I-TASSER results

I-TASSER results for job id Rv3015c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (337 residues)
MSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVA
IDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVA
GLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRL
TGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDAST
LQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRL
GVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI
Prediction	CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEHCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHCCHHHHHHHHHCCCCCCEHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
Conf.Score	9887764445679999999999999998467788765578888877789999986687677775774788588875578899999876678999999987656899858997687776666344799754468678999999999999999999999969987999858867776467667766554444565799999999999756886799858999989999977998999977788867899999997569889977756899888889999999999999998998666544366678889999999999999999999999999987559
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI
Prediction	7542030000001224304300410154116400100000710340200010021034030333442120044344224202410450041024104423453452100000000000000031454330032541023003200520251044016527130000000000220132423424424314314262024003200541713000000024230520370602000010132446105202501636210000000033553264054005202500551414472024200000000014242720240051024005303642667
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEHCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHCCHHHHHHHHHCCCCCCEHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
MSVFATATGIGSWPGTAAREAAQVVVGELAGALAYLTELPARGVGADMLGRAGGLLVDVAIDTVPRGYRIAARPGAVTRRAASLLDEDMDALEEAWETAGLRGCGRAVKVQAPGPVTLVAGLELANGHRAITDPGAVRDLAASLAEGVAAHRAALARRLDTPVVVQFDEPSLPAALGGRLTGVTALSPVAPLDETVAEALLDTCIAAVDADVALHSCSPDLPWDLLQRSRISAVSVDASTLQAADLDAVAAFVESGRTVVLGLVPVTAPERAPSMEEVAAAAVAVTDRLGVPRSALRDRLGVSPACGLANATGQWARTAVGLARDVAEAFARDPEAI

1xr2B

0.17

0.15

0.91

1.50

MUSTER

LPLF-PTTTIGSFPQTSKEEYEAFIKEQIKKGLDVLVH---EFERTDMVEFFAEKLNGIATTQNGWVLSYGSRCYRPPIIYGTVTRP--EPMTLKEITYAQSLTEKPVKGMLTGPVTIMSWSYYREDIP-------EREIAYQIALAINEEVKDLEEAGIK--IVQIDEPAFREKAPIKKSKWPEY-----FEWAINAFNLAANA-RPETQIHAHMCYSDFNIEYIHQLEFDVISIEASRSKGEIISAFENFKGWIKQIGVGVWDIHSP-AVPSINEMREIVERVLRVLP------KELIWINPDCGLKTRNWDEVIPSLRNMVALAKEMREK----

2nq5A2

0.19

0.15

0.80

1.90

dPPAS

LPLL-PTTTIGSFPQDAQAEIERWIRIQEDLDLDVLVH--GEFERVDMVEFFGQKLAGFTTPIIYGDVQHLEPI------------------TVEETVYAQSLTDRPVKGMLTGPITITNWSFERTDIP-------RDQLFNQIGLAIKDEIKLLENAGIA--IIQVDEAALREGLPLR-----KSKQKAYLDDAVHAFHIATSSVKDETQIHTHMCYSKFDIDAIRALDADVISILG--------------------IGLGVYDIHSP-RVPTKEEVVANIERPLRQLSPT------QFWVNPDCGLKTRQEPETIAALKVLVAATKEVRQK----

2nq5A2

0.20

0.16

0.80

2.63

wdPPAS

LPLL-PTTTIGSFPQDAQAEIERWIRIQEDLDLDVLVH--GEFERVDMVEFFGQKLAGFT--------IIYGD-------------QHLEPITVEETVYAQSLTDRPVKGMLTGPITITNWSFERTDIP-------RDQLFNQIGLAIKDEIKLLENAGIA--IIQVDEAALREGLPLR-----KSKQKAYLDDAVHAFHIATSSVKDETQIHTHMCYSKFDIDAIRALDADVISILG--------------------IGLGVYDIHSP-RVPTKEEVVANIERPLRQLS------PTQFWVNPDCGLKTRQEPETIAALKVLVAATKEVRQK----

