I-TASSER results

I-TASSER results for job id Rv2955c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (321 residues)
MQFQDVRLMRVVVCRRLGPAKGQRRWRPLDLGTTGCFENLGAQRPTYRMRAIRMLECAMP
NRLVRSLQRWRPFGLPPHRWRLAPWYWRGLQVTLEPGSAIAWIVRLTGGFEETEIDIAAA
LYSALYPDRCILDVGANVGIHSLAWARLAPVVALEPAPGTHSRLEANVAANGLQDRIRTL
RTAAGDAVGEVDFFVAADSAFSSLNDTGRIRIRERTRVPCTTLDALAAELPLPVGLLKID
VEGLERAVIAGAAELLRRDRPVLLVEIYGGAASNPDPERTIADIRAYGYEPFVYADDAGL
QPYQRHRDDRYCYFFIPSRKG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQFQDVRLMRVVVCRRLGPAKGQRRWRPLDLGTTGCFENLGAQRPTYRMRAIRMLECAMPNRLVRSLQRWRPFGLPPHRWRLAPWYWRGLQVTLEPGSAIAWIVRLTGGFEETEIDIAAALYSALYPDRCILDVGANVGIHSLAWARLAPVVALEPAPGTHSRLEANVAANGLQDRIRTLRTAAGDAVGEVDFFVAADSAFSSLNDTGRIRIRERTRVPCTTLDALAAELPLPVGLLKIDVEGLERAVIAGAAELLRRDRPVLLVEIYGGAASNPDPERTIADIRAYGYEPFVYADDAGLQPYQRHRDDRYCYFFIPSRKG
Prediction	CCCCCCHHHHEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCEEEEHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEHCCCCCHHHHHHHHCCCEEEHCCCHHHHHHHHHHHHHHCCCHHHEEEEEEEHCCCCEEEEEHCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHCCCCCEEEEHCCCHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCHHHHHHHHHHHCCEEEEEHCCCCCEEEHCCCCCCCCEEEHCCCCC
Conf.Score	986554444455544578887654444455566556666654576578888888887777776667777665446777656777765887999779865677788868888656999999999889997999958998599999986795999959999999999999987654444444455655885899986689888777776555666658999886688999979998599995898599999989999998698899996787778889999999999989989998589885665446777765676567789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQFQDVRLMRVVVCRRLGPAKGQRRWRPLDLGTTGCFENLGAQRPTYRMRAIRMLECAMPNRLVRSLQRWRPFGLPPHRWRLAPWYWRGLQVTLEPGSAIAWIVRLTGGFEETEIDIAAALYSALYPDRCILDVGANVGIHSLAWARLAPVVALEPAPGTHSRLEANVAANGLQDRIRTLRTAAGDAVGEVDFFVAADSAFSSLNDTGRIRIRERTRVPCTTLDALAAELPLPVGLLKIDVEGLERAVIAGAAELLRRDRPVLLVEIYGGAASNPDPERTIADIRAYGYEPFVYADDAGLQPYQRHRDDRYCYFFIPSRKG
Prediction	752551300000003324456343214313233212044035431430241042044004422142044234340443423003233441302023421000102234213440140042016205642000000010000000014202000000135005103422322202223211100021322303222343212112233332234422202013002004527130000000002102400420350055220000000003335342033005105734130010156330320342453410000135568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCHHHHEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCEEEEHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEEEHCCCCCHHHHHHHHCCCEEEHCCCHHHHHHHHHHHHHHCCCHHHEEEEEEEHCCCCEEEEEHCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHCCCCCEEEEHCCCHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCHHHHHHHHHHHCCEEEEEHCCCCCEEEHCCCCCCCCEEEHCCCCC
MQFQDVRLMRVVVCRRLGPAKGQRRWRPLDLGTTGCFENLGAQRPTYRMRAIRMLECAMPNRLVRSLQRWRPFGLPPHRWRLAPWYWRGLQVTLEPGSAIAWIVRLTGGFEETEIDIAAALYSALYPDRCILDVGANVGIHSLAWARLAPVVALEPAPGTHSRLEANVAANGLQDRIRTLRTAAGDAVGEVDFFVAADSAFSSLNDTGRIRIRERTRVPCTTLDALAAELPLPVGLLKIDVEGLERAVIAGAAELLRRDRPVLLVEIYGGAASNPDPERTIADIRAYGYEPFVYADDAGLQPYQRHRDDRYCYFFIPSRKG

