I-TASSER results

I-TASSER results for job id Rv2963

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (406 residues)
MTSTKVEDRVTAAVLGAIGHALALTASMTWEILWALILGFALSAVVQAVVRRSTIVTLLG
DDRPRTLVIATGLGAASSSCSYAAVALARSLFRKGANFTAAMAFEIGSTNLVVELGIILA
LLMGWQFTAAEFVGGPIMILVLAVLFRLFVGARLIDAAREQAERGLAGSMEGHAAMDMSI
KREGSFWRRLLSPPGFTSIAHVFVMEWLAILRDLILGLLIAGAIAAWVPESFWQSFFLAN
HPAWSAVWGPIIGPIVAIVSFVCSIGNVPLAAVLWNGGISFGGVIAFIFADLLILPILNI
YRKYYGARMMLVLLGTFYASMVVAGYLIELLFGTTNLIPSQRSATVMTAEISWNYTTWLN
VIFLVIAAALVVRFITSGGLPMLRMMGGSPDAPHDHHDRHDDHLGH

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTSTKVEDRVTAAVLGAIGHALALTASMTWEILWALILGFALSAVVQAVVRRSTIVTLLGDDRPRTLVIATGLGAASSSCSYAAVALARSLFRKGANFTAAMAFEIGSTNLVVELGIILALLMGWQFTAAEFVGGPIMILVLAVLFRLFVGARLIDAAREQAERGLAGSMEGHAAMDMSIKREGSFWRRLLSPPGFTSIAHVFVMEWLAILRDLILGLLIAGAIAAWVPESFWQSFFLANHPAWSAVWGPIIGPIVAIVSFVCSIGNVPLAAVLWNGGISFGGVIAFIFADLLILPILNIYRKYYGARMMLVLLGTFYASMVVAGYLIELLFGTTNLIPSQRSATVMTAEISWNYTTWLNVIFLVIAAALVVRFITSGGLPMLRMMGGSPDAPHDHHDRHDDHLGH
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9855788888888999999999999999999999999999999999998699999999689984789999999998766746899999999998998689999999856666999999999989567898999999999999999999856667777787765666666677766666555566646776656899999999999999999999999999999999878999999976888865558999999999999875664467999999998888899999999666568999999999885899999999999999999999999865687667666655555555655789999999999999999987577556655777777777777777777789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTSTKVEDRVTAAVLGAIGHALALTASMTWEILWALILGFALSAVVQAVVRRSTIVTLLGDDRPRTLVIATGLGAASSSCSYAAVALARSLFRKGANFTAAMAFEIGSTNLVVELGIILALLMGWQFTAAEFVGGPIMILVLAVLFRLFVGARLIDAAREQAERGLAGSMEGHAAMDMSIKREGSFWRRLLSPPGFTSIAHVFVMEWLAILRDLILGLLIAGAIAAWVPESFWQSFFLANHPAWSAVWGPIIGPIVAIVSFVCSIGNVPLAAVLWNGGISFGGVIAFIFADLLILPILNIYRKYYGARMMLVLLGTFYASMVVAGYLIELLFGTTNLIPSQRSATVMTAEISWNYTTWLNVIFLVIAAALVVRFITSGGLPMLRMMGGSPDAPHDHHDRHDDHLGH
Prediction	5545424540344024101300100111133123132211221120100024610341045440100010121013013100000000210143414200000000012301120011001334230011123312210220120001024552154234425224443344333243424333220331234400310031013002302312120001002000001230033002343222100111321230011010103000000110133411100000000033222000210233233200110213111110110122010132111123443343444414130010001212320222121012322121041255236465532332554458
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
MTSTKVEDRVTAAVLGAIGHALALTASMTWEILWALILGFALSAVVQAVVRRSTIVTLLGDDRPRTLVIATGLGAASSSCSYAAVALARSLFRKGANFTAAMAFEIGSTNLVVELGIILALLMGWQFTAAEFVGGPIMILVLAVLFRLFVGARLIDAAREQAERGLAGSMEGHAAMDMSIKREGSFWRRLLSPPGFTSIAHVFVMEWLAILRDLILGLLIAGAIAAWVPESFWQSFFLANHPAWSAVWGPIIGPIVAIVSFVCSIGNVPLAAVLWNGGISFGGVIAFIFADLLILPILNIYRKYYGARMMLVLLGTFYASMVVAGYLIELLFGTTNLIPSQRSATVMTAEISWNYTTWLNVIFLVIAAALVVRFITSGGLPMLRMMGGSPDAPHDHHDRHDDHLGH

