I-TASSER results

I-TASSER results for job id Rv3030

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (274 residues)
MCAFVPHVPRHSRGDNPPSASTASPAVLTLTGERTIPDLDIENYWFRRHQVVYQRLAPRC
TARDVLEAGCGEGYGADLIACVARQVIAVDYDETAVAHVRSRYPRVEVMQANLAELPLPD
ASVDVVVNFQVIEHLWDQARFVRECARVLRGSGLLMVSTPNRITFSPGRDTPINPFHTRE
LNADELTSLLIDAGFVDVAMCGLFHGPRLRDMDARHGGSIIDAQIMRAVAGAPWPPELAA
DVAAVTTADFEMVAAGHDRDIDDSLDLIAIAVRP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MCAFVPHVPRHSRGDNPPSASTASPAVLTLTGERTIPDLDIENYWFRRHQVVYQRLAPRCTARDVLEAGCGEGYGADLIACVARQVIAVDYDETAVAHVRSRYPRVEVMQANLAELPLPDASVDVVVNFQVIEHLWDQARFVRECARVLRGSGLLMVSTPNRITFSPGRDTPINPFHTRELNADELTSLLIDAGFVDVAMCGLFHGPRLRDMDARHGGSIIDAQIMRAVAGAPWPPELAADVAAVTTADFEMVAAGHDRDIDDSLDLIAIAVRP
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHCCCCEEEHCCHHHCCCCCCCEEEEEEHCCHHHCCCHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEEHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHCC
Conf.Score	9988888877788788888888767888875654457877555689999999999965789986999879998999999998897999869999999999989999799868888989999757898636556678999999999997689969999968998556776445688655568999999999998996899987766856777888757755667788887656788677778777666666666545555545577589999879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MCAFVPHVPRHSRGDNPPSASTASPAVLTLTGERTIPDLDIENYWFRRHQVVYQRLAPRCTARDVLEAGCGEGYGADLIACVARQVIAVDYDETAVAHVRSRYPRVEVMQANLAELPLPDASVDVVVNFQVIEHLWDQARFVRECARVLRGSGLLMVSTPNRITFSPGRDTPINPFHTRELNADELTSLLIDAGFVDVAMCGLFHGPRLRDMDARHGGSIIDAQIMRAVAGAPWPPELAADVAAVTTADFEMVAAGHDRDIDDSLDLIAIAVRP
Prediction	6423224335444574344345334311421111012414243212310230043017415433002011210200220052003000011146004303742570412201024031564100000000000114314300200010023301000000023221302412233412140316102500571404313232012112013113423121242312321454313451243133033441412444354414300000000338
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHCCCCEEEHCCHHHCCCCCCCEEEEEEHCCHHHCCCHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEEHCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHCC
MCAFVPHVPRHSRGDNPPSASTASPAVLTLTGERTIPDLDIENYWFRRHQVVYQRLAPRCTARDVLEAGCGEGYGADLIACVARQVIAVDYDETAVAHVRSRYPRVEVMQANLAELPLPDASVDVVVNFQVIEHLWDQARFVRECARVLRGSGLLMVSTPNRITFSPGRDTPINPFHTRELNADELTSLLIDAGFVDVAMCGLFHGPRLRDMDARHGGSIIDAQIMRAVAGAPWPPELAADVAAVTTADFEMVAAGHDRDIDDSLDLIAIAVRP

4kdcA

0.20

0.15

0.73

1.74

MUSTER

--------------------------EIAKFEAVASRWWDLEGEFKPLHRINPLRLG-GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHAIQVDYVQETVEEHAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYVPKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQN----------------------------------------------

4kdcA

0.20

0.15

0.74

2.38

dPPAS

--------------------------EIAKFEAVASRWWDLEGEFKPLHRINPLRLGYGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHAIQVDYVQETVEEHAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYVPKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQN----------------------------------------------

4kdcA

0.20

0.15

0.73

2.39

wdPPAS

--------------------------EIAKFEAVASRWWDLEGEFKPLHRINPLRLG-GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHAIQVDYVQETVEEHAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYVPKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQN----------------------------------------------

4kdcA

0.20

0.15

0.73

2.00

wMUSTER

--------------------------EIAKFEAVASRWWDLEGEFKPLHRINPLRLG-GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHAIQVDYVQETVEEHAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYVPKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQN----------------------------------------------

4kdcA

0.20

0.15

0.73

2.56

wPPAS

--------------------------EIAKFEAVASRWWDLEGEFKPLHRINPLRLG-GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHAIQVDYVQETVEEHAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYVPKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQN----------------------------------------------

