I-TASSER results

I-TASSER results for job id Rv2974c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (470 residues)
MNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWRGVELVVASMGGV
EVPGTIVSVLRAAAGAVDQCAHEGLAGAVTAAGDAAVIALEKTPEQLDVLADAGAVDAGG
RGLLVLLDALRSTICGQAPARAVYEPSPRALPTDTATQRPAPQFEVMYLLAVCDAAAADQ
LRDRLKELGESVAIAAAPPDSYSVHVHTDDAGAAVEAGLAVGRVSRIVISALGSGTSGLP
AGGWTRGRAVLAVVDGDGAAELFAGEGACVLRPGPDAVTPAADISAHQLVRAVVDTGAAH
VMVLPNGYVAAEELVAGCTAAIGWGVDVVPVPTGSMVQGLAALAVHDAARQAVDDGYSMA
RAAGASRHGSVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLASG
GDLVTVLIGAGVTEDVAVVLERHVHDHHPGTELVSYRTGHRGDALLIGVE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWRGVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAHEGLAGAVTAAGDAAVIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPARAVYEPSPRALPTDTATQRPAPQFEVMYLLAVCDAAAADQLRDRLKELGESVAIAAAPPDSYSVHVHTDDAGAAVEAGLAVGRVSRIVISALGSGTSGLPAGGWTRGRAVLAVVDGDGAAELFAGEGACVLRPGPDAVTPAADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCTAAIGWGVDVVPVPTGSMVQGLAALAVHDAARQAVDDGYSMARAAGASRHGSVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLASGGDLVTVLIGAGVTEDVAVVLERHVHDHHPGTELVSYRTGHRGDALLIGVE
Prediction	CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCHHHHHHHHHHHCCEEEEEEHCCCEEEEEEEHCCHHHHHHHHHHHCCEEEEEEHCCCHHHHHCCCCCCCCCEEEEEEHCCHHHHHHHHHHCCCEEEHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEEEEEEEHCCEHCCCCEEEEEHCCEEEEHCCCHHHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCEEEEEHC
Conf.Score	99876647899999999999998566677765566757999999999999999999847999866889999999999998757899999999999999999888888999986988876667889999999999788776666666765555666656677775899999679888899999999987997999985898899999959999999999998967888984554555445567777886999995898999999998997999678778888899899999999995999799958998589999999999987599599996898799999999958999999999999999996986899998765677676658986999988969998699999999999999757996999998899999999999999999899958999858998756999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWRGVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAHEGLAGAVTAAGDAAVIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPARAVYEPSPRALPTDTATQRPAPQFEVMYLLAVCDAAAADQLRDRLKELGESVAIAAAPPDSYSVHVHTDDAGAAVEAGLAVGRVSRIVISALGSGTSGLPAGGWTRGRAVLAVVDGDGAAELFAGEGACVLRPGPDAVTPAADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCTAAIGWGVDVVPVPTGSMVQGLAALAVHDAARQAVDDGYSMARAAGASRHGSVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLASGGDLVTVLIGAGVTEDVAVVLERHVHDHHPGTELVSYRTGHRGDALLIGVE
Prediction	75301100000000001000310453452434414403051014004300410040027422100000001100530361255302300310051035005503730520471300000000000001000200353325444454455435454354635110000000233561326403620472020000003364100000004302400410262030250202024343553556645341000000307201400461302000313433416442104200400470604200000013411300331332441571401012042100000001001473415402520350064032130120032041462504530000014440111164024002300540266500000000135035610540162047404501000030611100000001
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCHHHHHHHHHHHCCEEEEEEHCCCEEEEEEEHCCHHHHHHHHHHHCCEEEEEEHCCCHHHHHCCCCCCCCCEEEEEEHCCHHHHHHHHHHCCCEEEHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEEEEEEEEHCCEHCCCCEEEEEHCCEEEEHCCCHHHHHHHHHHHHHCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCEEEEEHC
MNGARGNSGVILSQILRGIAEVTATAAAASGAVLRAVDANALGAALWRGVELVVASMGGVEVPGTIVSVLRAAAGAVDQCAHEGLAGAVTAAGDAAVIALEKTPEQLDVLADAGAVDAGGRGLLVLLDALRSTICGQAPARAVYEPSPRALPTDTATQRPAPQFEVMYLLAVCDAAAADQLRDRLKELGESVAIAAAPPDSYSVHVHTDDAGAAVEAGLAVGRVSRIVISALGSGTSGLPAGGWTRGRAVLAVVDGDGAAELFAGEGACVLRPGPDAVTPAADISAHQLVRAVVDTGAAHVMVLPNGYVAAEELVAGCTAAIGWGVDVVPVPTGSMVQGLAALAVHDAARQAVDDGYSMARAAGASRHGSVRIATQKALTWAGTCKPGDGLGIAGDEVLIVADDVAAAAIGLVDLLLASGGDLVTVLIGAGVTEDVAVVLERHVHDHHPGTELVSYRTGHRGDALLIGVE

