I-TASSER results

I-TASSER results for job id Rv2854

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (346 residues)
MTGWVPDVLPGYWQCTIPLGPDPDDEGDIVATLVGRGPQTGKARGDTTGAHHTVLAVHGY
TDYFFHTELADHFANRGFAFYALDLRKCGRSRAPGQTPHFITDLARYDTELEHSLSIINE
QNRSAKVLVYGHSAGGLIVSLWLDRLRQRGEITRAGVTGLVLNSPFLDLQGPAILRLPLT
SAFFAAMARMRPKWVARPPKEGGYGCTLHRDYDGEFDYNLQWKPVGGFPVTFGWIHASRR
GHARLHRGIDVGVPNLILCSDHTVREKADPATLHRGDAVLDVTHITRWAGCIGNRSTVIA
VADAKHDVFLSLPQPRQMAYRRLDLWLDDYLGTHNDTDASASSGKG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGWVPDVLPGYWQCTIPLGPDPDDEGDIVATLVGRGPQTGKARGDTTGAHHTVLAVHGYTDYFFHTELADHFANRGFAFYALDLRKCGRSRAPGQTPHFITDLARYDTELEHSLSIINEQNRSAKVLVYGHSAGGLIVSLWLDRLRQRGEITRAGVTGLVLNSPFLDLQGPAILRLPLTSAFFAAMARMRPKWVARPPKEGGYGCTLHRDYDGEFDYNLQWKPVGGFPVTFGWIHASRRGHARLHRGIDVGVPNLILCSDHTVREKADPATLHRGDAVLDVTHITRWAGCIGNRSTVIAVADAKHDVFLSLPQPRQMAYRRLDLWLDDYLGTHNDTDASASSGKG
Prediction	CCCCCCCCCCCCCEEEHCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCHHHHCCCCHCCHHHHHHHHHHHCCCCEEEEHCCCEEEHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
Conf.Score	9987777788754444467889888887689987567876677788888885899988987555689999999998997999868999988899999987786999999999999999998899978999968789999999998655555556666579985776678888646678999999999876887756888876555544456666444454568777887679999999999999998699998789998588887776655554577566999999999986788689997995565346996899999999999999997778888888888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGWVPDVLPGYWQCTIPLGPDPDDEGDIVATLVGRGPQTGKARGDTTGAHHTVLAVHGYTDYFFHTELADHFANRGFAFYALDLRKCGRSRAPGQTPHFITDLARYDTELEHSLSIINEQNRSAKVLVYGHSAGGLIVSLWLDRLRQRGEITRAGVTGLVLNSPFLDLQGPAILRLPLTSAFFAAMARMRPKWVARPPKEGGYGCTLHRDYDGEFDYNLQWKPVGGFPVTFGWIHASRRGHARLHRGIDVGVPNLILCSDHTVREKADPATLHRGDAVLDVTHITRWAGCIGNRSTVIAVADAKHDVFLSLPQPRQMAYRRLDLWLDDYLGTHNDTDASASSGKG
Prediction	7652434204323323141341335613000000023243342424556231000000010001203300422062101100051122110334553302022032004003200510355246120000000000000010023135334433320100000000011432321223003300310031113030435345211310134352323123413224123010000200140052037417040000000013333444334413311311316202500650165030130450221011344620440052014004511654553645556678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCEEEHCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCHHHHCCCCHCCHHHHHHHHHHHCCCCEEEEHCCCEEEHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
MTGWVPDVLPGYWQCTIPLGPDPDDEGDIVATLVGRGPQTGKARGDTTGAHHTVLAVHGYTDYFFHTELADHFANRGFAFYALDLRKCGRSRAPGQTPHFITDLARYDTELEHSLSIINEQNRSAKVLVYGHSAGGLIVSLWLDRLRQRGEITRAGVTGLVLNSPFLDLQGPAILRLPLTSAFFAAMARMRPKWVARPPKEGGYGCTLHRDYDGEFDYNLQWKPVGGFPVTFGWIHASRRGHARLHRGIDVGVPNLILCSDHTVREKADPATLHRGDAVLDVTHITRWAGCIGNRSTVIAVADAKHDVFLSLPQPRQMAYRRLDLWLDDYLGTHNDTDASASSGKG