4kdcA

0.20

0.15

0.74

3.38

dPPAS2

--------------------------EIAKFEAVASRWWDLEGEFKPLHRINPLRLGYGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHAIQVDYVQETVEEHAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYVPKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQN----------------------------------------------

4kdcA

0.20

0.15

0.73

2.33

PPAS

--------------------------EIAKFEAVASRWWDLEGEFKPLHRINPLRLG-GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHAIQVDYVQETVEEHAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGARMVPKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQN----------------------------------------------

4kdcA

0.20

0.15

0.74

2.73

Env-PPAS

--------------------------EIAKFEAVASRWWDLEGEFKPLHRINPLRLGYGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHAIQVDYVQETVEEHAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYVPKFIKPAELLGWVDQTSLKERHITGLHYNPITNTFKLGPGVDVNYMLHTQN----------------------------------------------

4kwcA

0.12

0.11

0.92

1.74

MUSTER

MIQEKIKEVKRALAQSWFSDPDK-RKISSNYDNRETPFTR---FLSAETFTSYYQLTFKKTPVSILDIGCGQGQMLEYISKQLADLTGIDSSEEAIHCANKLNIKANFICTDIKNFSSHAKIYDVILIHLCFGLFENPIELLEQLLPYLSNESMIYIVDLNRDSIESGLSSVQSKE-EELYIYDQYHASLTLSEF-----------EQLLTYITKPREDMMYKIGTSII--GGFSPFSMEFLSLIGNGNLQQTLRQAPDVL---LHAWLIKNR-

3dliA

0.18

0.15

0.79

2.31

dPPAS

---------------------DYYFLFEEKF----------RGSRELVKARLRRYIPYFKGCRRVLDIGCGRGEFLELCKEEGIESIGVDINEDMIKFCEGKFN---VVKSDAIEYSLPDKYLDGVMISHFVEHLDPLFELLSLCYSKMKYSSYIVIESPNPTSLYSLINFYIDPTHKKPVHPETLKFILEYLGFRDVKIEFFEECEELTKLAKIDSNT--------------VSEEVIRVINENIEKLNRILF--------GPQDYAIIAKK-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.87

Estimated TM-score = 0.60±0.14

Estimated RMSD = 7.9±4.4Å

Download Model 2

C-score=-2.03

Download Model 3

C-score=-2.04

Download Model 4

C-score=-4.01

Download Model 5

C-score=-2.07

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4kvzA	0.692	3.55	0.093	0.858
2	4kwcA	0.673	3.72	0.120	0.850
3	4kdcA	0.667	2.20	0.198	0.737
4	4krgA	0.630	4.01	0.109	0.803
5	2vdwA	0.621	3.68	0.116	0.770
6	4ckbA	0.619	3.96	0.105	0.788
7	3vc1A	0.610	3.70	0.126	0.748
8	4pneA	0.609	3.77	0.165	0.748
9	2avnA	0.608	3.35	0.194	0.737
10	2ex4A	0.607	3.21	0.150	0.726

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.48	27	4qtuD	SAM	Rep, Mult	35,48,69,70,71,74,75,90,91,92,95,111,112,113,129,130,134
2	0.02	1	1p91A	SAM	Rep, Mult	48,69,70,71,72,73,74,75,129,130,159,160,164,266

