I-TASSER results

I-TASSER results for job id Rv2899c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (276 residues)
MGYATAHRRVRHLSADQVITRPETLAVEEPLEIRVNGTPVTVTMRTPGSDFELVQGFLLA
EGVVAHREDVLTVSYCGRRVEGNATGASTYNVLDVALAPGVKPPDVDVTRTFYTTSSCGV
CGKASLQAVSQVSRFAPGGDPATVAADTLKAMPDQLRRAQKVFARTGGLHAAALFGVDGA
MLAVREDIGRHNAVDKVIGWAFERDRIPLGASVLLVSGRASFELTQKALMAGIPVLAAVS
APSSLAVSLADASGITLVAFLRGDSMNVYTRADRIT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MGYATAHRRVRHLSADQVITRPETLAVEEPLEIRVNGTPVTVTMRTPGSDFELVQGFLLAEGVVAHREDVLTVSYCGRRVEGNATGASTYNVLDVALAPGVKPPDVDVTRTFYTTSSCGVCGKASLQAVSQVSRFAPGGDPATVAADTLKAMPDQLRRAQKVFARTGGLHAAALFGVDGAMLAVREDIGRHNAVDKVIGWAFERDRIPLGASVLLVSGRASFELTQKALMAGIPVLAAVSAPSSLAVSLADASGITLVAFLRGDSMNVYTRADRIT
Prediction	CCCCEEEEEEEEEHCCEEEEEEEEEEEEEEEEEEHCCEEEEEEEHCCCCHHHHHHHHHHHHCCCCCHHHEEEEEEHCCCCCCCCCCCCCEEEEEEEHCCCCCCHHHHHHCCCEEHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHCCCCCEEEEEEHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHCCEEEEEEHCCEEEEEHCCCCCC
Conf.Score	998668999999989978997546776788999999999999996899878999999998688899866677899767765555555555799999857765457877544445567887764478888765678888888766999999999999998699998698579999869998999998587678999999999999899988859999589879999999998997999856765899999999999799998799689985886799
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MGYATAHRRVRHLSADQVITRPETLAVEEPLEIRVNGTPVTVTMRTPGSDFELVQGFLLAEGVVAHREDVLTVSYCGRRVEGNATGASTYNVLDVALAPGVKPPDVDVTRTFYTTSSCGVCGKASLQAVSQVSRFAPGGDPATVAADTLKAMPDQLRRAQKVFARTGGLHAAALFGVDGAMLAVREDIGRHNAVDKVIGWAFERDRIPLGASVLLVSGRASFELTQKALMAGIPVLAAVSAPSSLAVSLADASGITLVAFLRGDSMNVYTRADRIT
Prediction	854434523033146653453543003022000102443000000124302000000010021054263044031245434243423423220202135514462453444332322223223310420452451432756240315202400530473151254140000000004622000000000000000000010034561414300000013002200200030400000010100310041046130000000267301000256228
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEEEEEEHCCEEEEEEEEEEEEEEEEEEHCCEEEEEEEHCCCCHHHHHHHHHHHHCCCCCHHHEEEEEEHCCCCCCCCCCCCCEEEEEEEHCCCCCCHHHHHHCCCEEHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHCCCCCEEEEEEHCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHCCEEEEEEHCCEEEEEHCCCCCC
MGYATAHRRVRHLSADQVITRPETLAVEEPLEIRVNGTPVTVTMRTPGSDFELVQGFLLAEGVVAHREDVLTVSYCGRRVEGNATGASTYNVLDVALAPGVKPPDVDVTRTFYTTSSCGVCGKASLQAVSQVSRFAPGGDPATVAADTLKAMPDQLRRAQKVFARTGGLHAAALFGVDGAMLAVREDIGRHNAVDKVIGWAFERDRIPLGASVLLVSGRASFELTQKALMAGIPVLAAVSAPSSLAVSLADASGITLVAFLRGDSMNVYTRADRIT

4pdeA

0.29

0.25

0.88

3.16

MUSTER

---ITGVRQIELWRDDLQHPRLDEVAEEVPVALVYNGISHVVMMASPKDLEYFALGFSLSEGIIESPRDIFGMDVVPSCNG---------LEVQIELSSRRFMGLKERRIGK---------------------PVQPLPFTQTFDLNKLDDALRHLNDFQPVGQLTGCTHAAAWMLPSGELVGGHEDVGRHVALDKLLGRRSQEGE-SWQQGAVLVSSRASYEMVQKSAMCGVEILFAVSAATTLAVEVAERCNLTLVGFCKPGRATVYTHPQRLS

