I-TASSER results

I-TASSER results for job id Rv2897c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (503 residues)
MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNSW
PMARLTLALSPATLPKMGSVYDIALAAAVLSAQQKKPWERLENTLLLGELSLDGRVRPVR
GVLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDVRGVRTLGQLQSWLRGSTGLAGRITT
ADTTPESAADLADVVGQSQARFAVEVAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPSLSG
SESLEVTAIHSVAGLLSGDTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGV
LFLDECAEISLSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANPCPCAPADPQDC
ICAAATKRRYLGKLSGPLLDRVDLRVQMHRLRAGAFSAADGESTSQVRQRVALAREAAAQ
RWRPHGFRTNAEVSGPLLRRKFRPSSAAMLPLRTALDRGLLSIRGVDRTLRVAWSLADLA
GRTSPGIDEVAAALSFRQTGARR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNSWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQQKKPWERLENTLLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDVRGVRTLGQLQSWLRGSTGLAGRITTADTTPESAADLADVVGQSQARFAVEVAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPSLSGSESLEVTAIHSVAGLLSGDTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGVLFLDECAEISLSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANPCPCAPADPQDCICAAATKRRYLGKLSGPLLDRVDLRVQMHRLRAGAFSAADGESTSQVRQRVALAREAAAQRWRPHGFRTNAEVSGPLLRRKFRPSSAAMLPLRTALDRGLLSIRGVDRTLRVAWSLADLAGRTSPGIDEVAAALSFRQTGARR
Prediction	CCEEEEEEEEEHCCCCEEEEEEEHCCCCCCCEEEEHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCEEEEHCCCCCCEEEHCCCHHHHHHHHHHHCCCEEEHCHHHHHHHHHCCCCEEEEHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEHCCCCEEEHCCCCCCCHHHHHHHHHHHHCCEEEEEHCCCEEEEHCCEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
Conf.Score	97789999899769867999999847999858998586899999999999999998998999768997788888888887658999999999889997875777998645798758857889999999999899889968667899998599899995789999999979877888888766666677775545558999999999985898589995999868999999887689999989999999999877888888865579988888766554554688899998444434698898577656676799999988766969999679789985646899966899899999876578899999999998788887657589967999888567899986999999999999999999667987677899899988648999999999999999799856899999999867765689899999999999986688889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNSWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQQKKPWERLENTLLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDVRGVRTLGQLQSWLRGSTGLAGRITTADTTPESAADLADVVGQSQARFAVEVAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPSLSGSESLEVTAIHSVAGLLSGDTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGVLFLDECAEISLSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANPCPCAPADPQDCICAAATKRRYLGKLSGPLLDRVDLRVQMHRLRAGAFSAADGESTSQVRQRVALAREAAAQRWRPHGFRTNAEVSGPLLRRKFRPSSAAMLPLRTALDRGLLSIRGVDRTLRVAWSLADLAGRTSPGIDEVAAALSFRQTGARR
Prediction	10000010000001603303020201433310000012450031014102000320405046330101011041323100000000000000124042630430000010103030220300000000024361310000220130022044020000000100010012123222222314222222221232411510110000000010000000112200000041025004615552021101020002304464301331000001110122000112253241100000010000000013044402520340154220101014230200020000000201003224344222324204400330043025203020204304253033652441440141023004103400573412000303272045104037501500420063030000000000000000020552650546001100100345468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEEEEEEHCCCCEEEEEEEHCCCCCCCEEEEHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCCEEEEHCCCCCCEEEHCCCHHHHHHHHHHHCCCEEEHCHHHHHHHHHCCCCEEEEHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCEHCCCCEEEHCCCCCCCHHHHHHHHHHHHCCEEEEEHCCCEEEEHCCEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCC
MALGRAFSVAVRGLDGEIVEIEADITSGLPGVHLVGLPDAALQESRDRVRAAVTNCGNSWPMARLTLALSPATLPKMGSVYDIALAAAVLSAQQKKPWERLENTLLLGELSLDGRVRPVRGVLPAVLAAKRDGWPAVVVPADNLPEASLVDGIDVRGVRTLGQLQSWLRGSTGLAGRITTADTTPESAADLADVVGQSQARFAVEVAAAGAHHLMLTGPPGVGKTMLAQRLPGLLPSLSGSESLEVTAIHSVAGLLSGDTPLITRPPFVAPHHSSSVAALVGGGSGMARPGAVSRAHRGVLFLDECAEISLSALEALRTPLEDGEIRLARRDGVACYPARFQLVLAANPCPCAPADPQDCICAAATKRRYLGKLSGPLLDRVDLRVQMHRLRAGAFSAADGESTSQVRQRVALAREAAAQRWRPHGFRTNAEVSGPLLRRKFRPSSAAMLPLRTALDRGLLSIRGVDRTLRVAWSLADLAGRTSPGIDEVAAALSFRQTGARR

