	1.1.1.44	NA
16	0.060	1pgjA	0.422	5.74	0.060	0.615	1.1.1.44	NA
17	0.060	2j5wA	0.424	6.64	0.053	0.704	1.16.3.1	NA
18	0.060	1yq2A	0.442	7.09	0.073	0.771	3.2.1.23	43
19	0.060	2ar0A	0.452	4.37	0.075	0.573	2.1.1.72	NA
20	0.060	2nxeA	0.416	3.28	0.153	0.492	2.1.1.-	91

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.29	0.470	2.63	0.20	0.53	3gdhA	GO:0000387 GO:0001510 GO:0005615 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006351 GO:0006355 GO:0008168 GO:0008173 GO:0009452 GO:0015030 GO:0016740 GO:0022613 GO:0030532 GO:0032259 GO:0036261 GO:0044255 GO:0071164 GO:0071167
1	0.09	0.400	3.26	0.17	0.47	1o9gA	GO:0008168 GO:0008989 GO:0016740 GO:0031167 GO:0032259 GO:0046677
2	0.07	0.365	3.04	0.15	0.42	3q87B	GO:0003676 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
3	0.07	0.480	4.90	0.13	0.63	2okcB	GO:0003676 GO:0003677 GO:0006306 GO:0008168 GO:0008170 GO:0009007 GO:0009307 GO:0016740 GO:0032259 GO:0032775
4	0.07	0.482	4.56	0.13	0.62	3ufbA	GO:0003676 GO:0003677 GO:0006306 GO:0008168 GO:0008170 GO:0016740 GO:0032259
5	0.06	0.435	3.77	0.11	0.52	2b3tA	GO:0003676 GO:0006415 GO:0006479 GO:0008168 GO:0008276 GO:0008757 GO:0010468 GO:0016740 GO:0018364 GO:0032259 GO:0036009
6	0.06	0.584	4.83	0.10	0.77	3s1sA	GO:0003676 GO:0003677 GO:0006306 GO:0008168 GO:0008170 GO:0032259 GO:0046872
7	0.06	0.386	6.02	0.06	0.59	5fl3A	GO:0005524 GO:0006810
8	0.06	0.367	5.74	0.03	0.55	1o0sA	GO:0003824 GO:0004470 GO:0004471 GO:0005739 GO:0005759 GO:0006108 GO:0008152 GO:0008948 GO:0016491 GO:0046872 GO:0051287 GO:0055114
9	0.06	0.359	5.54	0.07	0.51	4dibA	GO:0004365 GO:0006006 GO:0006096 GO:0016491 GO:0016620 GO:0050661 GO:0051287 GO:0055114
10	0.06	0.313	6.53	0.07	0.52	1htrB	GO:0002803 GO:0004190 GO:0005576 GO:0005615 GO:0006508 GO:0007586 GO:0008233 GO:0016787 GO:0030163 GO:0070062
11	0.06	0.273	7.03	0.03	0.48	2j7aB	GO:0006807 GO:0016491 GO:0042128 GO:0042279 GO:0042597 GO:0046872 GO:0055114
12	0.06	0.260	6.25	0.08	0.42	5cajA	GO:0005829 GO:0033194
13	0.06	0.262	5.70	0.10	0.38	2r11D	GO:0016787 GO:0052689
14	0.06	0.274	5.32	0.04	0.39	1cpyA	GO:0000324 GO:0004180 GO:0004185 GO:0005773 GO:0006508 GO:0007039 GO:0008233 GO:0016787 GO:0046938 GO:0051603
15	0.06	0.253	6.60	0.06	0.42	5c0pA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
16	0.06	0.261	6.40	0.03	0.43	5d6eA	GO:0004177 GO:0005737 GO:0005829 GO:0005886 GO:0006508 GO:0008233 GO:0008235 GO:0016485 GO:0016787 GO:0018206 GO:0022400 GO:0031365 GO:0044822 GO:0046872 GO:0070006 GO:0070084
17	0.06	0.287	6.04	0.06	0.43	3r5hA	GO:0000166 GO:0003824 GO:0004638 GO:0005524 GO:0006164 GO:0006189 GO:0016829 GO:0016874 GO:0034028 GO:0046872 GO:0051287 GO:0055114
18	0.06	0.224	6.29	0.08	0.36	5hbrB	GO:0005524 GO:0046872
19	0.06	0.222	6.65	0.05	0.36	4xz8A	GO:0019013

Consensus prediction of GO terms

Molecular Function	GO:0008173	GO:1901363	GO:0097159
GO-Score	0.57	0.35	0.35
Biological Processes	GO:0036260	GO:0022618	GO:0044763	GO:1903506	GO:0071166	GO:0051170	GO:0001510	GO:0010468	GO:0000398	GO:2000112	GO:0006629	GO:0006351
GO-Score	0.57	0.57	0.57	0.57	0.57	0.57	0.57	0.57	0.57	0.57	0.57	0.57
Cellular Component	GO:0030529	GO:0043232	GO:0044421	GO:0016604	GO:0044444
GO-Score	0.57	0.57	0.57	0.57	0.57

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.