I-TASSER results

I-TASSER results for job id Rv3026c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (304 residues)
MSAPAVTEHSWLPRATCGVSCVSVGDAAQVRRPLVVLRVALRVMLALLLVPGVPLVVMPL
PGRTRVQRIYCRLVLRLFGVRITVSGSPVRNLRGVLVVSGHVSWLDVFCIGSVLPGSFVA
RADMFTGRTIGIVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVAFPEGTTWCGRP
GDDAGRPAARAGAGCSHRGCGAFYPAMFQAAIDAGRPVQPLRLTYHHVDGTVSTAPAFVG
DDTLVRSVCRLLTVRRTLAWVRVESLQLPGTDRRNLARRCQSAVLAGALGQSGQRPGRRH
VPAT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSAPAVTEHSWLPRATCGVSCVSVGDAAQVRRPLVVLRVALRVMLALLLVPGVPLVVMPLPGRTRVQRIYCRLVLRLFGVRITVSGSPVRNLRGVLVVSGHVSWLDVFCIGSVLPGSFVARADMFTGRTIGIVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVAFPEGTTWCGRPGDDAGRPAARAGAGCSHRGCGAFYPAMFQAAIDAGRPVQPLRLTYHHVDGTVSTAPAFVGDDTLVRSVCRLLTVRRTLAWVRVESLQLPGTDRRNLARRCQSAVLAGALGQSGQRPGRRHVPAT
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCEEEEHCCCCHHHHHHHHHHCCCEEEEHHHHHHCCHHHHHHHHHCCEEEHCCCHHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
Conf.Score	9999888898877888887666788876556999999999999999999999999874677658999999999999989889998787889898899985886689999987468567775777758799999999899898689989999999999999997997999689889999877777666666666778887666447899999998998899999985889987766776677658999999998699599999879899999999999999999999999875557777789999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSAPAVTEHSWLPRATCGVSCVSVGDAAQVRRPLVVLRVALRVMLALLLVPGVPLVVMPLPGRTRVQRIYCRLVLRLFGVRITVSGSPVRNLRGVLVVSGHVSWLDVFCIGSVLPGSFVARADMFTGRTIGIVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVAFPEGTTWCGRPGDDAGRPAARAGAGCSHRGCGAFYPAMFQAAIDAGRPVQPLRLTYHHVDGTVSTAPAFVGDDTLVRSVCRLLTVRRTLAWVRVESLQLPGTDRRNLARRCQSAVLAGALGQSGQRPGRRHVPAT
Prediction	7544637523021313012210344523311212112223233233232233221100023212200000012001003030304245136720000000321301000000131100001210340100000033040010217436403500530261056421000000000243544444433434344444442123013000310361701000000003246154442100013230040012004345020102012033677404300530251025204634564456754458
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCEEEEHCCCCHHHHHHHHHHCCCEEEEHHHHHHCCHHHHHHHHHCCEEEHCCCHHHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
MSAPAVTEHSWLPRATCGVSCVSVGDAAQVRRPLVVLRVALRVMLALLLVPGVPLVVMPLPGRTRVQRIYCRLVLRLFGVRITVSGSPVRNLRGVLVVSGHVSWLDVFCIGSVLPGSFVARADMFTGRTIGIVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVAFPEGTTWCGRPGDDAGRPAARAGAGCSHRGCGAFYPAMFQAAIDAGRPVQPLRLTYHHVDGTVSTAPAFVGDDTLVRSVCRLLTVRRTLAWVRVESLQLPGTDRRNLARRCQSAVLAGALGQSGQRPGRRHVPAT

5l7dA

0.11

0.99

0.69

MUSTER

LVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADYPAVILFYVNACFFVGSIGWLAQFMDGARVCRADGTMRLGEPTSNETLSCVIIFVIVYYALMAGFVWFVTYAWHTSFKALQPLSGKTLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSARRQLADLEDNWETLN-DNLKVIEKADNAAQVKDALTKMRAAALDAQ-KATPPSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAE

5kn7B

0.12

0.10

0.82

0.83

dPPAS

----------------------------MNYQLLKTFSRQPIQFGRFLARLLAGLVNTLKITYFEFLSIWGSSNSKNISRIHRIEGEHFFAKKGVVLIVPHFGTWEVMNAWCAQSMTILYKADADR--FVREARSREQANLVPTD-----ESGVRQIFKALKQGETTVILPDHTPNVGGDMVNYF------------GVPLASSNLSAKLIQKTKAKALFLYAIRNENDGHIEPMDEKIYEGTADDGTYVIHQANP-------ALDNIYNIDPTEALKIVDRLKAEALKTSTQPEPIQTSVM--

1k30A2

0.15

0.11

0.72

1.83

wdPPAS

-----------------------------------------------------------SSDYYIFGQNYIRPLIDFGNSFVGKDIEEKLQQGNVVLISNHQTEADPAIISLLLETIFVAGDRVLADPLCKPFSIGRNLICVTETKRKANTRSLKEMALLLRGGQLIWIAPSGGRDRPDPS-------------TGEWYPAPFDDNMRRLIQHSDVPLFPLALLCHDIMPPPS------------QVEIEIRVIAFNGAGLSVAPEISTHKNREAYSKALFDSVAMQYNVLKTAISGKQGLGAS

1k30A

0.18

0.15

0.88

0.82

wMUSTER

LSKKETEAGK-LP-PNVAAG--AVIESGNPKADEIVLSNMTVALDRILLDVEDPFVFSSHHKAIRYYIFGQNYIRPLIDFG-FVGNLSLFQGHNVVLISNHQTEADPAIISLLLETIFVAGDRVLADPLCKPFSIGRNLICVTETKRKANTRSLKEMALLLRGGQLIWIAPSGGRDRDPSTGEWYPA--------------PFDDNMRRLIQHSDVPLFPLALLCHDIMPPPSQVIAFNG------------------AGLSVAPEISTHKNREAYSKALFDSVAMQYNVLKTAISGKQGLGAS

1k30A2

0.16

0.12

0.72

1.59

wPPAS

---------------------------------------------------------SSHHKAIRYYIFGQNYIRPLIDFG-FVGNLSLFQGHNVVLISNHQTEADPAIISLLLETIFVAGDRVLADPLCKPFSIGRNLICVTETKRKANTRSLKEMALLLRGGQLIWIAPSGGRDPDPSTGEWYPA--------------PFDDNMRRLIQHSDVPLFPLALLCHDIMPPPS----------QVEIEIRVIAFNG--AGLSVAPEISTHKNREAYSKALFDSVAMQYNVLKTAISGKQGLGAS

5kn7B

0.13

0.10

0.80

1.55

dPPAS2

IALPYLT----------------------PQQRIAITEKAVRNELTSYFEFLSIWGSSNSKNISRIHRIEGEHFFHEA----------LAAKKGVVLIVPHFGTWEVMNAWCAQSMTILYKADADR--FVREARSREQANLVPTD-----ESGVRQIFKALKQGETTVILPDHTPNVGGDMVNY----FGVPLASS--------NLSAKLIQKTKAKALFLYAIRNENDGHIEPMDEKIYEGTADDGTYVIHQAPAL--------DNIYNIDPTEALKIVDRLKAEALKTSTQPEPIQTSVM--

5kn7B

0.12

0.10

0.81

1.00

PPAS

FS--------RQP----------------IQFGRFLARLLAGLVNTLKITRTSKSIEL-PQQRIAITEKAVRNELTSY--IHRIEGEHFFAKKGVVLIVPHFGTWEVMNAWCAQSMTILYKPADADR-FVREARSREQANLVPTD-----ESGVRQIFKALKQGETTVILPDHTPNVGGDMVNY----FGV----------ASSNLSAKLIQKTKAKALFLYAIRNENDGHIEPMDEKIYEGTADDGTYVIHQA---------ALDNIYNIDPTEALKIVDRLKAEALKTSTQPEPIQTSVM--