1u1uA2

0.19

0.17

0.88

1.62

wMUSTER

LPIL-PTTTIGSFPQTVKEEIKKVVDLQEELDIDVLVHGEPER---NDVEYFGEQLSGFAFTANGWVQSYGSRCVKPPVIYGDV--SRPKATVFWS--AAQSTSRPK---GLTGPVTILNWSFVRNDQP-------RHETCYQIALAIKDEVEDLEKGGIG--VIQIDEAALREGLPLRKSEHAFY-----LDWAVHSFRITNCGVQDSTQIHTHCY-SHFNIHSIID-DADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSP-RIPSSEEIADRVNKL-AVLE------QNILWVNPDCGLKTRKYTEVKPALKN-VDAAKLIRSQ----

2nq5A2

0.20

0.16

0.80

2.81

wPPAS

LPLL-PTTTIGSFPQDAQAEIERWIRIQEDLDLDVLVH--GEFERVDMVEFFGQKLAGFT--------IIYGD-------------QHLEPITVEETVYAQSLTDRPVKGMLTGPITITNWS-------FERTDIPRDQLFNQIGLAIKDEIKLLENAGIA--IIQVDEAALREGLPLR-----KSKQKAYLDDAVHAFHIATSSVKDETQIHTHMCYSKFDIDAIRALDADVISILG--------------------IGLGVYDIHSP-RVPTKEEVVANIERPLRQLS------PTQFWVNPDCGLKTRQEPETIAALKVLVAATKEVRQK----

2nq5A2

0.20

0.16

0.80

5.67

dPPAS2

LPLL-PTTTIGSFPQDAQAEIERWIRIQEDLDLDVLVH--GEFERVDMVEFFGQKLAGFTT---PIIYGDVQHLE---------------PITVEETVYAQSLTDRPVKGMLTGPITITNWS-------FERTDIPRDQLFNQIGLAIKDEIKLLENAGIA--IIQVDEAALREGLPLR-----KSKQKAYLDDAVHAFHIATSSVKDETQIHTHMCYSKFDIDAIRALDADVISILG--------------------IGLGVYDIHSP-RVPTKEEVVANIERPLRQLSP------TQFWVNPDCGLKTRQEPETIAALKVLVAATKEVRQK----

3ppcA2

0.21

0.18

0.89

2.41

PPAS

LPLF-PTTTIGSFPQITAEEYEAFINKEIETVVRFQEEIGLDVERNDMVQYFGEQLNGFAFTVQSYGSRYVRPPIIVGDVSRP------KAMTVKESVYAQSITSKPMKGMLTGPVTILRWSFP-------RDDVSGKIQALQLGLALRDEVNDLEGAGIT--VIQVDEPAIREGLPLR----AGKERSDYLNWAAQSFRVATSGVENSTQIHSHFCYSDLDPNHIKALDADVVSIEFSPNYIQEFS------EYPNHIGLGLFDIHSP-RIPSKQEFVSRIEEILKVYP------ASKFWVNPDCGLKTRGWPEVKESLTNMVEAAKEFRAKY---

1ypxA

0.17

0.15

0.86

3.41

Env-PPAS

VAPFY-ADHVGSILRTTALELRKIENTEIKYIVEKQKEVITDGEFRRWHFDFLENLDGVEG----YSVKITGPIDF------------TTHPFIEDFIFLKEAVGDNHVAKQTIPSPALHYRGDIEYQPYLDD---AEKFANDLATAYQKAIQAFYDAGCR--YLQLDDTSWSYLCSDEGFDPETL-------QETYKNLINEAIKHKPADVITHICRGGYGETLFGKLNIDGFFLEYDNERFAPLKYVT---RPDLKIVLGLITSKTG--EEDEAAIKARIEEASEIVP------LSQLRLSPQCGFA--TEEEQWDKLRYVVRLANDIWGE----