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.136	2h11B	0.563	3.48	0.095	0.686	2.1.1.67	NA
2	0.129	3e05D	0.509	3.14	0.110	0.602	2.1.1.132	106
3	0.122	2iftA	0.452	3.46	0.103	0.555	2.1.1.52	NA
4	0.092	2ex4A	0.607	3.21	0.150	0.726	2.1.1.-	138
5	0.067	3e05B	0.509	3.24	0.120	0.606	2.1.1.132	35
6	0.067	1f38A	0.497	3.16	0.143	0.591	2.1.1.-	NA
7	0.067	3bwmA	0.524	3.14	0.122	0.628	2.1.1.6	133
8	0.067	2cl5A	0.525	3.10	0.128	0.628	2.1.1.6	133
9	0.067	3hnrA	0.505	3.12	0.121	0.595	2.1.1.-	NA
10	0.066	3gdhA	0.495	3.39	0.149	0.595	2.1.1.-	NA
11	0.066	1xcjA	0.547	3.74	0.130	0.682	2.1.1.2	NA
12	0.066	3grzB	0.483	2.88	0.105	0.562	2.1.1.-	31
13	0.066	1nt2A	0.499	2.95	0.109	0.588	2.1.1.-	NA
14	0.066	1pjzA	0.478	3.72	0.103	0.606	2.1.1.67	95,107,116
15	0.060	3bwbA	0.534	4.64	0.095	0.734	2.5.1.16	71,96
16	0.060	2e5wA	0.543	4.41	0.092	0.723	2.5.1.16	NA
17	0.060	2iipA	0.588	3.39	0.113	0.723	2.1.1.1	69,71,90
18	0.060	1wznA	0.578	3.37	0.154	0.693	2.1.1.-	52
19	0.060	1tw2B	0.579	3.76	0.154	0.723	2.1.1.-	NA
20	0.060	3lccA	0.567	3.41	0.121	0.682	2.1.1.-	69
21	0.060	3bgdA	0.564	3.63	0.113	0.693	2.1.1.67	NA
22	0.060	2qyoA	0.526	4.34	0.122	0.693	2.1.1.46	NA
23	0.060	3g5tA	0.580	3.86	0.132	0.730	2.1.1.145	19,70,87
24	0.060	1sqfA	0.540	4.23	0.133	0.690	2.1.1.-	NA
25	0.060	3eppB	0.583	3.41	0.131	0.715	2.1.1.56	70,75,131
26	0.060	2pxxA	0.544	3.08	0.169	0.646	3.4.24.71	NA
27	0.060	1fp2A	0.550	4.04	0.113	0.708	2.1.1.150	NA
28	0.060	1fp1D	0.534	3.92	0.105	0.679	2.1.1.-	NA
29	0.060	2i62C	0.580	3.39	0.103	0.719	2.1.1.1	69,71,91
30	0.060	1jq3A	0.551	4.45	0.112	0.730	2.5.1.16	69,112
31	0.060	1ri5A	0.592	3.47	0.150	0.723	2.1.1.56	69,75
32	0.060	1uirB	0.548	4.36	0.100	0.723	2.5.1.16	NA
33	0.060	1ri1A	0.591	3.45	0.155	0.723	2.1.1.56	69,90,130

