I-TASSER results

I-TASSER results for job id Rv2954c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (241 residues)
MRLPGMLRPTAERHFHSIFYLRHNARRQEHLATLGLDLGNKSVLEVGAGIGDHTQFFLDR
GCKVLCTEPRGENLDVIRQRFGSNPNVTVDHLDLDGDLPAEAHQYDVVYCYGVLYHLSRP
AEALAWMCDRAVDLLLLETCVSYSGEDEPFLVSERASSPSQAITGTGCRPSRVWVMNRLR
EKMPHVYVTATQPRHRQFPLDWRANGPIASTGLARAVFVASRAPLNLPTLVEELPMVQRR
C

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MRLPGMLRPTAERHFHSIFYLRHNARRQEHLATLGLDLGNKSVLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGSNPNVTVDHLDLDGDLPAEAHQYDVVYCYGVLYHLSRPAEALAWMCDRAVDLLLLETCVSYSGEDEPFLVSERASSPSQAITGTGCRPSRVWVMNRLREKMPHVYVTATQPRHRQFPLDWRANGPIASTGLARAVFVASRAPLNLPTLVEELPMVQRRC
Prediction	CCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCEEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHCCCCCEEEEHCCHHHCCCCCCCCCCEEEHCCCHHHCCCHHHHHHHHHHCCCCEEEEEEEEHCCCCCCEEHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCHHHHHHCCCCCCC
Conf.Score	9887766876556775544545678999999997899999858996899868999999989959998599999999999976899879998897776788889985798646634479999999999987699699988865688986565775666666655676555669999999987586577656788754455666667755567765445665456887645555545444569
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MRLPGMLRPTAERHFHSIFYLRHNARRQEHLATLGLDLGNKSVLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGSNPNVTVDHLDLDGDLPAEAHQYDVVYCYGVLYHLSRPAEALAWMCDRAVDLLLLETCVSYSGEDEPFLVSERASSPSQAITGTGCRPSRVWVMNRLREKMPHVYVTATQPRHRQFPLDWRANGPIASTGLARAVFVASRAPLNLPTLVEELPMVQRRC
Prediction	6423531433253212431223424411420362514174251122643032002310633053245410450053036415754403122120343141577423011012021216203500420172064200000002404543111164314314430421212102300241046504212144542524514141355352336313211110333716342005404445468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCEEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHCCCCCEEEEHCCHHHCCCCCCCCCCEEEHCCCHHHCCCHHHHHHHHHHCCCCEEEEEEEEHCCCCCCEEHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCHHHHHHCCCCCCC
MRLPGMLRPTAERHFHSIFYLRHNARRQEHLATLGLDLGNKSVLEVGAGIGDHTQFFLDRGCKVLCTEPRGENLDVIRQRFGSNPNVTVDHLDLDGDLPAEAHQYDVVYCYGVLYHLSRPAEALAWMCDRAVDLLLLETCVSYSGEDEPFLVSERASSPSQAITGTGCRPSRVWVMNRLREKMPHVYVTATQPRHRQFPLDWRANGPIASTGLARAVFVASRAPLNLPTLVEELPMVQRRC

4qnuA

0.22

0.21

0.95

1.79

MUSTER

ETLMRNLMPWRKGPFSNIDTEWRSDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGALAVGIDPTQLFLCQFEAVRKNDQRAHLLPLGIEQ-LPAL-KAFDTVFSMGVLYHRRSPLEHLWQLKDVNEGELVLETLVIDGDENTVLVPGDRYAQMRNVYFIPSALALKNWLKKCGFVDIRIADVSVTT-TEEQRRTEWMVTESL-------ADFLD---PHDPGKTVEGYPAPKRAV

4qnuA

0.20

0.18

0.90

2.20

dPPAS

ETLMRNLMPWRKGPFSLYGVNIDTDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGALAVGIDPTQLFLCQFEAVRKNDQRAHLLPLGIEQLP--ALKAFDTVFSMGVLYHRRSPLEHLWQLKDQNEGELVLETLVIDGDENTVLVPGDRYAQ----MRNVYFIPSALALKNWLKKCDIRIADVSVTTTEEQRRTEWMVTESEGYPAPKRAVLIARKP------------------

