I-TASSER results

I-TASSER results for job id Rv2927c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (245 residues)
MYRVFEALDELSAIVEEARGVPMTAGCVVPRGDVLELIDDIKDAIPGELDDAQDVLDARD
SMLQDAKTHADSMVSSATTEAESILNHARTEADRILSDAKAQADRMVSEARQHSERMVAD
AREEAIRIATAAKREYEASVSRAQAECDRLIENGNISYEKAVQEGIKEQQRLVSQNEVVA
AANAESTRLVDTAHAEADRLRGECDIYVDNKLAEFEEFLNGTLRSVGRGRHQLRTAAGTH
DYAVR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MYRVFEALDELSAIVEEARGVPMTAGCVVPRGDVLELIDDIKDAIPGELDDAQDVLDARDSMLQDAKTHADSMVSSATTEAESILNHARTEADRILSDAKAQADRMVSEARQHSERMVADAREEAIRIATAAKREYEASVSRAQAECDRLIENGNISYEKAVQEGIKEQQRLVSQNEVVAAANAESTRLVDTAHAEADRLRGECDIYVDNKLAEFEEFLNGTLRSVGRGRHQLRTAAGTHDYAVR
Prediction	CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
Conf.Score	87899999999999997788888887657999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999986576555689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MYRVFEALDELSAIVEEARGVPMTAGCVVPRGDVLELIDDIKDAIPGELDDAQDVLDARDSMLQDAKTHADSMVSSATTEAESILNHARTEADRILSDAKAQADRMVSEARQHSERMVADAREEAIRIATAAKREYEASVSRAQAECDRLIENGNISYEKAVQEGIKEQQRLVSQNEVVAAANAESTRLVDTAHAEADRLRGECDIYVDNKLAEFEEFLNGTLRSVGRGRHQLRTAAGTHDYAVR
Prediction	64403510540351047045130224111437402510450174026105505512641552264037305513650463155226504640551254046305513650463055126504630451154046315512640453254226514542553255145325423654543551454055136504630551274045204520550363045015414511540476344762568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
MYRVFEALDELSAIVEEARGVPMTAGCVVPRGDVLELIDDIKDAIPGELDDAQDVLDARDSMLQDAKTHADSMVSSATTEAESILNHARTEADRILSDAKAQADRMVSEARQHSERMVADAREEAIRIATAAKREYEASVSRAQAECDRLIENGNISYEKAVQEGIKEQQRLVSQNEVVAAANAESTRLVDTAHAEADRLRGECDIYVDNKLAEFEEFLNGTLRSVGRGRHQLRTAAGTHDYAVR

4tqlA

0.09

0.08

0.91

1.43

MUSTER

VQELEKARDRMEKLYKEM------------VELIQKAIELMRKIFQEVKQEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGGD---KQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKM-ELLEKIKKNIDDLKKIAEDLIKKAEENIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLKG------

4tqlA

0.08

0.07

0.93

1.32

dPPAS

---YKQMVQELEKARDRMEKL---------YKEMVELIQKAIELMRKIFQEVKQEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGDKQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKMDDELLEKIKKIDDLKKIAEDLIKKAEENIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLKG------

4tqlA

0.09

0.91

1.68

wdPPAS

-------YKQMVQELEKA------------RDRMEKLYKEMVELIQKAIELMRKIFQEVKQEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGGD---KQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKMDDLLEKIKKNIDDLKKIAEDLIKKAEENIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAE

4tqlA

0.06

0.91

1.77

wMUSTER

-------YKQMVQELEKA------------RDRMEKLYKEMVELIQKAIELMRKIFQEVKQEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGDKQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKLLEKIKKNIDDLKKIAEDLIKKAEENIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLKG--

4tqlA

0.08

0.91

1.79

wPPAS

VQELEKARDRMEKLYKEM------------VELIQKAIELMRKIFQEVKQEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGGD---KQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKMDDELLEKIKKNDDLKKIAEDLIKKAEENIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLKG------

5cwmA

0.14

0.13

0.90

2.30

dPPAS2

--DPEDELKRVEKLVKE-------------AEELLRQAKEKEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESEEALERALRVAEEAARLAKRVLELAEKQGPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER---------