4kppA

0.10

0.09

0.92

1.02

MUSTER

-DFTKEKFQLLAISSLTLPWLISLAFNYHPALTQTLLSGLAVVSASFLISWAAETAEMDVPRSFSLAIVALLAVLPEYA--VDGYFAWKAGSVGGEYVHYATANMTGANRLLIGIGWSLVAFIAFRLEIFFLFLATLYAFTLPLKGHISPFDALVFVSLYAIYIYLSTKAEREEVEVGGVPAYLCSLKTETRRLSVVVLFLFAGFTILMSVEAFSEGLLETARI---IDEFLAVQWIAPLASESPELIVAIYFVRRFVSASMNALISSKVNQWTLLIGT-IAIIYSISAFKLQSLPLDARQSEEVLLTAAQSLFAVAILLSWKEASALFLLFIVQLLFPGV------------EVRYIISAIYIILSLPILFAKRKEIV-ESFRTVKRLISLE-------------

5aymA

0.08

0.07

0.88

0.87

dPPAS

IETQLLLGRLLTRSGDQAWDFVVPFALLVIGKLQVAAFYYLIVKIGTFLLTPSSGKWIDTHPRIQVVKWGVWLQFFAILAGMVFFGMLDGLVRAGGRESWLLSVLFIALALSGVMASLGSQITDATEVGAPILAGALFPLAGLFLIGLWNLVSFVPEYFLLRNVIQRSGLKIKVLGSFSDPIFWLILSYALLWGVLLAAYLKDEMRLPETEIGLFRGLGAVFGLISTVSFPYLVRRLGLISSSRWHLGFQGVTLGIAVTAFAMGS-------TASVYVFLGCILLSRVGLYGFSNGEFELRQRLIPEGRRGELNSLSSLTTTSATLILFSAGSLLP------------QTEDFKYLVYVSLAAVLLANVVFIKWSSR-----------------------------

4k1cA

0.14

0.11

0.78

0.91

wdPPAS

QLSHTLTFLFNFLAIIPLAAILANATEELADKA--NTIGGLLNATFGNA--VELIVSII-KKGQVRIVQASMLGSLLS---LGLCFIFGGYNRVNQTAAQTMSSLLAIACASLLIPAAFRATLPFILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTISRNPHHSLS---------------------------VKSSLVILLGTTVIISFCADFL-IDNVVESTG----LSKTFIGLIVIPIVGNAAEH---VTSVLVAMKDKMDLALGVAIGSSLQ-LFVTPFMVLVGWMIDVPMTLNFSTFETATLFIAVFLSNYLILDGES------------------NWLEGVMSLAMYILIAMAFFYYPDE--------------------------

4k1cA

0.14

0.12

0.85

1.08

wMUSTER

AAVYDLQYILKASPLNFLLVFVPLGLIWGHFHTLTFLFNFLAIIPLAAIL-TEELADKAG--NTIGGLLNATFG------NAVELIVSIIALKKGQ-VRIVQASMLGSLLSNLLLVLGLCFIFGFNQTAAQTMSSLLAIACASLLIPAAFRATLIDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTISRNVKSSLVILLGTTVIISFCADFL-VGTIDNVV-ESTGLSKTFIGLIVIPIVGNAAEH--VTSVLVAMK--KMDLALGVAIGSSLQ-LFVTPFMVLVGWMIDVPMTLNFSTFETATLFIAVFLSNYLILDGES------------------NWLEGVMSLAMYILIAMAFFYYPDE--------------------------