4kdcA

0.18

0.15

0.85

2.40

wdPPAS

I---AKFEAVASRWWDLEGEFK-NPLRLGYIAERAGGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGQVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLPGGDVFFSTLNRNGKSWLMAVVGAEYILRM----PKFIKPLLGWVDQT---SLKERHIT-----------------GLHYNPITNTFKLGPGVDVNYMLHTQN--------

4qnuA

0.22

0.20

0.93

2.10

wMUSTER

ETLMRNLMPWRKGPFSLYGVNIDTDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGALAVGIDPTQLFLCQFEAVRKNDQRAHLLPLGIEQ-LPAL-KAFDTVFSMGVLYHRRSPLEHLWQLKDVNEGELVLETLVIDGDENTVLVPGDRYAQMRNVYFIPSALALKNWLKKCGFVDIRIADVSVTT-TEEQRRTEWMVTESLA--------FLD---PHDPGKTVEGYPAPKR--

4kdcA

0.18

0.15

0.84

2.40

wPPAS

I---AKFEAVASRWWDLEGEFK-NPLRLGYIAERAGGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGQVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLPGGDVFFSTLNRNGKSWLMAVVGAEYILRM------FIKPLLGWVDQ----SLKERHIT-----------------GLHYNPITNTFKLGPGVDVNYMLHTQN--------

4qnuA

0.22

0.20

0.90

3.78

dPPAS2

ETLMRNLMPWRKGPFSLYGVNIDTDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGALAVGIDPTQLFLCQFEAVRKNDQRAHLLPLGIEQ-LPA-LKAFDTVFSMGVLYHRRSPLEHLWQLKDVNEGELVLETLVIDGDENTVLVPGDRYAQ----MRNVYFIPSALALKNWLKKCDIRIADVSVTTTEEQRRTEWMVTESEGYPAPKRAVLIARKP------------------

4qnuA

0.22

0.20

0.89

2.09

PPAS

ETLMRNLMPWRKGPFSLYGVNIDTDWKWDRVLPHLSDLTGRTILDVGCGSGYHMWRMIGAGALAVGIDPTQLFLCQFEAVRKNDQRAHLLPLGIEQ-LPA-LKAFDTVFSMGVLYHRRSPLEHLWQLKDVNEGELVLETLVIDGDENTVLVPGDRYAQ----MRNVYFIPSALALKNWLKK--IRIADVSVTTTEEQRRTEWMVTESEGYPAPKRAVLIARKP------------------

4kdcA

0.17

0.15

0.87

2.45

Env-PPAS

IKFEAVASRWWDLEGEFKPLHRINPLRLGYIAERAGGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESIQVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLPGGDVFFSTLNRNGKS---WLMAVVGAEYILRMVPKFIKPLLGWVDQT---SLKERHIT-----------------GLHYNPITNTFKLGPGVDVNYMLHTQN--------

4p7cA

0.21

0.19

0.92

1.57

MUSTER

RKALLGLSPWRKGPFNHIDTEWRSDWKWSRVSPH-LDLKGKRVLDVGCGNGYYQWRLGAGADSVIGVDPNWLFFCQFQARYLPDLPAWHLPFALED-LPANLEGFDTVFS-GVLYHRKSPIDHLLALKDCKGGELVE-TLVIPGDVHQVLVPEDRYAQ-----RNVWFLPSVPALELWRRAGFTRCVDVSHTTVEEQRSTEWRFQS-----------LGDYLDPNDHSKTVEGLPAPRAVI

