I-TASSER results

I-TASSER results for job id Rv2956

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (243 residues)
MKSLKLARFIARSAAFEVSRRYSERDLKHQFVKQLKSRRVDVVFDVGANSGQYAAGLRRA
AYKGRIVSFEPLSGPFTILESKASTDPLWDCRQHALGDSDGTVTINIAGNAGQSSSVLPM
LKSHQNAFPPANYVGTQEASIHRLDSVAPEFLGMNGVAFLKVDVQGFEKQVLAGGKSTID
DHCVGMQLELSFLPLYEGGMLIPEALDLVYSLGFTLTGLLPCFIDANNGRMLQADGIFFR
EDD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MKSLKLARFIARSAAFEVSRRYSERDLKHQFVKQLKSRRVDVVFDVGANSGQYAAGLRRAAYKGRIVSFEPLSGPFTILESKASTDPLWDCRQHALGDSDGTVTINIAGNAGQSSSVLPMLKSHQNAFPPANYVGTQEASIHRLDSVAPEFLGMNGVAFLKVDVQGFEKQVLAGGKSTIDDHCVGMQLELSFLPLYEGGMLIPEALDLVYSLGFTLTGLLPCFIDANNGRMLQADGIFFREDD
Prediction	CCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHCCCCEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEEEEHHHHHHHHCCCCCCEEEEEHCCCHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCCCCCEEEEEEEEEHCCC
Conf.Score	974445566546654677676555579999999985789988999589987999999998999889999789999999999998789857988665678878999976899988766666555455456665557899999865889999758899669999789869999998999998769889999856544568999999999999989989998566457889858999999996799
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MKSLKLARFIARSAAFEVSRRYSERDLKHQFVKQLKSRRVDVVFDVGANSGQYAAGLRRAAYKGRIVSFEPLSGPFTILESKASTDPLWDCRQHALGDSDGTVTINIAGNAGQSSSVLPMLKSHQNAFPPANYVGTQEASIHRLDSVAPEFLGMNGVAFLKVDVQGFEKQVLAGGKSTIDDHCVGMQLELSFLPLYEGGMLIPEALDLVYSLGFTLTGLLPCFIDANNGRMLQADGIFFREDD
Prediction	441142032012303130023134340132005205746230000133201000100042046020000121350052035224424203211000024423020201444421112223344444324544444323120232220034246264010000001311330042035105621000000002231364452043025115724230230243224464221110000002588
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHCCCCEEEEEEHCCCCCEEEEEHCCCCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEEEEHHHHHHHHCCCCCCEEEEEHCCCHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCCCCCEEEEEEEEEHCCC
MKSLKLARFIARSAAFEVSRRYSERDLKHQFVKQLKSRRVDVVFDVGANSGQYAAGLRRAAYKGRIVSFEPLSGPFTILESKASTDPLWDCRQHALGDSDGTVTINIAGNAGQSSSVLPMLKSHQNAFPPANYVGTQEASIHRLDSVAPEFLGMNGVAFLKVDVQGFEKQVLAGGKSTIDDHCVGMQLELSFLPLYEGGMLIPEALDLVYSLGFTLTGLLPCFIDANNGRMLQADGIFFREDD

2py6A2

0.15

0.12

0.81

1.21

MUSTER

QTLYAVLNFHL-TCEPEYYHEVERPYSTLYFRSGLLRFSDSEKVDCGASIGESLAGLIGVTGKFERVWIEPDRINLQTLQNVLRRYT----------DTNFASRITVHGCGAGENTIRVPFDL---------------IDVRPIDDII------DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISA-----YHRSTDLLDLTNYILSIDYQIGLRH---HTPDR----WDTCLYFY---

2py6A2

0.15

0.12

0.81

1.23

dPPAS

VQTLYAVLNFHLTCEPEYYHEVERPYSTLYFRSGLLRFSDSEKVDCGASIGESLAGLIGVTKKFERVWIEPDRINLQTLQNVLRRYT----------DTNFASRITVHGCGAGENTIRVPFDL---------------IDVRPIDDII------DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISA-----YHRSTDLLDLTNYILSIDYQIGLRHHTPDRWDTCLYFY----------

2py6A2

0.14

0.12

0.81

2.09

wdPPAS

LADDYSVQTLYATCEPEYYHEVERPYSTLYFRSGLLRFSDSEKVDCGASIGESLAGLIGV-GKFERVWIEPDRINLQTLQNVLRRYTDTNFASRITVHGCGAG-------------------------ENTIRVPFDLIDVRPIDDII------DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISA-----YHRSTDLLDLTNYILSIDYQIGLRHHTPDRWD-------TCLYFY---

