I-TASSER results

I-TASSER results for job id Rv2972c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (237 residues)
MNRRTLLWLSAIAALALVVAYQTLGSSAGRHADEFAARAGVPTVQPGADVLAGIAVLPKR
IHRYDYRRSAFGHPWDDRNDAPGGHNGCDTRDDILDRDLVDKTYVSIKRCPNAVATGTLR
DPYTNTTVAFQRGASVGQSVQIDHIVPLSYAWDMGAYRWPNSERMRFANDPANLLAVQGQ
ANQDKGDSPPAQWMPPNKAFACQYAMQFIAVLRGYSLPVDQPSSDVLRQAAATCPTG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MNRRTLLWLSAIAALALVVAYQTLGSSAGRHADEFAARAGVPTVQPGADVLAGIAVLPKRIHRYDYRRSAFGHPWDDRNDAPGGHNGCDTRDDILDRDLVDKTYVSIKRCPNAVATGTLRDPYTNTTVAFQRGASVGQSVQIDHIVPLSYAWDMGAYRWPNSERMRFANDPANLLAVQGQANQDKGDSPPAQWMPPNKAFACQYAMQFIAVLRGYSLPVDQPSSDVLRQAAATCPTG
Prediction	CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHCCCCCCCEEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHCCHHHHHCCCHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
Conf.Score	985688999999999999987556788888888888888988847999999868656788898998878778877788888888888868999999978887675689998578888875898995898756788875667754445899999978779999999986797776547857878766899777799996678799999999999989999999999999999969999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MNRRTLLWLSAIAALALVVAYQTLGSSAGRHADEFAARAGVPTVQPGADVLAGIAVLPKRIHRYDYRRSAFGHPWDDRNDAPGGHNGCDTRDDILDRDLVDKTYVSIKRCPNAVATGTLRDPYTNTTVAFQRGASVGQSVQIDHIVPLSYAWDMGAYRWPNSERMRFANDPANLLAVQGQANQDKGDSPPAQWMPPNKAFACQYAMQFIAVLRGYSLPVDQPSSDVLRQAAATCPTG
Prediction	653221000101111000001022223244444544444543434403510550433475474530406414420334444534553142233004222561433435534131342303020234304244346444403111000023014321540467214500313520331336205632754144122435511030022003004417041366125004510751478
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEHCCCCCCCEEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHCCHHHHHCCCHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
MNRRTLLWLSAIAALALVVAYQTLGSSAGRHADEFAARAGVPTVQPGADVLAGIAVLPKRIHRYDYRRSAFGHPWDDRNDAPGGHNGCDTRDDILDRDLVDKTYVSIKRCPNAVATGTLRDPYTNTTVAFQRGASVGQSVQIDHIVPLSYAWDMGAYRWPNSERMRFANDPANLLAVQGQANQDKGDSPPAQWMPPNKAFACQYAMQFIAVLRGYSLPVDQPSSDVLRQAAATCPTG

5axwA

0.11

0.10

0.93

0.81

MUSTER

INLILDELWHTNDNQIAIFNRLKLVPKKVDLSQQKEIPTTLILSPVVKRSFIQSKVINAIIKKYGLEKNSKDAQKMINEMQKRNRQTNERIEEIIRTTGKENAKYLIEKIKLHDMQEG-KCLYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFD---------------NSFNNKVLVKQEEASKKGNRTPFQYLSDSKISYETFKKHILNLAKGKGR-ISKTKKEYLLEERFSVQKD

5axwA2

0.12

0.08

0.61

0.67

dPPAS

------------------------------------------NSKDAQKMINEMQKRNRQTNERIEEIIR--------TTGKENAKYLIEKIKLHDMQEG-------------------KCLYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFD---------------NSFNNKVLVKQEEASKKGNRTPFQYLSDSKISYETFKKHILNLAKGKGRISKTKKEYLLEE--------

5axwA2

0.14

0.08

0.57

1.59

wdPPAS

------------------------------------------NSKDAQKMINEMERIEEIIRTTGKENAK-------------------EKIKLHDMQ----------EGKC---------LYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFD---------------NSFNNKVLVKQEEASKKGNRTPFQYLSDSKISYETFKKHILNLAKGKGR-ISKTKKEYLLEE-------

