I-TASSER results

I-TASSER results for job id Rv2877c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (287 residues)
MNEALIGLAFAAGLVAALNPCGFAMLPAYLLLVVYGQDSAGRTGPLSAVGRAAAATVGMA
LGFLTVFGIFGALTISAATAVQRYLPYATVLIGLALIALGGWLLLGRGLTALTPRSLGVR
WAPTVRLGSMYGYGISYAVASLSCTIGPFLAVTGAGLRGGSVVGSVAIYLAYVAGLTLVV
GVLAVAAATASSALADRLRRILPFVNRISGALLVVVGLYVGYYGLYELRLIAGVGANPQD
AVIAAAGRLQGALAGWVNQHGAWPWAVLLVVLVVGAFAGTWFRRVRR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNEALIGLAFAAGLVAALNPCGFAMLPAYLLLVVYGQDSAGRTGPLSAVGRAAAATVGMALGFLTVFGIFGALTISAATAVQRYLPYATVLIGLALIALGGWLLLGRGLTALTPRSLGVRWAPTVRLGSMYGYGISYAVASLSCTIGPFLAVTGAGLRGGSVVGSVAIYLAYVAGLTLVVGVLAVAAATASSALADRLRRILPFVNRISGALLVVVGLYVGYYGLYELRLIAGVGANPQDAVIAAAGRLQGALAGWVNQHGAWPWAVLLVVLVVGAFAGTWFRRVRR
Prediction	CCCCHHHHHHHHHHHHHHCHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
Conf.Score	98658999999999999755555678888888754666655555456789999999999999999999999999999999999999999999999999999998564444568567777557888855699999999999865557899999999997688999999999999999999999999999999999999889999999999999999999999999999999986655567899999999999999999987558999999999999999999854469
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNEALIGLAFAAGLVAALNPCGFAMLPAYLLLVVYGQDSAGRTGPLSAVGRAAAATVGMALGFLTVFGIFGALTISAATAVQRYLPYATVLIGLALIALGGWLLLGRGLTALTPRSLGVRWAPTVRLGSMYGYGISYAVASLSCTIGPFLAVTGAGLRGGSVVGSVAIYLAYVAGLTLVVGVLAVAAATASSALADRLRRILPFVNRISGALLVVVGLYVGYYGLYELRLIAGVGANPQDAVIAAAGRLQGALAGWVNQHGAWPWAVLLVVLVVGAFAGTWFRRVRR
Prediction	64312023233333323301311133123101001234454454444221200110111121333132331321133132133333323323122133323332333313322344234434553101102231312131112102113101101003223322011113011313231322212132322430252044114203111112123302313333333220222332323211121133013101200342332112100212111120010234558
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHCHCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCC
MNEALIGLAFAAGLVAALNPCGFAMLPAYLLLVVYGQDSAGRTGPLSAVGRAAAATVGMALGFLTVFGIFGALTISAATAVQRYLPYATVLIGLALIALGGWLLLGRGLTALTPRSLGVRWAPTVRLGSMYGYGISYAVASLSCTIGPFLAVTGAGLRGGSVVGSVAIYLAYVAGLTLVVGVLAVAAATASSALADRLRRILPFVNRISGALLVVVGLYVGYYGLYELRLIAGVGANPQDAVIAAAGRLQGALAGWVNQHGAWPWAVLLVVLVVGAFAGTWFRRVRR

2n4xA

0.14

0.09

0.66

1.50

MUSTER

-----QLMAFALGILSVFSPAVLPVVPLIFAG----------------SRGRALDAFLIVAGLTISMLILGYTASLFF-------GFFRVVAMLFLLIFALILLSDDEKVSIFASRMTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSE----NPLVMLSYGLGMAVTIAAVFKMGEKFVKA-------NFQLIRKVTGAIVLLYLAYFALTEVLLLE----------------------------------------------------------

2n4xA

0.12

0.08

0.67

1.23

dPPAS

-----QLMAFALGILSVFSPAVLPVVPLIFAGS----------------RGRALDAFLIVAGLTISMLILGYTASLFFGFFRVVAMLFLLIFALILLSD-----ELDEKVSIFASRMTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSEN----PLVMLSYGLGMAVTIAAVFKMGEKFVKA-------NFQLIRKVTGAIVLLYLAYFALTEVLLLE----------------------------------------------------------

2n4xA

0.14

0.09

0.66

2.47

wdPPAS

-----QLMAFALGILSVFSPAVLPVVPLIFAGSR----------------GRALDAFLIVAGLTISMLILGYTASLFF-------GFFRVVAMLFLLIFALILLSDELDEKVSASRMTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSE----NPLVMLSYGLGMAVTIAAVFKMGEKFVKA-------NFQLIRKVTGAIVLLYLAYFALTEVLLLE----------------------------------------------------------