3g5lA

0.15

0.13

0.83

2.19

dPPAS

-------------------EGLKAAGEWHELKKMLPDFNQKTVLDLGCGFGWHCIYAAEHGAKVLGIDLSERMLTEAKRKT-TSPVVCYEQKAI-EDIAIEPDAYNVVLSSLALHYIASFDDICKKVYINSSGSFIFSVEYTDETGNKLHWPVDRYFNESMRTSHKYHRTVTTYIQTLLKNGFQINSVIEPEPAPE---LKDLPEMQDEYRRPMMLLISATKQE-----------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.55

Estimated TM-score = 0.64±0.13

Estimated RMSD = 6.9±4.1Å

Download Model 2

C-score=-1.77

Download Model 3

C-score=-2.96

Download Model 4

C-score=-2.64

Download Model 5

C-score=-2.76

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4qnuA	0.817	2.11	0.197	0.905
2	4p7cA	0.782	2.30	0.212	0.880
3	5kn4A	0.722	3.11	0.108	0.859
4	3vc1A	0.708	3.28	0.111	0.875
5	3hemA	0.706	3.26	0.088	0.859
6	4ineA	0.704	3.43	0.106	0.867
7	4iv0A	0.700	3.34	0.108	0.855
8	3ha3A	0.698	3.47	0.095	0.871
9	2o57A	0.697	3.30	0.107	0.859
10	3uj6A	0.692	3.57	0.104	0.863

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.52	30	4qnuH	GEK	Rep, Mult	12,27,46,47,49,68,69,70,73,93,94,95,111,112,113,115,117,215
2	0.01	1	4fs8A	CA	Rep, Mult	31,47
3	0.01	1	3bgdB	PM6	Rep, Mult	33,37,134,136,186,219
4	0.01	1	3ofkA	SAH	Rep, Mult	10,20,22,26,27,47,49,68,69,70,93,94,111,112,113,116
5	0.01	1	1l1eA	CO3	Rep, Mult	112,115,138,139
6	0.01	1	3jwgA	MG	Rep, Mult	47,111
7	0.01	1	3e8sA	SAH	Rep, Mult	4,7,14,26,47,48,49,52,68,69,73,89,90,91,111,112

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.192	2iftA	0.544	3.14	0.144	0.660	2.1.1.52	48,58,60
2	0.179	3e05D	0.572	3.02	0.106	0.685	2.1.1.132	48,74
3	0.144	3lccA	0.588	3.51	0.093	0.730	2.1.1.-	47,74,111
4	0.097	1xxlA	0.662	3.28	0.124	0.797	2.1.1.-	NA
5	0.078	3e05B	0.569	2.96	0.101	0.676	2.1.1.132	NA
6	0.077	1f38A	0.562	2.98	0.133	0.676	2.1.1.-	NA
7	0.071	3hnrA	0.568	3.67	0.132	0.714	2.1.1.-	NA
8	0.067	3grzB	0.545	3.05	0.101	0.656	2.1.1.-	54
9	0.067	1pjzA	0.565	3.83	0.093	0.743	2.1.1.67	98
10	0.067	2cl5A	0.584	3.66	0.104	0.743	2.1.1.6	72
11	0.067	3bwmA	0.587	3.72	0.088	0.747	2.1.1.6	63
12	0.067	3cbgA	0.578	3.45	0.070	0.718	2.1.1.-	NA
13	0.067	3gdhA	0.569	3.54	0.111	0.710	2.1.1.-	NA
14	0.067	2pxxA	0.571	3.64	0.091	0.710	3.4.24.71	NA
15	0.067	1nt2A	0.569	3.45	0.092	0.701	2.1.1.-	NA
16	0.060	1kphC	0.700	3.39	0.083	0.855	2.1.1.79	165
17	0.060	1ri1A	0.619	3.65	0.120	0.780	2.1.1.56	24,47
18	0.060	1tw2B	0.596	3.84	0.135	0.772	2.1.1.-	NA
19	0.060	3g5tA	0.596	4.34	0.066	0.805	2.1.1.145	NA
20	0.060	1jq3A	0.627	3.66	0.129	0.801	2.5.1.16	47,71
21	0.060	3c6mD	0.591	3.49	0.102	0.734	2.5.1.22	NA
22	0.060	3bwbA	0.613	3.95	0.128	0.801	2.5.1.16	49,71
23	0.060	3bgdA	0.631	3.27	0.104	0.776	2.1.1.67	97
24	0.060	2b2cA	0.592	3.93	0.166	0.776	2.5.1.16	47,68
25	0.060	2aovA	0.620	3.96	0.094	0.801	2.1.1.8	69
26	0.060	2ex4A	0.628	3.16	0.152	0.759	2.1.1.-	NA
27	0.060	2h11B	0.636	3.15	0.109	0.776	2.1.1.67	10
28	0.060	1xj5A	0.623	3.85	0.136	0.805	2.5.1.16	47
29	0.060	2okcB	0.620	3.93	0.059	0.809	2.1.1.72	NA
30	0.060	1ri5A	0.608	3.81	0.117	0.772	2.1.1.56	NA
31	0.060	2o06A	0.617	4.01	0.133	0.813	2.5.1.16	47,49,124
32	0.060	2a14A	0.624	3.57	0.114	0.788	2.1.1.49	47,49,89
33	0.060	3duwA	0.605	3.47	0.104	0.755	2.1.1.-	NA
34	0.060	1kpgA	0.682	3.40	0.093	0.842	2.1.1.79	125

