I-TASSER results

I-TASSER results for job id Rv2915c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (370 residues)
MKRVDTIRPRSRAVRLHVRGLGLPDETAIQLWIVDGRISTEPVAGADTVFDGGWILPGLV
DAHCHVGLGKHGNVELDEAIAQAETERDVGALLLRDCGSPTDTRGLDDHEDLPRIIRAGR
HLARPKRYIAGFAVELEDESQLPAAVAEQARRGDGWVKLVGDWIDRQIGDLAPLWSDDVL
KAAIDTAHAQGARVTAHVFSEDALPGLINAGIDCIEHGTGLTDDTIALMLEHGTALVPTL
INLENFPGIADAAGRYPTYAAHMRDLYARGYGRVAAAREAGVPVYAGTDAGSTIEHGRIA
DEVAALQRIGMTAHEALGAACWDARRWLGRPGLDDRASADLLCYAQDPRQGPGVLQHPDL
VILRGRTFGP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKRVDTIRPRSRAVRLHVRGLGLPDETAIQLWIVDGRISTEPVAGADTVFDGGWILPGLVDAHCHVGLGKHGNVELDEAIAQAETERDVGALLLRDCGSPTDTRGLDDHEDLPRIIRAGRHLARPKRYIAGFAVELEDESQLPAAVAEQARRGDGWVKLVGDWIDRQIGDLAPLWSDDVLKAAIDTAHAQGARVTAHVFSEDALPGLINAGIDCIEHGTGLTDDTIALMLEHGTALVPTLINLENFPGIADAAGRYPTYAAHMRDLYARGYGRVAAAREAGVPVYAGTDAGSTIEHGRIADEVAALQRIGMTAHEALGAACWDARRWLGRPGLDDRASADLLCYAQDPRQGPGVLQHPDLVILRGRTFGP
Prediction	CCCCCCCEEHCCCEEEEEHCCCCCCCCCEEEEEHCCEEEEHCCCCCEEEHCCCEEHCCCEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEHCCCCCHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCEHCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHCCHHHHHHHHHHCCCEEHCCCCCCHHHHHHHHHHCCEEHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEHCCEEEEHCCCCCCHHHHCCCCEEEHCCEEHCC
Conf.Score	9887654554565579997887788888599999999998668985899689589558533445766799997589999999999999798476578986888887677898757874655567888888766778999999999999999899878875674557899988889999999999999999997999867899999999999988875888999999999998979985665678888776556899899999999999999999999998996998688899988757999999999989999999999989999998999776876575999959955597885698699989699789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKRVDTIRPRSRAVRLHVRGLGLPDETAIQLWIVDGRISTEPVAGADTVFDGGWILPGLVDAHCHVGLGKHGNVELDEAIAQAETERDVGALLLRDCGSPTDTRGLDDHEDLPRIIRAGRHLARPKRYIAGFAVELEDESQLPAAVAEQARRGDGWVKLVGDWIDRQIGDLAPLWSDDVLKAAIDTAHAQGARVTAHVFSEDALPGLINAGIDCIEHGTGLTDDTIALMLEHGTALVPTLINLENFPGIADAAGRYPTYAAHMRDLYARGYGRVAAAREAGVPVYAGTDAGSTIEHGRIADEVAALQRIGMTAHEALGAACWDARRWLGRPGLDDRASADLLCYAQDPRQGPGVLQHPDLVILRGRTFGP
Prediction	7541530234144020001021133456010003423014322744311042300010224000000001321220230131022013000001010102320221443330110010020001111102200230520630140024004300300120000003223221110233002000410372712000001024002200410010000011014400210254300000000001101312542222231142034215301300320271402000000001001011001001101514321330020001200200413412003300000012013500510540412035230131
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCEEHCCCEEEEEHCCCCCCCCCEEEEEHCCEEEEHCCCCCEEEHCCCEEHCCCEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEHCCCCCHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCEHCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHCCHHHHHHHHHHCCCEEHCCCCCCHHHHHHHHHHCCEEHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEHCCEEEEHCCCCCCHHHHCCCCEEEHCCEEHCC
MKRVDTIRPRSRAVRLHVRGLGLPDETAIQLWIVDGRISTEPVAGADTVFDGGWILPGLVDAHCHVGLGKHGNVELDEAIAQAETERDVGALLLRDCGSPTDTRGLDDHEDLPRIIRAGRHLARPKRYIAGFAVELEDESQLPAAVAEQARRGDGWVKLVGDWIDRQIGDLAPLWSDDVLKAAIDTAHAQGARVTAHVFSEDALPGLINAGIDCIEHGTGLTDDTIALMLEHGTALVPTLINLENFPGIADAAGRYPTYAAHMRDLYARGYGRVAAAREAGVPVYAGTDAGSTIEHGRIADEVAALQRIGMTAHEALGAACWDARRWLGRPGLDDRASADLLCYAQDPRQGPGVLQHPDLVILRGRTFGP