4zwnA

0.17

0.14

0.86

1.90

MUSTER

-SAPYPYKVQTVPELQY-----ENFDGAKFGYMFW------PVQNGTNEVRGRVLLIHGFGETKIQFRLMDHLSLNGYESFTFDQRGAGVTSPGR--SKGVTDEYHVFNDLEHFVEKNLSECKGIPLFMWGHSMGGGICLNYACQG-----KHKNEISGYIGSGPLIILH-PHTMYNKPTQIIAPLLAKFSPRVRIDTGLD---LKGITSDKAYRAFL-GSDPMSVPLYGSFRQIHDFMQRGAKLYKNFAKDKPVIIMHGQD--------------DTINDPKGSEKFIRDCSADKELKLYPGARHSIFSETDKVFNTVFNDMKQWLDKHTTTE------------

4zwnA

0.17

0.14

0.85

2.46

dPPAS

---------------SAPYPYKVQTTVPELQYENFDGAKFWPVQNGTNEVRGRVLLIHGFGETKIQFRLMDHLSLNGYESFTFDQRGAGVTSPG--RSKGVTDEYHVFNDLEHFVEKNLSECKGIPLFMWGHSMGGGICLNYACQG-----KHKNEISGYIGSGPLIILH-PHTMYNKPTQIIAPLLAKFSPRVRIDTGLD---LKGITSDKAYRAFLGSDPM-SVPLYGSFRQIHDFMQRGAKLYKNFAKDKPVIIMHGQD--------------DTINDPKGSEKFIRDCSADKELKLYPGARHSIFSETDKVFNTVFNDMKQWLDKHTTTE------------

4zwnA

0.17

0.14

0.84

2.78

wdPPAS

---------------SAPYPYKVQTTVP--LQYENFDGAKFGYQNGTNEVRGRVLLIHGFGETKIQFRLMDHLSLNGYESFTFDQRGAGVTSP--GRSKGVTDEYHVFNDLEHFVEKNLSECKGIPLFMWGHSMGGGICLNYACQG-----KHKNEISGYIGSGPLIILH-PHTMYNKPTQIIAPLLAKFSPRVRIDTGLD---LKGITSDKAYRAFLGSD--PMSVPLYSFRQIHDFMQRGAKLYKNFAKDKPVIIMHGQD--------------DTINDPKGSEKFIRDCSADKELKLYPGARHSIFSETDKVFNTVFNDMKQWLDKHTTTE------------

4zwnA

0.17

0.14

0.85

2.38

wMUSTER

-------------SAPYPYKVQTTPELQYENF-AKFGYMFWPVQNGTNEVRGRVLLIHGFGETKIQFRLMDHLSLNGYESFTFDQRGAGVTSPGR--SKGVTDEYHVFNDLEHFVEKNLSECKGIPLFMWGHSMGGGICLNYACQG-----KHKNEISGYIGSGPLIILH-PHTMYNKPTQIIAPLLAKFSPRVRIDTGLD---LKGITSDKAYRAFLGSDPM-SVPLYGSFRQIHDFMQRGAKLYKNFAKDKPVIIMHGQD--------------DTINDPKGSEKFIRDCSADKELKLYPGARHSIFSETDKVFNTVFNDMKQWLDKHTTTE------------

4zwnA

0.18

0.14

0.82

2.95

wPPAS

---------------SAPYPYKVQPELQYENF-AK------PVQNGTNEVRGRVLLIHGFGETKIQFRLMDHLSLNGYESFTFDQRGAGVTSP--GRSKGVTDEYHVFNDLEHFVEKNLSECKGIPLFMWGHSMGGGICLNYACQG-----KHKNEISGYIGSGPLIILH-PHTMYNKPTQIIAPLLAKFSPRVRIDTGLDL---KGITSDKAYRAFLGSD--PMSVPLYSFRQIHDFMQRGAKLYKNFAKDKPVIIMHGQD--------------DTINDPKGSEKFIRDCPADKELKLYPGARHSIFSETDKVFNTVFNDMKQWLDKHTTTE------------

4zwnA

0.16

0.14

0.84

4.27

dPPAS2

-----------------SAPYPYKVQTTVPLQYENFDYMFWPVQNGTNEVRGRVLLIHGFGETKIQFRLMDHLSLNGYESFTFDQRGAGVTSPG--RSKGVTDEYHVFNDLEHFVEKNLSECKGIPLFMWGHSMGGGICLNYACQG-----KHKNEISGYIGSGPLIILH-PHTMYNKPTQIIAPLLAKFSPRVRIDTGLD---LKGITSDKAYRAFLGSDPM-SVPLYGSFRQIHDFMQRGAKLYKNFAKDKPVIIMHGQD--------------DTINDPKGSEKFIRDCSADKELKLYPGARHSIFSETDKVFNTVFNDMKQWLDKHTTTE------------