4kjsA

0.15

0.11

0.72

1.28

wPPAS

-----------------------IFFILVAAGVPLSVIGSLMSAVLFAV--ASYMGRATES---LSIRIGGLLNATFG--NAVELIISMFALKEGL-TGIVLASLTGSVLGNLLLVAGLSFFVGFNIHDARHNSGLLIFAIIVAFVIPEVFSVG-----------------------MGNASKLNLSIGISIIMILLYVAALYFKSGKVATIVLFAATIVVAYISENLTFHSVAEQFG-----SELFIGVIIVAIVGNAAEH--ASAIIMAFK------KMDIAVEIAVGSMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISN--------------DGDSNWFEGATLLAAYVIMAIGFFLL---------------------------------

4wgvA

0.11

0.09

0.86

1.38

dPPAS2

MLLQSMTVRLGIALAQMTRHFLSKPVAIIFWIIAELAIIATDIAEVIGS--AIALDLIFGIPLIVGALITVFDVFLLLFIMRFGFRKIEAIVGT-LIFTVLAIFVFEVFISSPQLTDILNGFVPHKEIVT---NQGILYIALGIIGATIMPHNLYLHSSIVQSRKYDRHDNEE-------------KAQAIKYATIDSNLQLSIAFVVNCLLLTLGAALFGGFYDLYHALKTEPVLGATLGGVMSTLFAVALLASGQNSTITGTLAGQIVMEGFLRLSIPNWLRRLITRS-LAVIPVIICLIIFKGNSEKIEQLLVFSQVFLSIALPFSLIPLQL-------ATSNKKLMGPFINKTWVNIISWTLIVILSGLNVY------------------------------

4wgvA

0.11

0.09

0.85

1.49

PPAS

MLLQSMTVRLGIATGKDLAQMTRHFLSKPVAIIFWIIAELAIIATDIAEVSAIALDLIFGIPLIVGALITVFDVFLLLFIMRFGFRKIEAIVGTLI-FTVLAIFVFEVFISSPQLTDILNGFVPHKEIVTNQGILYIALGIIGATIMPH--NLYLHSSIVQ--------------SRKYDRHDNEEKAQAIKYATIDSNLQLSIAFVVNCLLLTLGAALFFYDLYHALKTPVLGATLG---GVMSTLFAVALLASGQNSTITGTLAGQIVMEGFLRLSIPLRRLITRSLA-PVIICLIIFKGNSEKIEQLLVFSQVFLSIALPFSLIPLQLATSNKKLMG-----------PFINKTWVNIISWTLIVILSGLNVY------------------------------

4f91B1

0.09

0.08

0.92

0.82

Env-PPAS

L-DHCMHDHFNAEIVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGISHRHLSDHL-----SELVEQTLSDLEQSKC----ISIEDEMDVAPLNLGMIAAYYY----INYTTIELFSMSLNAKTK----VRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPH------VKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALA-----AMELAQMVTQAMDSYLKQLPHFT-SEHIKRCTDKGVE--SVFDIMEMEDEERNALLQLTDSQIADVARFCYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGAHNYTLYDAYMGC

4k1cA

0.15

0.13

0.85

0.98

MUSTER

AAVYDLQYILKASPLNFLLVFVPLGLIWGHFHTLTFLFNFLAIIPLAAIL-TEELADKAG------NTIGGLLNATFG--NAVELIVSIIALKKGQ-VRIVQASMLGSLLSNLLLVLGLCFIFGFNQTAAQTMSSLLAIACASLLIPAAFRATLIDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEETDEVMSTISRNVKSSLVILLGTTVIISFCADFL-VGTIDNVV-ESTGLSKTFIGLIVIPIVGNAAEH---VTSVLVAMKDKMDLALGVAIGSSLQ-LFVTPFMVLVGWMIDVPMTLNFSTFETATLFIAVFLSNYLILDGES------------------NWLEGVMSLAMYILIAMAFFYYPDE--------------------------