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.31	0.687	3.35	0.13	0.84	4ax8A	GO:0000166 GO:0004672 GO:0005524 GO:0005886 GO:0006468 GO:0008168 GO:0009103 GO:0009243 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0032259
1	0.31	0.810	2.16	0.21	0.90	4p7cA	GO:0002098 GO:0006400 GO:0008033 GO:0016300 GO:0016740 GO:0016765 GO:0030488
2	0.30	0.817	2.11	0.20	0.90	4qnuA	GO:0002098 GO:0006400 GO:0008033 GO:0016300 GO:0016740 GO:0016765 GO:0030488
3	0.28	0.568	3.67	0.13	0.71	3hnrA	GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
4	0.28	0.693	3.28	0.14	0.85	3busA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
5	0.27	0.573	2.93	0.11	0.67	5cm2Z	GO:0000049 GO:0002098 GO:0005634 GO:0005737 GO:0005829 GO:0008152 GO:0008168 GO:0008198 GO:0016300 GO:0016706 GO:0030488 GO:0032259 GO:0055114
6	0.25	0.589	3.72	0.11	0.75	1vlmA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0032259
7	0.25	0.656	3.48	0.13	0.81	2gluA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
8	0.24	0.617	3.16	0.15	0.74	3h2bB	GO:0008168 GO:0016740 GO:0032259
9	0.23	0.586	3.15	0.08	0.71	4qtuB	GO:0000056 GO:0000447 GO:0005634 GO:0005730 GO:0005737 GO:0006364 GO:0008152 GO:0008168 GO:0008757 GO:0016435 GO:0016740 GO:0032259 GO:0070476
10	0.22	0.669	3.64	0.10	0.84	3kkzA	GO:0046872 GO:0051536 GO:0051539
11	0.22	0.708	3.29	0.08	0.86	1l1eA	GO:0005737 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0009405 GO:0016740 GO:0032259 GO:0042783 GO:0046500 GO:0052167 GO:0071768
12	0.21	0.656	3.69	0.08	0.83	3f4kA	GO:0005737 GO:0008168 GO:0008757 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
13	0.21	0.618	3.62	0.13	0.76	3g5lA
14	0.21	0.701	3.67	0.11	0.88	4krhA	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
15	0.20	0.668	3.59	0.12	0.83	3e7pA	GO:0046872 GO:0051536 GO:0051539
16	0.20	0.554	3.34	0.15	0.68	3cggA	GO:0008168 GO:0016740 GO:0032259
17	0.20	0.621	3.75	0.13	0.79	3mggB	GO:0008168 GO:0016740 GO:0032259
18	0.19	0.596	3.63	0.14	0.75	2gs9A	GO:0008152 GO:0008168 GO:0032259
19	0.19	0.618	3.65	0.11	0.78	3egeA	GO:0008152 GO:0008168 GO:0032259
20	0.19	0.562	2.98	0.13	0.68	1f38A	GO:0006479 GO:0008168 GO:0008276 GO:0009236 GO:0016740 GO:0032259 GO:0046140
21	0.18	0.620	3.77	0.13	0.78	2avnA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
22	0.17	0.576	3.47	0.11	0.72	3fycA	GO:0000154 GO:0000179 GO:0003723 GO:0005737 GO:0006364 GO:0008168 GO:0008649 GO:0016433 GO:0016740 GO:0031167 GO:0032259