2py6A

0.18

0.15

0.87

0.95

MUSTER

LNVRHERPCEVIAAVDDFRYHSGELYYGLPIISTDRFTELATHDRDGPKRFFDQICRTHGIPHLNFEQAVRAFGLQGNVDYRVDDWGADIV-RLADDQTLYAVLNFHLTCEPEYYHEVERPYSTLFSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYTFASRITVHGCGAGENTIRVPF----------------------DLIDVRPIDDIIDD---APT-FIKDIEGSELSALKGARRAISEHKPKLAISAYHRST---DLLDLTNYILSIDYQIGLRHHTP-------DRWDTCLYFY------

2py6A2

0.14

0.10

0.70

1.31

dPPAS

---------------------------------DYRVDDWGADIVRNIPAFQTLAQRLADDYSVQTLYAVLNF-------------------------HLTCEPEYYHEVERPYSTLYFRSGLLRFSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYT-------------DTNFASRITVHGCGAGENTIRVPFDL------IDVRPIDDII----DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISAYHRSTD---LLDLTNYILSI-------RPDYQIGLRHHTPDRWDTCLYFY----

2py6A2

0.14

0.10

0.68

2.16

wdPPAS

---------------------------------DYRVDDWGADIVRNIPAFQTLAQRLADDYSVQTLYAVLNFHLTCE-----------------------PEYYHEVERPYSTLYFRSGL--LRFSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYTDTNFASRIT-------------------VHGCGAGENTIRVPFDLIDVRPIDDIID----DAPTFIKDIEGSELSALKGARRAISEHKPKLAISAYHRST---DLLDLTNYILSIDYQIGLRHHTPDLYFY------------------

2py6A

0.17

0.15

0.86

1.20

wMUSTER

VRHERP--CEVIAAVDDFRYHSGELYYGLPIISTDRFTELATHDRDGPKRFFDQICRTHGIPHLNFEQAVRAFGLQGNVDYRVDDWGADIV-RLADDQTLYAVLNFHLTCEPEYYHEVERPYSTLFSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYTFASRITVHGCGAGENTIRVP----------------------FDLIDVRPIDDIID----DAPTFIKDIEGSELSALKGARRAISEHKPKLAISAYHRST---DLLDLTNYILSIDYQIGLRHH-------TPDRWDTCLYFY------

2py6A2

0.16

0.11

0.68

2.57

wPPAS

---------------------------------DYRVDDWGADIVRNIPAFQTLAQRDYSVQTLYAVLNFHLTC---------------------------PEYYHEVERPYSTLYFRSGL--LRFSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYTDTSRITVHGCGAGENTIRVP----------------------FDLIDVRPIDDIID----DAPTFIKDIEGSELSALKGARRAISEHKPKLAISAYHRST---DLLDLTNYILSIDYQIGLRHHT-------PDRWDTCLYFY------

2py6A2

0.15

0.10

0.70

3.78

dPPAS2

---------------------------------DYRVDDWGADIVRNIPAFQTLAQRLADDYSVQTLYAVLNFHLTCEP-----------EYYHEVERPYSTLYFRSGLL--------------RFSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYT-------------DTNFASRITVHGCGAGENTIRVPFDL------IDVRPIDDII----DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISAYHRSTD---LLDLTNYILSI-------RPDYQIGLRHHTPDRWDTCLYFY----

2py6A2

0.18

0.12

0.69

1.97

PPAS

---------------------------------DYRVDDWGADIVRNIPAFQTLAQRLADDYSVQTLYAVLNFHLTCE-----------------------PEYYHEVERPYSTLYFRSGL--LRFSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYTDTSRITVHGCGAGENTIRVPF----------------------DLIDVRPIDDII----DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISAYHRST---DLLDLTNYILSIDYQIGLRHHT-------PDRWDTCLYFY------

2py6A2

0.16

0.11

0.69

2.61

Env-PPAS

---------------------------------DYRVDDWGADIVRNIPAFQTLAQRLADDYSVQTLYAVLNFHL-----------TCEPEYYHEVERPYSTLYFRSGLL--------------RFSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYTDTSRITVHGCGAGENTIRVPF----------------------DLIDVRPIDDII----DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISAYHRSTD---LLDLTNYILSIDYQIGLRHHTPDR---------WDTCLYFY----

