I-TASSER results

I-TASSER results for job id Rv2837c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (336 residues)
MTTIDPRSELVDGRRRAGARVDAVGAAALLSAAARVGVVCHVHPDADTIGAGLALALVLD
GCGKRVEVSFAAPATLPESLRSLPGCHLLVRPEVMRRDVDLVVTVDIPSVDRLGALGDLT
DSGRELLVIDHHASNDLFGTANFIDPSADSTTTMVAEILDAWGKPIDPRVAHCIYAGLAT
DTGSFRWASVRGYRLAARLVEIGVDNATVSRTLMDSHPFTWLPLLSRVLGSAQLVSEAVG
GRGLVYVVVDNREWVAARSEEVESIVDIVRTTQQAEVAAVFKEVEPHRWSVSMRAKTVNL
AAVASGFGGGGHRLAAGYTTTGSIDDAVASLRAALG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTIDPRSELVDGRRRAGARVDAVGAAALLSAAARVGVVCHVHPDADTIGAGLALALVLDGCGKRVEVSFAAPATLPESLRSLPGCHLLVRPEVMRRDVDLVVTVDIPSVDRLGALGDLTDSGRELLVIDHHASNDLFGTANFIDPSADSTTTMVAEILDAWGKPIDPRVAHCIYAGLATDTGSFRWASVRGYRLAARLVEIGVDNATVSRTLMDSHPFTWLPLLSRVLGSAQLVSEAVGGRGLVYVVVDNREWVAARSEEVESIVDIVRTTQQAEVAAVFKEVEPHRWSVSMRAKTVNLAAVASGFGGGGHRLAAGYTTTGSIDDAVASLRAALG
Prediction	CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEHCCCCHHHCCHHHHHHHHCCCEEEEHCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEHCCCCCEEEEEEEEHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEEHCCCEEEEEEHCCCCCHHHHHHHHCCCCCCCCCEEEHCCCHHHHHHHHHHHHC
Conf.Score	965689887655554456788999999999979959999589998579999999999999979968999958987777888758875566755567779899997799967766578998768968998589999988658997799857999999999998999999999999999776479877898747999999999999999999999756998999999999997656764689799999983467877999999999999985579959999999985999999998699869999999899845467578877999999999999989
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTTIDPRSELVDGRRRAGARVDAVGAAALLSAAARVGVVCHVHPDADTIGAGLALALVLDGCGKRVEVSFAAPATLPESLRSLPGCHLLVRPEVMRRDVDLVVTVDIPSVDRLGALGDLTDSGRELLVIDHHASNDLFGTANFIDPSADSTTTMVAEILDAWGKPIDPRVAHCIYAGLATDTGSFRWASVRGYRLAARLVEIGVDNATVSRTLMDSHPFTWLPLLSRVLGSAQLVSEAVGGRGLVYVVVDNREWVAARSEEVESIVDIVRTTQQAEVAAVFKEVEPHRWSVSMRAKTVNLAAVASGFGGGGHRLAAGYTTTGSIDDAVASLRAALG
Prediction	752424625434544313020205302510560641012014203230200000002004624250200002565224104304616303346324640000000001326104404510622420000000244743031110224000000000100442726024400100000000003303262031020002005240326302520277233510400330053041234332100000012422541613351033004102405301000000135742000000045120230054151210420000316240540153037318
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEHCCCCHHHCCHHHHHHHHCCCEEEEHCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEHCCCCCEEEEEEEEHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEEEEHCCCEEEEEEHCCCCCHHHHHHHHCCCCCCCCCEEEHCCCHHHHHHHHHHHHC
MTTIDPRSELVDGRRRAGARVDAVGAAALLSAAARVGVVCHVHPDADTIGAGLALALVLDGCGKRVEVSFAAPATLPESLRSLPGCHLLVRPEVMRRDVDLVVTVDIPSVDRLGALGDLTDSGRELLVIDHHASNDLFGTANFIDPSADSTTTMVAEILDAWGKPIDPRVAHCIYAGLATDTGSFRWASVRGYRLAARLVEIGVDNATVSRTLMDSHPFTWLPLLSRVLGSAQLVSEAVGGRGLVYVVVDNREWVAARSEEVESIVDIVRTTQQAEVAAVFKEVEPHRWSVSMRAKTVNLAAVASGFGGGGHRLAAGYTTTGSIDDAVASLRAALG