5kn7B

0.11

0.10

0.89

1.26

Env-PPAS

FS--------RQPIQLLAGLVNTLKITRTSKSIELNLRIAPQQRIAITEKAVRNELTS----YFEFLSIWGSSNSKNISRIHRIEGEHFFHKKGVVLIVPHFGTWEVMNAWCAQSMTILYKPADADR-FVREARSREQANLVPTD-----ESGVRQIFKALKQGETTVILPDHTPNVGGDMVNY----FGVPL--------ASSNLSAKLIQKTKAKALFLYAIRNENDGHIEPMDEKIYEGTADDGTYVIHQAIEQLIYQYPEPALDNNIDPTEALKIVDRLKAEALKTSTQPEPIQTSVM--

4iv9A

0.12

0.95

0.67

MUSTER

ISTSTTFPDPGVVDTELHYRGWPAGKKPLFRRVYEGWQSLLSEGYLLLVAPLDITAMLKSGRLEEAAIAWQGWLNVFRDCSFYFTGRHPPGGDRW------ARPEDFELFGSLGIGS-GGFLPVFQAGFTEILRMVINGYRLIPDGISSLAARLADLRDRVREAEKIIIQ----TEAGEQRVFDRSSNRAMQMIHCLTDSESFLSRDVARAVRE-TGSSKLFILTRTKFWIKNKLPTTIQSDGLVRGVYCLPDEPEGHGVVLLS--MLAMPDKKTRCQVLVDDLAAIHPTFASYLLPVDGDYER

3eqxA1

0.07

0.06

0.81

0.72

dPPAS

---------EWQAEQAYNHLPPLPLDSKLAELAETLPILKACIPARAALAELKQAGELLPNQINLLPLLEAQGSSEIENIV--------------------TTTDKLFQYAQEDSQADPTKEALRYRTALYQCFTQL-------SNRPLCVTTALEICSTIKSVQ-------DVRKVPGTSLTNQATGEVIYTPPAGESVIRDLLSNWEAFLHNQDDVDPLIKAAHYQFEAIHPFIDGNGRTGRVLNILYLIDQQLL---------SAPILYLSRYIVAHKQDYYRLLLNVTTQQEW------Q

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.53

Estimated TM-score = 0.42±0.14

Estimated RMSD = 12.2±4.4Å

Download Model 2

C-score=-3.38

Download Model 3

C-score=-4.24

Download Model 4

C-score=-4.29

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1k30A	0.748	3.76	0.138	0.928
2	5kn7B	0.494	4.11	0.064	0.632
3	2vz8B	0.481	5.71	0.058	0.740
4	3zu2A	0.476	5.36	0.066	0.707
5	5e7pA	0.475	5.52	0.071	0.707
6	4ggoA	0.475	5.37	0.054	0.711
7	4eueA	0.473	5.24	0.073	0.697
8	3s8mA	0.466	5.18	0.062	0.674
9	5kf6A	0.461	6.33	0.106	0.780
10	5it5F	0.455	5.72	0.045	0.681