2nq5A

0.18

0.15

0.85

1.43

MUSTER

LPLL-PTTTIGSFPQDAIQAEIERWIRIQEDDLDVLVH---EFERVDMVEFFGQKLAGFTTTKFGWVQSYGSRAVKPPIIYGDVQHL--EPITVEETVYAQSLTDRPVKGMLTGPITITNWSFERTDIP-------RDQLFNQIGLAIKDEIKLLENAGIA--IIQVDEAALREGLPLRKSKQKAY-----LDDAVHAFHIATSSVKDETQIHTHMCYSKFDIDAIRALDADVISILG--------------------IGLGVYDIHSP-RVPTKEEVVANIERPLRQLS------PTQFWVNPDCGLKTRQEPETIAALKVLVAATKEVRQK----

1ypxA

0.18

0.15

0.85

1.86

dPPAS

VAPF-YADHVGSILRTKNTEIKYIVEKQKEVGLKSITD----GEFRRWHFDFLENLDGVEG----YSVKITGPIDFTTH----------PFIEDFIFLKEAVGDNHVAKQTIPSPALHYRGDIEYQPYL-----DDAEKFANDLATAYQKAIQAFYDAGCRY--LQLDDTSWSYLCSDEGFDPETL-------QETYKNLINEAIKHKPADVITHICRGGYGETLFGKLNIDGFFLEYDNERFAPLKYVT---RPDLKIVLGLITSKTG--EEDEAAIKARIEEASEIVP------LSQLRLSPQCGFAT--EEEQWDKLRYVVRLANDIWGE----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.31

Estimated TM-score = 0.75±0.10

Estimated RMSD = 5.8±3.6Å

Download Model 2

C-score=-2.96

Download Model 3

C-score=-3.39

Download Model 4

C-score=-3.30

Download Model 5

C-score=-4.42

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1xr2B	0.860	1.70	0.163	0.911
2	1u1uA2	0.829	1.82	0.201	0.884
3	2nq5A	0.810	1.65	0.170	0.855
4	1ypxA	0.747	2.81	0.147	0.846
5	3cyvA	0.731	3.33	0.113	0.861
6	1jpkA	0.725	3.45	0.112	0.864
7	2infA	0.721	3.37	0.089	0.855
8	1j93A	0.709	3.49	0.110	0.858
9	2ejaA	0.708	3.53	0.131	0.852
10	1qbaA	0.662	4.94	0.071	0.899

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.45	19	1xdjA	ZN	Rep, Mult	215,217,237,306
2	0.30	10	1u1hA	MET	Rep, Mult	10,11,12,42,48,111,168,170,215,217,306,307
3	0.09	6	1xr2B	C2F	Rep, Mult	46,65,69,70,121,174
4	0.01	1	2inf0	III	Rep, Mult	132,173,174,238,266,272,278,306
5	0.01	1	3cyv0	III	Rep, Mult	132,174,176,238,277
6	0.01	1	1u1hA	ZN	Rep, Mult	224,228