3gnhA

0.22

0.21

0.98

2.47

MUSTER

-------EIKAVSAARLLDVASGKYVDNPLVIVTDGRITSIGKGATAVDLPGVTLLPGLIDMHVHLDSLAEVGGWSVVQTANAKKTLEAGFTTVRNVGAGLREAIDAGYVPGPRIVTAAISFGATGGHCDSTFFNSDSPDEARKAVRTLKKYGAQVIICTGGVFSRGNEPGQQQLTYEEMKAVVDEAHMAGIKVAAHAHGASGIREAVRAGVDTIEHASLVDDEGIKLAVQKGAYFSMDIYNTDYTQAEGKKNGVLEDNLRKDRDIGELQRENFRKALKAGVKMVYGTDAGI-YPHGDNAKQFAVMVRYGATPLQAIQSATLTAAEALGRGQVAVGRYGDMIAVAGDPLADVTTLEKPVFVMKGGAVVKA

3gnhA

0.22

0.21

0.98

2.70

dPPAS

-------EIKAVSAARLLDVASGKYVDNPLVIVTDGRITSIGAGATAVDLPGVTLLPGLIDMHVHLDSLAEVGGWSVVQTANAKKTLEAGFTTVRNVGAGLREAIDAGYVPGPRIVTAAISFGATGGHCDSNPFNSDSPDEARKAVRTLKKYGAQVIICTGGVFSRGNEPGQQQLTYEEMKAVVDEAHMAGIKVAAHAHGASGIREAVRAGVDTIEHASLVDDEGIKLAVQKGAYFSMDIYNTDYTQAEGKKNGVLEDNLRKDRDIGELQRENFRKALKAGVKMVYGTDAGI-YPHGDNAKQFAVMVRYGATPLQAIQSATLTAAEALGRGQVAVGRYGDMIAVAGDPLADVTTLEKPVFVMKGGAVVKA

3be7A

0.20

0.19

0.98

3.48

wdPPAS

------SEDFLIKSKGYLDIQTGE-IIKADLLIRNGKIAEIGKDATVISIPDLILIPGLMDSHVHIVGNDSKGEGTVWGVVNAEKTLMAGFTTVRNVGASVRDAIERGVINGPTMLVSGPALGITGGHCDSSEGVVDSPWEARKMVRKNRKYGADLIKFCAGVMSRNTDVNAKQFTLEEMKAIVDEAHNHGMKVAAHAHGLIGIKAAIKAGVDSVEHASFIDDETIDMAIKNNTVLSMDIFVSDYILGEGAKAGIREESLNKERLVGKKQRENFMNAHRRGAIITFGTDAG-IFDHGDNAKQFAYMVEWGMTPLEAIQASTIKTATLFGIGQIKEGFDADIVGVIENPLANIRTLEEVAFVMKEGKVYKR

3gnhA

0.22

0.21

0.98

3.42

wMUSTER

-------EIKAVSAARLLDVASGKYVDNPLVIVTDGRITSIGKGATAVDLPGVTLLPGLIDMHVHLDSLAEVGFWSVVQTANAKKTLEAGFTTVRNVGAGLREAIDAGYVPGPRIVTAAISFGATGGHCDSTFFNSDSPDEARKAVRTLKKYGAQVIICTGGVFSRGNEPGQQQLTYEEMKAVVDEAHMAGIKVAAHAHGASGIREAVRAGVDTIEHASLVDDEGIKLAVQKGAYFSMDIYNTDYTQAEGKKNGVLEDNLRKDRDIGELQRENFRKALKAGVKMVYGTDAGI-YPHGDNAKQFAVMVRYGATPLQAIQSATLTAAEALGRGQVAVGRYGDMIAVAGDPLADVTTLEKPVFVMKGGAVVKA