5cwmA

0.15

0.13

0.91

1.70

PPAS

--DPEDELKRVEKLVKEAE-----------ELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESEEALERALRVAEEAARLAKRVLELAEKQGD-PEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER---------

3rcwA

0.15

0.07

0.46

0.61

Env-PPAS

LTPLTVLLRSVLDQLQDKDPAIFAQP--VSLKEVPDYLDHIKH--PMDFATMRKRLEAQGKNLHEFEEDFDLIIDNCMKYNAR-----DTVFYRAAVRLRDQGGVVLRQARREVDSIGLEA----------------------------------------------------------------------------------------------------------------------------

5cwqA

0.12

0.11

0.93

1.34

MUSTER

--------EELERESEEAERR---------LQEARKRSEEARERLKELAEALIEEARAVQELARVACERNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH

5cwqA

0.10

0.94

1.29

dPPAS

-EELERESEEAERRLQE-------------ARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.65

Estimated TM-score = 0.51±0.15

Estimated RMSD = 9.5±4.6Å

Download Model 2

C-score=-1.98

Download Model 3

C-score=-3.27

Download Model 4

C-score=-3.41

Download Model 5

C-score=-3.89

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cwqA	0.857	1.99	0.109	0.939
2	3m71A	0.696	4.11	0.047	0.935
3	2npmA	0.647	3.32	0.057	0.804
4	4j6sB	0.645	3.65	0.055	0.833
5	2btpA	0.640	3.36	0.047	0.804
6	4kf7A	0.639	4.50	0.052	0.910
7	3a0oA	0.633	4.29	0.069	0.861
8	2o98B	0.631	3.13	0.103	0.780
9	4c1sA	0.621	3.88	0.056	0.833
10	1a38A	0.617	3.23	0.061	0.763

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.13	8	1qjbA	III	Rep, Mult	52,56,63,116,117,167,168,171,175,222,228,229,234
2	0.05	3	2o98A	FSC	Rep, Mult	57,61,64,113,116,117,220,221,224,225
3	0.05	3	2w6dA	CPL	Rep, Mult	173,174,175,176,177
4	0.03	2	2o98A	FSC	Rep, Mult	46,50,53,105,108,109,213,214,217,218
5	0.03	2	1ywtB	III	Rep, Mult	53,60,64,108,115,116,164,165,168,172,214,218,221,224,225,228,230
6	0.03	2	3m51A	YR1	Rep, Mult	45,46,53,101,108,157,158,214
7	0.03	2	2w6dA	CPL	Rep, Mult	156,159,160,164
8	0.02	1	1sumB	FE	Rep, Mult	205,209
9	0.02	1	3rdhA	3RD	Rep, Mult	63,64,116,119
10	0.02	1	3j000	PEV	Rep, Mult	108,111,115
11	0.02	1	3rdhB	3RD	Rep, Mult	53,108,161,218
12	0.02	1	3j001	PEV	Rep, Mult	191,195
13	0.02	1	3l39A	PO4	Rep, Mult	134,203,205
14	0.02	1	3axyI	III	Rep, Mult	56,60,67,109,112,119,120,168,225
15	0.02	1	2d4cA	CA	Rep, Mult	148,152

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1h12A	0.575	4.71	0.046	0.837	3.2.1.8	NA
2	0.060	1lf6A	0.546	4.91	0.042	0.829	3.2.1.3	NA
3	0.060	1ojnA	0.587	4.70	0.065	0.878	4.2.2.1	NA
4	0.060	1js4A	0.569	4.90	0.070	0.837	3.2.1.4	NA
5	0.060	1fmiA	0.576	4.43	0.060	0.833	3.2.1.113	59
6	0.060	1gaiA	0.581	4.99	0.048	0.886	3.2.1.3	NA
7	0.060	1ks8A	0.555	4.96	0.084	0.820	3.2.1.4	NA
8	0.060	1i8qA	0.585	4.76	0.046	0.869	4.2.2.1	58
9	0.060	1g87B	0.580	4.72	0.065	0.829	3.2.1.4	NA
10	0.060	1f1sA	0.583	4.76	0.046	0.869	4.2.2.1	NA
11	0.060	1kktA	0.563	4.48	0.043	0.833	3.2.1.113	NA
12	0.060	1ayxA	0.591	5.12	0.051	0.918	3.2.1.3	NA
13	0.060	1fp3A	0.614	4.66	0.087	0.906	5.1.3.8	190,226
14	0.060	3evhA	0.597	4.24	0.055	0.820	4.2.2.3	NA
15	0.060	1ug9A	0.578	4.94	0.076	0.861	3.2.1.70	82
16	0.060	1nxcA	0.568	5.06	0.062	0.886	3.2.1.113	NA
17	0.060	2vn7A	0.596	4.78	0.038	0.882	3.2.1.3	NA
18	0.060	1hn0A	0.542	4.84	0.065	0.820	4.2.2.20	122
19	0.060	1fo2A	0.574	4.60	0.051	0.845	3.2.1.113	95,111