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	3id7A	ZN	Rep, Mult	101,106,172
2	0.05	3	5d57A	78M	Rep, Mult	273,276,284
3	0.05	3	2ewwA	ATP	Rep, Mult	81,104,105,106,107,108,109,226,258
4	0.03	2	4pr9B	PIO	Rep, Mult	273,274
5	0.03	2	1rxcA	R1P	Rep, Mult	101,144
6	0.02	1	1a82A	MG	Rep, Mult	64,106,172
7	0.02	1	2pywB	EDO	Rep, Mult	96,208,215,217,218
8	0.02	1	4xk8L	CLA	Rep, Mult	19,47
9	0.02	1	1smyF	MG	Rep, Mult	99,280
10	0.02	1	3euhD	GLY	Rep, Mult	171,172
11	0.02	1	1oczB	HEA	Rep, Mult	50,69
12	0.02	1	4k1cA	CA	Rep, Mult	264,287
13	0.02	1	1yxmB	ADE	Rep, Mult	120,121,142,143,171,203
14	0.02	1	4f8hC	LMD	Rep, Mult	282,285
15	0.02	1	3lu2B	ZN	Rep, Mult	101,106
16	0.02	1	1iuqA	GOL	Rep, Mult	49,50,53
17	0.02	1	3ak1B	EDO	Rep, Mult	47,70
18	0.02	1	2b36F	5PP	Rep, Mult	118,119,204,207
19	0.02	1	3k31A	NAD	Rep, Mult	120,143,153,154

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2jfdA	0.330	6.33	0.077	0.562	2.3.1.85	117
2	0.060	2o2yC	0.413	5.03	0.052	0.582	1.3.1.9	NA
3	0.060	1k30A	0.748	3.76	0.138	0.928	2.3.1.15	101,106
4	0.060	3grkB	0.414	4.88	0.105	0.579	1.3.1.9	204,207
5	0.060	2qioA	0.415	4.84	0.101	0.572	1.3.1.9	204,207
6	0.060	3gr6D	0.415	4.84	0.070	0.576	1.3.1.9	NA
7	0.060	2o2sA	0.426	5.13	0.070	0.609	1.3.1.9	NA
8	0.060	1uwkA	0.420	5.69	0.056	0.648	4.2.1.49	NA
9	0.060	2pffD	0.437	5.36	0.056	0.655	2.3.1.86	NA
10	0.060	2dgaA	0.415	6.16	0.068	0.678	3.2.1.21	NA
11	0.060	3ce6A	0.414	6.36	0.055	0.701	3.3.1.1	NA
12	0.060	1nhdD	0.121	3.83	0.019	0.155	1.3.1.9	150
13	0.060	3n58A	0.416	5.68	0.087	0.645	3.3.1.1	78
14	0.060	2vz9B	0.355	5.53	0.061	0.543	2.3.1.85	NA
15	0.060	3h9uC	0.417	6.12	0.056	0.688	3.3.1.1	NA
16	0.060	1d7oA	0.411	5.26	0.021	0.589	1.3.1.9	138
17	0.060	1yxmA	0.434	4.69	0.077	0.609	1.3.1.38	173
18	0.060	2fr0A	0.420	5.00	0.049	0.599	2.3.1.94	NA
19	0.060	2ptgB	0.358	4.79	0.040	0.497	1.3.1.9	289