1g8pA

0.24

0.14

0.59

1.50

MUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVFPFSAIVGQEDMKLALLLTAVDIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVSSPNVEMIPVLSTNVIRKPTPVVDLPLGVSEDRVVGAGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEG--------------------DLRPQLLDRFGLSVEVLSPDVETRVEVIRRRDTYDADPKAFLEEWRPKDMD---IRNQILEARERLPKVEAPNTALYDCAALCIALGSDGLRGELTLLRSARALAALEGATAVGRDHLKRVATMALSHRLR

1g8pA

0.24

0.14

0.59

2.32

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVFPFSAIVGQEDMKLALLLTAVDIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVSSPNVEMATVLSTNVIRKPTPVVDLPLGVSEDRVVGKGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEG--------------------DLRPQLLDRFGLSVEVLSPRDVETRVEV--IRRRDTYDADPKAFLEEWRPKDMDIRNQILEARERLPKVEAPNTALYDCAALCIALGSDGLRGELTLLRSARALAALEGATAVGRDHLKRVATMALSHRLR

1g8pA

0.25

0.15

0.58

2.62

wdPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVFPFSAIVGQEDMKLALLLTAV-IGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVEMIPDWATVLST-NVIRKPTPVVDLPLGVSEDRVVGAGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEGD--------------------LRPQLLDRFGLSVEVSPRDVETRVEVIRRRDTYDADPKAFLEEWRPKDMD---IRNQILEARERLPKVEAPNTALYDCAALCIALGSDGLRGELTLLRSARALAALEGATAVGRDHLKRVATMALSHRLR

1g8pA

0.25

0.15

0.58

1.78

wMUSTER

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVFPFSAIVGQEDMKLALLLTAVDIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVEMIPDWATVLSTN-VIRKPTPVVDLPLGVSEDRVVGAGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEG--------------------DLRPQLLDRFGLSVEVLSPDVETRVEVIRRRDTYDADPKAFLEEWRPKDMD---IRNQILEARERLPKVEAPNTALYDCAALCIALGSDGLRGELTLLRSARALAALEGATAVGRDHLKRVATMALSHRLR

1g8pA

0.26

0.15

0.58

2.29

wPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVFPFSAIVGQEDMKLALLLTAVDIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVEMIPDWATVLS-TNVIRKPTPVVDLPLGVSEDRVVGAGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEG--------------------DLRPQLLDRFGLSVEVLSPRDVETRVE-RRRDTYDADPKAFLEEWRPKDMD---IRNQILEARERLPKVEAPNTALYDCAALCIALGSDGLRGELTLLRSARALAALEGATAVGRDHLKRVATMALSHRLR

1g8pA

0.24

0.14

0.59

4.18

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVFPFSAIVGQEDMKLALLLTAVDIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVSSPNVEMATVLSTNVIRKPTPVVDLPLGVSEDRVVGKGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEG--------------------DLRPQLLDRFGLSVEVLSPDVETRVEVIRRRDTYDADPKAFLEEWRPKDMDIRNQILEA---RERLPKVEAPNTALYDCAALCIALGSDGLRGELTLLRSARALAALEGATAVGRDHLKRVATMALSHRLR

1g8pA

0.24

0.14

0.59

2.56

PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVFPFSAIVGQEDMKLALLLTAVDIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVSSPNVEMIPVLSTNVIRKPTPVVDLPLGVSEDRVVGKGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEG--------------------DLRPQLLDRFGLSVEVLSPRDVETRVEVRRRDTYDADPKAFLEEWRPKDMD---IRNQILEARERLPKVEAPNTALYDCAALCIALGSDGLRGELTLLRSARALAALEGATAVGRDHLKRVATMALSHRLR

1g8pA

0.24

0.14

0.59

4.95

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVFPFSAIVGQEDMKLALLLTAVDIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVSSPNVEMIPVLSTNVIRKPTPVVDLPLGVSEDRVVGKGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEG--------------------DLRPQLLDRFGLSVEVLSPRDVETRVEVRRRDTYDADPKAFLEEWRPKDMD---IRNQILEARERLPKVEAPNTALYDCAALCIALGSDGLRGELTLLRSARALAALEGATAVGRDHLKRVATMALSHRLR

