I-TASSER results

I-TASSER results for job id Rv2990c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (286 residues)
MCVTWAEMPKIAALIRHIEDLHARHGRSYILRAGISSLFRYIEGVHGERPWGTVLDAGTG
VKSLQWIQTLPTERWTAVTAARSLADKTRAALGSAMRPQDRLLVGNWVDDSLLAGETFDT
ILVDYLVGAIEGFAPYWQDRVFERLRPHLADHGRLYLVGLEPYVQFEPETESGKIIWEIG
RVRDACLLLAGERPYREFPLDWMLGRLGLAGFRILEARRFPIRYRARYVNGQLNMCLARI
ERFSSNGLGMAMRAYVEELRARALQLNERQDGLWHGNDYVIAVEPM

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MCVTWAEMPKIAALIRHIEDLHARHGRSYILRAGISSLFRYIEGVHGERPWGTVLDAGTGVKSLQWIQTLPTERWTAVTAARSLADKTRAALGSAMRPQDRLLVGNWVDDSLLAGETFDTILVDYLVGAIEGFAPYWQDRVFERLRPHLADHGRLYLVGLEPYVQFEPETESGKIIWEIGRVRDACLLLAGERPYREFPLDWMLGRLGLAGFRILEARRFPIRYRARYVNGQLNMCLARIERFSSNGLGMAMRAYVEELRARALQLNERQDGLWHGNDYVIAVEPM
Prediction	CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEHCCCCCHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEEHCHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHCCCEEEEEHCC
Conf.Score	9877665655788999888877656764445777569999999997578875588758886688899867778589987789999999999876567765798777778776787745566567788887655655689999999998588978999976666666778875567777888888899886678765564999999998879689876765544566677677888988887757889999999999999999998876546645546479987659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MCVTWAEMPKIAALIRHIEDLHARHGRSYILRAGISSLFRYIEGVHGERPWGTVLDAGTGVKSLQWIQTLPTERWTAVTAARSLADKTRAALGSAMRPQDRLLVGNWVDDSLLAGETFDTILVDYLVGAIEGFAPYWQDRVFERLRPHLADHGRLYLVGLEPYVQFEPETESGKIIWEIGRVRDACLLLAGERPYREFPLDWMLGRLGLAGFRILEARRFPIRYRARYVNGQLNMCLARIERFSSNGLGMAMRAYVEELRARALQLNERQDGLWHGNDYVIAVEPM
Prediction	6023215133002004204502344144312335231003203533674411300202323410311142444301002224511540463254443341300000023451136440100002100100210022312300530261034401000000221363457361030013024123001310463112510150035107434131140331113134520342041035305404574025204520540353036145544313211200000358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEHCCCCCHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEEEHCHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHCCCEEEEEHCC
MCVTWAEMPKIAALIRHIEDLHARHGRSYILRAGISSLFRYIEGVHGERPWGTVLDAGTGVKSLQWIQTLPTERWTAVTAARSLADKTRAALGSAMRPQDRLLVGNWVDDSLLAGETFDTILVDYLVGAIEGFAPYWQDRVFERLRPHLADHGRLYLVGLEPYVQFEPETESGKIIWEIGRVRDACLLLAGERPYREFPLDWMLGRLGLAGFRILEARRFPIRYRARYVNGQLNMCLARIERFSSNGLGMAMRAYVEELRARALQLNERQDGLWHGNDYVIAVEPM

2yqzA

0.12

0.11

0.90

1.50

MUSTER

-----------SSALLRAAYAYDRLRA--HPPEVAGQIATAASAVHPKGEEPVFLELGVGTGRIALPLIARGYRYIALDADA-ALEVFRQKIAG-VDRKVQVVQADARAIPL-PDESVHGVIVVHLWHLVPD-----WPKVLAEAIRVLKPGGALLEGWD-----QAEASPEWTLQERWRAFAAEEGF-PVERGLHAKRLKEVEEALRRLGLRTREVARWREERTPREALEALSERLYSFTQGLPEPVHARVERLWAWAEAELGDLDR---PFPVEKRFLLRVSRL