2py6A2

0.15

0.12

0.80

1.55

wMUSTER

LALYAVLNFHL-TCEPEYYHEVERPYSTLYFRSGLLRFSDSEKVDCGASIGESLAGLIGV-GKFERVWIEPDRINLQTLQNVLRRYT----------DTNFASRITVHGCGAGENTIRVPFDL---------------IDVRPIDDII------DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISA-----YHRSTDLLDLTNYILSIDYQIGLRH---HTPDRWD----TCLYFY---

2py6A2

0.17

0.12

0.73

2.44

wPPAS

LALYAVLNFHL-TCEPEYYHEVERPYSTLYFRSGLLRFSDSEKVDCGASIGESLAGLIGV-GKFERVWIEPDRINLQTLQNVLRRYTDTTVHGCGAGENTIRVPF-------------------------------DLIDVRPIDDII------DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISA-----YHRSTDLLDLTNYILSIDYQ---------------------IGLRHHT

2py6A2

0.15

0.12

0.78

2.95

dPPAS2

QTLYAVLNFHL-TCEPEYYHEVERPYSTLYFRSGLLRFSDSEKVDCGASIGESLAGLIGVTKKFERVWIEPDRINLQTLQNVLRRYT----------DTNFASRITVHGCGAGENTIRVPFDL---------------IDVRPIDDII------DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISA-----YHRSTDLLDLTNYILSIDYQIGLRHHTPDRWY----------------

2py6A2

0.15

0.12

0.80

2.00

PPAS

QTLYAVLNFHLTCE-PEYYHEVERPYSTLYFRSGLLRFSDSEKVDCGASIGESLAGLIGV-GKFERVWIEPDRINLQTLQNVLRRYT----------DTNFASRITVHGCGAGENTIRVPFDL---------------IDVRPIDDII------DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISA-----YHRSTDLLDLTNYILSIDYQIGLRHHTPDR-------WDTCLYFY---

2py6A2

0.15

0.12

0.81

2.29

Env-PPAS

QTLYAVLNFHLTCE-PEYYHEVERPYSTLYFRSGLLRFSDSEKVDCGASIGESLAGLIGVTGKFERVWIEPDRINLQTLQNVLRRYTDT----------NFASRITVHGCGAGENTIRVPFDL---------------IDVRPIDDII------DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISA-----YHRSTDLLDLTNYILSIDYQIGLRHHTPD-------RWDTCLYFY---

3e05D

0.11

0.08

0.74

0.90

MUSTER

VIGIDDDEFATAKKLI------TKQEVRAVTLSKLRLQDDLVMWDIGAGSASVSIEASNLMPNGRIFALERNPQYLGFIRDNLKKFVARN------------VTLVEAFAPEGL-------------------------------------DDLPDPDRVFIGSGGMLEEIIDAVDRRLKSEG-VIVLNA-------TLDTLTKAVEFLEDHGYEVACVNVAKTKGLTEYHNPVYIITAWKSD

3e05D

0.11

0.08

0.77

0.84

dPPAS

VIGIDDDEFATAKKLI------TKQEVRAVTLSKLRLQDDLVMWDIGAGSASVSIEASNLMPNGRIFALERNPQYLGFIRDNLKKFVARNVTLVEAFAPEGLDDLPDPDRVFIGGSGGMLEEIIDAVDRRLKSEGVIVLNAVTLDTLTKAVEFLEGYMVEVACVNVAKTKGL-TEYKMFESHNPVYIITAWKSDE------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.94

Estimated TM-score = 0.60±0.14

Estimated RMSD = 7.8±4.4Å

Download Model 2

C-score=-1.84

Download Model 3

C-score=-0.89

Download Model 4

C-score=-3.71

Download Model 5

C-score=-4.18

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2py6A2	0.742	1.92	0.142	0.811
2	2hnkB	0.590	3.50	0.077	0.737
3	4ckbA2	0.589	3.72	0.081	0.737
4	4qvkA	0.585	3.33	0.113	0.724
5	5a22A	0.583	4.07	0.087	0.765
6	2zwaB	0.579	3.92	0.072	0.761
7	4fp9A	0.578	3.86	0.104	0.737
8	3cbgA	0.578	3.52	0.084	0.728
9	4n48A	0.578	3.73	0.048	0.733
10	3bgvC	0.577	3.69	0.087	0.728