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.267	1xi3A	0.461	3.51	0.100	0.564	2.5.1.3	235
2	0.258	2infA	0.721	3.37	0.089	0.855	4.1.1.37	47
3	0.256	1j93A	0.709	3.49	0.110	0.858	4.1.1.37	47
4	0.182	1tqxA	0.480	3.91	0.063	0.602	5.1.3.1	NA
5	0.145	2infC	0.722	3.45	0.092	0.858	4.1.1.37	NA
6	0.121	3cyvA	0.731	3.33	0.113	0.861	4.1.1.37	47
7	0.102	1j2wA	0.479	3.39	0.112	0.579	4.1.2.4	NA
8	0.095	1nsjA	0.466	3.58	0.089	0.564	5.3.1.24	NA
9	0.093	2v81A	0.473	3.51	0.119	0.576	4.1.2.21	NA
10	0.075	1vcvA	0.500	3.30	0.110	0.594	4.1.2.4	NA
11	0.067	3f4wA	0.481	3.63	0.121	0.591	4.1.2.-	7,214
12	0.067	2czfA	0.466	3.78	0.046	0.582	4.1.1.23	NA
13	0.067	1xi3B	0.461	3.55	0.099	0.567	2.5.1.3	319
14	0.067	1w0mA	0.487	3.66	0.132	0.596	5.3.1.1	NA
15	0.066	2cz5A	0.476	3.55	0.062	0.579	4.1.1.23	220
16	0.066	1mxsA	0.468	3.58	0.089	0.570	4.1.2.14	NA
17	0.066	2h6rB	0.469	3.50	0.073	0.570	5.3.1.1	NA
18	0.066	1mzhA	0.489	3.82	0.067	0.608	4.1.2.4	NA
19	0.060	1o7aA	0.646	4.41	0.041	0.846	3.2.1.52	86,87
20	0.060	2pbgA	0.648	3.98	0.050	0.828	3.2.1.85	NA
21	0.060	2e9lA	0.645	4.01	0.060	0.834	3.2.1.21	NA
22	0.060	1kwgA	0.642	4.11	0.106	0.831	3.2.1.23	NA
23	0.060	1gowA	0.643	4.42	0.064	0.855	3.2.1.23	NA
24	0.060	1uroA	0.725	3.46	0.109	0.864	4.1.1.37	308
25	0.060	1c7sA	0.664	4.88	0.077	0.899	3.2.1.52	NA
26	0.060	1veoA	0.649	4.00	0.082	0.831	3.2.1.2	NA
27	0.060	1b90A	0.649	4.17	0.074	0.840	3.2.1.2	NA
28	0.060	1bgaA	0.644	4.11	0.070	0.834	3.2.1.21	NA
29	0.060	1gnxA	0.646	4.04	0.099	0.828	3.2.1.21	NA
30	0.060	1fa2A	0.653	4.31	0.055	0.858	3.2.1.2	NA
31	0.060	2ejaA	0.708	3.53	0.131	0.852	4.1.1.37	47
32	0.060	3bq5A	0.854	1.70	0.164	0.905	2.1.1.14	NA
33	0.060	2gjxA	0.645	4.46	0.044	0.849	3.2.1.52	86,87
34	0.060	1t7lA	0.866	1.69	0.165	0.917	2.1.1.14	NA
35	0.060	2nq5A	0.810	1.65	0.170	0.855	2.1.1.14	NA
36	0.060	1qbaA	0.662	4.94	0.071	0.899	3.2.1.52	NA
37	0.060	3cmjA	0.648	3.92	0.108	0.822	3.2.1.21	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.56	0.864	1.75	0.19	0.92	1u1hA	GO:0003871 GO:0005507 GO:0005737 GO:0005774 GO:0005777 GO:0005794 GO:0005829 GO:0005886 GO:0008168 GO:0008270 GO:0008652 GO:0008705 GO:0009086 GO:0009506 GO:0009507 GO:0009570 GO:0009651 GO:0010043 GO:0016020 GO:0016740 GO:0032259 GO:0046686 GO:0046872 GO:0048046 GO:0050667
1	0.49	0.854	1.70	0.16	0.91	3bq5A	GO:0003871 GO:0005576 GO:0005829 GO:0008168 GO:0008270 GO:0008652 GO:0008705 GO:0009086 GO:0016740 GO:0032259 GO:0046872 GO:0050667
2	0.49	0.866	1.69	0.17	0.92	1t7lA	GO:0003871 GO:0005576 GO:0005829 GO:0008168 GO:0008270 GO:0008652 GO:0008705 GO:0009086 GO:0016740 GO:0032259 GO:0046872 GO:0050667