5axwA

0.12

0.11

0.88

0.90

wMUSTER

LSLKAINLILDELWHT-QIAIFNRLKLVPKKVDLSQQKEIPTTLIQSIKVINAILPNDAREKNSKDAQKM-------NEMQKRNRQTNERIEEIIRTTGKENAKYLIEKIK-DMQEG--KCLYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFD---------------NSFNNKVLVKQEEASKKGNRTPFQYLSDSKISYETFKKHILNLAKGKGR-ISKTKKEYLLE--FSVQKD

5axwA2

0.14

0.08

0.57

1.57

wPPAS

------------------------------------------NSKDAQKMINEMERIEEIIRTTGKENAKY------------------EKIKLHDMQ----------EGKC---------LYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFD---------------NSFNNKVLVKQEEASKKGNRTPFQYLSDSKISYETFKKHILNLAKGKGR-ISKTKKEYLLEE-------

5axwA2

0.16

0.08

0.54

1.07

dPPAS2

-------------------------------------------------------------------------------------NSKDAQKMINEMQKREEIIRTTGKENAKYLIEKIKCLYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFD---------------NSFNNKVLVKQEEASKKGNRTPFQYLSDSKISYETFKKHILNLAKGKGR-ISKTKKEYLLEE-------

5axwA2

0.14

0.08

0.59

1.17

PPAS

------------------------------------------NSKDAQKMINEM---RQTNERIEEIIRTTGKENAKYL---------IEKIKLHDMQE--------------------KCLYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFD---------------NSFNNKVLVKQEEASKKGNRTPFQYLSDSKISYETFKKHILNLAKGKGR-ISKTKKEYLLEE-------

5axwA2

0.14

0.08

0.61

1.64

Env-PPAS

------------------------------------------NSKDAQKMINEMKRNRQTNERIEEIIRTTGKENAKYL---------IEKIKLHDMQE-------------------GKCLYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFD---------------NSFNNKVLVKQEEASKKGNRTPFQYLSDSKISYETFKKHILNLAKGKGR-ISKTKKEYLLEE-------

4b2nA

0.10

0.09

0.92

0.67

MUSTER

LMADERQRRAWNSGWWAYNNLSPSWTGYPSDNIVASELRRVPRAIYNNGGPIYSPLGPNIEEPTGYIAPPLYGAWAT---APYFHNGSPNLWGVLKPSDRPKLWKRPYTAAGIGGKNAGYDYYDWQKLGWTAVACNNSIFTSPFLPCTHNMATIDILYSMWDNVAAQYLNLAYQSPPPITDQQIKSRMVYNSYLYGNDNG------------HDFTQSLTDSERWALIEYIKTL---

5gaoE

0.14

0.12

0.87

0.63

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA----------AAAAAARAAAAAAAAAAAAAAAAAAAAA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.58

Estimated TM-score = 0.32±0.11

Estimated RMSD = 14.3±3.8Å

Download Model 2

C-score=-3.92

Download Model 3

C-score=-3.94

Download Model 4

C-score=-4.32

Download Model 5

C-score=-4.55

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5axwA	0.542	3.67	0.125	0.683
2	4ogcA	0.501	4.72	0.150	0.717
3	1y791	0.434	6.05	0.051	0.764
4	1j36A	0.434	5.87	0.034	0.738
5	5l43A	0.434	6.28	0.022	0.785
6	3jd8A	0.433	5.70	0.022	0.705
7	3bkkA	0.433	6.00	0.065	0.751
8	4mt1A	0.422	5.92	0.046	0.713
9	1is2A	0.422	5.70	0.054	0.713
10	4rf6A	0.419	5.49	0.043	0.671

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.15	8	4ogcA	MG	Rep, Mult	143,182
2	0.04	2	2fonB	FAD	Rep, Mult	77,88,90,91,94,134,136
3	0.04	2	2xy9A	UUU	Rep, Mult	91,94,95,137
4	0.04	2	3dntA	MG	Rep, Mult	169,170
5	0.04	2	3bwhA	XYP	Rep, Mult	143,177
6	0.04	2	3bklA	UUU	Rep, Mult	94,97,98,169,171
7	0.04	2	2dtiA	MN	Rep, Mult	169,170,185
8	0.02	1	3ajpA	MG	Rep, Mult	193,202
9	0.02	1	2rh1A	CLR	Rep, Mult	209,231
10	0.02	1	3attA	MG	Rep, Mult	173,187
11	0.02	1	4z90A	4LE	Rep, Mult	51,55
12	0.02	1	2cziA	CA	Rep, Mult	93,96,220
13	0.02	1	3dugA	ZN	Rep, Mult	123,185