4ls9A

0.74

0.69

0.93

3.02

MUSTER

-----------------GARVDARGAADLLTAASSVSVICHVYPDADTIGAGLALAQVLAASGKHVEVSFATPAQLPESLQSLPGGHLLVAPEA-RRDADLVVTVDIPSINRLGALSGLAGPGREVLVIDHHASNQLFGTANYIDPSADST-TLVAELLDAWGKPIDEKVAHCLYAGLTTDTGSFRWATARAHRLAARLVELGVDNASISRTLLDTHPFAWLP-LSRVLATARLLPDALDGRGFVYAVVPHDEWSEARPEEVESIVDIVRTTQQAEVAAVFKEIEPH---WSVSRKSVNLASVASAFGGGGHPHAAGYSATGSADDVVQALARALG

4ls9A

0.74

0.69

0.93

5.02

dPPAS

-----------------GARVDARGAADLLTAASSVSVICHVYPDADTIGAGLALAQVLAASGKHVEVSFATPAQLPESLQSLPGGHLLVAPEARR-DADLVVTVDIPSINRLGALSGLAGPGREVLVIDHHASNQLFGTANYIDPSADST-TLVAELLDAWGKPIDEKVAHCLYAGLTTDTGSFRWATARAHRLAARLVELGVDNASISRTLLDTHPFAWLP-LSRVLATARLLPDALDGRGFVYAVVPHDEWSEARPEEVESIVDIVRTTQQAEVAAVFKEIEPH---WSVSRKSVNLASVASAFGGGGHPHAAGYSATGSADDVVQALARALG

4ls9A

0.74

0.69

0.93

5.53

wdPPAS

-----------------GARVDARGAADLLTAASSVSVICHVYPDADTIGAGLALAQVLAASGKHVEVSFATPAQLPESLQSLPGGHLLVAPEAR-RDADLVVTVDIPSINRLGALSGLAGPGREVLVIDHHASNQLFGTANYIDPSADST-TLVAELLDAWGKPIDEKVAHCLYAGLTTDTGSFRWATARAHRLAARLVELGVDNASISRTLLDTHPFAWLP-LSRVLATARLLPDALDGRGFVYAVVPHDEWSEARPEEVESIVDIVRTTQQAEVAAVFKEIEP---HWSVSRKSVNLASVASAFGGGGHPHAAGYSATGSADDVVQALARALG

4ls9A

0.74

0.69

0.93

3.77

wMUSTER

-----------------GARVDARGAADLLTAASSVSVICHVYPDADTIGAGLALAQVLAASGKHVEVSFATPAQLPESLQSLPGGHLLVAPEA-RRDADLVVTVDIPSINRLGALSGLAGPGREVLVIDHHASNQLFGTANYIDPSADST-TLVAELLDAWGKPIDEKVAHCLYAGLTTDTGSFRWATARAHRLAARLVELGVDNASISRTLLDTHPFAWLP-LSRVLATARLLPDALDGRGFVYAVVPHDEWSEARPEEVESIVDIVRTTQQAEVAAVFKEIEPH---WSVSRKSVNLASVASAFGGGGHPHAAGYSATGSADDVVQALARALG

4ls9A

0.74

0.69

0.93

4.71

wPPAS

-----------------GARVDARGAADLLTAASSVSVICHVYPDADTIGAGLALAQVLAASGKHVEVSFATPAQLPESLQSLPGGHLLVAPEAR-RDADLVVTVDIPSINRLGALSGLAGPGREVLVIDHHASNQLFGTANYIDPSADST-TLVAELLDAWGKPIDEKVAHCLYAGLTTDTGSFRWATARAHRLAARLVELGVDNASISRTLLDTHPFAWLP-LSRVLATARLLPDALDGRGFVYAVVPHDEWSEARPEEVESIVDIVRTTQQAEVAAVFKEIEP---HWSVSRKSVNLASVASAFGGGGHPHAAGYSATGSADDVVQALARALG