1g8pA1

0.25

0.11

0.42

1.10

MUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVFPFSAIVGQEDMKLALLLTAVDIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVSSPNVEMIPVLSTNVIRKPTPVVDLPLGVSEDRVVGKGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEG--------------------DLRPQLLDRFGLSVEVLSPRDVE------TRVEVIRRRDTYDADPKAFLEEW-------------------------------------------------------------------------------

1g8pA1

0.25

0.11

0.42

1.89

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RPVFPFSAIVGQEDMKLALLLTAVDIGGVLVFGDRGTGKSTAVRALAALLPEIEAVEGCPVSSPNVEMATVLSTNVIRKPTPVVDLPLGVSEDRVVGKGEKAFEPGLLARANRGYLYIDECNLLEDHIVDLLLDVAQSGENVVERDGLSIRHPARFVLVGSGNPEEG--------------------DLRPQLLDRFGLSVEVLSPRDVE------TRVEVIRRRDTYDADPKAFLEEW-------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.80

Estimated TM-score = 0.39±0.13

Estimated RMSD = 14.3±3.8Å

Download Model 2

C-score=-3.03

Download Model 3

C-score=-3.42

Download Model 4

C-score=-3.45

Download Model 5

C-score=-3.75

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1g8pA	0.575	1.16	0.231	0.587
2	3ja85	0.506	4.98	0.104	0.644
3	3ja86	0.494	4.92	0.117	0.626
4	3ja87	0.488	4.48	0.106	0.594
5	3ja84	0.488	5.41	0.098	0.630
6	3ja83	0.483	4.97	0.111	0.610
7	3ja82	0.482	5.58	0.108	0.640
8	3f9vA	0.449	5.11	0.088	0.573
9	3nbxX	0.439	3.32	0.165	0.499
10	2r44A	0.428	3.31	0.135	0.483

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.20	10	1ofiB	ADP	Rep, Mult	190,194,195,197,219,221,222,223,224,225,226,391,399
2	0.10	5	3u5zB	MG	Rep, Mult	225,304,305
3	0.04	2	1ea0A	F3S	Rep, Mult	243,244,245,246,247,248,249,254
4	0.04	2	3u60E	MG	Rep, Mult	225,304,305,464
5	0.02	1	2fgzA	CA	Rep, Mult	473,476,488
6	0.02	1	1sxjE	AGS	Rep, Mult	318,377
7	0.02	1	2ya0A	NA	Rep, Mult	296,300,301,340,342
8	0.02	1	3u5zC	08T	Rep, Mult	322,381
9	0.02	1	3u5zE	MG	Rep, Mult	225,304,471
10	0.02	1	3ja83	ADP	Rep, Mult	322,463,464,467