3	0.47	0.778	3.03	0.11	0.89	3ppfA	GO:0003871 GO:0006555 GO:0008168 GO:0008270 GO:0008652 GO:0009086 GO:0009277 GO:0009986 GO:0016740 GO:0030446 GO:0032259 GO:0034605 GO:0044416 GO:0046872
4	0.46	0.864	1.63	0.17	0.91	3t0cA	GO:0003871 GO:0008168 GO:0008270 GO:0008652 GO:0009086 GO:0016740 GO:0032259 GO:0046872
5	0.37	0.822	2.05	0.19	0.89	3ppcB	GO:0003871 GO:0006555 GO:0008168 GO:0008270 GO:0008652 GO:0009086 GO:0009277 GO:0009986 GO:0016740 GO:0030446 GO:0032259 GO:0034605 GO:0044416 GO:0046872
6	0.33	0.857	2.03	0.18	0.93	4ztxA	GO:0003871 GO:0008168 GO:0008270 GO:0008652 GO:0009086 GO:0016740 GO:0032259
7	0.28	0.755	2.80	0.15	0.85	1ypxA	GO:0003871 GO:0005576 GO:0005829 GO:0008270 GO:0008705 GO:0009086 GO:0032259 GO:0050667
8	0.16	0.830	2.31	0.19	0.91	4qquA	GO:0003871 GO:0006555 GO:0008168 GO:0008270 GO:0008652 GO:0009086 GO:0009277 GO:0009986 GO:0016740 GO:0030446 GO:0032259 GO:0034605 GO:0044416 GO:0046872
9	0.15	0.801	2.45	0.16	0.88	3rpdA	GO:0003871 GO:0008168 GO:0008270 GO:0009086 GO:0016740 GO:0032259
10	0.07	0.590	4.58	0.04	0.80	3emcA	GO:0000272 GO:0004553 GO:0005737 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0045493
11	0.07	0.513	4.60	0.06	0.68	3thuA	GO:0000287 GO:0003824 GO:0005975 GO:0008152 GO:0008927 GO:0009063 GO:0016052 GO:0016829 GO:0046872
12	0.06	0.417	6.13	0.07	0.66	3ooqF	GO:0016787 GO:0016810 GO:0019239
13	0.06	0.310	6.76	0.04	0.54	4v38A	GO:0016740 GO:0016757
14	0.06	0.311	6.82	0.04	0.54	2ii6A	GO:0016740 GO:0016757
15	0.06	0.278	6.98	0.06	0.49	1jhdA	GO:0000103 GO:0000166 GO:0004781 GO:0005524 GO:0016740 GO:0016779 GO:0070814
16	0.06	0.279	7.11	0.05	0.50	4dnxA	GO:0000103 GO:0000166 GO:0004781 GO:0005524 GO:0016740 GO:0016779 GO:0070814
17	0.06	0.268	4.17	0.06	0.35	3ewqA	GO:0001172 GO:0003723 GO:0003968 GO:0004197 GO:0006508 GO:0008233 GO:0008234 GO:0008242 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016740 GO:0016787 GO:0019079 GO:0019082 GO:0030430 GO:0030683 GO:0033644 GO:0036459 GO:0039503 GO:0039520 GO:0039548 GO:0039648 GO:0044220 GO:0046872
18	0.06	0.282	6.96	0.05	0.50	2cy8A	GO:0003824 GO:0008483 GO:0016740 GO:0030170

Consensus prediction of GO terms

Molecular Function	GO:0003871	GO:0008270	GO:0008705	GO:0005507
GO-Score	0.97	0.97	0.89	0.56
Biological Processes	GO:0032259	GO:0009086	GO:0050667	GO:0010043	GO:0046686	GO:0009651	GO:0044416	GO:0034605
GO-Score	0.97	0.97	0.89	0.56	0.56	0.56	0.47	0.47
Cellular Component	GO:0005829	GO:0005774	GO:0009506	GO:0009570	GO:0005794	GO:0048046	GO:0005886	GO:0005777	GO:0030446	GO:0009986
GO-Score	0.89	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.47	0.47

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.