I-TASSER results

I-TASSER results for job id Rv2868c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (387 residues)
MTVGLGMPQPPAPTLAPRRATRQLMVGNVGVGSDHPVSVQSMCTTKTHDVNSTLQQIAEL
TAAGCDIVRVACPRQEDADALAEIARHSQIPVVADIHFQPRYIFAAIDAGCAAVRVNPGN
IKEFDGRVGEVAKAAGAAGIPIRIGVNAGSLDKRFMEKYGKATPEALVESALWEASLFEE
HGFGDIKISVKHNDPVVMVAAYELLAARCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSR
GIGDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLEIVSCPSCGRAQVDVYTLANEVTAG
LDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVRGEVIKTVPEAQIVETLIE
EAMRLAAEMGEQDPGATPSGSPIVTVS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVGLGMPQPPAPTLAPRRATRQLMVGNVGVGSDHPVSVQSMCTTKTHDVNSTLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPVVADIHFQPRYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPIRIGVNAGSLDKRFMEKYGKATPEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVAAYELLAARCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLEIVSCPSCGRAQVDVYTLANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVRGEVIKTVPEAQIVETLIEEAMRLAAEMGEQDPGATPSGSPIVTVS
Prediction	CCCCCCCCCCCCCCCCCCCCCEEEEHCCEHCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHCCCCCEEEEHCCCHHHHHHHHHHHCCEEEHCCCCCCCHHHHHHHHHHHHHHHCCCEEEHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCEHCCCCCCCCEHCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCHHHHCCCCEEEHCCCCEEEEEHCCEEEEHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHCC
Conf.Score	988888888888877777787568987777589987799856899977799999999999999898999986999999999999985999889975576789999999848768859998887689999999999998997799757787759999998999999999999999999999899959999985899999999999999899986776656899888736789999999998999789998899974778999999999887777887555889987654589999999999976889967998655566856654588798678995899879999875798999999999999999997554566777788756679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTVGLGMPQPPAPTLAPRRATRQLMVGNVGVGSDHPVSVQSMCTTKTHDVNSTLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPVVADIHFQPRYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPIRIGVNAGSLDKRFMEKYGKATPEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVAAYELLAARCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLEIVSCPSCGRAQVDVYTLANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVRGEVIKTVPEAQIVETLIEEAMRLAAEMGEQDPGATPSGSPIVTVS
Prediction	644724134234443162351240401503012610000000021425304300510330160102000000225600500450175050000001212031003003300300000011135345202400510374710000000001035401741453104000000040041037260410000000120420040033007406000000000013344010100000010014110000000014413500500230041032244625133243222331313410530263057162503000000001022103300000011433010025344245055650053026204510563466556555553441438
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCEEEEHCCEHCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHCCCCCEEEEHCCCHHHHHHHHHHHCCEEEHCCCCCCCHHHHHHHHHHHHHHHCCCEEEHCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCEHCCCCCCCCEHCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCHHHHCCCCEEEHCCCCEEEEEHCCEEEEHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHCC
MTVGLGMPQPPAPTLAPRRATRQLMVGNVGVGSDHPVSVQSMCTTKTHDVNSTLQQIAELTAAGCDIVRVACPRQEDADALAEIARHSQIPVVADIHFQPRYIFAAIDAGCAAVRVNPGNIKEFDGRVGEVAKAAGAAGIPIRIGVNAGSLDKRFMEKYGKATPEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVAAYELLAARCDYPLHLGVTEAGPAFQGTIKSAVAFGALLSRGIGDTIRVSLSAPPVEEVKVGNQVLESLNLRPRSLEIVSCPSCGRAQVDVYTLANEVTAGLDGLDVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQIFVRGEVIKTVPEAQIVETLIEEAMRLAAEMGEQDPGATPSGSPIVTVS