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2vumA	0.393	5.74	0.048	0.650	2.7.7.6	99
2	0.060	1y791	0.434	6.05	0.051	0.764	3.4.15.5	NA
3	0.060	1j38A	0.429	5.56	0.024	0.709	3.4.15.1	139
4	0.060	3hi7A	0.387	5.95	0.068	0.675	1.4.3.22	NA
5	0.060	1e3pA	0.395	5.59	0.039	0.654	2.7.7.8	NA
6	0.060	1f13A	0.389	5.56	0.054	0.633	2.3.2.13	NA
7	0.060	1xdpA	0.391	5.91	0.042	0.679	2.7.4.1	129,204
8	0.060	1l1lA	0.388	6.30	0.061	0.696	1.17.4.2	NA
9	0.060	1i1iP	0.390	6.14	0.060	0.683	3.4.24.16	NA
10	0.060	1xc6A	0.393	5.88	0.045	0.692	3.2.1.23	123
11	0.060	1g0dA	0.395	5.63	0.048	0.646	2.3.2.13	NA
12	0.060	2f6dA	0.409	5.57	0.069	0.671	3.2.1.3	209,216,218
13	0.060	1is2A	0.422	5.70	0.054	0.713	1.3.3.6	NA
14	0.060	1oqzB	0.387	6.14	0.064	0.700	3.5.1.93	NA
15	0.060	3h0pB	0.294	5.91	0.027	0.510	2.3.1.39	NA
16	0.060	3btaA	0.409	6.02	0.054	0.705	3.4.24.69	NA
17	0.060	3bkkA	0.433	6.00	0.065	0.751	3.4.15.1	NA
18	0.060	2fonB	0.354	6.00	0.044	0.616	1.3.3.6	NA
19	0.060	2vuaA	0.321	5.76	0.025	0.553	3.4.24.69	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.330	6.39	0.06	0.60	4n9nA	GO:0000978 GO:0000981 GO:0001077 GO:0003677 GO:0003796 GO:0003824 GO:0005634 GO:0006351 GO:0006355 GO:0006366 GO:0008152 GO:0008270 GO:0009253 GO:0016020 GO:0016787 GO:0016798 GO:0016998 GO:0019076 GO:0019835 GO:0030430 GO:0035961 GO:0035969 GO:0042742 GO:0045944 GO:0046872 GO:0048471 GO:0071456 GO:1904741
1	0.06	0.505	4.71	0.15	0.72	4ogeA	GO:0003676 GO:0003677 GO:0003723 GO:0004518 GO:0004519 GO:0016787 GO:0046872 GO:0051607 GO:0090305
2	0.06	0.325	5.29	0.08	0.52	5i0nA	GO:0000166 GO:0000287 GO:0002561 GO:0003796 GO:0003824 GO:0004430 GO:0005524 GO:0005739 GO:0005765 GO:0005768 GO:0005794 GO:0005829 GO:0005886 GO:0005887 GO:0006661 GO:0008152 GO:0009253 GO:0016020 GO:0016023 GO:0016301 GO:0016310 GO:0016740 GO:0016787 GO:0016798 GO:0016998 GO:0019835 GO:0030054 GO:0030425 GO:0030672 GO:0031083 GO:0031224 GO:0031410 GO:0031901 GO:0032403 GO:0035651 GO:0035838 GO:0042734 GO:0042742 GO:0042995 GO:0043005 GO:0043025 GO:0043204 GO:0043231 GO:0043234 GO:0044231 GO:0045121 GO:0045202 GO:0046854 GO:0070382 GO:0098779
3	0.06	0.316	5.08	0.05	0.48	4phuA	GO:0003796 GO:0003824 GO:0004871 GO:0004930 GO:0005085 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0008152 GO:0008289 GO:0009253 GO:0016020 GO:0016021 GO:0016787 GO:0016798 GO:0016998 GO:0019076 GO:0019835 GO:0030073 GO:0030430 GO:0032024 GO:0042593 GO:0042742 GO:0043547 GO:0045125 GO:0051928 GO:0070542
4	0.06	0.319	6.27	0.06	0.57	4exmC	GO:0003796 GO:0003824 GO:0008152 GO:0009253 GO:0016787 GO:0016798 GO:0016998 GO:0019076 GO:0019835 GO:0030430 GO:0042742
5	0.06	0.271	6.29	0.03	0.49	4qrzA	GO:0005215 GO:0006810