2py6A2

0.16

0.11

0.69

0.91

MUSTER

---------------------------------DYRVDDWGADIVRNIPAFQTLAQRLADDYSVQTLYAVLNFHLTCE------------------------PEYYHEVERPYSTLYFR--SGLLRSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYTFASRITVHGCGAGENTIRVPF----------------------DLIDVRPIDDIID----DAPTFIKDIEGSELSALKGARRAISEHKPKLAISAYHRST---DLLDLTNYILSIDYQIGLRHH---------TPDRWDTCLYFY----

2py6A

0.15

0.13

0.87

1.12

dPPAS

LNVRHERPCEVIAAVDDFRYHSGELYYGLPIISTDRFTELATHDRDGPKRFFDQICRTHGIPHLNFEQAVRAFGLQGNVD----YRVDDWGADIVRNIPAFQTLAQRLADDYSVQTLYAVLNFHLFSDSEKVDCGASIGESLAGLIGVFERVWIEPDRINLQTLQNVLRRYT-------------DTNFASRITVHGCGAGENTIRVPFDL------IDVRPIDDII----DDAPTFIKDIEGSELSALKGARRAISEHKPKLAISAYHRSTDLLDLTNYILSIR----------PDYQIGLRHHTPDRWDTCLYFY----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.88

Estimated TM-score = 0.49±0.15

Estimated RMSD = 10.7±4.6Å

Download Model 2

C-score=-1.95

Download Model 3

C-score=-2.95

Download Model 4

C-score=-3.20

Download Model 5

C-score=-3.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2py6A	0.707	2.66	0.154	0.791
2	1sqfA	0.517	4.43	0.100	0.670
3	2yxlA	0.508	4.59	0.113	0.667
4	5kn4A	0.507	4.36	0.054	0.657
5	3vseA	0.505	4.62	0.103	0.673
6	4n48A	0.498	4.96	0.062	0.670
7	2b78A	0.497	4.59	0.076	0.660
8	1uwvA	0.497	3.96	0.128	0.614
9	4fp9A	0.491	4.12	0.130	0.623
10	4atnA	0.487	4.88	0.081	0.670

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.38	19	4m37A	SAH	Rep, Mult	112,133,134,135,136,137,141,154,155,156,160,182,183,184,241,248
2	0.04	2	2jgoB	ZN	Rep, Mult	242,245
3	0.04	2	2x2vA	DPV	Rep, Mult	238,242
4	0.02	1	3ke6A	MN	Rep, Mult	133,134,138,139
5	0.02	1	3ke6A	MN	Rep, Mult	133,240,296
6	0.02	1	2hneA	MG	Rep, Mult	133,155,186