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.748	3.76	0.14	0.93	1k30A	GO:0004366 GO:0006629 GO:0006650 GO:0008152 GO:0008654 GO:0009507 GO:0009536 GO:0009570 GO:0016024 GO:0016740 GO:0016746
1	0.07	0.435	4.89	0.08	0.62	4fc6B	GO:0005102 GO:0005777 GO:0005778 GO:0006629 GO:0006631 GO:0006636 GO:0008670 GO:0016491 GO:0019166 GO:0044255 GO:0055114
2	0.06	0.408	4.82	0.05	0.58	4j1qA	GO:0003824 GO:0005737 GO:0008152 GO:0016740 GO:0016746 GO:0016874 GO:0017000 GO:0031177
3	0.06	0.378	5.68	0.07	0.58	2et6A	GO:0003824 GO:0005777 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0016491 GO:0016616 GO:0016829 GO:0016853 GO:0055114
4	0.06	0.392	5.09	0.07	0.57	4k6cA	GO:0000166 GO:0005737 GO:0016491 GO:0018454 GO:0042619 GO:0055114
5	0.06	0.369	6.41	0.04	0.62	5a2aA	GO:0003824 GO:0004556 GO:0005975 GO:0008152 GO:0016020 GO:0016021 GO:0016787 GO:0016798
6	0.06	0.399	4.68	0.07	0.56	4nbuB	GO:0000166 GO:0016491 GO:0055114
7	0.06	0.394	4.79	0.06	0.56	3ezlA	GO:0005737 GO:0016491 GO:0018454 GO:0042619 GO:0055114
8	0.06	0.388	5.57	0.07	0.59	5d2eA	GO:0003824 GO:0008152 GO:0031177
9	0.06	0.400	4.90	0.07	0.57	3vzpB	GO:0005737 GO:0016491 GO:0018454 GO:0042619 GO:0055114
10	0.06	0.380	4.65	0.07	0.53	5cejA	GO:0004316 GO:0006633 GO:0016491 GO:0051287 GO:0055114 GO:0102132
11	0.06	0.391	5.03	0.07	0.57	1q7bA	GO:0004316 GO:0005829 GO:0006629 GO:0006631 GO:0006633 GO:0008610 GO:0009102 GO:0016491 GO:0030497 GO:0042802 GO:0046872 GO:0050661 GO:0051287 GO:0055114 GO:0102132
12	0.06	0.394	4.82	0.06	0.56	3osuA	GO:0004316 GO:0006629 GO:0006631 GO:0006633 GO:0016491 GO:0051287 GO:0055114 GO:0102132
13	0.06	0.402	4.93	0.07	0.57	4bo4C	GO:0004316 GO:0006629 GO:0006631 GO:0006633 GO:0016491 GO:0030497 GO:0050661 GO:0051287 GO:0055114 GO:0102132
14	0.06	0.367	5.05	0.01	0.53	2obyA	GO:0003960 GO:0005829 GO:0006739 GO:0008270 GO:0016491 GO:0042803 GO:0042981 GO:0048038 GO:0055114 GO:0070062 GO:0070402
15	0.06	0.357	6.34	0.06	0.59	5e5nC	GO:0003824 GO:0005737 GO:0008152 GO:0016491 GO:0016740 GO:0016746 GO:0017000 GO:0031177 GO:0055114
16	0.06	0.319	6.24	0.03	0.53	5bp1A	GO:0003824 GO:0008152 GO:0016491 GO:0016740 GO:0016746 GO:0031177 GO:0050111 GO:0055114
17	0.06	0.372	5.56	0.06	0.57	1zsyA	GO:0005634 GO:0005737 GO:0005739 GO:0006629 GO:0006631 GO:0006633 GO:0008270 GO:0016491 GO:0019166 GO:0055114
18	0.06	0.397	5.13	0.05	0.57	5c37A	GO:0001649 GO:0003824 GO:0004312 GO:0004313 GO:0004314 GO:0004315 GO:0004316 GO:0004317 GO:0004319 GO:0004320 GO:0005737 GO:0005739 GO:0005794 GO:0005829 GO:0005886 GO:0005913 GO:0006084 GO:0006629 GO:0006631 GO:0006633 GO:0008144 GO:0008152 GO:0009058 GO:0015939 GO:0016020 GO:0016295 GO:0016296 GO:0016297 GO:0016491 GO:0016740 GO:0016787 GO:0016788 GO:0016829 GO:0019171 GO:0030879 GO:0031177 GO:0031325 GO:0035338 GO:0042470 GO:0042587 GO:0042802 GO:0042803 GO:0044822 GO:0047117 GO:0047451 GO:0055114 GO:0070062 GO:0070402 GO:0071353 GO:0098609 GO:0098641 GO:0102132

Consensus prediction of GO terms

Molecular Function	GO:0016740
GO-Score	0.36
Biological Processes	GO:0044710	GO:0044238	GO:0071704
GO-Score	0.47	0.40	0.38
Cellular Component	GO:0009570	GO:0005778
GO-Score	0.12	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.