4ls9A

0.74

0.69

0.93

9.81

dPPAS2

-----------------GARVDARGAADLLTAASSVSVICHVYPDADTIGAGLALAQVLAASGKHVEVSFATPAQLPESLQSLPGGHLLVAPEARR-DADLVVTVDIPSINRLGALSGLAGPGREVLVIDHHASNQLFGTANYIDPSADST-TLVAELLDAWGKPIDEKVAHCLYAGLTTDTGSFRWATARAHRLAARLVELGVDNASISRTLLDTHPFAWLP-LSRVLATARLLPDALDGRGFVYAVVPHDEWSEARPEEVESIVDIVRTTQQAEVAAVFKEIEPH---WSVSRKSVNLASVASAFGGGGHPHAAGYSATGSADDVVQALARALG

4ls9A

0.74

0.69

0.93

4.34

PPAS

-----------------GARVDARGAADLLTAASSVSVICHVYPDADTIGAGLALAQVLAASGKHVEVSFATPAQLPESLQSLPGGHLLVAPEAR-RDADLVVTVDIPSINRLGALSGLAGPGREVLVIDHHASNQLFGTANYIDPSADST-TLVAELLDAWGKPIDEKVAHCLYAGLTTDTGSFRWATARAHRLAARLVELGVDNASISRTLLDTHPFAWLP-LSRVLATARLLPDALDGRGFVYAVVPHDEWSEARPEEVESIVDIVRTTQQAEVAAVFKEIEPH---WSVSRKSVNLASVASAFGGGGHPHAAGYSATGSADDVVQALARALG

4ls9A

0.74

0.69

0.93

6.91

Env-PPAS

-----------------GARVDARGAADLLTAASSVSVICHVYPDADTIGAGLALAQVLAASGKHVEVSFATPAQLPESLQSLPGGHLLVAPEAR-RDADLVVTVDIPSINRLGALSGLAGPGREVLVIDHHASNQLFGTANYIDPSADST-TLVAELLDAWGKPIDEKVAHCLYAGLTTDTGSFRWATARAHRLAARLVELGVDNASISRTLLDTHPFAWLP-LSRVLATARLLPDALDGRGFVYAVVPHDEWSEARPEEVESIVDIVRTTQQAEVAAVFKEIEPH---WSVSRKSVNLASVASAFGGGGHPHAAGYSATGSADDVVQALARALG

3devA

0.23

0.21

0.90

2.40

MUSTER

--------------------VEIFNEIQRVKEAETIIIHRHVRPDPDAYGSQLGLKLYLERKFPEKNIYATG--EAEPSLSFIGDLDEI---DDSVYSDALVIVCDTANAPRIDD--QRYLNGQSLIKIDHHPATDQYGDVNFVNTEASSTSEIIFDFISHFNDIIDEHVARVLYLGIVGDTGRFLFSNTSHTEVASQLLAYPFN---HNAELNKSEKDPKLPFQGYVLQNFELSDS--HEYCQIKITNDVLKQFDIQPNEASQFVNTVADISGLKIWFGVDE--GDQIRCRIRSKGITINDVANQFGGGGHPNASGVSVYSEFEELAQALRQKLL

3devA

0.23

0.21

0.90

3.85

dPPAS

--------------------VEIFNEIQRVKEAETIIIHRHVRPDPDAYGSQLGLKLYLERKFPEKNIYATG--EAEPSLSFIGDLDEI---DDSVYSDALVIVCDTANAPRIDDQR--YLNGQSLIKIDHHPATDQYGDVNFVNTEASSTSEIIFDFISHFNDIIDEHVARVLYLGIVGDTGRFLFSNTSHTEVASQLLAYPFN---HNAELNKSEKDPKLPFQGYVLQNFELS--DSHEYCQIKITNDVLKQFDIQPNEASQFVNTVADISGLKIWFGVD--EGDQIRCRIRSKGITINDVANQFGGGGHPNASGVSVYSEFEELAQALRQKLL