3noyA

0.50

0.45

0.90

3.55

MUSTER

--------------MIQKRKTRQIRVGNVKIGGDAPIVVQSMTSTKTHDVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVKKSPMPVIADIHFAPSYAFLSMEKGVHGIRINPGNIGK-EEIVREIVEEAKRRGVAVRIGVNSGSLEKDLLEKYGYPSAEALAESALRWSEKFEKWGFTNYKVSIKGSDVLQNVRANLIFAERTDVPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDPVVEVETAYEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVKTPLKVAVMGCVVNAIGEAREADIGLACGRGFAWLFKHGKPIKKVDESEMVDELLKEIQN-----------------------

3noyA

0.50

0.45

0.90

9.08

dPPAS

--------------MIQKRKTRQIRVGNVKIGGDAPIVVQSMTSTKTHDVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVKKSPMPVIADIHFAPSYAFLSMEKGVHGIRINPGNIGK-EEIVREIVEEAKRRGVAVRIGVNSGSLEKDLLEKYGYPSAEALAESALRWSEKFEKWGFTNYKVSIKGSDVLQNVRANLIFAERTDVPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDPVVEVETAYEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVKTPLKVAVMGCVVNAIGEAREADIGLACGRGFAWLFKHGKPIKKVDESEMVDELLKEIQN-----------------------

3noyA

0.50

0.45

0.90

6.99

wdPPAS

--------------MIQKRKTRQIRVGNVKIGGDAPIVVQSMTSTKTHDVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVKKSPMPVIADIHFAPSYAFLSMEKGVHGIRINPGNIGK-EEIVREIVEEAKRRGVAVRIGVNSGSLEKDLLEKYGYPSAEALAESALRWSEKFEKWGFTNYKVSIKGSDVLQNVRANLIFAERTDVPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDPVVEVETAYEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVKTPLKVAVMGCVVNAIGEAREADIGLACGRGFAWLFKHGKPIKKVDESEMVDELLKEIQN-----------------------

3noyA

0.51

0.45

0.90

4.05

wMUSTER

---------------IQKRKTRQIRVGNVKIGGDAPIVVQSMTSTKTHDVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVKKSPMPVIADIHFAPSYAFLSMEKGVHGIRINPGNIGK-EEIVREIVEEAKRRGVAVRIGVNSGSLEKDLLEKYGYPSAEALAESALRWSEKFEKWGFTNYKVSIKGSDVLQNVRANLIFAERTDVPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDPVVEVETAYEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVKTPLKVAVMGCVVNAIGEAREADIGLACGRGFAWLFKHGKPIKKVDESEMVDELLKEIQN-----------------------

3noyA

0.50

0.45

0.90

5.01

wPPAS

--------------MIQKRKTRQIRVGNVKIGGDAPIVVQSMTSTKTHDVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVKKSPMPVIADIHFAPSYAFLSMEKGVHGIRINPGNIGK-EEIVREIVEEAKRRGVAVRIGVNSGSLEKDLLEKYGYPSAEALAESALRWSEKFEKWGFTNYKVSIKGSDVLQNVRANLIFAERTDVPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDPVVEVETAYEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVKTPLKVAVMGCVVNAIGEAREADIGLACGRGFAWLFKHGKPIKKVDESEMVDELLKEIQN-----------------------

3noyA

0.50

0.45

0.90

12.48

dPPAS2

--------------MIQKRKTRQIRVGNVKIGGDAPIVVQSMTSTKTHDVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVKKSPMPVIADIHFAPSYAFLSMEKGVHGIRINPGNIGK-EEIVREIVEEAKRRGVAVRIGVNSGSLEKDLLEKYGYPSAEALAESALRWSEKFEKWGFTNYKVSIKGSDVLQNVRANLIFAERTDVPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDPVVEVETAYEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVKTPLKVAVMGCVVNAIGEAREADIGLACGRGFAWLFKHGKPIKKVDESEMVDELLKEIQN-----------------------