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.22	12	3nvkI	SAM	Rep, Mult	47,49,53,69,70,71,110,111,112,164,165,166
2	0.11	6	5lqnA	72O	Rep, Mult	47,49,69,70,71,110,111,112,113,165,166,167
3	0.06	3	1kczA	MG	Rep, Mult	163,189,242
4	0.04	2	1gsaA	MG	Rep, Mult	163,189
5	0.02	1	3jwgA	MG	Rep, Mult	47,160
6	0.02	1	3bb1H	MG	Rep, Mult	115,163
7	0.02	1	1hdxB	CXL	Rep, Mult	9,220
8	0.02	1	1qgxA	MG	Rep, Mult	161,189

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.067	1suiA	0.566	3.64	0.101	0.728	2.1.1.104	NA
2	0.067	3e05D	0.554	2.62	0.091	0.642	2.1.1.132	48
3	0.067	1f38A	0.531	3.06	0.108	0.634	2.1.1.-	NA
4	0.067	2avdA	0.556	3.84	0.103	0.720	2.1.1.-	NA
5	0.067	1nt2A	0.553	3.07	0.103	0.667	2.1.1.-	NA
6	0.067	3grzB	0.511	3.07	0.110	0.617	2.1.1.-	NA
7	0.067	3bwmA	0.560	3.45	0.095	0.687	2.1.1.6	NA
8	0.067	3hnrA	0.524	3.09	0.113	0.630	2.1.1.-	NA
9	0.067	3c3yA	0.573	3.59	0.112	0.733	2.1.1.104	121
10	0.066	1pjzA	0.522	3.96	0.051	0.687	2.1.1.67	52,67,72,144
11	0.066	1g8aA	0.545	3.19	0.087	0.667	2.1.1.-	NA
12	0.066	2iftA	0.506	3.27	0.071	0.617	2.1.1.52	48,50,163
13	0.066	2ex4A	0.540	3.11	0.065	0.663	2.1.1.-	166
14	0.060	1fbnA	0.550	3.44	0.082	0.679	2.1.1.-	NA
15	0.060	1susD	0.564	3.63	0.095	0.724	2.1.1.104	163
16	0.060	2ytzA	0.560	3.46	0.073	0.700	2.1.1.32	163
17	0.060	2o2sA	0.549	4.37	0.073	0.749	1.3.1.9	NA
18	0.060	2a14A	0.560	3.99	0.091	0.728	2.1.1.49	47,196
19	0.060	2bh2A	0.575	3.43	0.093	0.708	2.1.1.-	NA
20	0.060	1kpiA	0.563	3.58	0.068	0.708	2.1.1.79	NA
21	0.060	2opbB	0.571	3.91	0.057	0.749	2.1.1.28	47,72,196
22	0.060	3cbgA	0.578	3.52	0.084	0.728	2.1.1.-	204
23	0.060	1ri1A	0.557	3.27	0.105	0.679	2.1.1.56	47
24	0.060	1xxlA	0.558	3.23	0.108	0.679	2.1.1.-	NA
25	0.060	2h11B	0.561	3.47	0.075	0.704	2.1.1.67	54,80
26	0.060	2e5wA	0.554	3.77	0.052	0.708	2.5.1.16	NA
27	0.060	2cl5A	0.559	3.49	0.106	0.687	2.1.1.6	NA
28	0.060	2pffD	0.539	4.65	0.078	0.753	2.3.1.86	47,51,54
29	0.060	3eppB	0.573	3.71	0.082	0.724	2.1.1.56	47,107
30	0.060	2i62C	0.562	4.07	0.077	0.741	2.1.1.1	47,79
31	0.060	1mjfA	0.552	3.73	0.058	0.704	2.5.1.16	NA
32	0.060	3duwA	0.575	3.58	0.091	0.724	2.1.1.-	173