2pw9D

0.24

0.21

0.86

4.44

dPPAS

--PLSIMQKSVVIRPGGRQEMDEHVAIETPYAIALNDRVIGSSMVLPVDLEEFGAGFLFGQGYIKKAEEIREILVCPQG----------RISVYADVENEEPKIPKEMLEEFAPLADYCLP------------------------FAEIKSFIREALHSSPLGPQTHCVHGCGLWN-NGRLQVYHEDVGRHNAVDKVLGSILLG--RASNNSAVYTTGRLTSDMVLKCARIGIPIIMSRTSPSSLGLALAKRSGATLVAYSRPERINVFNAPERIL

2pw9D

0.24

0.21

0.86

5.92

wdPPAS

--PLSIMQKSVVIRPGGRQEMDEHVAIETPYAIALNDRVIGSSMVLPVDLEEFGAGFLFGQGYIKKAEEIREILVCPQG----------RISVYADVENEEPKIPKEMLEEFAPLADYCLP------------------------FAEIKSFIREALHSSPLGPQTHCVHGCGLWN-NGRLQVYHEDVGRHNAVDKVLGSILLGR--ASNNSAVYTTGRLTSDMVLKCARIGIPIIMSRTSPSSLGLALAKRSGATLVAYSRPERINVFNAPERIL

4pdeA

0.29

0.25

0.87

3.83

wMUSTER

----TGVRQIELWRDDLQHPRLDEVAEEVPVALVYNGISHVVMMASPKDLEYFALGFSLSEGIIESPRDIFGMDVVPSC---------NGLEVQIELSSRRFMGLKERRI-------GK--------------PVQPLPFTQTFDLNKLDDALRHLNDFQPVGQLTGCTHAAAWMLPSGELVGGHEDVGRHVALDKLLGRRSQEG-ESWQQGAVLVSSRASYEMVQKSAMCGVEILFAVSAATTLAVEVAERCNLTLVGFCKPGRATVYTHPQRLS

2pw9D

0.24

0.21

0.86

6.13

wPPAS

--PLSIMQKSVVIRPGGRQEMDEHVAIETPYAIALNDRVIGSSMVLPVDLEEFGAGFLFGQGYIKKAEEIREILVCPQ----------GRISVYADVENEEPKIPKEMLEEFAPLADYC------------------------LPFAEIKSFIREALHSSPLGPQTHCVHGCGLWN-NGRLQVYHEDVGRHNAVDKVLGSILLGR--ASNNSAVYTTGRLTSDMVLKCARIGIPIIMSRTSPSSLGLALAKRSGATLVAYSRPERINVFNAPERIL

2pw9D

0.24

0.21

0.86

10.55

dPPAS2

--PLSIMQKSVVIRPGGRQEMDEHVAIETPYAIALNDRVIGSSMVLPVDLEEFGAGFLFGQGYIKKAEEIREILVCPQG----------RISVYADVENEEPKIPKEMLEEFAPLADYCLP------------------------FAEIKSFIREALHSSPLGPQTHCVHGCGLWN-NGRLQVYHEDVGRHNAVDKVLGSILLG--RASNNSAVYTTGRLTSDMVLKCARIGIPIIMSRTSPSSLGLALAKRSGATLVAYSRPERINVFNAPERIL

2pw9D

0.24

0.21

0.86

5.11

PPAS

--PLSIMQKSVVIRPGGRQEMDEHVAIETPYAIALNDRVIGSSMVLPVDLEEFGAGFLFGQGYIKKAEEIREILVCPQG----------RISVYADVENEEPKIPKEMLEEFAPLADYCLP------------------------FAEIKSFIREALHSSPLGPQTHCVHGCGLWN-NGRLQVYHEDVGRHNAVDKVLGSILLG--RASNNSAVYTTGRLTSDMVLKCARIGIPIIMSRTSPSSLGLALAKRSGATLVAYSRPERINVFNAPERIL