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1v6sA	0.465	5.89	0.047	0.704	2.7.2.3	NA
2	0.060	2vz8B	0.482	5.11	0.069	0.670	2.3.1.85	NA
3	0.060	1e3lA	0.469	5.55	0.072	0.692	1.1.1.1	251
4	0.060	13pkA	0.491	5.36	0.064	0.717	2.7.2.3	NA
5	0.060	1a71A	0.482	5.23	0.063	0.685	1.1.1.1	142
6	0.060	2dphA	0.466	5.16	0.063	0.667	1.2.99.4	NA
7	0.060	2w98B	0.470	5.15	0.041	0.660	1.3.1.48	207
8	0.060	3c6kD	0.467	5.08	0.076	0.651	2.5.1.22	NA
9	0.060	1cdoA	0.478	5.22	0.071	0.679	1.1.1.1	NA
10	0.060	1tehA	0.485	5.15	0.071	0.682	1.1.1.284,1.1.1.1	262,265
11	0.060	1cdoB	0.474	5.48	0.051	0.685	1.1.1.1	164,177
12	0.060	2j3jB	0.471	5.55	0.035	0.689	1.3.1.74	139
13	0.060	1f8fA	0.480	5.37	0.068	0.689	1.1.1.90	NA
14	0.060	1d1tA	0.481	5.37	0.081	0.692	1.1.1.1	262
15	0.060	2vz8A	0.481	5.11	0.077	0.670	2.3.1.85	NA
16	0.060	1p0fA	0.476	5.23	0.057	0.682	1.1.1.2	246,263
17	0.060	2as0A	0.476	4.79	0.116	0.642	2.1.1.-	NA
18	0.060	1m6hA	0.483	5.15	0.074	0.682	1.1.1.284,1.1.1.1	NA
19	0.060	3cosD	0.479	5.34	0.056	0.689	1.1.1.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.32	0.712	2.63	0.14	0.79	2py6A	GO:0008168 GO:0016740 GO:0032259
1	0.13	0.425	3.45	0.10	0.51	2ipxA	GO:0000494 GO:0001094 GO:0001649 GO:0001651 GO:0001652 GO:0003723 GO:0005634 GO:0005654 GO:0005730 GO:0006364 GO:0006396 GO:0008033 GO:0008168 GO:0008649 GO:0015030 GO:0016020 GO:0016074 GO:0016740 GO:0030529 GO:0031167 GO:0031428 GO:0032040 GO:0032259 GO:0044822 GO:0048254 GO:0051117 GO:0070062 GO:1990258 GO:1990259
2	0.10	0.508	4.59	0.11	0.67	2yxlA	GO:0003723 GO:0006364 GO:0008168 GO:0008757 GO:0032259
3	0.09	0.517	4.43	0.10	0.67	1sqfA	GO:0003723 GO:0005737 GO:0005829 GO:0006355 GO:0006364 GO:0008168 GO:0008649 GO:0009383 GO:0016434 GO:0016740 GO:0031167 GO:0032259 GO:0070475
4	0.08	0.418	3.13	0.09	0.49	3mb5A	GO:0008033 GO:0008168 GO:0016429 GO:0016740 GO:0030488 GO:0031515 GO:0032259
5	0.07	0.492	4.16	0.12	0.63	4fzvA	GO:0003723 GO:0005739 GO:0005762 GO:0006364 GO:0008168 GO:0016740 GO:0019843 GO:0031167 GO:0032259 GO:0042254 GO:0042256 GO:0070131 GO:0070181
6	0.07	0.468	4.29	0.16	0.61	3m6wA	GO:0003723 GO:0005737 GO:0006364 GO:0008168 GO:0016740 GO:0032259
7	0.07	0.486	4.17	0.09	0.63	1ixkA	GO:0003723 GO:0006364 GO:0008168 GO:0008757 GO:0032259
8	0.07	0.472	4.56	0.13	0.62	4dmgA	GO:0003723 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
9	0.07	0.476	4.16	0.12	0.60	2frxA	GO:0003723 GO:0005737 GO:0006364 GO:0008168 GO:0008649 GO:0008757 GO:0009383 GO:0016434 GO:0016740 GO:0031167 GO:0032259 GO:0070475
10	0.07	0.473	4.20	0.14	0.60	3m4xA	GO:0003723 GO:0005737 GO:0006364 GO:0008168 GO:0008757 GO:0016740 GO:0032259
11	0.07	0.404	5.38	0.09	0.60	3m6uB	GO:0003723 GO:0005737 GO:0006364 GO:0008168 GO:0016740 GO:0032259
12	0.06	0.419	3.22	0.09	0.50	4pooB	GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
13	0.06	0.443	3.06	0.14	0.51	1m6yA	GO:0005737 GO:0006364 GO:0008168 GO:0016740 GO:0032259 GO:0070475 GO:0071424
14	0.06	0.420	3.69	0.14	0.51	3tmaA	GO:0003723 GO:0008168 GO:0016740 GO:0032259
15	0.06	0.428	3.54	0.11	0.51	3eeyA	GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
16	0.06	0.422	3.27	0.14	0.50	4df3A	GO:0003723 GO:0006364 GO:0008033 GO:0008168 GO:0016740 GO:0032259
17	0.06	0.408	3.07	0.10	0.48	1eizA	GO:0000027 GO:0000453 GO:0001510 GO:0005737 GO:0005829 GO:0006364 GO:0008168 GO:0008650 GO:0016436 GO:0016740 GO:0032259
18	0.06	0.418	3.15	0.15	0.49	2gpyB	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0003676	GO:0008173	GO:0008757
GO-Score	0.58	0.42	0.42
Biological Processes	GO:0001510	GO:0000154	GO:0006399
GO-Score	0.42	0.42	0.40
Cellular Component	GO:0015030	GO:0031428	GO:0032040	GO:0001651	GO:0001652	GO:0070062	GO:0016020	GO:0005829	GO:0031515
GO-Score	0.13	0.13	0.13	0.13	0.13	0.13	0.13	0.09	0.08

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.