2n4xA

0.14

0.09

0.66

2.23

wMUSTER

-----QLMAFALGILSVFSPAVLPVVPLIFAGSR----------------GRALDAFLIVAGLTISMLILGYTASLFF-------GFFRVVAMLFLLIFALILLSDELDEKVSASRMTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSE----NPLVMLSYGLGMAVTIAAVFKMGEKFVKA-------NFQLIRKVTGAIVLLYLAYFALTEVLLLE----------------------------------------------------------

2n4xA

0.14

0.09

0.66

4.47

wPPAS

-----QLMAFALGILSVFSPAVLPVVPLIFAGSR----------------GRALDAFLIVAGLTISMLILGYTASLFF-------GFFRVVAMLFLLIFALILLSDELDEKVSASRMTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSE----NPLVMLSYGLGMAVTIAAVFKMGEKFVKA-------NFQLIRKVTGAIVLLYLAYFALTEVLLLE----------------------------------------------------------

2n4xA

0.12

0.08

0.67

2.65

dPPAS2

-----QLMAFALGILSVFSPAVLPVVPLIFAGS----------------RGRALDAFLIVAGLTISMLILGYTASLFFGFFRVVAMLFLLIFALILLSD-----ELDEKVSIFASRMTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSEN----PLVMLSYGLGMAVTIAAVFKMGEKFVKA-------NFQLIRKVTGAIVLLYLAYFALTEVLLLE----------------------------------------------------------

2n4xA

0.14

0.09

0.66

3.21

PPAS

-----QLMAFALGILSVFSPAVLPVVPLIFAGS----------------RGRALDAFLIVAGLTISMLILGYTASLFF-------GFFRVVAMLFLLIFALILLSDELDEKVSASRMTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSE----NPLVMLSYGLGMAVTIAAVFKMGEK-------FVKANFQLIRKVTGAIVLLYLAYFALTEVLLLE----------------------------------------------------------

2n4xA

0.14

0.09

0.66

4.29

Env-PPAS

-----QLMAFALGILSVFSPAVLPVVPLIFAGS----------------RGRALDAFLIVAGLTISMLILGYTASLFF-------GFFRVVAMLFLLIFALILLSDEEKVSIFASRMTSGLSWKIQTLPSFFFGMLLAFLWLPAILPFAGIAISQTLLSE----NPLVMLSYGLGMAVTIAAVFKMGEK-------FVKANFQLIRKVTGAIVLLYLAYFALTEVLLLE----------------------------------------------------------

4n7wA

0.10

0.09

0.92

1.00

MUSTER

ITRLFPVWALLLSVAAYFRP-IGPYVGPLLMLIMFAM-----TLRLDDFKRVLSRPAPVAAATFLHYLIMPLTAWILAMLFR-----MPPDLSAGMVLVGSVASGT-----ASNVMIYLAK-------GDVALSVTISAVST-LVGVFATPLLTRLYVDATISVDVVGMLKSILQIVVIPITAGLVIHHTFTKTVKRIEPYLPAMSMVCILAIISAVVAGSQSHIASVGFVVIIAVILHNGIGLLSGYWGGKLFGFDESTCPGALFSVWHNLSGSLLAGYWSGKPVK

4kjsA

0.08

1.00

0.86

dPPAS

IFFILVAAGVPLSVIGSLMH-WPSAVLFAVYCVTIIALASYMGRATESLSIRIGGLLNATFGNAVELIISMFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGGLKYARQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIMILLYVAALYFKVATIVLFAATIVVAYISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAVGSTLQIAMFVAPVLVICSIFFTLPELVAMVSAVLLMIAISNDGD

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 2 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.29

Estimated TM-score = 0.55±0.15

Estimated RMSD = 9.0±4.6Å

Download Model 2

C-score=-0.97

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2n4xA	0.628	1.54	0.132	0.662
2	1ufaA	0.443	6.46	0.069	0.770
3	4cmrA	0.438	6.45	0.041	0.753
4	1st6A	0.426	5.88	0.064	0.686
5	3vvnA	0.425	5.93	0.053	0.697
6	4lz6A	0.414	6.03	0.049	0.697
7	2wyhA1	0.413	6.57	0.057	0.728
8	3ir7A	0.412	6.22	0.045	0.693
9	5fnoA	0.412	6.13	0.063	0.707
10	2iagA	0.410	5.25	0.089	0.617