2pw9D

0.24

0.21

0.86

6.84

Env-PPAS

--PLSIMQKSVVIRPGGRQEMDEHVAIETPYAIALNDRVIGSSMVLPVDLEEFGAGFLFGQGYIKKAEEIREILVCPQG----------RISVYADVENEEPKIPKEMLEEFAPLADYCLP------------------------FAEIKSFIREALHSSPLGPQTHCVHGCGLWN-NGRLQVYHEDVGRHNAVDKVLGSILLG--RASNNSAVYTTGRLTSDMVLKCARIGIPIIMSRTSPSSLGLALAKRSGATLVAYSRPERINVFNAPERIL

2pw9D

0.24

0.21

0.86

3.12

MUSTER

--PLSIMQKSVVIRPGGRQEMDEHVAIETPYAIALNDRVIGSSMVLPVDLEEFGAGFLFGQGYIKKAEEIREILVCPQ----------GRISVYADVENEEPKIPKEMLEEFAPLADYC------------------------LPFAEIKSFIREALHSSPLGPQTHCVHGCGLWN-NGRLQVYHEDVGRHNAVDKVLGSILLG--RASNNSAVYTTGRLTSDMVLKCARIGIPIIMSRTSPSSLGLALAKRSGATLVAYSRPERINVFNAPERIL

4pdeA

0.29

0.25

0.88

4.41

dPPAS

---ITGVRQIELWRDDLQHPRLDEVAEEVPVALVYNGISHVVMMASPKDLEYFALGFSLSEGIIESPRDIFGMDVVPSCNG---------LEVQIELSSRRFMGLKERRI---------------------GKPVQPLPFTQTFDLNKLDDALRHLNDFQPVGQLTGCTHAAAWMLPSGELVGGHEDVGRHVALDKLLGRRSQ-EGESWQQGAVLVSSRASYEMVQKSAMCGVEILFAVSAATTLAVEVAERCNLTLVGFCKPGRATVYTHPQRLS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.34

Estimated TM-score = 0.76±0.10

Estimated RMSD = 5.3±3.4Å

Download Model 2

C-score=-0.61

Download Model 3

C-score=-1.38

Download Model 4

C-score=-1.92

Download Model 5

C-score=-1.22

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4pdeA	0.793	2.04	0.272	0.866
2	2pw9D	0.785	2.05	0.250	0.855
3	5c70A	0.462	5.81	0.087	0.728
4	3cmgA	0.462	5.92	0.057	0.743
5	4jkmA	0.460	5.69	0.086	0.721
6	4cu6A	0.456	6.07	0.059	0.757
7	4ypjA	0.453	6.06	0.052	0.754
8	3gm8A	0.453	5.92	0.069	0.743
9	3k46A	0.450	5.97	0.052	0.728
10	3czjA	0.450	5.87	0.056	0.725

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	7	5cfuA	MN	Rep, Mult	190,191
2	0.14	7	1usyB	HIS	Rep, Mult	192,195
3	0.08	4	4pe1A	DCD	Rep, Mult	194,197
4	0.04	2	4y49A	G4P	Rep, Mult	199,227
5	0.02	1	2pw90	III	Rep, Mult	6,8,10,11,12,13,14,15,18,21,23,25,26,27,28,44,146,166,167,168,170,188,219,221,222,241,242,243,244,245,247,260,264,265,266,267,268,269
6	0.02	1	1yq2A	MG	Rep, Mult	250,254,256
7	0.02	1	1hn1C	NA	Rep, Mult	163,166,167,169
8	0.02	1	4u0bD	III	Rep, Mult	156,160