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3lxuX	0.337	7.18	0.051	0.537	3.4.14.10	296
2	0.060	1ofdA	0.314	7.82	0.047	0.535	1.4.7.1	NA
3	0.060	3iceC	0.331	5.93	0.071	0.461	3.6.1.-	NA
4	0.060	2pffA	0.348	7.58	0.038	0.592	2.3.1.41,2.3.1.86	NA
5	0.060	2fhbA	0.357	6.75	0.038	0.535	3.2.1.41	NA
6	0.060	1bglA	0.332	7.20	0.060	0.527	3.2.1.23	44
7	0.060	1peuA	0.335	7.10	0.054	0.533	1.17.4.1	NA
8	0.060	2pffD	0.353	7.84	0.033	0.602	2.3.1.86	196,200
9	0.060	1kmhB	0.330	7.00	0.064	0.509	3.6.3.14	81,85,161
10	0.060	1n1hA	0.361	7.60	0.057	0.594	2.7.7.48	NA
11	0.060	1g8pA	0.575	1.16	0.231	0.587	6.6.1.1	464
12	0.060	2e8yA	0.343	7.71	0.060	0.581	3.2.1.41	298
13	0.060	1s76D	0.317	7.33	0.036	0.507	2.7.7.6	NA
14	0.060	2bhzA	0.342	7.61	0.046	0.571	3.2.1.141	NA
15	0.060	1eh9A	0.333	7.62	0.056	0.563	3.2.1.141	NA
16	0.060	1mswD	0.312	7.59	0.047	0.517	2.7.7.6	NA
17	0.060	2vdcF	0.357	7.33	0.042	0.575	1.4.1.13	233
18	0.060	2fj0A	0.330	7.39	0.065	0.543	3.1.1.1	NA
19	0.060	1aroP	0.340	7.30	0.030	0.547	2.7.7.6	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.575	1.16	0.23	0.59	1g8pA	GO:0000166 GO:0005524 GO:0015979 GO:0015995 GO:0016851 GO:0016874 GO:0030494
1	0.15	0.492	4.79	0.12	0.61	3jc77	GO:0000166 GO:0000727 GO:0000781 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0006348 GO:0007049 GO:0016787 GO:0017116 GO:0030466 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0097373 GO:1990163
2	0.14	0.488	4.48	0.11	0.59	3ja87	GO:0000166 GO:0000727 GO:0000781 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0006348 GO:0007049 GO:0016787 GO:0017116 GO:0030466 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0097373 GO:1990163
3	0.09	0.502	5.38	0.11	0.65	3jc75	GO:0000166 GO:0000727 GO:0000784 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006270 GO:0006271 GO:0006343 GO:0006348 GO:0007049 GO:0016787 GO:0017116 GO:0030174 GO:0031261 GO:0031298 GO:0031939 GO:0032508 GO:0033260 GO:0042555
4	0.08	0.406	3.79	0.13	0.48	4r7zA	GO:0000166 GO:0003677 GO:0004519 GO:0005524 GO:0006260 GO:0016539 GO:0046872 GO:0051301 GO:0090305
5	0.07	0.480	5.40	0.12	0.63	3jc56	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003688 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0097373 GO:1990163
6	0.07	0.488	5.41	0.10	0.63	3ja84	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003688 GO:0003697 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0043596 GO:0097373 GO:1990163
7	0.07	0.483	4.97	0.11	0.61	3ja83	GO:0000166 GO:0000727 GO:0000781 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006270 GO:0006271 GO:0006348 GO:0016787 GO:0016887 GO:0017116 GO:0030466 GO:0031261 GO:0031298 GO:0032508 GO:0033260 GO:0042555
8	0.07	0.482	5.58	0.11	0.64	3ja82	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006270 GO:0006271 GO:0006974 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0032508 GO:0033260 GO:0042555 GO:0046872 GO:1902450
9	0.07	0.459	4.29	0.10	0.56	4r7yA	GO:0000166 GO:0003677 GO:0004386 GO:0004519 GO:0005524 GO:0006260 GO:0016539 GO:0016787 GO:0046872 GO:0051301 GO:0090305
10	0.07	0.451	4.25	0.10	0.55	3jc72	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003682 GO:0003688 GO:0003697 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006270 GO:0006271 GO:0006974 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0032508 GO:0033260 GO:0042555 GO:0046872 GO:1902450
11	0.07	0.449	5.11	0.09	0.57	3f9vA	GO:0000166 GO:0003677 GO:0004386 GO:0005524 GO:0006260 GO:0016787
12	0.06	0.422	4.66	0.10	0.51	3f8tA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
13	0.06	0.425	4.49	0.10	0.51	3jc54	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003688 GO:0003697 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0043596 GO:0097373 GO:1990163
14	0.06	0.306	3.37	0.14	0.35	4qhtC	GO:0000160 GO:0000166 GO:0003677 GO:0003700 GO:0005524 GO:0005622 GO:0006351 GO:0006355 GO:0008134 GO:0043565
15	0.06	0.318	4.90	0.11	0.40	4l4uA	GO:0000160 GO:0000166 GO:0003677 GO:0005524 GO:0005622 GO:0006351 GO:0006355 GO:0008134 GO:0043565
16	0.06	0.303	3.43	0.18	0.35	2viiA	GO:0000160 GO:0000166 GO:0003677 GO:0005524 GO:0005737 GO:0006351 GO:0006355 GO:0008134 GO:0043565 GO:0045892 GO:0045893
17	0.06	0.202	6.70	0.04	0.31	1um8A	GO:0000166 GO:0005524 GO:0006457 GO:0008270 GO:0046872 GO:0046983 GO:0051082
18	0.06	0.290	7.09	0.07	0.47	3k1jA	GO:0000166 GO:0004176 GO:0004252 GO:0005524 GO:0006355 GO:0006508 GO:0008134 GO:0008233 GO:0016020 GO:0016021 GO:0030163

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0043138	GO:0009378	GO:0017116	GO:0003688	GO:0003697	GO:0003682	GO:0016851
GO-Score	0.57	0.53	0.53	0.34	0.34	0.34	0.34	0.30
Biological Processes	GO:0032508	GO:0000727	GO:0006267	GO:0006271	GO:0006348	GO:0006270	GO:0030494	GO:0015979
GO-Score	0.53	0.34	0.34	0.34	0.34	0.34	0.30	0.30
Cellular Component	GO:0098687	GO:0031261	GO:0005737	GO:0031298	GO:0005656	GO:0042555
GO-Score	0.53	0.34	0.34	0.34	0.34	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.