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.29	0.556	3.28	0.15	0.66	3l8dA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
1	0.28	0.677	3.72	0.10	0.86	5dm2A	GO:0008168 GO:0016740 GO:0032259
2	0.26	0.565	2.47	0.12	0.64	4qtuB	GO:0000056 GO:0000447 GO:0005634 GO:0005730 GO:0005737 GO:0006364 GO:0008152 GO:0008168 GO:0008757 GO:0016435 GO:0016740 GO:0032259 GO:0070476
3	0.26	0.519	3.23	0.17	0.62	3jwgA	GO:0001510 GO:0008168 GO:0008171 GO:0008173 GO:0016740 GO:0032259
4	0.26	0.514	3.24	0.15	0.61	1dusA	GO:0008168 GO:0016740 GO:0032259
5	0.25	0.544	3.04	0.13	0.64	3dtnA	GO:0046872
6	0.25	0.521	3.27	0.20	0.61	3sm3A	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872
7	0.22	0.584	3.63	0.12	0.73	1bhjA	GO:0001887 GO:0005542 GO:0005634 GO:0005737 GO:0005829 GO:0006544 GO:0008168 GO:0008757 GO:0016594 GO:0016740 GO:0017174 GO:0032259 GO:0046498 GO:0046500 GO:0046655 GO:0051262 GO:0051289 GO:0098603 GO:1901052
8	0.22	0.560	3.43	0.12	0.68	3bxoA	GO:0008168 GO:0008757 GO:0016740 GO:0017000 GO:0032259 GO:0042803
9	0.21	0.488	3.69	0.11	0.61	2xvaA	GO:0005737 GO:0005829 GO:0008168 GO:0008757 GO:0009636 GO:0016740 GO:0032259 GO:0046677 GO:0046690
10	0.21	0.576	3.71	0.15	0.71	4necB	GO:0008168 GO:0016740 GO:0032259
11	0.20	0.547	3.68	0.17	0.66	3busA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
12	0.20	0.667	2.20	0.20	0.74	4kdcA	GO:0005829 GO:0006744 GO:0008168 GO:0008425 GO:0008689 GO:0008757 GO:0016740 GO:0032259 GO:0043431 GO:0061542 GO:0102004
13	0.20	0.551	3.37	0.18	0.67	3mggB	GO:0008168 GO:0016740 GO:0032259
14	0.20	0.572	3.02	0.17	0.68	4htfB	GO:0008033 GO:0008168 GO:0016740 GO:0032259
15	0.19	0.512	3.14	0.15	0.61	4xcxA	GO:0001510 GO:0003723 GO:0005737 GO:0008168 GO:0008171 GO:0008173 GO:0016740 GO:0031047 GO:0032259 GO:0034587 GO:0043186 GO:0046872
16	0.19	0.526	3.07	0.18	0.61	2gluA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
17	0.18	0.578	3.37	0.15	0.69	1wznA
18	0.18	0.584	3.20	0.18	0.69	1ve3B	GO:0046872 GO:0051536 GO:0051539
19	0.18	0.577	3.28	0.12	0.69	4oqdC	GO:0008168 GO:0008757 GO:0016740 GO:0017000 GO:0032259 GO:0042803
20	0.18	0.568	3.10	0.15	0.67	3e23A	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
21	0.18	0.477	3.24	0.12	0.57	2i6gB	GO:0005737 GO:0008168 GO:0008757 GO:0016740 GO:0032259 GO:0046690
22	0.18	0.606	3.17	0.15	0.73	5je1A	GO:0008168 GO:0016740 GO:0032259
23	0.17	0.521	3.40	0.18	0.62	1vl5A	GO:0008152 GO:0008168 GO:0016740 GO:0032259
24	0.17	0.579	2.93	0.18	0.68	4qdkA	GO:0005737 GO:0008168 GO:0008757 GO:0015979 GO:0015995 GO:0016740 GO:0032259 GO:0036068 GO:0046406
25	0.17	0.587	3.41	0.14	0.70	4iv8A	GO:0000234 GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
26	0.17	0.511	3.16	0.16	0.61	3jwhA	GO:0001510 GO:0008171 GO:0008173
27	0.15	0.555	2.93	0.12	0.65	3cggA	GO:0008168 GO:0016740 GO:0032259
28	0.15	0.555	3.45	0.12	0.67	1l1eA	GO:0005737 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0009405 GO:0016740 GO:0032259 GO:0042783 GO:0046500 GO:0052167 GO:0071768
29	0.14	0.555	2.95	0.19	0.65	3dh0B	GO:0005737 GO:0008757 GO:0032259 GO:0046872 GO:0051536 GO:0051539
30	0.14	0.513	3.35	0.14	0.62	4qpnA	GO:0005622 GO:0005737 GO:0008168 GO:0016740 GO:0032259
31	0.14	0.608	3.73	0.17	0.74	4pneB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
32	0.13	0.589	3.10	0.17	0.69	3d2lC	GO:0008168 GO:0016740 GO:0032259
33	0.13	0.512	3.30	0.11	0.61	3ccfB	GO:0008152 GO:0008168 GO:0016740 GO:0030798 GO:0032259
34	0.13	0.512	3.03	0.16	0.61	3cc8A
35	0.13	0.592	3.53	0.16	0.72	4qvgC	GO:0008168 GO:0008171 GO:0032259
36	0.12	0.483	2.88	0.10	0.56	3grzB	GO:0005737 GO:0006479 GO:0008168 GO:0008276 GO:0016740 GO:0032259
37	0.12	0.545	3.12	0.14	0.65	3g5lA
38	0.11	0.523	4.05	0.12	0.67	5bp7A	GO:0005737 GO:0008168 GO:0008757 GO:0016740 GO:0032259
39	0.07	0.595	3.71	0.08	0.74	3ggdA
40	0.07	0.550	3.01	0.19	0.65	3bkwA	GO:0008152 GO:0008168 GO:0032259
41	0.07	0.605	3.93	0.14	0.76	4mwzB	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
42	0.07	0.569	3.43	0.08	0.69	1y8cA	GO:0008168 GO:0016740 GO:0032259
43	0.07	0.545	3.86	0.17	0.69	5bp9A	GO:0008168 GO:0016740 GO:0032259
44	0.07	0.472	3.05	0.12	0.55	1ne2B
45	0.07	0.484	3.94	0.13	0.62	3fzgA	GO:0008168 GO:0008649 GO:0031167 GO:0032259 GO:0046677 GO:0046872 GO:0051536 GO:0051539
46	0.07	0.561	3.56	0.19	0.68	3dliA
47	0.07	0.559	4.24	0.11	0.72	2o57A
48	0.07	0.530	3.82	0.17	0.66	4dcmA	GO:0003676 GO:0005737 GO:0006364 GO:0008168 GO:0008990 GO:0016740 GO:0031167 GO:0032259 GO:0052916 GO:0070475

Consensus prediction of GO terms

Molecular Function	GO:0008649
GO-Score	0.52
Biological Processes	GO:0000462	GO:0000466	GO:0070475	GO:0000054	GO:0036265	GO:0000479
GO-Score	0.52	0.52	0.52	0.52	0.52	0.52
Cellular Component	GO:0043232	GO:0031981
GO-Score	0.52	0.52

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.