3be7A

0.20

0.19

0.98

3.79

wPPAS

------SEDFLIKSKGYLDIQTGEI-IKADLLIRNGKIAEIGKDATVISIPDLILIPGLMDSHVHIVGNDSKGEGTVWGVVNAEKTLMAGFTTVRNVGASVRDAIERGVINGPTMLVSGPALGITGGHCDSSEGVVDSPWEARKMVRKNRKYGADLIKFCAGVMSRNTDVNAKQFTLEEMKAIVDEAHNHGMKVAAHAHGLIGIKAAIKAGVDSVEHASFIDDETIDMAIKNNTVLSMDIFVSDYILGEGAKAGIREESLNKERLVGKKQRENFMNAHRRGAIITFGTDAG-IFDHGDNAKQFAYMVEWGMTPLEAIQASTIKTATLFGIGQIKEGFDADIVGVIENPLANIRTLEEVAFVMKEGKVYKR

3gnhA

0.22

0.21

0.98

4.27

dPPAS2

-------EIKAVSAARLLDVASGKYVDNPLVIVTDGRITSIGAGATAVDLPGVTLLPGLIDMHVHLDSLAEVGGWSVVQTANAKKTLEAGFTTVRNVGAGLREAIDAGYVPGPRIVTAAISFGATGGHCDSNPFNSDSPDEARKAVRTLKKYGAQVIICTGGVFSRGNEPGQQQLTYEEMKAVVDEAHMAGIKVAAHAHGASGIREAVRAGVDTIEHASLVDDEGIKLAVQKGAYFSMDIYNTDYTQAEGKKNGVLEDNLRKDRDIGELQRENFRKALKAGVKMVYGTDAGI-YPHGDNAKQFAVMVRYGATPLQAIQSATLTAAEALGRGQVAVGRYGDMIAVAGDPLADVTTLEKPVFVMKGGAVVKA

3gnhA

0.22

0.21

0.98

3.63

PPAS

-------EIKAVSAARLLDVASGKYVDNPLVIVTDGRITSIGAGATAVDLPGVTLLPGLIDMHVHLDSLAEVGGWSVVQTANAKKTLEAGFTTVRNVGAGLREAIDAGYVPGPRIVTAAISFGATGGHCDSNPFNSDSPDEARKAVRTLKKYGAQVIICTGGVFSRGNEPGQQQLTYEEMKAVVDEAHMAGIKVAAHAHGASGIREAVRAGVDTIEHASLVDDEGIKLAVQKGAYFSMDIYNTDYTQAEGKKNGVLEDNLRKDRDIGELQRENFRKALKAGVKMVYGTDAGIY-PHGDNAKQFAVMVRYGATPLQAIQSATLTAAEALGRGQVAVGRYGDMIAVAGDPLADVTTLEKPVFVMKGGAVVKA

3gnhA

0.22

0.98

4.50

Env-PPAS

-------EIKAVSAARLLDVASGKYVDNPLVIVTDGRITSIGKKGDAVDLPGVTLLPGLIDMHVHLDSLAEVGGWSVVQTANAKKTLEAGFTTVRNVGAGLREAIDAGYVPGPRIVTAAISFGATGGHCDSNPFNSDSPDEARKAVRTLKKYGAQVIICTGGVFSRGNEPGQQQLTYEEMKAVVDEAHMAGIKVAAHAHGASGIREAVRAGVDTIEHASLVDDEGIKLAVQKGAYFSMDIYNTDYTQAEGKKNGVLEDNLRKDRDIGELQRENFRKALKAGVKMVYGTDAGI-YPHGDNAKQFAVMVRYGATPLQAIQSATLTAAEALGRGQVAVGRYGDMIAVAGDPLADVTTLEKPVFVMKGGAVVKA

3be7A

0.20

0.19

0.98

2.45

MUSTER

------SEDFLIKSKGYLDIQTGEI-IKADLLIRNGKIAEIGKDATVISIPDLILIPGLMDSHVHIVGNDSKGMGTVWGVVNAEKTLMAGFTTVRNVGASVRDAIERGVINGPTMLVSGPALGITGGHCDSSEGVVDSPWEARKMVRKNRKYGADLIKFCAGVMSRNTDVNAKQFTLEEMKAIVDEAHNHGMKVAAHAHGLIGIKAAIKAGVDSVEHASFIDDETIDMAIKNNTVLSMDIFVSDYILGEGAKAGIREESLNKERLVGKKQRENFMNAHRRGAIITFGTDAGI-FDHGDNAKQFAYMVEWGMTPLEAIQASTIKTATLFGIGQIKEGFDADIVGVIENPLANIRTLEEVAFVMKEGKVYKR