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.17	0.645	3.65	0.06	0.83	4j6sB	GO:0000086 GO:0005080 GO:0005159 GO:0005737 GO:0005739 GO:0005829 GO:0005925 GO:0006469 GO:0006605 GO:0008426 GO:0009966 GO:0016020 GO:0019904 GO:0030659 GO:0030971 GO:0031988 GO:0032869 GO:0043209 GO:0044822 GO:0045664 GO:0048167 GO:0061024 GO:0070062 GO:0071901 GO:1900740
1	0.16	0.631	3.13	0.10	0.78	2o98B	GO:0019904
2	0.14	0.626	3.28	0.07	0.78	4dx0A	GO:0019904
3	0.13	0.555	3.35	0.07	0.69	1a37A	GO:0005615 GO:0005634 GO:0005737 GO:0005925 GO:0008134 GO:0019901 GO:0019904 GO:0031625 GO:0042470 GO:0042802 GO:0044822 GO:0051683 GO:0070062 GO:0072562 GO:0090168
4	0.12	0.638	3.35	0.05	0.79	4jc3A	GO:0000079 GO:0001836 GO:0003334 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0005913 GO:0006469 GO:0006977 GO:0007165 GO:0008426 GO:0008630 GO:0010482 GO:0010839 GO:0019901 GO:0019904 GO:0030216 GO:0030307 GO:0030659 GO:0031424 GO:0043154 GO:0043588 GO:0045606 GO:0046827 GO:0051219 GO:0051726 GO:0061024 GO:0061436 GO:0070062 GO:0071901 GO:0098609 GO:0098641 GO:1900740
5	0.10	0.570	3.57	0.06	0.72	4f7rD	GO:0019904
6	0.10	0.690	4.12	0.05	0.93	3m73A	GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0046677 GO:0046690 GO:0055085
7	0.10	0.631	3.46	0.06	0.80	4zdrA	GO:0000166 GO:0000287 GO:0001558 GO:0001894 GO:0001944 GO:0002039 GO:0004672 GO:0004674 GO:0005524 GO:0005615 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005829 GO:0005913 GO:0005925 GO:0006468 GO:0006605 GO:0006914 GO:0006915 GO:0006974 GO:0007049 GO:0007050 GO:0007165 GO:0007283 GO:0007286 GO:0007409 GO:0008134 GO:0008285 GO:0010212 GO:0010508 GO:0010941 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0019901 GO:0019904 GO:0030010 GO:0030111 GO:0030154 GO:0030168 GO:0030275 GO:0030295 GO:0030308 GO:0030511 GO:0030659 GO:0031625 GO:0032147 GO:0036398 GO:0036399 GO:0042470 GO:0042593 GO:0042802 GO:0043066 GO:0043276 GO:0043488 GO:0044822 GO:0045059 GO:0046777 GO:0046872 GO:0048814 GO:0050731 GO:0050772 GO:0050852 GO:0051055 GO:0051645 GO:0051683 GO:0051896 GO:0060070 GO:0060770 GO:0061024 GO:0070062 GO:0071493 GO:0071902 GO:0072332 GO:0072562 GO:0090168 GO:0097484 GO:0098609 GO:0098641 GO:1900182 GO:1900740 GO:1901796 GO:1904262
8	0.08	0.640	3.54	0.06	0.82	2c74A	GO:0002028 GO:0003779 GO:0005159 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006713 GO:0006886 GO:0014704 GO:0017080 GO:0019899 GO:0019904 GO:0021762 GO:0030659 GO:0035259 GO:0042921 GO:0044325 GO:0045664 GO:0045893 GO:0046982 GO:0048167 GO:0050774 GO:0061024 GO:0070062 GO:0086010 GO:1900740 GO:2000649