2btdA

0.16

0.04

0.27

1.49

dPPAS2

LSSVGGASGPLFGTFFIRAAQATQARQ--------SLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQSVPVALEAASSIAESAAQSTITMQARKGRASHQDPGATSVMFMMQMLALAAKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1un8A2

0.24

0.06

0.25

1.02

dPPAS2

TVVMGGSSGVLMSIFFTAAGQKLEQGAN-------------VVEALNTGLAQMKFYGGADEGDRTMIDALQPALTSLLAQPKN-----LQAAFDAAQAGAERTCLSSKANAELGNMDPGAQRLAMVFKALAESE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3w1hA

0.09

0.08

0.86

0.64

MUSTER

FAKAYP--EIYVVKAAREVAEKYRKE-----IEGARADLNGFLEDVERKIKSLMKP-NIKRVTGVVIPLSKDVINFISEIANGYSNLEYNLEEGKRGSRIAHIEKYLNELTGAEVVNNNAGAVFLVLNTLAE---GKEVIISRGELVEIGGSFRIPDIMKKSG-AILREVGTTNKTKVSDYEGAINQNTALLMKVHKSNFYMEGFVEEVKLEDLVKLGHKYG-YYDAGSGLLINLKEFGISVDEP-------------NFRDCISLGIDLVSGSGDLLGPQAIVGKKNLIEKIKKNPIAR---LRIDKLTLSGLEMTLKLYFEK----------RYEDIPVIRMLTQDEKALRQKAKRLEKLLKDIPGLKISVIKDKAKPGGGSLPELELPTYC--AIRHDRLS----SQELSRRLRLAEPPIVCRIRDQ-VFHEDLKTIKKTLQELLSI--------------------

2btdA

0.16

0.04

0.27

0.65

dPPAS

LSSVGGASGPLFGTFFIRAAQATQARQ--------SLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQSVPVALEAASSIAESAAQSTITMQARKGRASHQDPGATSVMFMMQMLALAAKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2btdA

0.16

0.04

0.27

0.92

wdPPAS

LSSVGGASGPLFGTFFIRAAQATQARQ--------SLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQSVPVALEAASSIAESAAQSTITMQARKGRASHQDPGATSVMFMMQMLALAAKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3au2A

0.15

0.14

0.93

0.65

wMUSTER

FLGDRVRAYHQAARTLYDLDTPIEEIAEKGKEALMELPAEKILEFLRTGVRKHEELSRKVPRGVLEVMEVPKTARLLYEGLGDSLEKLKAALDRGDLTRLKGFERIREGLALAQAAGK-LGAVLSLARSLLEAIRALPGVERAELCGSARRYKDTVGD-------LDFLVASRE---GERAVEGFVRLPQVKEVYAKGKERATVFLQVD-PPESYGAGLQY------KAHSIRLRALAQEKGLKLSEYGVFR---GETEEEVYAALGL-------PWIPPPLREDQGEVEAALEGRLPKDLQVHSTYSDGQNTLEELWEAAKTMGYRYLAVTDHSPAVRVA---GPSPE-EALKRVGEIRRFNETHGPPYLLAGAEVDIHPDGTLDPDWVLRELDLVLVSVHSPKADQTKRLLKALENPFVHVLALLGRRAPIEADWEAVFQKAKEK--GVAVEIDGYYDRMDLISLSTD

2btdA

0.16

0.04

0.27

0.89

wPPAS

LSSVGGASGPLFGTFFIRAAQATQARQ--------SLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQSVPVALEAASSIAESAAQSTITMQARKGRASHQDPGATSVMFMMQMLALAAKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g7zA