3be7A

0.20

0.19

0.98

2.66

dPPAS

------SEDFLIKSKGYLDIQTGE-IIKADLLIRNGKIAEIGKDATVISIPDLILIPGLMDSHVHIVGNDSKGEGTVWGVVNAEKTLMAGFTTVRNVGASVRDAIERGVINGPTMLVSGPALGITGGHCDHNLLPVDSPWEARKMVRKNRKYGADLIKFCAGVMSRNTDVNAKQFTLEEMKAIVDEAHNHGMKVAAHAHGLIGIKAAIKAGVDSVEHASFIDDETIDMAIKNNTVLSMDIFVSDYILGEGAKAGIREESLNKERLVGKKQRENFMNAHRRGAIITFGTDAGI-FDHGDNAKQFAYMVEWGMTPLEAIQASTIKTATLFGIGQIKEGFDADIVGVIENPLANIRTLEEVAFVMKEGKVYKR

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.98

Estimated TM-score = 0.85±0.08

Estimated RMSD = 4.6±3.0Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3gnhA	0.957	1.12	0.221	0.978
2	3be7A	0.946	1.37	0.202	0.978
3	2r8cA	0.926	1.73	0.230	0.976
4	3feqN	0.926	1.74	0.211	0.976
5	4c5yA	0.892	2.29	0.217	0.973
6	2qs8A	0.891	1.98	0.228	0.949
7	4whbE	0.865	2.85	0.194	0.962
8	4wgxA	0.865	3.01	0.195	0.970
9	2p9bA	0.849	2.70	0.259	0.946
10	2g3fA	0.782	3.06	0.178	0.895

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.71	162	3cakB	EFS	Rep, Mult	63,65,158,197,217,289
2	0.10	23	5ch9B	CO	Rep, Mult	63,158,197,217
3	0.09	24	3n2cB	LWY	Rep, Mult	63,65,128,158,164,197,199,217,242,243,289
4	0.03	9	3mtwA	M3R	Rep, Mult	63,128,158,163,164,197,199,217,239,242,263,266,270,289
5	0.01	3	3mkvG	CO3	Rep, Mult	128,163,164,197,199
6	0.01	2	3be7F	MG	Rep, Mult	114,364
7	0.00	1	3dugA	ZN	Rep, Mult	278,315

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.410	3d6nA	0.748	3.51	0.118	0.881	3.5.2.3	288,289
2	0.408	2gokA	0.765	3.36	0.170	0.892	3.5.2.7	289
3	0.336	1zzmA	0.525	3.37	0.130	0.622	3.1.21.-	288
4	0.246	2qt3A	0.732	3.11	0.149	0.851	3.5.99.4	57,326,328
5	0.242	2qt3B	0.731	3.13	0.143	0.851	3.5.99.4	57,326,328
6	0.155	2vhlB	0.709	3.47	0.115	0.843	3.5.1.25	NA
7	0.142	2vunD	0.728	2.98	0.175	0.832	3.5.2.18	NA
8	0.131	1ybqA	0.709	3.53	0.141	0.838	3.4.19.1	84,100,292
9	0.115	3iv8D	0.704	3.44	0.107	0.835	3.5.1.25	NA
10	0.115	2p50A	0.702	3.47	0.146	0.832	3.5.1.25	NA
11	0.113	1ra0A	0.745	3.54	0.122	0.886	3.5.4.1	NA
12	0.094	2uz9A	0.746	3.31	0.102	0.878	3.5.4.3	323
13	0.092	3e0lA	0.743	3.22	0.111	0.873	3.5.4.3	NA
14	0.085	1v77A	0.456	2.81	0.115	0.516	3.1.26.5	216
15	0.077	1xrtA	0.714	3.31	0.118	0.832	3.5.2.3	288,289
16	0.066	2wjfA	0.466	3.94	0.087	0.581	3.1.3.48	325
17	0.060	3gipA	0.759	3.91	0.142	0.924	3.5.1.82	NA
18	0.060	2ftwA	0.730	4.03	0.128	0.900	3.5.2.2	289
19	0.060	2oofA	0.743	3.36	0.141	0.878	3.5.2.7	NA
20	0.060	3egjA	0.704	3.40	0.114	0.832	3.5.1.25	196,201
21	0.060	1kraC	0.728	3.69	0.153	0.865	3.5.1.5	302
22	0.060	1p1mA	0.747	2.93	0.149	0.851	3.5.4.28	NA
23	0.060	2puzA	0.765	3.37	0.170	0.892	3.5.2.7	NA
24	0.060	1onxA	0.711	3.55	0.145	0.838	3.4.19.-	289
25	0.060	1nfgA	0.727	4.05	0.146	0.892	3.5.2.2	289
26	0.060	1ie7C	0.722	3.76	0.131	0.862	3.5.1.5	NA
27	0.060	1k6wA	0.747	3.40	0.123	0.878	3.5.4.1	302
28	0.060	1e9yB	0.721	3.65	0.126	0.854	3.5.1.5	NA
29	0.060	2vr2A	0.721	4.08	0.120	0.892	3.5.2.2	288,289
30	0.060	2i9uA	0.736	3.35	0.109	0.870	3.5.4.3	NA
31	0.060	3hm7B	0.731	3.74	0.136	0.878	3.5.2.5	148
32	0.060	3griB	0.717	3.70	0.118	0.857	3.5.2.3	185
33	0.060	2g3fA	0.782	3.06	0.178	0.895	3.5.2.7	NA
34	0.060	1k1dA	0.731	3.99	0.134	0.895	3.5.2.-	289