3noyA

0.50

0.45

0.90

4.94

PPAS

--------------MIQKRKTRQIRVGNVKIGGDAPIVVQSMTSTKTHDVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVKKSPMPVIADIHFAPSYAFLSMEKGVHGIRINPGNIGK-EEIVREIVEEAKRRGVAVRIGVNSGSLEKDLLEKYGYPSAEALAESALRWSEKFEKWGFTNYKVSIKGSDVLQNVRANLIFAERTDVPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDPVVEVETAYEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVKTPLKVAVMGCVVNAIGEAREADIGLACGRGFAWLFKHGKPIKKVDESEMVDELLKEIQN-----------------------

3noyA

0.50

0.45

0.90

8.85

Env-PPAS

--------------MIQKRKTRQIRVGNVKIGGDAPIVVQSMTSTKTHDVEATLNQIKRLYEAGCEIVRVAVPHKEDVEALEEIVKKSPMPVIADIHFAPSYAFLSMEKGVHGIRINPGNIGK-EEIVREIVEEAKRRGVAVRIGVNSGSLEKDLLEKYGYPSAEALAESALRWSEKFEKWGFTNYKVSIKGSDVLQNVRANLIFAERTDVPLHIGITEAGMGTKGIIKSSVGIGILLYMGIGDTVRVSLTDDPVVEVETAYEILKSLGLRRRGVEIVACPTCGRIEVDLPKVVKEVQEKLSGVKTPLKVAVMGCVVNAIGEAREADIGLACGRGFAWLFKHGKPIKKVDESEMVDELLKEIQN-----------------------

2y0fA

0.38

0.35

0.93

2.98

MUSTER

----------------MRRPTPTVYVGRVPIGGAHPIAVQSMTNTPTRDVEATTAQVLELHRAGSEIVRLTVNDEEAAKAVPEIKRRVEVPLVGDFHFNGHLLLRKYPKMADKFRINPGTLGHKDEHFAEMIRIAMDLGKPVRIGANWGSLDPALLTELMDRVLEALVESAVRAYEAALEMGLDKLVLSAKVSKARDLVWVYRELARRTQAPLHLGLTEAGMGVKGIVASAAALAPLLLEGIGDTIRVSLTPSPTKEVEVAQEILQALGLRAFAPEVTSCPGCGRTTSTFQELAEEVSRRLKERLEELKVAVMGCVVNGPGESKHAHIGISGEEPKAPVYADGKLLTILKGEGIAEEFLRLVEDYVKTRFAPKA-------------

2y0fA

0.38

0.35

0.93

7.25

dPPAS

----------------MRRPTPTVYVGRVPIGGAHPIAVQSMTNTPTRDVEATTAQVLELHRAGSEIVRLTVNDEEAAKAVPEIKRRVEVPLVGDFHFNGHLLLRKYPKMADKFRINPGTLGRKDEHFAEMIRIAMDLGKPVRIGANWGSLDPALLTELMDRVLEALVESAVRAYEAALEMGLDKLVLSAKVSKARDLVWVYRELARRTQAPLHLGLTEAGMGVKGIVASAAALAPLLLEGIGDTIRVSLTPSPTKEVEVAQEILQALGLRAFAPEVTSCPGCGRTTSTFQELAEEVSRRLKEGVEELKVAVMGCVVNGPGESKHAHIGISGEEPKAPVYADGKLLTILKGEGIAEEFLRLVEDYVKTRFAPKA-------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.50

Estimated TM-score = 0.78±0.10

Estimated RMSD = 5.7±3.6Å

Download Model 2

C-score=-1.38

Download Model 3

C-score=-0.28

Download Model 4

C-score=-1.79

Download Model 5

C-score=0.28

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3noyA	0.892	0.80	0.504	0.902
2	2y0fA	0.816	2.77	0.365	0.917
3	4mwaA	0.617	1.83	0.494	0.651
4	4n7qA	0.584	3.71	0.090	0.690
5	3epmA	0.577	3.79	0.103	0.687
6	2h9aA	0.568	3.86	0.083	0.682
7	4djdC	0.565	4.05	0.071	0.693
8	1wkyA	0.560	4.91	0.069	0.734
9	3aboA	0.556	3.81	0.110	0.661
10	3w37A	0.554	5.85	0.083	0.814