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	1ijdD	BCL	Rep, Mult	210,213
2	0.04	2	2r9rB	PGW	Rep, Mult	194,208
3	0.04	2	3wmoJ	BCL	Rep, Mult	213,216,220
4	0.04	2	3ddlB	PCW	Rep, Mult	18,22,26
5	0.04	2	1hnz4	III	Rep, Mult	38,59,61,63,143,144,145,146,147
6	0.04	2	3or1F	UUU	Rep, Mult	13,21
7	0.02	1	2vjt1	III	Rep, Mult	175,208,211,214,218
8	0.02	1	3h6kB	33T	Rep, Mult	26,29
9	0.02	1	2v463	III	Rep, Mult	141,144,216
10	0.02	1	1s56B	XE	Rep, Mult	63,249,253
11	0.02	1	3j0eG	NUC	Rep, Mult	197,200
12	0.02	1	3sn5B	UNX	Rep, Mult	16,183,184,187
13	0.02	1	5f1rA	42O	Rep, Mult	66,67,70
14	0.02	1	2r9rB	PGW	Rep, Mult	214,218
15	0.02	1	1xmeC	HAS	Rep, Mult	57,61
16	0.02	1	2vjt3	III	Rep, Mult	14,50,51,52,54,55,58
17	0.02	1	5li3B	9RB	Rep, Mult	64,67