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.56	0.921	1.94	0.23	0.98	2qs8A	GO:0016787 GO:0016810 GO:0046872
1	0.50	0.960	1.11	0.22	0.98	3mtwA	GO:0016787 GO:0016810 GO:0046872
2	0.50	0.927	1.70	0.21	0.98	3n2cA
3	0.47	0.928	1.75	0.23	0.98	3mkvA	GO:0016787 GO:0016810 GO:0046872
4	0.47	0.946	1.37	0.20	0.98	3be7A
5	0.40	0.765	3.36	0.17	0.89	2gokA	GO:0005506 GO:0005737 GO:0006547 GO:0006548 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0019556 GO:0019557 GO:0046872 GO:0050480
6	0.39	0.732	3.92	0.14	0.89	1gkpA	GO:0005737 GO:0016787 GO:0016810 GO:0046872
7	0.37	0.865	2.85	0.19	0.96	4whbA	GO:0016787 GO:0016810
8	0.35	0.714	3.31	0.12	0.83	1xrtA	GO:0004151 GO:0006221 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0044205 GO:0046872
9	0.35	0.865	2.95	0.19	0.97	4ub9A	GO:0016787 GO:0016810
10	0.34	0.870	2.63	0.25	0.96	2p9bA	GO:0016787 GO:0016810
11	0.33	0.731	3.74	0.14	0.88	3hm7B	GO:0000256 GO:0004038 GO:0006144 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0046872 GO:0050897
12	0.32	0.761	3.24	0.16	0.89	2oofA	GO:0005506 GO:0005737 GO:0006547 GO:0006548 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0019556 GO:0019557 GO:0046872 GO:0050480
13	0.32	0.736	3.35	0.11	0.87	2i9uA	GO:0006147 GO:0008270 GO:0008892 GO:0016787 GO:0016810 GO:0046872
14	0.23	0.731	3.99	0.11	0.89	3sfwA	GO:0005737 GO:0016787 GO:0016810 GO:0046872
15	0.22	0.709	3.53	0.14	0.84	1ybqA	GO:0005737 GO:0005829 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008798 GO:0016787 GO:0016810 GO:0046872
16	0.21	0.877	2.59	0.22	0.97	4c60A	GO:0006508 GO:0016787 GO:0016805 GO:0016810 GO:0046872 GO:0102009 GO:1900817
17	0.19	0.727	3.71	0.14	0.87	1gkrA	GO:0000256 GO:0004038 GO:0008270 GO:0016787 GO:0016810 GO:0046872 GO:0050897
18	0.18	0.681	3.70	0.14	0.81	3ooqF	GO:0016787 GO:0016810 GO:0019239
19	0.15	0.713	3.52	0.18	0.85	3nqbA	GO:0000034 GO:0006146 GO:0016787 GO:0016810
20	0.15	0.772	2.89	0.15	0.88	4v1xE	GO:0005737 GO:0016787 GO:0016810 GO:0018788 GO:0019381 GO:0046872
21	0.15	0.730	4.05	0.15	0.89	1nfgA	GO:0005737 GO:0016787 GO:0016810 GO:0046872
22	0.14	0.759	3.91	0.14	0.92	3gipA	GO:0016787 GO:0016810 GO:0016811 GO:0047421
23	0.14	0.757	3.06	0.13	0.88	2oodA	GO:0006147 GO:0008270 GO:0008892 GO:0016787 GO:0016810 GO:0046098 GO:0046872