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.61	9	3noyA	SF4	Rep, Mult	280,281,282,283,285,286,313,314,315,319,322
2	0.39	6	4g9pA	CDI	Rep, Mult	42,69,95,97,115,143,147,191,218,219,247,249
3	0.05	1	3noyB	SF4	Rep, Mult	161,162
4	0.03	1	3aboC	NA	Rep, Mult	59,254,255,259

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.205	2vp8B	0.494	3.16	0.136	0.563	2.5.1.15	95,192,248
2	0.203	1xbzB	0.453	2.71	0.112	0.509	4.1.1.85	79,80
3	0.108	2yr1B	0.511	3.10	0.128	0.579	4.2.1.10	248
4	0.067	3js3A	0.504	3.12	0.144	0.574	4.2.1.10	NA
5	0.060	1iq8A	0.520	5.14	0.069	0.695	2.4.2.29	NA
6	0.060	1gqnA	0.502	3.05	0.158	0.569	4.2.1.10	NA
7	0.060	2yr1A	0.510	3.10	0.128	0.579	4.2.1.10	NA
8	0.060	2eqdA	0.506	4.96	0.103	0.685	3.2.1.151	NA
9	0.060	2i2xA	0.511	3.80	0.052	0.610	2.1.1.90	235
10	0.060	1rh9A	0.505	3.91	0.065	0.618	3.2.1.78	NA
11	0.060	3h2aB	0.528	3.07	0.133	0.602	2.5.1.15	NA
12	0.060	1g7uA	0.508	3.23	0.110	0.587	2.5.1.55,4.1.2.16	NA
13	0.060	3ivtB	0.512	4.03	0.079	0.612	2.3.3.14	NA
14	0.060	2vegA	0.508	3.02	0.155	0.581	2.5.1.15	231
15	0.060	1wkyA	0.560	4.91	0.069	0.734	3.2.1.78	NA
16	0.060	2vtfA	0.522	5.44	0.070	0.736	3.2.1.96	136,141,172,214
17	0.060	3e9aA	0.515	3.05	0.115	0.587	2.5.1.55	NA
18	0.060	1edgA	0.508	3.93	0.081	0.628	3.2.1.4	202
19	0.060	2qezF	0.537	3.58	0.083	0.633	4.3.1.7	NA
20	0.060	1xc6A	0.548	4.84	0.076	0.724	3.2.1.23	118,145
21	0.060	1d9eD	0.511	3.01	0.112	0.581	2.5.1.55,4.1.2.16	NA
22	0.060	1dioA	0.535	4.13	0.083	0.659	4.2.1.28	NA
23	0.060	1aj0A	0.513	3.23	0.120	0.592	2.5.1.15	69,271