0.07

0.03

0.45

1.02

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGTIKIVTDSSITIEPELIKALDITSVIDSSKSLPKTSQPPVGLFAETYENLVVTDIVAIHLSPALSGTIEASRQGAEIAEAPVTVLDSGFTDQAKFQVVEAAAGASLNEILAAVQAIKSKTEVSTLENLVKGGRIGRVTGLNVKVVALKNDELKTLVKTFTKWLDSYLAKNSHRPIAEIAISYAGE--ASLALTLKERIAAYYNH-SISVLETG-----------

2btdA

0.16

0.04

0.27

0.83

PPAS

LSSVGGASGPLFGTFFIRAAQATQARQ--------SLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQSVPVALEAASSIAESAAQSTITMQARKGRASHQDPGATSVMFMMQMLALAAKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2btdA

0.16

0.04

0.27

0.91

Env-PPAS

LSSVGGASGPLFGTFFIRAAQATQARQ--------SLTLEELYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQSVPVALEAASSIAESAAQSTITMQARKGRASHQDPGATSVMFMMQMLALAAKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.04

Estimated TM-score = 0.28±0.09

Estimated RMSD = 17.5±2.6Å

Download Model 2

C-score=-4.53

Download Model 3

C-score=-4.19

Download Model 4

C-score=-2.90

Download Model 5

C-score=-4.97

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2aeuA	0.509	5.26	0.085	0.677
2	1ordA	0.494	5.88	0.067	0.698
3	1eqbB	0.487	5.26	0.093	0.649
4	1bj4A	0.483	5.48	0.073	0.657
5	2jisB	0.483	6.23	0.077	0.700
6	3fz7F	0.483	6.12	0.044	0.702
7	2okjB	0.482	6.15	0.055	0.698
8	2dkjA	0.482	5.05	0.112	0.632
9	3hbxA	0.482	5.70	0.051	0.672
10	1wyvB	0.481	5.98	0.099	0.683

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	7	1i43A	PLP	Rep, Mult	118,119,120,147,195,228,230,274,276,277
2	0.05	3	3adrA	ZN	Rep, Mult	205,207,346,389
3	0.03	2	3w1jB	THJ	Rep, Mult	424
4	0.03	2	1rvyB	PLG	Rep, Mult	117,119,125
5	0.03	2	2vmqA	MPD	Rep, Mult	124,128,159,166
6	0.02	1	4katC	DU	Rep, Mult	14,17
7	0.02	1	3fz7A	PO4	Rep, Mult	128,129,130,298,300,301
8	0.02	1	1htwA	MG	Rep, Mult	114,117
9	0.02	1	1ocyA	ZN	Rep, Mult	205,207
10	0.02	1	1c3xB	CA	Rep, Mult	189,190
11	0.02	1	3w1jB	THJ	Rep, Mult	88,300,305
12	0.02	1	3ee6A	ZN	Rep, Mult	207,463
13	0.02	1	2viaA	MPD	Rep, Mult	181,186,217,221,222
14	0.02	1	4l6v6	CLA	Rep, Mult	8,12
15	0.02	1	1rvyA	PO4	Rep, Mult	168,170,185
16	0.02	1	2g7zA	ZN	Rep, Mult	396,397
17	0.02	1	3rl3A	MN	Rep, Mult	420,422
18	0.02	1	3w1jA	THJ	Rep, Mult	382,383
19	0.02	1	1bjyA	CTC	Rep, Mult	181,185