3kkzA

0.11

0.09

0.86

1.51

dPPAS

--------KTIHDFELNLICDFFSNERQG--PGSPEVTLKALSFIDNLTEKSLIADIGCGTGGQTVLAGHVTGQVTGLDFLSGFIDIFNRNARQSGLQNRVTGIVGSDDLPF-RNEELDLIWSEGAIYNIG------FERGLNEWRKYLKKGGYLAVSECSWFTDERP-----------AEINDFWDAYPEIDT-----IPNQVAKIHKAGYLPVATFILP---ENCWTDHYFTPKVAAQKIFLTKYAGNKIAEEFSLQSIEEELYHKYKEYYGY---TFFIAKKI

3mggA

0.14

0.11

0.83

1.94

wdPPAS

-----------------------------------ETLEKLLHHDTVYPPGAKVLEAGCGIGAQTVILAKNNAEITSIDISPESLEKARENTEKNGIKNVKFLQANIFSLPF-EDSSFDHIFVCFVLEHLQS-----PEEALKSLKKVLKPGGTITVIEGD-HGSCYFHPEGKKAIEAWNCLIRVQAYKGNSLV-----GRQIYPLLQESGFEKIRVEPRVYIDSPELVDGFILKTIIPVEGVKEQSLKQIKEEEWEKGIEELHKTAEHGGTFCYTFFKGWGTK--

2yqzA

0.12

0.10

0.89

1.77

wMUSTER

--------------SSALLRAAYAYDRLRAHPPEAGQIATAASAVHPKGEEPVFLELGVGTGRIALPLIARGYRYIALDADA-ALEVFRQKIAGVD-RKVQVVQADARAIPL-PDESVHGVIVVHLWHLVPD-----WPKVLAEAIRVLKPGGALLEGWD-----QAEASPEWTLQERWRAFAAEEGF-PVERGLHAKRLKEVEEALRRLGLKPRTREVARWRRTPREALEALSERLYSFTQGLPEPVHARVERLWAWAEAELGDL---DRPFPVEKRFLLRVSRL

2yqzA

0.16

0.14

0.90

2.25

wPPAS

--------------SSALLRAAYAYDRRAHPPEVAGQIATAASAVHPKGEEPVFLELGVGTGRIALPLIARGYRYIALDADA-ALEVFRQKIAGVD-RKVQVVQADARAIPL-PDESVHGVIVVHLWHLVPD-----WPKVLAEAIRVLKPGGALLEGWDQ------AEASPEWTLQERWRAFAAEEGFPVERGLHAKRLKEVEEALRRLGLKPRTREVARWR-EERTPREALEALSERLYSFTQ-GLPEPVHARVERLWAWAEAELDLDRPFPVEKRFLLRVSRL

3kkzA

0.11

0.09

0.86

2.29

dPPAS2

--------KTIHDFELNLICDFFSNERQG--PGSPEVTLKALSFIDNLTEKSLIADIGCGTGGQTVLAGHVTGQVTGLDFLSGFIDIFNRNARQSGLQNRVTGIVGSDDLPF-RNEELDLIWSEGAIYNIG------FERGLNEWRKYLKKGGYLAVSECSWFTDERP-----------AEINDFWDAYPEIDT-----IPNQVAKIHKAGYLPVATFILP---ENCWTDHYFTPKVAAQKIFLTKYAGNKIAEEFSLQSIEEELYHKYKEYYGY---TFFIAKKI

2yqzA

0.15

0.13

0.90

1.91

PPAS

----------SSALLRAAYAYDRLRA---HPPEVAGQIATAASAVHPKGEEPVFLELGVGTGRIALPLIARGYRYIALDADA-ALEVFRQKIAG-VDRKVQVVQADARAIPL-PDESVHGVIVVHLWHLVPD-----WPKVLAEAIRVLKPGGALLEGW------DQAEASPEWTLQERWRAFAAEEGFPVERGLHAKRLKEVEEALRRLGLRTREVARWREERTPREALEALSERLYSFTQGLPEPVHARVERLWAWAEAELGDLDR---PFPVEKRFLLRVSRL