24	0.14	0.746	3.52	0.13	0.89	3g77A	GO:0004131 GO:0005829 GO:0006209 GO:0008198 GO:0008270 GO:0016787 GO:0016810 GO:0019858 GO:0035888 GO:0042802 GO:0046872
25	0.14	0.770	2.87	0.17	0.88	4dykA	GO:0004000 GO:0016787 GO:0016810 GO:0019700 GO:0046872 GO:0050270
26	0.14	0.748	3.50	0.11	0.88	4bjhA	GO:0004151 GO:0006221 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0044205 GO:0046872
27	0.14	0.729	4.02	0.12	0.89	4kirA	GO:0004157 GO:0005737 GO:0016787 GO:0016810 GO:0046872
28	0.13	0.738	3.65	0.14	0.88	3mpgA	GO:0004151 GO:0006221 GO:0008270 GO:0009220 GO:0016787 GO:0016810 GO:0016812 GO:0044205 GO:0046872
29	0.12	0.704	3.44	0.11	0.84	3iv8D	GO:0005975 GO:0006044 GO:0006046 GO:0008448 GO:0016787 GO:0016810 GO:0019262 GO:0046872 GO:0051289
30	0.11	0.752	2.78	0.17	0.85	3hpaA
31	0.10	0.729	3.72	0.16	0.88	2z00A	GO:0004151 GO:0006221 GO:0008270 GO:0016787 GO:0016810 GO:0016812 GO:0044205 GO:0046872
32	0.10	0.709	3.47	0.12	0.84	2vhlB	GO:0005506 GO:0005975 GO:0006044 GO:0006046 GO:0008448 GO:0016787 GO:0016810 GO:0019262 GO:0042803 GO:0046872
33	0.10	0.704	3.40	0.11	0.83	3egjA	GO:0005975 GO:0006044 GO:0006046 GO:0008448 GO:0016787 GO:0016810 GO:0019262 GO:0046872 GO:0051289
34	0.10	0.731	3.99	0.13	0.89	1k1dA	GO:0005737 GO:0016787 GO:0016810 GO:0046872
35	0.08	0.730	3.44	0.13	0.85	3ighX	GO:0006259 GO:0016810 GO:0016888
36	0.08	0.727	4.03	0.13	0.89	4tqtD	GO:0004157 GO:0005737 GO:0016787 GO:0016810
37	0.08	0.730	4.04	0.14	0.90	4gz7A	GO:0005737 GO:0016787 GO:0016810 GO:0046872
38	0.08	0.729	3.86	0.12	0.89	4b3zD	GO:0000226 GO:0005737 GO:0005815 GO:0005819 GO:0005829 GO:0005856 GO:0006139 GO:0007399 GO:0007411 GO:0010977 GO:0016787 GO:0016810 GO:0031005 GO:0048666 GO:1904530
39	0.08	0.735	4.03	0.13	0.91	2ftyA	GO:0004157 GO:0016787 GO:0016810 GO:0046872
40	0.07	0.729	4.07	0.11	0.90	4cnuA	GO:0005615 GO:0005737 GO:0005829 GO:0010975 GO:0010976 GO:0010977 GO:0016787 GO:0016810 GO:0017124 GO:0030027 GO:0030334 GO:0030336 GO:0030426 GO:0031005 GO:0031941 GO:0035374 GO:0042995 GO:0044297 GO:0048666 GO:0048678 GO:0051017 GO:0051260 GO:0051491 GO:0051764 GO:0070382 GO:0071345
41	0.07	0.713	3.45	0.14	0.83	3icjA	GO:0006259 GO:0016810 GO:0016888 GO:0046872
42	0.07	0.724	4.03	0.14	0.89	3dc8A	GO:0005737 GO:0016787 GO:0016810 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0016810
GO-Score	0.88	0.88
Biological Processes
GO-Score
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.