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ordA	0.494	5.88	0.067	0.698	4.1.1.17	NA
2	0.060	2dgmC	0.479	5.91	0.061	0.683	4.1.1.15	306
3	0.060	3gbxA	0.459	5.16	0.089	0.606	2.1.2.1	NA
4	0.060	1j04A	0.460	5.69	0.084	0.634	2.6.1.44	NA
5	0.060	1wyuB	0.482	6.00	0.102	0.685	1.4.4.2	NA
6	0.060	1ejiA	0.487	5.74	0.070	0.670	2.1.2.1	NA
7	0.060	1d7rA	0.450	6.08	0.077	0.651	4.1.1.64	NA
8	0.060	2hufA	0.459	5.74	0.096	0.636	2.6.1.44	123
9	0.060	3dxvB	0.462	6.00	0.103	0.655	5.1.1.15	NA
10	0.060	2jg2A	0.451	5.35	0.077	0.602	2.3.1.50	NA
11	0.060	1oatA	0.451	6.32	0.081	0.668	2.6.1.13	NA
12	0.060	1dfoB	0.487	5.26	0.090	0.649	2.1.2.1	NA
13	0.060	2hdyA	0.450	6.27	0.081	0.668	4.4.1.16	NA
14	0.060	1sf2A	0.445	6.08	0.073	0.640	2.6.1.19,2.6.1.22	NA
15	0.060	1vjoA	0.451	5.87	0.076	0.632	2.6.1.44	NA
16	0.060	2dkjA	0.482	5.05	0.112	0.632	2.1.2.1	NA
17	0.060	3f9tA	0.476	5.22	0.061	0.628	4.1.1.25	NA
18	0.060	1szkC	0.445	6.23	0.082	0.649	2.6.1.19,2.6.1.22	119,177
19	0.060	2zsmA	0.451	5.79	0.065	0.625	5.4.3.8	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.474	5.06	0.11	0.62	1kkjA	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008652 GO:0016740 GO:0019264 GO:0030170 GO:0035999
1	0.07	0.494	5.88	0.07	0.70	1ordA	GO:0003824 GO:0004586 GO:0005737 GO:0006520 GO:0016829 GO:0016831
2	0.07	0.509	5.26	0.09	0.68	2aeuA	GO:0003824 GO:0004125 GO:0097056
3	0.07	0.486	5.56	0.09	0.66	4uqvG	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008652 GO:0016740 GO:0016829 GO:0019264 GO:0030170
4	0.07	0.481	6.02	0.06	0.69	3n75A	GO:0003824 GO:0005737 GO:0006520 GO:0006554 GO:0008923 GO:0016829 GO:0016831 GO:0042802
5	0.07	0.481	5.95	0.06	0.69	2vycA	GO:0003824 GO:0005737 GO:0005829 GO:0006520 GO:0006527 GO:0008792 GO:0016829 GO:0016831 GO:0030170 GO:0051454
6	0.07	0.488	5.37	0.06	0.66	4oytA	GO:0003824 GO:0008168 GO:0016740 GO:0032259
7	0.07	0.485	5.31	0.08	0.65	4n0wA	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008168 GO:0008652 GO:0016740 GO:0019264 GO:0030170 GO:0032259 GO:0035999
8	0.07	0.481	5.34	0.07	0.64	4o6zA	GO:0003824 GO:0004372 GO:0005737 GO:0005739 GO:0006730 GO:0008168 GO:0016740 GO:0020011 GO:0032259 GO:0070178
9	0.07	0.482	5.05	0.11	0.63	2dkjA	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008652 GO:0016740 GO:0019264 GO:0030170 GO:0035999
10	0.07	0.475	5.36	0.08	0.63	4msoA	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008168 GO:0008652 GO:0016740 GO:0019264 GO:0030170 GO:0032259 GO:0035999
11	0.07	0.470	5.23	0.08	0.62	3pgyB	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008652 GO:0016740 GO:0019264 GO:0030170 GO:0035999
12	0.07	0.461	5.26	0.08	0.61	3n0lB	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008652 GO:0016740 GO:0019264 GO:0030170 GO:0035999
13	0.07	0.457	5.35	0.10	0.61	4p3mB	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008652 GO:0016740 GO:0019264 GO:0030170 GO:0035999
14	0.07	0.464	5.81	0.06	0.65	2x3lB	GO:0003824
15	0.07	0.459	5.59	0.09	0.64	3wksB	GO:0003824 GO:0006412 GO:0016740 GO:0043766 GO:0071952
16	0.07	0.442	5.56	0.10	0.60	4bhdB	GO:0003824 GO:0004372 GO:0005737 GO:0006544 GO:0006545 GO:0006563 GO:0006730 GO:0008652 GO:0016740 GO:0016829 GO:0019264 GO:0030170
17	0.07	0.437	5.15	0.07	0.57	3jzlA	GO:0003824 GO:0030170
18	0.06	0.425	4.97	0.10	0.54	1pg8A	GO:0003824 GO:0016829 GO:0018826 GO:0030170 GO:0047982

Consensus prediction of GO terms

Molecular Function	GO:0048037	GO:0016742	GO:0043168
GO-Score	0.36	0.36	0.36
Biological Processes	GO:0008652	GO:0009070	GO:0006544
GO-Score	0.36	0.36	0.36
Cellular Component	GO:0044424
GO-Score	0.57

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.