4ineA2

0.13

0.12

0.90

2.64

Env-PPAS

--TTDATITFRDFLDKQYTNTGIDAGVNFISPGGYDENLKIIKRFGDFKPGQTMLDIGVGIGGGARQVADEGVHVHGIDLSSNMLAIALERLHEEKDSRVKYSITDALVYQF-EDNSFDYVFSRDCIQHIP-----DTEKLFSRIYKALKPGGKVLITMYGKGYGEQS---------------DKFKTYVAQRAYFLKNLKEIADIANKTGFVNVQTENM-----TPRFKEILLEERGHLEQNEAEFMSKFTQRERDSLISGWTDKLGYIEKDNHNWNFFLAQKPF

4iv0A

0.12

0.10

0.91

1.48

MUSTER

ISEP-VDIKYLENNQDEGIKAYEFIFGEDYISSGGIIATTKILSDIQLDANSKVLDIGSGLGGGCKYINEKGAHVHGVDICEKMVTIAKLRNQ--DKAKIEFEAKDILKKDF-PESTFDMIYSRDSILHL---SYADKKMLFEKCYKWLKPNGILLITDY--------------CADKIENWDEEFKAYIKKRKYTLMPIQEYGDLIKSCKFQNVEAKDISDYW-LELLQLELSKLEEKKEEFLKVYSIKEYNSLKDGWTRKIKDTKR---LQKWG--YFKAQKMI

4ineA2

0.12

0.10

0.91

1.48

dPPAS

-TTDATITFRDFLDKTQYTNTGIDAGVNFISPGGYDENLKIIKRFGDFKPGQTMLDIGVGIGGGARQVADEGVHVHGIDLSSNMLAIALERLHEEKDSRVKYSITDALVYQF-EDNSFDYVFSRDCIQHIPD-----TEKLFSRIYKALKPGGKVLITMYGKGYGEQS---------------DKFKTYVAQRAYFLKNLKEIADIANKTGFVNVQTENM-----TPRFKEILLEERGHLEQNEAEFMSKFTQRERDSLISGWTDKLGYIEKDNHNWNFFLAQKPF

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.98

Estimated TM-score = 0.59±0.14

Estimated RMSD = 8.3±4.5Å

Download Model 2

C-score=-1.22

Download Model 3

C-score=-1.37

Download Model 4

C-score=-2.84

Download Model 5

C-score=-4.72

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1m6eX	0.744	3.68	0.096	0.951
2	5f2kA	0.739	3.69	0.078	0.937
3	2yqzA	0.736	3.14	0.103	0.881
4	5egpA	0.735	3.92	0.111	0.916
5	2eg5E	0.730	3.43	0.115	0.909
6	3g5tA	0.724	3.42	0.090	0.885
7	3b5iA	0.694	3.68	0.092	0.878
8	3mggA	0.676	3.38	0.124	0.815
9	3hemA	0.676	4.43	0.117	0.895
10	4pneA	0.665	3.88	0.110	0.829

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.49	31	1kpgA	SAH	Rep, Mult	28,29,58,59,60,79,80,84,106,107,108,124,125,126,129,130
2	0.02	1	1p91A	SAM	Rep, Mult	26,58,59,60,61,62,63,64,124,125,159,160,277
3	0.02	1	4er6A	AW2	Rep, Mult	41,56,58,59,60,64,79,80,81,105,106,107,122,124,130,156,157,279