23	0.17	0.623	3.19	0.11	0.75	1ve3B	GO:0046872 GO:0051536 GO:0051539
24	0.17	0.641	3.76	0.15	0.80	1vl5A	GO:0008152 GO:0008168 GO:0016740 GO:0032259
25	0.16	0.606	3.20	0.08	0.73	3sm3A	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872
26	0.16	0.607	3.55	0.15	0.75	3ccfB	GO:0008152 GO:0008168 GO:0016740 GO:0030798 GO:0032259
27	0.15	0.625	2.69	0.14	0.73	3e23A	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
28	0.14	0.595	4.69	0.13	0.81	2yqzA	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
29	0.12	0.706	3.34	0.09	0.86	1tpyA	GO:0005618 GO:0005737 GO:0005886 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0016740 GO:0032259 GO:0071768
30	0.12	0.700	3.34	0.08	0.85	1kpgA	GO:0005737 GO:0005886 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0016740 GO:0032259 GO:0046500 GO:0071768
31	0.11	0.464	3.96	0.13	0.61	4dzrA	GO:0003676 GO:0006479 GO:0008168 GO:0008276 GO:0016740 GO:0018364 GO:0032259 GO:0036009 GO:0046872
32	0.10	0.691	3.22	0.13	0.84	4uw0A	GO:0004672 GO:0005524 GO:0006468
33	0.10	0.524	4.58	0.10	0.73	4hg2B	GO:0008152 GO:0008168 GO:0016740 GO:0032259
34	0.10	0.700	3.25	0.12	0.85	4pneB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
35	0.08	0.653	3.58	0.15	0.79	4kdcA	GO:0005829 GO:0006744 GO:0008168 GO:0008425 GO:0008689 GO:0008757 GO:0016740 GO:0032259 GO:0043431 GO:0061542 GO:0102004
36	0.07	0.575	3.23	0.13	0.71	3dh0B	GO:0005737 GO:0008757 GO:0032259 GO:0046872 GO:0051536 GO:0051539
37	0.07	0.647	4.26	0.10	0.85	4rsrA	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
38	0.07	0.617	3.17	0.13	0.74	4qdkA	GO:0005737 GO:0008168 GO:0008757 GO:0015979 GO:0015995 GO:0016740 GO:0032259 GO:0036068 GO:0046406
39	0.07	0.628	3.62	0.11	0.78	5je1A	GO:0008168 GO:0016740 GO:0032259
40	0.07	0.635	3.14	0.14	0.76	3bkwA	GO:0008152 GO:0008168 GO:0032259
41	0.07	0.617	3.39	0.13	0.76	3d2lC	GO:0008168 GO:0016740 GO:0032259
42	0.07	0.514	3.39	0.10	0.64	3i9fB	GO:0008152 GO:0008168 GO:0032259 GO:0046872
43	0.07	0.570	3.83	0.06	0.73	3dlcA	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
44	0.07	0.626	4.04	0.09	0.82	3hp7A	GO:0003723 GO:0008168 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0016300	GO:0016765	GO:0005524	GO:0004672
GO-Score	0.52	0.52	0.31	0.31
Biological Processes	GO:0030488	GO:0002098	GO:0006468	GO:0009243
GO-Score	0.52	0.52	0.31	0.31
Cellular Component	GO:0005886
GO-Score	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.