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2c4mC	0.425	6.18	0.043	0.717	2.4.1.1	NA
2	0.060	1bhgA	0.421	6.30	0.051	0.725	3.2.1.31	NA
3	0.060	1vdzA	0.390	5.99	0.083	0.634	3.6.3.14	NA
4	0.060	2qe7A	0.390	6.11	0.049	0.641	3.6.1.34	NA
5	0.060	2akzA	0.393	6.14	0.055	0.652	4.2.1.11	196
6	0.060	3bq5A	0.423	6.00	0.047	0.707	2.1.1.14	NA
7	0.060	3aboA	0.439	5.63	0.081	0.692	4.3.1.7	213,241
8	0.060	1yq2A	0.445	5.94	0.058	0.717	3.2.1.23	NA
9	0.060	2psnC	0.399	5.79	0.024	0.634	4.2.1.11	227
10	0.060	1u22A	0.396	5.44	0.040	0.616	2.1.1.14	155,212
11	0.060	2qtcB	0.369	6.26	0.067	0.641	1.2.4.1	NA
12	0.060	1elsA	0.399	5.90	0.033	0.638	4.2.1.11	56,221
13	0.060	2e8yA	0.426	6.14	0.037	0.714	3.2.1.41	191
14	0.060	1l8aA	0.384	6.27	0.063	0.667	1.2.4.1	NA
15	0.060	2azdB	0.430	6.05	0.077	0.728	2.4.1.1	NA
16	0.060	2ptxA	0.391	6.03	0.054	0.645	4.2.1.11	NA
17	0.060	2ptwA	0.394	6.02	0.039	0.659	4.2.1.11	NA
18	0.060	2g25A	0.308	5.94	0.054	0.496	1.2.4.1	NA
19	0.060	1iyxA	0.381	6.02	0.057	0.627	4.2.1.11	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.50	0.793	2.04	0.27	0.87	4pdeA	GO:0003824 GO:0005737 GO:0005829 GO:0006777 GO:0006810 GO:0016783 GO:0043546 GO:0097163
1	0.34	0.785	2.05	0.25	0.86	2pw9D	GO:0003824 GO:0005737 GO:0006777 GO:0006810 GO:0016783 GO:0097163
2	0.07	0.462	5.92	0.06	0.74	3cmgA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
3	0.07	0.300	6.58	0.04	0.54	4jkkA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
4	0.07	0.453	6.06	0.05	0.75	4ypjA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
5	0.07	0.462	5.68	0.05	0.71	3decA	GO:0003824 GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0009341 GO:0016787 GO:0016798 GO:0030246 GO:0043231
6	0.07	0.449	5.91	0.06	0.72	3lpfA	GO:0004553 GO:0004566 GO:0005829 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0019391 GO:0043231
7	0.07	0.460	5.69	0.09	0.72	4jkmA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
8	0.07	0.462	5.81	0.09	0.73	5c70A	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
9	0.07	0.453	5.92	0.07	0.74	3gm8A	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
10	0.07	0.456	6.03	0.06	0.75	4cu7A	GO:0004553 GO:0004565 GO:0005576 GO:0005618 GO:0005975 GO:0008152 GO:0016020 GO:0016787 GO:0016798
11	0.07	0.445	5.94	0.06	0.72	1yq2A	GO:0003824 GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0009341 GO:0016787 GO:0016798 GO:0030246 GO:0046872
12	0.07	0.430	6.08	0.08	0.72	3fn9C	GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0016787 GO:0016798
13	0.07	0.369	6.66	0.08	0.68	2vzsA	GO:0000272 GO:0004553 GO:0005576 GO:0005615 GO:0005975 GO:0006032 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0052761
14	0.06	0.421	6.30	0.05	0.72	1bhgA	GO:0004553 GO:0004566 GO:0005102 GO:0005615 GO:0005764 GO:0005975 GO:0006027 GO:0008152 GO:0016020 GO:0016787 GO:0016798 GO:0019904 GO:0030214 GO:0043202 GO:0043231 GO:0070062
15	0.06	0.311	6.18	0.05	0.53	1xi6A	GO:0046854
16	0.06	0.406	6.04	0.04	0.68	3bgaA	GO:0003824 GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0009341 GO:0016787 GO:0016798 GO:0030246 GO:0043231 GO:0046872
17	0.06	0.355	6.52	0.07	0.63	3slkA	GO:0000166 GO:0003824 GO:0008152 GO:0008270 GO:0016491 GO:0016740 GO:0031177 GO:0055114
18	0.06	0.252	6.37	0.04	0.45	4gvhA	GO:0004553 GO:0004563 GO:0005737 GO:0005975 GO:0007049 GO:0008152 GO:0008360 GO:0009252 GO:0009254 GO:0016787 GO:0016798 GO:0046677 GO:0051301 GO:0071555

Consensus prediction of GO terms

Molecular Function	GO:0016783	GO:0097163	GO:0043546	GO:0016798
GO-Score	0.67	0.67	0.50	0.37
Biological Processes	GO:0006777	GO:0006810
GO-Score	0.67	0.67
Cellular Component	GO:0005829
GO-Score	0.50

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.