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.206	2p35A	0.623	3.57	0.121	0.783	2.1.1.144	58,76
2	0.170	3g5tA	0.724	3.42	0.090	0.885	2.1.1.145	133
3	0.157	2iftA	0.468	3.23	0.124	0.552	2.1.1.52	63,124
4	0.152	3e05D	0.529	2.96	0.101	0.612	2.1.1.132	92,102
5	0.143	2h11B	0.585	3.57	0.101	0.717	2.1.1.67	25,129
6	0.095	2pxxA	0.547	3.16	0.151	0.643	3.4.24.71	NA
7	0.087	2ex4A	0.591	3.34	0.127	0.710	2.1.1.-	128
8	0.067	1f38A	0.523	3.02	0.119	0.608	2.1.1.-	NA
9	0.067	3e05B	0.528	2.92	0.100	0.608	2.1.1.132	NA
10	0.067	3hnrA	0.534	3.58	0.143	0.647	2.1.1.-	NA
11	0.067	2cl5A	0.526	3.08	0.130	0.619	2.1.1.6	NA
12	0.067	3bwmA	0.525	3.15	0.130	0.619	2.1.1.6	NA
13	0.066	3grzB	0.489	2.74	0.163	0.559	2.1.1.-	NA
14	0.060	1xxlA	0.597	3.85	0.130	0.745	2.1.1.-	NA
15	0.060	2qyoA	0.524	4.25	0.084	0.692	2.1.1.46	NA
16	0.060	2fk8A	0.644	4.55	0.120	0.857	2.1.1.-	NA
17	0.060	2o06A	0.542	3.91	0.089	0.685	2.5.1.16	58,60,105
18	0.060	3bgdA	0.581	3.73	0.106	0.720	2.1.1.67	109,129
19	0.060	1wznA	0.586	3.48	0.100	0.692	2.1.1.-	NA
20	0.060	1ri1A	0.594	3.64	0.127	0.727	2.1.1.56	58
21	0.060	1kpiA	0.673	4.43	0.118	0.888	2.1.1.79	NA
22	0.060	3lccA	0.574	3.26	0.145	0.689	2.1.1.-	5,58,129
23	0.060	1kyzE	0.564	3.94	0.116	0.717	2.1.1.68	NA
24	0.060	1im8A	0.583	3.47	0.107	0.699	2.1.1.-	NA
25	0.060	3c6mD	0.537	3.92	0.109	0.675	2.5.1.22	NA
26	0.060	1xcjA	0.569	3.85	0.149	0.713	2.1.1.2	5,124
27	0.060	1kpgA	0.648	4.51	0.094	0.864	2.1.1.79	NA
28	0.060	2aovA	0.641	4.38	0.064	0.864	2.1.1.8	87
29	0.060	1kywC	0.559	3.92	0.102	0.710	2.1.1.68	NA
30	0.060	3c6kD	0.537	3.91	0.109	0.675	2.5.1.22	86,126
31	0.060	1fp1D	0.552	3.67	0.089	0.689	2.1.1.-	NA
32	0.060	1ri5A	0.595	3.65	0.127	0.727	2.1.1.56	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.27	0.704	3.40	0.12	0.85	3mggB	GO:0008168 GO:0016740 GO:0032259
1	0.27	0.743	3.23	0.12	0.89	2yqzA	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
2	0.27	0.641	3.56	0.11	0.80	3ccfB	GO:0008152 GO:0008168 GO:0016740 GO:0030798 GO:0032259
3	0.25	0.658	3.34	0.12	0.79	3egeA	GO:0008152 GO:0008168 GO:0032259
4	0.23	0.545	3.64	0.16	0.67	3h2bB	GO:0008168 GO:0016740 GO:0032259
5	0.22	0.549	2.87	0.15	0.64	4qtuB	GO:0000056 GO:0000447 GO:0005634 GO:0005730 GO:0005737 GO:0006364 GO:0008152 GO:0008168 GO:0008757 GO:0016435 GO:0016740 GO:0032259 GO:0070476
6	0.21	0.582	3.75	0.16	0.71	1ve3B	GO:0046872 GO:0051536 GO:0051539
7	0.21	0.653	4.24	0.12	0.85	3kkzA	GO:0046872 GO:0051536 GO:0051539
8	0.21	0.496	3.07	0.10	0.58	5cm2Z	GO:0000049 GO:0002098 GO:0005634 GO:0005737 GO:0005829 GO:0008152 GO:0008168 GO:0008198 GO:0016300 GO:0016706 GO:0030488 GO:0032259 GO:0055114
9	0.21	0.666	3.91	0.10	0.83	4pneB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
10	0.20	0.534	3.58	0.14	0.65	3hnrA	GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