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.55	0.892	0.96	0.50	0.91	3noyB	GO:0003824 GO:0005506 GO:0008299 GO:0016114 GO:0016491 GO:0019288 GO:0046429 GO:0046872 GO:0051536 GO:0051539 GO:0055114
1	0.50	0.625	1.83	0.49	0.66	4mwaF	GO:0003824 GO:0005506 GO:0008299 GO:0016114 GO:0016491 GO:0019288 GO:0044237 GO:0046429 GO:0046872 GO:0051536 GO:0051539 GO:0055114
2	0.42	0.716	3.46	0.31	0.82	4g9pA	GO:0005506 GO:0008299 GO:0016114 GO:0016491 GO:0019288 GO:0044237 GO:0046429 GO:0046872 GO:0051536 GO:0051539 GO:0055114
3	0.09	0.503	2.94	0.16	0.57	4lu0D	GO:0003824 GO:0005737 GO:0008152 GO:0008676 GO:0009058 GO:0009103 GO:0009276 GO:0015976 GO:0016740 GO:0019294
4	0.08	0.426	3.72	0.09	0.51	3fs2A	GO:0003824 GO:0005737 GO:0008152 GO:0008676 GO:0009058 GO:0009103 GO:0016740 GO:0019294
5	0.06	0.465	4.11	0.09	0.57	1jpmA	GO:0003824 GO:0008152 GO:0016853 GO:0016998 GO:0046872 GO:0071555
6	0.06	0.397	4.56	0.08	0.52	3ijqA	GO:0000287 GO:0003824 GO:0006518 GO:0008152 GO:0016853 GO:0016854 GO:0046872 GO:0071555
7	0.06	0.467	3.89	0.13	0.56	3i4kA	GO:0003824 GO:0008152 GO:0016853 GO:0018849 GO:0018850 GO:0030145 GO:0046872
8	0.06	0.403	4.75	0.11	0.54	2zadA	GO:0003824 GO:0008152 GO:0016853 GO:0016855 GO:0016998 GO:0046872 GO:0071555
9	0.06	0.267	6.23	0.04	0.40	1b5oA	GO:0003824 GO:0004069 GO:0005737 GO:0008483 GO:0009058 GO:0016740 GO:0030170 GO:0080130
10	0.06	0.293	6.07	0.05	0.44	3sxpD	GO:0000166 GO:0003824 GO:0005975 GO:0008712 GO:0016853 GO:0050661 GO:0050662 GO:0097171
11	0.06	0.280	6.01	0.09	0.42	3cisG	GO:0000166 GO:0001666 GO:0005524 GO:0005618 GO:0005829 GO:0005886 GO:0006950 GO:0009405 GO:0040007 GO:0040008 GO:0085014
12	0.06	0.261	6.51	0.07	0.42	2ap1A	GO:0000166 GO:0005524 GO:0005975 GO:0006044 GO:0008270 GO:0009254 GO:0016301 GO:0016310 GO:0016740 GO:0045127 GO:0046835 GO:0046872
13	0.06	0.270	5.56	0.08	0.38	2jaxA	GO:0000166 GO:0001666 GO:0005524 GO:0005618 GO:0005829 GO:0005886 GO:0006950 GO:0009405 GO:0040007 GO:0040008 GO:0085014
14	0.06	0.268	7.22	0.05	0.48	3ab4A	GO:0000166 GO:0004072 GO:0005524 GO:0008152 GO:0008652 GO:0009085 GO:0009088 GO:0009089 GO:0016301 GO:0016310 GO:0016597 GO:0016740 GO:0019877
15	0.06	0.250	5.87	0.07	0.38	2dx7A	GO:0006520 GO:0006807 GO:0008152 GO:0016853 GO:0016855 GO:0036361 GO:0047689
16	0.06	0.280	7.08	0.07	0.48	3aawC	GO:0000166 GO:0004072 GO:0005524 GO:0008152 GO:0008652 GO:0009085 GO:0009088 GO:0009089 GO:0016301 GO:0016310 GO:0016597 GO:0016740 GO:0019877
17	0.06	0.225	7.17	0.07	0.39	1y11A	GO:0000166 GO:0004016 GO:0005524 GO:0005622 GO:0005886 GO:0006171 GO:0007165 GO:0008289 GO:0009190 GO:0009268 GO:0009405 GO:0016829 GO:0016849 GO:0030145 GO:0035556 GO:0046872
18	0.06	0.217	6.52	0.05	0.35	3ndcA	GO:0008152 GO:0008168 GO:0009236 GO:0016740 GO:0032259 GO:0046026 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0046429	GO:0051539	GO:0005506	GO:0016765
GO-Score	0.87	0.87	0.87	0.32
Biological Processes	GO:0019288	GO:0055114	GO:0016114	GO:0046400	GO:0046394	GO:0009103
GO-Score	0.87	0.87	0.87	0.32	0.32	0.32
Cellular Component	GO:0044424
GO-Score	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.