4zwnA

0.17

0.14

0.83

2.69

PPAS

---------------SAPYPYKVQTTVP--AKFGYMF----PVQNGTNEVRGRVLLIHGFGETKIQFRLMDHLSLNGYESFTFDQRGAGVTSPG--RSKGVTDEYHVFNDLEHFVEKNLSECKGIPLFMWGHSMGGGICLNYACQG-----KHKNEISGYIGSGPLIILH-PHTMYNKPTQIIAPLLAKFSPRVRIDTGLDL---KGITSDKAYRAFLGSD--PMSVPLYSFRQIHDFMQRGAKLYKNFAKDKPVIIMHGQD--------------DTINDPKGSEKFIRDCPADKELKLYPGARHSIFSETDKVFNTVFNDMKQWLDKHTTTE------------

4zwnA

0.16

0.14

0.86

3.26

Env-PPAS

SAPYPYKVQTTVPELQY-----ENFDGAKFGYMFWP------VQNGTNEVRGRVLLIHGFGETKIQFRLMDHLSLNGYESFTFDQRGAGVTSPG--RSKGVTDEYHVFNDLEHFVEKNLSECKGIPLFMWGHSMGGGICLNYACQG-----KHKNEISGYIGSGPLIILH-PHTMYNKPTQIIAPLLAKFSPRVRIDTGLDLKG---ITSDKAYRAFLGSDPM-SVPLYGSFRQIHDFMQRGAKLYKNFAKDKPVIIMHGQD--------------DTINDPKGSEKFIRDCPADKELKLYPGARHSIFSETDKVFNTVFNDMKQWLDKHTTTE------------

3jw8A

0.15

0.12

0.81

1.64

MUSTER

----SPRRTPQSIPYQ-DLPHLVNADGQYLFCRYW---------KPTGTPKALIFVSHGAGESGRYEELARL--GLDLLVFAHDHVGHGQSEGE----RVVSDFHVFVRDVLQHVDSQKDY-PGLPVFLLGHSGGAIAILTAAER--------PGHFAGVLISPLVLANPESA---TTFKVLAAKVLNLVLPNLSLGPIDSSV----LSRNKTEVDIYN-SDPLICRAGLKVCFGIQLLNAVSRVERALKLTVPFLLLQGSA--------------DRLCDSKGAYLLELAKSQDKTLKIYEGAYHVLHKEL-PEVTNSVFHEINWVSQRTA--------------

3jw8A

0.16

0.12

0.79

2.03

dPPAS

-------------------SPRRTPQSIPLPHLVNADGQFCRYWKPTGTPKALIFVSHGAGESGRYEELARL--GLDLLVFAHDHVGHGQSEG----ERVVSDFHVFVRDVLQHVDSQKDY-PGLPVFLLGHSGGAIAILTAAER--------PGHFAGVLISPLVLANPESA---TTFKVLAAKVLNLVLPNLSLGPIDSSV----LSRNKTEVDIYNSDPL-ICRAGLKVCFGIQLLNAVSRVERALPLTVPFLLLQGSA--------------DRLCDSKGAYLLELAKSQDKTLKIYEGAYHVLHKEL-PEVTNSVFHEINWVSQRTA--------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.59

Estimated TM-score = 0.64±0.13

Estimated RMSD = 7.8±4.4Å

Download Model 2

C-score=-2.56

Download Model 3

C-score=-2.27

Download Model 4

C-score=-1.71

Download Model 5

C-score=-3.15

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4zwnA	0.804	1.62	0.171	0.844
2	1k8qA	0.692	3.97	0.111	0.850
3	3jw8A	0.691	2.75	0.164	0.780
4	2hdwA	0.675	3.79	0.113	0.835
5	5t6oA	0.665	4.00	0.128	0.818
6	4qlaA	0.656	4.13	0.122	0.821
7	5f4zA	0.652	4.01	0.087	0.815
8	4i19A	0.650	4.09	0.074	0.809
9	2rauA	0.650	3.69	0.121	0.786
10	3kdaA	0.649	3.66	0.125	0.786

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.24	8	1r4zA	RIL	Rep, Mult	59,60,62,132,133,134,279,280,306
2	0.09	3	3pe6A	ZYH	Rep, Mult	59,61,132,133,134,169,174,200,202,208,209,214,215,218,238,239,279,306,307,310
3	0.07	2	3hjuA	GOL	Rep, Mult	59,60,62,65,132,307
4	0.03	1	3a2mA	SUC	Rep, Mult	286,289,296,297,298
5	0.03	1	4zxfC	4S7	Rep, Mult	59,133,134,166,169,175,178,181,182,200,228,238,239,306
6	0.03	1	3a2mB	SUC	Rep, Mult	49,50,76
7	0.03	1	3jweA	F4P	Rep, Mult	60,133,134,167,168,239,242,279,280,306
8	0.03	1	3muoA	ZPR	Rep, Mult	56,80,130,132,133,164,306,320,324