11	0.20	0.571	3.47	0.13	0.69	2gs9A	GO:0008152 GO:0008168 GO:0032259
12	0.19	0.484	2.46	0.12	0.54	4iscA	GO:0008168 GO:0008757 GO:0009312 GO:0009877 GO:0016740 GO:0032259
13	0.19	0.523	3.02	0.12	0.61	1f38A	GO:0006479 GO:0008168 GO:0008276 GO:0009236 GO:0016740 GO:0032259 GO:0046140
14	0.19	0.643	4.36	0.11	0.83	4ineA	GO:0000773 GO:0005737 GO:0006656 GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0080101
15	0.19	0.601	3.89	0.11	0.75	2gluA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
16	0.19	0.638	4.55	0.10	0.84	3f4kA	GO:0005737 GO:0008168 GO:0008757 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
17	0.18	0.651	4.33	0.10	0.84	3e7pA	GO:0046872 GO:0051536 GO:0051539
18	0.18	0.610	3.81	0.14	0.76	5je1A	GO:0008168 GO:0016740 GO:0032259
19	0.18	0.598	3.24	0.14	0.72	4qdkA	GO:0005737 GO:0008168 GO:0008757 GO:0015979 GO:0015995 GO:0016740 GO:0032259 GO:0036068 GO:0046406
20	0.18	0.590	3.91	0.13	0.72	4htfB	GO:0008033 GO:0008168 GO:0016740 GO:0032259
21	0.17	0.565	3.34	0.15	0.67	3sm3A	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872
22	0.17	0.621	3.81	0.15	0.79	4hg2B	GO:0008152 GO:0008168 GO:0016740 GO:0032259
23	0.17	0.609	3.66	0.14	0.74	1vl5A	GO:0008152 GO:0008168 GO:0016740 GO:0032259
24	0.16	0.491	3.43	0.13	0.59	3cggA	GO:0008168 GO:0016740 GO:0032259
25	0.16	0.694	3.68	0.09	0.88	3b5iA	GO:0000287 GO:0008168 GO:0009944 GO:0010252 GO:0016740 GO:0032259 GO:0042802 GO:0046872 GO:0051749
26	0.16	0.622	4.29	0.12	0.80	3busA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
27	0.15	0.586	3.48	0.10	0.69	1wznA
28	0.15	0.566	3.49	0.10	0.67	3dlcA	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
29	0.15	0.592	3.75	0.11	0.72	2avnA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
30	0.14	0.570	3.31	0.12	0.67	1vlmA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0032259
31	0.14	0.744	3.68	0.10	0.95	1m6eX	GO:0008168 GO:0016740 GO:0032259 GO:0046872
32	0.13	0.730	3.43	0.12	0.91	2eg5E	GO:0008168 GO:0009820 GO:0016740 GO:0032259
33	0.13	0.739	3.69	0.08	0.94	5f2kA	GO:0008168 GO:0032259
34	0.13	0.740	3.47	0.10	0.93	2efjA	GO:0008168 GO:0009820 GO:0016740 GO:0032259
35	0.13	0.563	2.95	0.13	0.65	3dh0B	GO:0005737 GO:0008757 GO:0032259 GO:0046872 GO:0051536 GO:0051539
36	0.08	0.653	3.56	0.09	0.79	1p91A	GO:0005737 GO:0006364 GO:0008168 GO:0008270 GO:0008989 GO:0016740 GO:0032259 GO:0046872 GO:0052911 GO:0070475
37	0.08	0.664	4.50	0.10	0.88	1kpgA	GO:0005737 GO:0005886 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0016740 GO:0032259 GO:0046500 GO:0071768
38	0.07	0.483	2.88	0.11	0.56	3i9fB	GO:0008152 GO:0008168 GO:0032259 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0051540	GO:0043169	GO:0008757
GO-Score	0.53	0.53	0.53
Biological Processes	GO:0032259
GO-Score	0.77
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.