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.747	1.90	0.15	0.81	2py6A	GO:0008168 GO:0016740 GO:0032259
1	0.18	0.566	3.64	0.10	0.73	1suiA	GO:0008168 GO:0008171 GO:0009699 GO:0009809 GO:0016740 GO:0032259 GO:0042409 GO:0046872
2	0.16	0.535	3.32	0.14	0.65	1o54A	GO:0016429 GO:0030488 GO:0031515
3	0.14	0.590	3.50	0.08	0.74	2hnkB	GO:0008168 GO:0008171 GO:0016740 GO:0032259
4	0.13	0.549	3.02	0.10	0.65	3mb5A	GO:0008033 GO:0008168 GO:0016429 GO:0016740 GO:0030488 GO:0031515 GO:0032259
5	0.07	0.523	2.57	0.10	0.61	2esrA	GO:0003676 GO:0008168 GO:0016740 GO:0031167 GO:0032259
6	0.07	0.529	2.83	0.08	0.62	3p9nA	GO:0003676 GO:0008168 GO:0031167 GO:0032259
7	0.07	0.488	2.98	0.10	0.59	1ws6A	GO:0008168 GO:0016740 GO:0031167 GO:0032259
8	0.07	0.526	2.83	0.09	0.63	2fhpA	GO:0003676 GO:0008168 GO:0031167 GO:0032259
9	0.07	0.581	3.58	0.09	0.73	3duwA	GO:0008168 GO:0008171 GO:0016740 GO:0032259
10	0.07	0.518	3.19	0.07	0.62	2fpoC	GO:0003676 GO:0006364 GO:0008168 GO:0016740 GO:0031167 GO:0032259 GO:0052913 GO:0070475
11	0.07	0.590	3.23	0.10	0.72	4ymgB	GO:0008171 GO:0032259 GO:0046872 GO:0051536 GO:0051539
12	0.07	0.569	2.98	0.09	0.69	3ntvA	GO:0008171 GO:0032259
13	0.07	0.588	3.73	0.08	0.74	4ckcD	GO:0000166 GO:0003723 GO:0003824 GO:0004482 GO:0004484 GO:0004651 GO:0005525 GO:0006351 GO:0006353 GO:0006355 GO:0006370 GO:0006397 GO:0008152 GO:0008168 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0032259 GO:0036265 GO:0046872 GO:0050355 GO:0098507
14	0.07	0.519	3.21	0.07	0.63	4qtuB	GO:0000056 GO:0000447 GO:0005634 GO:0005730 GO:0005737 GO:0006364 GO:0008152 GO:0008168 GO:0008757 GO:0016435 GO:0016740 GO:0032259 GO:0070476
15	0.07	0.572	3.71	0.08	0.73	3tr6A	GO:0008168 GO:0008171 GO:0016740 GO:0032259
16	0.07	0.477	3.05	0.07	0.57	5bxyA	GO:0008168 GO:0032259
17	0.07	0.506	3.27	0.07	0.62	2iftA	GO:0003676 GO:0006364 GO:0008168 GO:0016740 GO:0031167 GO:0032259 GO:0052913
18	0.07	0.577	3.93	0.08	0.74	3bgvB	GO:0003723 GO:0004482 GO:0005634 GO:0005654 GO:0005730 GO:0005845 GO:0006366 GO:0006370 GO:0006397 GO:0008168 GO:0016740 GO:0032259 GO:0036265 GO:0043235
19	0.07	0.556	3.84	0.10	0.72	2avdA	GO:0005739 GO:0008168 GO:0008171 GO:0016020 GO:0016021 GO:0016740 GO:0032259
20	0.07	0.573	3.59	0.11	0.73	3c3yA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0042409 GO:0046872
21	0.07	0.568	3.72	0.11	0.72	4pcaA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
22	0.07	0.578	3.52	0.08	0.73	3cbgA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046872
23	0.07	0.564	3.36	0.10	0.69	4p7kA	GO:0000287 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006584 GO:0007565 GO:0007612 GO:0007614 GO:0008168 GO:0008171 GO:0008210 GO:0009712 GO:0014070 GO:0016020 GO:0016021 GO:0016036 GO:0016206 GO:0016740 GO:0030424 GO:0030425 GO:0032259 GO:0032496 GO:0032502 GO:0035814 GO:0042135 GO:0042417 GO:0042420 GO:0042493 GO:0043197 GO:0044297 GO:0045211 GO:0045963 GO:0046498 GO:0046500 GO:0046872 GO:0048265 GO:0048609 GO:0048662 GO:0050668 GO:0051930 GO:0070062
24	0.07	0.573	3.70	0.07	0.73	3tfwA	GO:0008168 GO:0008171 GO:0016740 GO:0032259
25	0.07	0.551	3.32	0.07	0.68	3ccfB	GO:0008152 GO:0008168 GO:0016740 GO:0030798 GO:0032259
26	0.07	0.556	3.42	0.07	0.69	3e7pA	GO:0046872 GO:0051536 GO:0051539
27	0.07	0.547	3.42	0.10	0.69	3c3pA	GO:0008168 GO:0008171 GO:0016740 GO:0032259
28	0.07	0.558	3.42	0.09	0.69	3kkzA	GO:0046872 GO:0051536 GO:0051539
29	0.07	0.546	3.38	0.09	0.68	3mggB	GO:0008168 GO:0016740 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0016426	GO:0043169
GO-Score	0.54	0.36
Biological Processes	GO:0001510	GO:0006400	GO:0009808	GO:1901362	GO:0044550	GO:0019438
GO-Score	0.54	0.54	0.36	0.36	0.36	0.36
Cellular Component	GO:0043527
GO-Score	0.54

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.