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.433	1mt3A	0.631	3.79	0.144	0.754	3.4.11.5	133,277,306
2	0.379	1iunB	0.622	3.36	0.110	0.734	3.7.1.9	277,306
3	0.353	1a8sA	0.615	3.46	0.176	0.720	1.11.1.10	133,164,277,306
4	0.297	1qj4A	0.565	3.76	0.147	0.682	4.1.2.37	133,277,306
5	0.294	1dwoA	0.565	3.82	0.135	0.691	4.1.2.37	133,277,306
6	0.279	3hjuA	0.703	2.90	0.161	0.795	3.1.1.23	89,133,208
7	0.264	2ocgA	0.585	3.31	0.150	0.694	3.1.-.-	133,135,256,277,306
8	0.232	1a88B	0.616	3.59	0.166	0.728	1.11.1.10	NA
9	0.226	3a2lA	0.634	3.55	0.106	0.766	3.8.1.5	NA
10	0.195	2vf2A	0.623	3.58	0.138	0.746	3.7.1.8	89
11	0.185	1va4A	0.613	3.40	0.183	0.720	3.1.1.2	68,133
12	0.179	1auoA	0.479	2.65	0.141	0.535	3.1.1.1	133,306
13	0.146	2r11D	0.606	4.02	0.133	0.754	3.1.1.1	315
14	0.102	1u2eA	0.629	3.31	0.124	0.740	3.7.1.-	133,277,306
15	0.100	1j1iA	0.601	3.25	0.149	0.699	3.7.1.8	59,133
16	0.073	3bf7A	0.558	3.44	0.157	0.665	3.1.-.-	NA
17	0.060	1a7uA	0.612	3.42	0.128	0.717	1.11.1.10	133,277,306
18	0.060	1cpyA	0.631	5.01	0.086	0.844	3.4.16.5	277,306
19	0.060	1mj5A	0.637	3.73	0.122	0.780	3.8.1.5	306
20	0.060	3e3aB	0.622	3.14	0.108	0.720	1.11.1.-	59,84,309
21	0.060	1a88A	0.616	3.57	0.166	0.728	1.11.1.10	133,277,306
22	0.060	2og1A	0.628	3.31	0.125	0.737	3.7.1.8	53
23	0.060	1zd3A	0.629	4.01	0.125	0.777	3.3.2.10	78
24	0.060	3nwoA	0.616	3.59	0.131	0.734	3.4.11.5	133,169
25	0.060	1c4xA	0.622	3.62	0.131	0.749	3.7.1.8	133,310
26	0.060	1azwA	0.631	3.77	0.129	0.777	3.4.11.5	133,277,306
27	0.060	1y37A	0.625	3.74	0.128	0.766	3.8.1.3	221
28	0.060	1zoiA	0.615	3.41	0.151	0.723	3.1.1.-	133,277,306
29	0.060	2v9zA	0.635	3.64	0.119	0.775	3.8.1.5	108
30	0.060	1a8qA	0.621	3.17	0.148	0.720	1.11.1.10	133,277,306
31	0.060	2pu5A	0.626	3.26	0.125	0.734	3.7.1.8	NA
32	0.060	1k8qA	0.692	3.97	0.111	0.850	3.1.1.3	133
33	0.060	1hlgA	0.693	3.90	0.115	0.850	3.1.1.3	133,277,306
34	0.060	1ac5A	0.621	4.88	0.098	0.821	3.4.16.6	133
35	0.060	2psfA	0.627	4.11	0.092	0.786	1.13.12.5	306