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.53

Estimated TM-score = 0.78±0.09

Estimated RMSD = 5.3±3.4Å

Download Model 2

C-score=-0.34

Download Model 3

C-score=-0.55

Download Model 4

C-score=-2.66

Download Model 5

C-score=-3.71

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4ls9A	0.916	1.08	0.752	0.934
2	3devA	0.742	3.16	0.219	0.884
3	3dmaA	0.702	4.24	0.204	0.908
4	2zxoA	0.611	4.81	0.151	0.833
5	3jc5c	0.567	5.55	0.089	0.833
6	5f54A	0.566	5.35	0.138	0.816
7	2hawB	0.563	4.38	0.144	0.714
8	2qb6A	0.557	5.01	0.091	0.753
9	5dgoA	0.557	5.62	0.098	0.830
10	4rpaA	0.556	4.50	0.124	0.708

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.73	68	1k23D	MN	Rep, Mult	47,106,131,132,151,181
2	0.21	23	2eb0A	MN	Rep, Mult	41,45,48,106
3	0.03	4	2hawA	F	Rep, Mult	45,47,106,181
4	0.02	4	2enxB	2PN	Rep, Mult	41,45,106,131,132,181,233,321,322
5	0.01	1	1i74A	SO4	Rep, Mult	41,45,106,131,132,181,233
6	0.01	2	2eb0A	MN	Rep, Mult	41,45,48,106,233
7	0.01	2	1k200	III	Rep, Mult	131,132,134,135,143,144,145,146
8	0.00	1	2enxA	TRP	Rep, Mult	55,127,129,142