6	0.06	0.310	5.56	0.02	0.52	5bz6A	GO:0003796 GO:0003824 GO:0005262 GO:0005739 GO:0005743 GO:0006810 GO:0006811 GO:0006816 GO:0006851 GO:0008152 GO:0009253 GO:0015292 GO:0016020 GO:0016021 GO:0016787 GO:0016798 GO:0016998 GO:0019722 GO:0019835 GO:0031305 GO:0032024 GO:0034704 GO:0035786 GO:0036444 GO:0042593 GO:0042742 GO:0042802 GO:0051560 GO:0051561 GO:0070588 GO:1990246
7	0.06	0.272	6.51	0.05	0.51	4n6kA	GO:0006810 GO:0030288
8	0.06	0.425	5.01	0.10	0.62	4cmqB	GO:0003677 GO:0003723 GO:0004518 GO:0004519 GO:0004520 GO:0004527 GO:0008408 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
9	0.06	0.307	6.21	0.06	0.54	2qb0B	GO:0003796 GO:0003824 GO:0008152 GO:0009253 GO:0016787 GO:0016798 GO:0016998 GO:0019076 GO:0019835 GO:0030430 GO:0042742
10	0.06	0.437	4.50	0.11	0.59	4zt0A	GO:0003677 GO:0003723 GO:0004518 GO:0004519 GO:0004520 GO:0004527 GO:0008408 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
11	0.06	0.290	6.24	0.06	0.51	3efbD	GO:0003677 GO:0030246
12	0.06	0.313	6.17	0.04	0.57	4cmpA	GO:0003677 GO:0003723 GO:0004518 GO:0004519 GO:0004520 GO:0004527 GO:0008408 GO:0016787 GO:0043571 GO:0046872 GO:0051607 GO:0090305
13	0.06	0.341	5.53	0.06	0.55	4wtvA	GO:0000166 GO:0003796 GO:0003824 GO:0004430 GO:0005524 GO:0005737 GO:0005829 GO:0006661 GO:0008152 GO:0009253 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0016787 GO:0016798 GO:0016998 GO:0019076 GO:0019835 GO:0030430 GO:0042742 GO:0046854
14	0.06	0.320	6.18	0.06	0.56	4xesA	GO:0001659 GO:0003085 GO:0003254 GO:0003796 GO:0003824 GO:0004871 GO:0004930 GO:0005737 GO:0005739 GO:0005783 GO:0005794 GO:0005886 GO:0005887 GO:0007165 GO:0007186 GO:0007218 GO:0007612 GO:0008152 GO:0008344 GO:0009253 GO:0009898 GO:0009986 GO:0014049 GO:0014054 GO:0016020 GO:0016021 GO:0016492 GO:0016787 GO:0016798 GO:0016998 GO:0019076 GO:0019835 GO:0030424 GO:0030425 GO:0030430 GO:0032280 GO:0033993 GO:0042742 GO:0042803 GO:0043025 GO:0043065 GO:0043066 GO:0043195 GO:0043197 GO:0043198 GO:0043204 GO:0043576 GO:0043679 GO:0044309 GO:0045121 GO:0045202 GO:0046982 GO:0047485 GO:0050965 GO:0051280 GO:0051281 GO:0051930 GO:0060732 GO:0070779 GO:0071545 GO:0090238 GO:0097151 GO:0098900 GO:1990123 GO:2001259
15	0.06	0.307	5.88	0.03	0.52	4nguA	GO:0006810 GO:0030288
16	0.06	0.307	5.21	0.06	0.47	4e97B	GO:0003796 GO:0003824 GO:0008152 GO:0009253 GO:0016787 GO:0016798 GO:0016998 GO:0019076 GO:0019835 GO:0030430 GO:0042742
17	0.06	0.331	5.59	0.06	0.55	4yx7C	GO:0003796 GO:0003824 GO:0008152 GO:0009253 GO:0009405 GO:0016787 GO:0016798 GO:0016998 GO:0019076 GO:0019835 GO:0030430 GO:0042742
18	0.06	0.297	6.22	0.04	0.54	2ppqA	GO:0000166 GO:0004413 GO:0005524 GO:0008652 GO:0009088 GO:0016301 GO:0016310 GO:0016740

Consensus prediction of GO terms

Molecular Function	GO:0004553
GO-Score	0.46
Biological Processes	GO:0000270	GO:0044248	GO:0006027	GO:0044036	GO:0098542	GO:0009617	GO:0019058
GO-Score	0.46	0.46	0.46	0.46	0.46	0.46	0.36
Cellular Component	GO:0033646
GO-Score	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.