4k1cA

0.11

0.10

0.87

0.86

dPPAS

---------------TAWRAAVYDLQYILKASPLNFLLVFVPLGLIWGHFQ------------LSHTLTFLFNFLAIIPLAAILANATEELADK-AGNTIGGLLNATFGNAVELIVSIIALKKGQASMLGSLLSNLLLVLGLCFIFGGYNRVQQTQTAAQTMSSLLAIACASLLIPAAFRATLPFIDGKILELSRGTSIVILIVYVLFLYFQLGSHHALFEQQEEET--DEVMSTISRNPHHSLSVKSSLVILLGTTVIISFCADFLVGTIDNVVESGLSKTFIGLIVIPIVGNAAEHVTSVLVAMKDKMDLALGVAIGSSLQVALFVTPFMVLVGW------MIDVPMTLNFSTFETATLFIAVFLSNYLILDGESNAMAFFYYPDE------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.76

Estimated TM-score = 0.62±0.14

Estimated RMSD = 8.6±4.5Å

Download Model 2

C-score=-2.32

Download Model 3

C-score=-1.24

Download Model 4

C-score=-1.90

Download Model 5

C-score=-2.38

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4kppA	0.893	1.40	0.104	0.924
2	4k1cA	0.668	3.89	0.101	0.808
3	4kjsA	0.615	3.24	0.123	0.719
4	3v5sA	0.559	3.67	0.105	0.675
5	3bkkA	0.405	7.21	0.040	0.677
6	3ir7A	0.404	7.28	0.068	0.697
7	3ayfA	0.400	6.66	0.056	0.645
8	2c6fA	0.398	7.25	0.034	0.670
9	1r4lA	0.398	7.28	0.044	0.670
10	1j36A	0.395	7.23	0.034	0.663

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	5hwxA	NA	Rep, Mult	73,74,77,78,243,272
2	0.06	3	1jb0F	CLA	Rep, Mult	32,36
3	0.04	2	2fkwD	BCL	Rep, Mult	217,220
4	0.04	2	3bklA	UUU	Rep, Mult	78,83,84
5	0.02	1	1mz9A	VDY	Rep, Mult	22,25,36
6	0.02	1	2c6nB	NDG	Rep, Mult	39,42,43,46,242
7	0.02	1	1gz7A	GOL	Rep, Mult	128,266,269,270,273
8	0.02	1	5hxcA	MYC	Rep, Mult	141,144,302
9	0.02	1	5hwxA	NA	Rep, Mult	77,78,82,83,242,243
10	0.02	1	1g20B	SF4	Rep, Mult	45,46
11	0.02	1	3my9A	MG	Rep, Mult	271,274
12	0.02	1	1dltA	LIO	Rep, Mult	251,252,313
13	0.02	1	2xy9A	UUU	Rep, Mult	46,49,50,77
14	0.02	1	3gjcA	BOG	Rep, Mult	258,261
15	0.02	1	1gz7A	GOL	Rep, Mult	101,104,231,232,233
16	0.02	1	4gbgA	EAC	Rep, Mult	328,329
17	0.02	1	4xk83	CLA	Rep, Mult	58,59
18	0.02	1	2vt4B	SOG	Rep, Mult	316,319
19	0.02	1	1siwA	SF4	Rep, Mult	46,74,75,76,79,80
20	0.02	1	3r2lA	FE	Rep, Mult	101,104,105,108,276