9	0.08	0.647	3.32	0.06	0.80	2npmA	GO:0019904
10	0.08	0.627	3.24	0.10	0.78	2br9A	GO:0000086 GO:0001764 GO:0003064 GO:0005737 GO:0005739 GO:0005829 GO:0005871 GO:0005913 GO:0005925 GO:0006605 GO:0015459 GO:0016020 GO:0016032 GO:0019899 GO:0019904 GO:0021762 GO:0021766 GO:0021987 GO:0023026 GO:0030424 GO:0030659 GO:0031625 GO:0032403 GO:0035308 GO:0035329 GO:0035556 GO:0042470 GO:0042826 GO:0043154 GO:0044325 GO:0044822 GO:0046982 GO:0050815 GO:0051219 GO:0060306 GO:0061024 GO:0070062 GO:0086013 GO:0086091 GO:0098609 GO:0098641 GO:1900034 GO:1900740 GO:1901016 GO:1902309
11	0.08	0.640	3.36	0.05	0.80	2btpA	GO:0005737 GO:0005739 GO:0005829 GO:0005925 GO:0006605 GO:0007264 GO:0008022 GO:0016020 GO:0019904 GO:0021762 GO:0030659 GO:0034766 GO:0043234 GO:0044325 GO:0045892 GO:0047485 GO:0061024 GO:0070062 GO:0071889 GO:1900740
12	0.07	0.633	3.43	0.08	0.79	3axyC	GO:0005634 GO:0005737 GO:0019904
13	0.07	0.580	4.37	0.04	0.81	4dnkB	GO:0000165 GO:0003714 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0005913 GO:0005925 GO:0006605 GO:0008022 GO:0016020 GO:0016032 GO:0017053 GO:0019899 GO:0019904 GO:0030659 GO:0032403 GO:0035308 GO:0035329 GO:0042470 GO:0042826 GO:0043085 GO:0043234 GO:0043488 GO:0045744 GO:0045892 GO:0048471 GO:0050815 GO:0051219 GO:0051220 GO:0051291 GO:0061024 GO:0070062 GO:0098609 GO:0098641 GO:1900740
14	0.07	0.551	4.10	0.08	0.75	3efzB	GO:0019904
15	0.06	0.358	5.88	0.04	0.61	1qycA
16	0.06	0.283	4.51	0.06	0.39	2mhsA	GO:0001709 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005741 GO:0005759 GO:0005829 GO:0006915 GO:0007275 GO:0008630 GO:0008637 GO:0015266 GO:0016020 GO:0016021 GO:0019725 GO:0030154 GO:0034097 GO:0042803 GO:0042981 GO:0043066 GO:0046982 GO:0051434 GO:0071806 GO:0097136 GO:0097192 GO:1903378 GO:2000811 GO:2001020 GO:2001240 GO:2001243
17	0.06	0.266	6.09	0.04	0.45	3zc7A	GO:0000166 GO:0000287 GO:0005524 GO:0009405 GO:0016740 GO:0016779 GO:0018117 GO:0042803 GO:0070733
18	0.06	0.173	5.11	0.09	0.27	4brjA	GO:0005506 GO:0016491 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0003723	GO:0019904	GO:0030291	GO:1990782	GO:0005102
GO-Score	0.55	0.54	0.54	0.34	0.34
Biological Processes	GO:1901030	GO:1900739	GO:0071900	GO:1903749	GO:0001933	GO:0033673	GO:0050767	GO:0032868	GO:0050804	GO:0071375	GO:0044772	GO:0050803	GO:0006886	GO:0030182	GO:0044839
GO-Score	0.54	0.54	0.54	0.54	0.54	0.54	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34
Cellular Component	GO:0005924	GO:0044433	GO:0012506	GO:0016023	GO:0070062
GO-Score	0.55	0.54	0.54	0.54	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.