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1vlbA	0.393	6.72	0.055	0.704	1.2.99.7	60,156
2	0.060	3d3lA	0.401	5.59	0.056	0.603	1.13.11.31	NA
3	0.060	1ea0A	0.385	6.59	0.057	0.686	1.4.1.13	NA
4	0.060	2dqbA	0.390	6.28	0.067	0.662	3.1.5.1	96,117
5	0.060	1ofdA	0.391	6.58	0.052	0.697	1.4.7.1	NA
6	0.060	2vumB	0.305	5.62	0.060	0.474	2.7.7.6	142,177
7	0.060	3b9jC	0.383	7.04	0.054	0.718	1.17.3.2,1.17.1.4	NA
8	0.060	2ckjA	0.368	6.60	0.039	0.645	1.17.1.4,1.17.3.2	NA
9	0.060	1z8lA	0.393	6.48	0.065	0.683	3.4.17.21	NA
10	0.060	3eqmA	0.396	5.24	0.060	0.585	1.14.14.1	149
11	0.060	2q9fA	0.396	5.08	0.084	0.578	1.14.13.98	144
12	0.060	2wyhA	0.413	6.57	0.057	0.728	3.2.1.24	151,177
13	0.060	1frvB	0.375	5.55	0.063	0.596	1.12.2.1	144
14	0.060	1fo4A	0.391	6.68	0.039	0.711	1.17.1.4	NA
15	0.060	1yrqI	0.389	5.49	0.098	0.599	1.12.2.1	101
16	0.060	1dgjA	0.391	6.74	0.063	0.704	1.2.-.-	NA
17	0.060	1ii0B	0.389	6.50	0.067	0.693	3.6.3.16	93
18	0.060	1yqwR	0.389	5.48	0.098	0.599	1.12.2.1	144
19	0.060	1xc6A	0.378	6.51	0.060	0.658	3.2.1.23	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.628	1.54	0.13	0.66	2n4xA	GO:0016020 GO:0016021
1	0.07	0.444	6.37	0.06	0.76	3p0bA	GO:0003824 GO:0003844 GO:0005975 GO:0005977 GO:0005978 GO:0016740 GO:0016757
2	0.07	0.443	6.42	0.04	0.76	4cmrA	GO:0003824 GO:0005975 GO:0016787
3	0.06	0.323	6.43	0.04	0.56	2b5dX
4	0.06	0.373	6.95	0.04	0.70	3n8tA	GO:0000150 GO:0000166 GO:0000400 GO:0000730 GO:0003690 GO:0003697 GO:0003824 GO:0003844 GO:0004134 GO:0004520 GO:0004556 GO:0004557 GO:0005975 GO:0006312 GO:0008094 GO:0010212 GO:0016740 GO:0016757 GO:0030979 GO:0042148 GO:0051060
5	0.06	0.282	7.07	0.04	0.54	4ia5B	GO:0006631 GO:0016491 GO:0050151 GO:0055114 GO:0071949
6	0.06	0.318	6.09	0.03	0.52	4iggB	GO:0001541 GO:0001669 GO:0005198 GO:0005737 GO:0005794 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005915 GO:0005925 GO:0007015 GO:0007155 GO:0007163 GO:0007406 GO:0007568 GO:0008013 GO:0008584 GO:0014070 GO:0014704 GO:0015629 GO:0016020 GO:0016264 GO:0016342 GO:0016600 GO:0017166 GO:0030027 GO:0030054 GO:0031103 GO:0034332 GO:0034613 GO:0042127 GO:0042475 GO:0043066 GO:0043231 GO:0043297 GO:0043627 GO:0044822 GO:0045295 GO:0045296 GO:0045880 GO:0051015 GO:0051149 GO:0051291 GO:0071681 GO:0090136 GO:0098641 GO:2000146 GO:2001045 GO:2001240 GO:2001241
7	0.06	0.346	5.55	0.06	0.53	2xkrA	GO:0004497 GO:0005506 GO:0005618 GO:0005886 GO:0006707 GO:0016491 GO:0016705 GO:0020037 GO:0031073 GO:0036199 GO:0046872 GO:0055114
8	0.06	0.322	6.32	0.07	0.55	4fj0D	GO:0000166 GO:0016491 GO:0055114
9	0.06	0.309	7.12	0.08	0.59	1rpnC	GO:0008446 GO:0009103 GO:0016829 GO:0019673 GO:0070401
10	0.06	0.298	6.52	0.06	0.51	3cghA	GO:0046872
11	0.06	0.426	5.88	0.06	0.69	1st6A	GO:0001725 GO:0002009 GO:0002162 GO:0003779 GO:0005198 GO:0005623 GO:0005737 GO:0005743 GO:0005856 GO:0005886 GO:0005903 GO:0005911 GO:0005912 GO:0005913 GO:0005915 GO:0005916 GO:0005925 GO:0005927 GO:0007155 GO:0008013 GO:0015629 GO:0016020 GO:0017166 GO:0030018 GO:0030032 GO:0030054 GO:0030334 GO:0030486 GO:0031594 GO:0031625 GO:0034333 GO:0034394 GO:0042383 GO:0042803 GO:0043034 GO:0043234 GO:0043297 GO:0045121 GO:0045294 GO:0045296 GO:0048675 GO:0051015 GO:0051371 GO:0051393 GO:0070062 GO:0070527 GO:0090136 GO:0090636 GO:0090637 GO:0097110 GO:0098723 GO:1903561 GO:1990357
12	0.06	0.277	6.65	0.06	0.48	4k1nA	GO:0001541 GO:0001669 GO:0005198 GO:0005737 GO:0005794 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005915 GO:0005925 GO:0007015 GO:0007155 GO:0007163 GO:0007406 GO:0007568 GO:0008013 GO:0008584 GO:0014070 GO:0014704 GO:0015629 GO:0016020 GO:0016264 GO:0016342 GO:0016600 GO:0017166 GO:0030027 GO:0030054 GO:0031103 GO:0034613 GO:0042127 GO:0042475 GO:0043066 GO:0043231 GO:0043297 GO:0043627 GO:0044822 GO:0045295 GO:0045296 GO:0045880 GO:0046982 GO:0051015 GO:0051291 GO:0071681 GO:0090136 GO:2000146 GO:2001045 GO:2001240 GO:2001241
13	0.06	0.302	5.95	0.06	0.49	1sj8A	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
14	0.06	0.293	5.27	0.09	0.44	3ll9B	GO:0000166 GO:0005524 GO:0008299 GO:0016301 GO:0016310 GO:0016740 GO:0102043
15	0.06	0.275	5.69	0.04	0.44	3mdsA	GO:0004784 GO:0006801 GO:0016491 GO:0019430 GO:0046872 GO:0055114
16	0.06	0.287	6.07	0.05	0.47	4wnlC	GO:0003723 GO:0003729 GO:0005634 GO:0005737 GO:0005789 GO:0005934 GO:0006810 GO:0007533 GO:0008289 GO:0008298 GO:0051028
17	0.06	0.340	7.07	0.04	0.65	4ia6B	GO:0006631 GO:0016491 GO:0050151 GO:0055114 GO:0071949
18	0.06	0.270	4.99	0.06	0.39	4k1oA	GO:0005198 GO:0005634 GO:0005737 GO:0005856 GO:0005886 GO:0005912 GO:0005913 GO:0007155 GO:0007275 GO:0007409 GO:0015629 GO:0016020 GO:0016323 GO:0016337 GO:0021942 GO:0030027 GO:0030054 GO:0030154 GO:0030424 GO:0042995 GO:0045296 GO:0048813 GO:0048854 GO:0051015 GO:0051823 GO:0060134 GO:0097481

Consensus prediction of GO terms

Molecular Function	GO:0003844	GO:0000150	GO:0003690	GO:0000166	GO:0004557	GO:0004134	GO:0004520	GO:0004556	GO:0051060	GO:0000400	GO:0008094	GO:0003697
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0044238
GO-Score	0.31
Cellular Component	GO:0031224
GO-Score	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.