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1maaD	0.300	7.02	0.053	0.488	3.1.1.7	NA
2	0.060	1cleA	0.380	6.96	0.044	0.613	3.1.1.3	NA
3	0.060	1ofdA	0.288	7.54	0.036	0.515	1.4.7.1	NA
4	0.060	1pn0C	0.363	6.14	0.039	0.544	1.14.13.7	309
5	0.060	1fohC	0.361	6.09	0.097	0.542	1.14.13.7	NA
6	0.060	2fahA	0.354	6.54	0.038	0.562	4.1.1.32	NA
7	0.060	1lpsA	0.376	6.81	0.037	0.599	3.1.1.3	NA
8	0.060	2vdcF	0.347	7.38	0.041	0.608	1.4.1.13	NA
9	0.060	2ogsA	0.355	7.11	0.051	0.581	3.1.1.1	272
10	0.060	3bkkA	0.405	7.21	0.040	0.677	3.4.15.1	105
11	0.060	1k4yA	0.360	6.90	0.034	0.586	3.1.1.1	NA
12	0.060	2c6fA	0.398	7.25	0.034	0.670	3.4.15.1	105
13	0.060	1f6wA	0.379	6.86	0.042	0.608	3.1.1.13,3.1.1.3	43
14	0.060	2vdcA	0.351	7.30	0.054	0.608	1.4.1.13	NA
15	0.060	1c7jA	0.359	6.84	0.029	0.579	3.1.1.-	NA
16	0.060	3eifA	0.362	6.93	0.045	0.594	3.4.21.110	NA
17	0.060	1b41A	0.298	7.32	0.062	0.515	3.1.1.7	NA
18	0.060	3dt7A	0.351	6.58	0.048	0.562	4.1.1.32	NA
19	0.060	1ea0A	0.330	7.17	0.028	0.549	1.4.1.13	284