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.40	0.703	2.90	0.16	0.79	3hjuA	GO:0004622 GO:0005654 GO:0005737 GO:0005789 GO:0005829 GO:0005886 GO:0006629 GO:0006631 GO:0006633 GO:0006954 GO:0009966 GO:0016020 GO:0016042 GO:0016787 GO:0019369 GO:0019433 GO:0019898 GO:0036155 GO:0042803 GO:0046464 GO:0047372 GO:0050727 GO:0051930 GO:0052689 GO:2000124
1	0.31	0.603	2.95	0.14	0.69	2wtmA
2	0.30	0.566	3.73	0.16	0.69	3dqzA	GO:0009611 GO:0016139 GO:0016787 GO:0016829 GO:0046593
3	0.29	0.805	1.66	0.17	0.85	4zwnB	GO:0005737 GO:0005739 GO:0005741 GO:0005783 GO:0005811 GO:0006641 GO:0009966 GO:0016020 GO:0016787 GO:0019433 GO:0047372
4	0.28	0.569	3.31	0.16	0.66	3dkrA	GO:0052689
5	0.28	0.624	2.86	0.15	0.71	4lheA	GO:0016787 GO:0047372 GO:0052689
6	0.26	0.590	3.35	0.14	0.70	3kxpA	GO:0016787 GO:0042803 GO:0042820 GO:0047411
7	0.24	0.596	3.03	0.13	0.69	3pf8A	GO:0016787
8	0.23	0.622	3.62	0.13	0.75	1c4xA	GO:0016787 GO:0018774
9	0.22	0.634	3.89	0.11	0.79	5esrA	GO:0003824 GO:0016787 GO:0018786
10	0.21	0.610	3.31	0.15	0.71	1hkhA	GO:0003824 GO:0004601 GO:0098869
11	0.21	0.614	3.33	0.18	0.72	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
12	0.21	0.640	3.78	0.12	0.79	3sk0A	GO:0003824 GO:0009636 GO:0016787 GO:0018786
13	0.20	0.585	3.31	0.15	0.69	2ocgA	GO:0005739 GO:0005741 GO:0006520 GO:0006805 GO:0009636 GO:0016787 GO:0047658 GO:0070062
14	0.19	0.582	4.11	0.13	0.72	3qitB	GO:0003824 GO:0008152 GO:0016740 GO:0031177
15	0.19	0.650	3.69	0.14	0.79	4opmA	GO:0004806 GO:0016787
16	0.19	0.502	3.18	0.16	0.58	1dinA	GO:0008806 GO:0016787 GO:0019439 GO:0052689
17	0.18	0.619	3.65	0.15	0.75	4x00A	GO:0016787
18	0.18	0.632	3.91	0.14	0.79	1qtrA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0016787
19	0.17	0.602	3.87	0.11	0.73	4pw0A	GO:0016787
20	0.16	0.615	3.72	0.12	0.75	4ns4A	GO:0016787 GO:0016788
21	0.16	0.616	3.57	0.17	0.73	1a88A	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
22	0.11	0.620	3.68	0.11	0.75	4i3fA	GO:0016787
23	0.11	0.581	2.50	0.17	0.64	4ke6E	GO:0016787 GO:0047372 GO:0052689
24	0.10	0.692	3.97	0.11	0.85	1k8qA	GO:0004806 GO:0005576 GO:0006629 GO:0016042 GO:0016787 GO:0016788
25	0.10	0.611	3.26	0.11	0.71	2xuaH	GO:0016787 GO:0042952 GO:0047570
26	0.10	0.693	3.90	0.12	0.85	1hlgA	GO:0004806 GO:0005576 GO:0005739 GO:0006108 GO:0006629 GO:0006641 GO:0008289 GO:0016042 GO:0016615 GO:0016787 GO:0016788 GO:0055114
27	0.09	0.619	3.92	0.12	0.76	5bovB	GO:0003824 GO:0016787
28	0.07	0.625	3.97	0.15	0.77	4ufoA	GO:0003824 GO:0016787
29	0.07	0.621	3.17	0.15	0.72	1a8qA	GO:0003824 GO:0004601 GO:0016491 GO:0017000 GO:0055114 GO:0098869
30	0.07	0.615	3.46	0.18	0.72	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
31	0.07	0.616	3.52	0.12	0.72	2xmzA	GO:0009234 GO:0016787 GO:0016829 GO:0070205
32	0.07	0.620	3.40	0.17	0.73	4dgqA	GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869

Consensus prediction of GO terms

Molecular Function	GO:0047372	GO:0042803	GO:0004622	GO:0046593
GO-Score	0.57	0.40	0.40	0.30
Biological Processes	GO:0019433	GO:0006633	GO:0036155	GO:2000124	GO:0019369	GO:0051930	GO:0050727	GO:0009611	GO:0016139
GO-Score	0.57	0.40	0.40	0.40	0.40	0.40	0.40	0.30	0.30
Cellular Component	GO:0031966	GO:0043232	GO:0031968	GO:0005886	GO:0005789	GO:0005654	GO:0005829	GO:0019898
GO-Score	0.58	0.58	0.58	0.40	0.40	0.40	0.40	0.40

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.