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.143	1i74A	0.552	4.38	0.143	0.702	3.6.1.1	45,54,131,181
2	0.067	2hawB	0.563	4.38	0.144	0.714	3.6.1.1	132,181
3	0.067	1wppA	0.562	4.17	0.135	0.708	3.6.1.1	41,45,132
4	0.060	1ja1A	0.446	5.32	0.072	0.646	1.6.2.4	NA
5	0.060	1ofdA	0.394	6.63	0.051	0.681	1.4.7.1	NA
6	0.060	1ycfA	0.421	6.33	0.081	0.676	1.7.99.7	NA
7	0.060	2bf4A	0.436	5.70	0.045	0.646	1.6.2.4	NA
8	0.060	1ho5A	0.372	7.05	0.017	0.667	3.1.3.5,3.6.1.45	270
9	0.060	2eb0B	0.533	4.27	0.158	0.673	3.6.1.1	45,146
10	0.060	1tmoA	0.409	5.69	0.039	0.601	1.7.2.3	NA
11	0.060	1bxrA	0.411	5.90	0.066	0.622	6.3.5.5	NA
12	0.060	2ex0A	0.431	6.03	0.058	0.676	2.4.99.4,2.4.99.6,2.4.99.9	NA
13	0.060	1g8kE	0.437	4.77	0.045	0.595	1.20.98.1	NA
14	0.060	3dzcB	0.432	5.71	0.081	0.667	5.1.3.14	157
15	0.060	1g8kA	0.438	4.83	0.045	0.598	1.20.98.1	NA
16	0.060	1pg3B	0.427	6.19	0.060	0.664	6.2.1.1	151,261
17	0.060	1f20A	0.326	6.32	0.040	0.533	1.14.13.39	176
18	0.060	2eabA	0.409	6.33	0.031	0.673	3.2.1.63	NA
19	0.060	3dzcA	0.432	5.93	0.071	0.681	5.1.3.14	NA
20	0.060	1wpnB	0.474	2.55	0.174	0.530	3.6.1.1	45,132,181
21	0.060	1oidA	0.422	6.68	0.030	0.732	3.6.1.45,3.1.3.5	NA
22	0.060	2nyaA	0.460	4.86	0.048	0.628	1.7.99.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.67	0.930	1.10	0.75	0.95	4ls9A	GO:0003676 GO:0046872
1	0.60	0.682	4.18	0.77	0.83	5cetA	GO:0004518 GO:0004527 GO:0008441 GO:0016311 GO:0016787 GO:0040007 GO:0090305
2	0.54	0.757	3.13	0.21	0.90	3devA	GO:0003676 GO:0046872
3	0.47	0.555	4.24	0.14	0.70	1k20A	GO:0004427 GO:0005737 GO:0016462 GO:0016787 GO:0030145 GO:0046872
4	0.45	0.562	4.28	0.14	0.71	1i74A	GO:0004427 GO:0005737 GO:0016462 GO:0016787 GO:0030145 GO:0046872
5	0.45	0.543	3.45	0.17	0.65	1k23D	GO:0004427 GO:0005737 GO:0016462 GO:0016787 GO:0030145 GO:0046872
6	0.44	0.564	4.22	0.12	0.75	2zxrA	GO:0003676 GO:0003677 GO:0004518 GO:0004527 GO:0016787 GO:0046872 GO:0090305
7	0.42	0.533	4.27	0.16	0.67	2eb0B	GO:0004427 GO:0005737 GO:0016462 GO:0016787 GO:0030145 GO:0046872
8	0.38	0.553	4.37	0.14	0.70	2enxA	GO:0004427 GO:0005737 GO:0016462 GO:0016787 GO:0030145 GO:0046872
9	0.37	0.611	4.81	0.15	0.83	2zxoA	GO:0003676 GO:0003677 GO:0004518 GO:0004527 GO:0016787 GO:0046872 GO:0090305
10	0.28	0.721	4.22	0.21	0.93	4py9A	GO:0046872
11	0.07	0.563	4.38	0.14	0.71	2hawB	GO:0004427 GO:0005737 GO:0016462 GO:0016787 GO:0030145 GO:0046872
12	0.07	0.571	5.37	0.13	0.82	5f55A	GO:0003676 GO:0004527 GO:0006281 GO:0006310 GO:0008409 GO:0090305
13	0.07	0.556	4.50	0.12	0.71	4rpaA	GO:0004427 GO:0005737 GO:0016462 GO:0016787 GO:0030145 GO:0046872
14	0.06	0.391	5.50	0.10	0.59	1iirA	GO:0005975 GO:0008152 GO:0016740 GO:0016757 GO:0016758 GO:0017000 GO:0030259 GO:0033072
15	0.06	0.365	6.38	0.06	0.60	1t90A	GO:0004029 GO:0004491 GO:0008152 GO:0016491 GO:0016620 GO:0018478 GO:0019310 GO:0055114
16	0.06	0.340	6.56	0.06	0.57	3g0tA	GO:0003824 GO:0008483 GO:0009058 GO:0016740 GO:0030170
17	0.06	0.319	6.72	0.06	0.54	3oqqA	GO:0046872
18	0.06	0.322	6.37	0.11	0.53	3vifA	GO:0004553 GO:0005975 GO:0008152 GO:0008422 GO:0016787 GO:0016798 GO:0102483
19	0.06	0.267	5.81	0.05	0.41	2zatA	GO:0000253 GO:0001758 GO:0004090 GO:0005739 GO:0005777 GO:0016491 GO:0042574 GO:0055114
20	0.06	0.280	4.28	0.04	0.37	3b9xC	GO:0005509 GO:0005829 GO:0006152 GO:0006206 GO:0008152 GO:0008477 GO:0016787 GO:0016798 GO:0016799 GO:0042802 GO:0045437 GO:0046133 GO:0046872 GO:0050263
21	0.06	0.273	6.42	0.07	0.45	4j6cA	GO:0004497 GO:0005506 GO:0016491 GO:0016705 GO:0020037 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0003676	GO:0004427	GO:0030145	GO:0008441	GO:0004527
GO-Score	0.85	0.71	0.71	0.60	0.60
Biological Processes	GO:0016311	GO:0040007	GO:0090305
GO-Score	0.60	0.60	0.60
Cellular Component	GO:0005737
GO-Score	0.71

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.