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.893	1.40	0.10	0.92	4kppA	GO:0016020 GO:0016021 GO:0046872 GO:0055085
1	0.21	0.619	3.41	0.12	0.73	4kjrA	GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006812 GO:0006816 GO:0008324 GO:0015297 GO:0015369 GO:0016020 GO:0016021 GO:0055085 GO:0070588
2	0.09	0.668	3.89	0.10	0.81	4k1cA	GO:0000324 GO:0000329 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0006812 GO:0006816 GO:0006828 GO:0006874 GO:0008324 GO:0015085 GO:0015369 GO:0015386 GO:0016020 GO:0016021 GO:0046872 GO:0055085 GO:0070588 GO:0071805 GO:0098655
3	0.07	0.405	7.21	0.04	0.68	3bkkA	GO:0001822 GO:0001974 GO:0002003 GO:0002005 GO:0002019 GO:0002446 GO:0002474 GO:0003081 GO:0003779 GO:0004175 GO:0004180 GO:0005576 GO:0005615 GO:0005737 GO:0005764 GO:0005768 GO:0005886 GO:0006508 GO:0007283 GO:0008144 GO:0008217 GO:0008233 GO:0008237 GO:0008238 GO:0008240 GO:0008241 GO:0008270 GO:0009897 GO:0014910 GO:0016020 GO:0016021 GO:0016787 GO:0019229 GO:0031404 GO:0031434 GO:0031711 GO:0032943 GO:0042312 GO:0042447 GO:0043171 GO:0046872 GO:0050435 GO:0050482 GO:0051019 GO:0060047 GO:0060177 GO:0060218 GO:0061098 GO:0070062 GO:0070573 GO:0071838 GO:1900086 GO:1902033 GO:1903597 GO:2000170
4	0.07	0.570	3.64	0.12	0.68	5hwyA	GO:0005262 GO:0005509 GO:0005886 GO:0005887 GO:0006874 GO:0008273 GO:0016020 GO:0016021 GO:0030955 GO:0031402 GO:0035725 GO:0055085 GO:0070588
5	0.06	0.406	7.37	0.06	0.70	3egwA	GO:0005886 GO:0008940 GO:0009055 GO:0009061 GO:0009325 GO:0016020 GO:0016491 GO:0030151 GO:0031224 GO:0031235 GO:0042126 GO:0042128 GO:0043546 GO:0044799 GO:0046872 GO:0051536 GO:0051539 GO:0055114
6	0.06	0.398	7.27	0.03	0.67	5am8D	GO:0001822 GO:0001974 GO:0002003 GO:0002005 GO:0002019 GO:0002446 GO:0002474 GO:0003081 GO:0003779 GO:0004175 GO:0004180 GO:0005576 GO:0005615 GO:0005737 GO:0005764 GO:0005768 GO:0005886 GO:0006508 GO:0007283 GO:0008144 GO:0008217 GO:0008233 GO:0008237 GO:0008238 GO:0008240 GO:0008241 GO:0008270 GO:0009897 GO:0014910 GO:0016020 GO:0016021 GO:0016787 GO:0019229 GO:0031404 GO:0031434 GO:0031711 GO:0032943 GO:0042312 GO:0042447 GO:0043171 GO:0046872 GO:0050435 GO:0050482 GO:0051019 GO:0060047 GO:0060177 GO:0060218 GO:0061098 GO:0070062 GO:0070573 GO:0071838 GO:1900086 GO:1902033 GO:1903597 GO:2000170
7	0.06	0.347	7.10	0.06	0.59	3ml1A	GO:0005506 GO:0006777 GO:0008940 GO:0009055 GO:0016491 GO:0030151 GO:0042128 GO:0042597 GO:0046872 GO:0051536 GO:0051539 GO:0055114
8	0.06	0.350	7.14	0.06	0.60	2ivfA	GO:0016491 GO:0030151 GO:0046872 GO:0051536 GO:0051539 GO:0055114
9	0.06	0.341	7.34	0.04	0.59	1h0hA	GO:0008863 GO:0009055 GO:0016491 GO:0030151 GO:0042597 GO:0043546 GO:0045333 GO:0046872 GO:0047111 GO:0051536 GO:0051539 GO:0055114
10	0.06	0.298	7.62	0.05	0.54	1fdiA	GO:0005829 GO:0008863 GO:0009055 GO:0015942 GO:0015944 GO:0016491 GO:0030151 GO:0046872 GO:0051536 GO:0051539 GO:0055114
11	0.06	0.401	7.15	0.04	0.67	4aa1A	GO:0004180 GO:0005576 GO:0005615 GO:0006508 GO:0007289 GO:0007291 GO:0007552 GO:0008233 GO:0008237 GO:0008241 GO:0008270 GO:0009609 GO:0016020 GO:0016787 GO:0046872
12	0.06	0.312	7.13	0.05	0.53	2vpwA	GO:0016491 GO:0030151 GO:0046872 GO:0051536 GO:0051539 GO:0055114
13	0.06	0.345	7.15	0.03	0.58	2ajfA	GO:0001618 GO:0001817 GO:0001948 GO:0002003 GO:0002005 GO:0003051 GO:0003081 GO:0004175 GO:0004180 GO:0004181 GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008241 GO:0008270 GO:0009986 GO:0015827 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0019229 GO:0032800 GO:0042127 GO:0042312 GO:0045121 GO:0046718 GO:0046813 GO:0046872 GO:0050727 GO:0060452 GO:0070062 GO:1903598 GO:1903779 GO:2000379
14	0.06	0.315	7.54	0.06	0.56	1eu1A	GO:0009055 GO:0016491 GO:0030151 GO:0042597 GO:0046872 GO:0050626 GO:0055114
15	0.06	0.329	7.54	0.04	0.58	5chcA	GO:0016491 GO:0030151 GO:0046872 GO:0051536 GO:0051539 GO:0055114
16	0.06	0.336	7.24	0.04	0.58	1kqfA	GO:0008430 GO:0008863 GO:0009055 GO:0009061 GO:0009326 GO:0015944 GO:0016020 GO:0016491 GO:0030151 GO:0030288 GO:0036397 GO:0042597 GO:0043546 GO:0045333 GO:0046872 GO:0047111 GO:0051536 GO:0051539 GO:0055114
17	0.06	0.317	7.44	0.04	0.56	4v4cA	GO:0016491 GO:0018706 GO:0030151 GO:0046872 GO:0055114
18	0.06	0.331	7.26	0.05	0.56	2v45A	GO:0005506 GO:0006777 GO:0008940 GO:0009055 GO:0016491 GO:0030151 GO:0042128 GO:0042597 GO:0046872 GO:0051536 GO:0051539 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0051139	GO:0015368	GO:0046872
GO-Score	0.56	0.56	0.44
Biological Processes	GO:0070588	GO:0072503	GO:0055074	GO:0006875
GO-Score	0.33	0.31	0.31	0.31
Cellular Component	GO:0016021	GO:0031226
GO-Score	0.59	0.52

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.