I-TASSER results

I-TASSER results for job id Rv2827c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (295 residues)
MVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGW
LVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGR
IPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGP
EALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Prediction	CCCCCCCCCCCCHHHHHHHHHHHHCCCEEHCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEHCCCCCCCCCCCCHHHHHHHHHCCCCCEEHCHHHHHHHHHHHHCCCCCCCCEHCCCCCCCCCCCCCEEEEEEHCCCCCCHHHCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
Conf.Score	9987887766655789999998656874555899999999988888999999999998754347887668766888777788865688998748887554335799999987756888876555587546876454456788756654443445778765566666756645786767867888888758755687678899999999986577999999858778898876666558984788888887576556645655676666676544554444467788999876579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Prediction	7443543433014002400530435321112244035204644173524400430431100051434111310343523342221203000242630211221310110121134336451422223454135313431310312342234222443213314550422221431202303100010144244143144015204400340475303521544244205301200434243430531244442532332411344453455531244141034001100311468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCHHHHHHHHHHHHCCCEEHCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEHCCCCCCCCCCCCHHHHHHHHHCCCCCEEHCHHHHHHHHHHHHCCCCCCCCEHCCCCCCCCCCCCCEEEEEEHCCCCCCHHHCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
MVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

1zelB

0.99

0.98

0.99

2.55

MUSTER

VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSG---ESVWAPEYQLVDELVVPLLRVIGKA

1zelB

1.00

0.99

3.24

dPPAS

VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHS---GESVWAPEYQLVDELVVPLLRVIGKA

1zelB

1.00

0.99

4.89

wdPPAS

VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHS---GESVWAPEYQLVDELVVPLLRVIGKA

1zelB

0.99

0.98

0.99

3.12

wMUSTER

VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHSG---ESVWAPEYQLVDELVVPLLRVIGKA

1zelB

1.00

0.99

4.47

wPPAS

VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHS---GESVWAPEYQLVDELVVPLLRVIGKA

1zelB

1.00

0.99

4.63

dPPAS2

VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHS---GESVWAPEYQLVDELVVPLLRVIGKA

1zelB

1.00

0.99

3.97

PPAS

VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHS---GESVWAPEYQLVDELVVPLLRVIGKA

1zelB

1.00

0.99

7.79

Env-PPAS

VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAISDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGEPARGQALLAKRHTEVMPVTRFTTAHS---GESVWAPEYQLVDELVVPLLRVIGKA

1zelB2

1.00

0.48

0.97

MUSTER

---------------------------------------------------------------------------------DPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGR------------------------------------------------------------------------

1zelB2

1.00

0.48

1.48

dPPAS

---------------------------------------------------------------------------------DPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPALLVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGR------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.66

Estimated TM-score = 0.95±0.05

Estimated RMSD = 2.8±2.1Å

Download Model 2

C-score=-4.06

Download Model 3

C-score=-4.56

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1zelB	0.980	0.66	0.997	0.990
2	2cqtA	0.438	5.86	0.051	0.692
3	5a2vA	0.437	5.94	0.068	0.712
4	2okxA	0.434	5.97	0.050	0.695
5	2qj0A	0.432	6.61	0.043	0.769
6	5bqnA	0.427	6.28	0.055	0.725
7	1ulvA	0.427	6.22	0.053	0.715
8	3v0aB	0.426	6.30	0.042	0.709
9	3vuoA	0.426	6.27	0.016	0.712
10	1z5hA	0.426	6.06	0.049	0.702

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1a9x1	III	Rep, Mult	13,15,16,55,56,61
2	0.04	2	1lm1A	F3S	Rep, Mult	17,18,22,35,36,37,40,44,45
3	0.04	2	1n2jA	BAL	Rep, Mult	188,191
4	0.04	2	1rwtH	CLA	Rep, Mult	200,203,204,224,228
5	0.04	2	1zelB	NA	Rep, Mult	26,34,37,38
6	0.04	2	5hmiA	62T	Rep, Mult	32,35
7	0.02	1	3cu0B	MN	Rep, Mult	82,203,215
8	0.02	1	1sw1A	ZN	Rep, Mult	47,49
9	0.02	1	3hlnJ	CA	Rep, Mult	24,25
10	0.02	1	1hgyA	GLC	Rep, Mult	71,124,197
11	0.02	1	3urqA	IMD	Rep, Mult	82,83,86
12	0.02	1	2byoA	LNL	Rep, Mult	19,26
13	0.02	1	1ebeA	O	Rep, Mult	57,60
14	0.02	1	3lw5K	CLA	Rep, Mult	227,231
15	0.02	1	3e49B	IMD	Rep, Mult	174,175,178,179,180
16	0.02	1	2b51A	MN	Rep, Mult	82,114
17	0.02	1	3nyhA	IOD	Rep, Mult	135,136,190
18	0.02	1	1nx0B	III	Rep, Mult	18,22
19	0.02	1	1y10D	CA	Rep, Mult	77,94
20	0.02	1	1c6cA	AR	Rep, Mult	216,231

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ojnA	0.415	5.98	0.063	0.681	4.2.2.1	NA
2	0.060	1g5aA	0.405	6.32	0.070	0.685	2.4.1.4	NA
3	0.060	1hn0A	0.417	6.62	0.043	0.732	4.2.2.20	NA
4	0.060	1i8qA	0.405	6.63	0.033	0.725	4.2.2.1	81,140
5	0.060	1ta9B	0.395	6.27	0.076	0.664	1.1.1.6	NA
6	0.060	1jqnA	0.407	6.06	0.060	0.668	4.1.1.31	NA
7	0.060	3hkzJ	0.397	6.53	0.072	0.685	2.7.7.6	5,61
8	0.060	1lf6A	0.419	6.35	0.038	0.712	3.2.1.3	54
9	0.060	3mwdA	0.422	5.90	0.054	0.681	2.3.3.8	NA
10	0.060	2cqsA	0.439	6.04	0.076	0.705	2.4.1.20	NA
11	0.060	2ztgA	0.396	6.16	0.039	0.664	6.1.1.7	5
12	0.060	1h54B	0.387	6.20	0.024	0.637	2.4.1.8	NA
13	0.060	3cf4A	0.407	6.16	0.065	0.685	1.2.99.2	NA
14	0.060	1xkvB	0.399	6.69	0.073	0.698	4.1.1.49	9,85
15	0.060	2zuwC	0.391	6.58	0.061	0.692	2.4.1.211	25,58
16	0.060	2qf7A	0.400	6.40	0.065	0.685	6.4.1.1	NA
17	0.060	1r7aA	0.388	6.30	0.048	0.671	2.4.1.7	NA
18	0.060	2q1fA	0.397	6.96	0.044	0.712	4.2.2.21	NA
19	0.060	1s46A	0.406	6.30	0.051	0.685	2.4.1.4	22

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.428	6.23	0.05	0.72	5a2vB	GO:0000287 GO:0002134 GO:0004652 GO:0005524 GO:0005739 GO:0006378 GO:0030145 GO:0042802 GO:0042803 GO:0043231 GO:0044822 GO:0071044
1	0.06	0.425	6.14	0.08	0.70	1v7vA	GO:0003824 GO:0005975 GO:0016740 GO:0030246 GO:0046872
2	0.06	0.393	5.89	0.04	0.63	3cihA	GO:0003824
3	0.06	0.395	5.75	0.08	0.62	3w5mA	GO:0003824 GO:0046872
4	0.06	0.423	6.17	0.07	0.68	4zlfA	GO:0003824 GO:0005975 GO:0030246
5	0.06	0.347	7.08	0.04	0.66	3qdeA	GO:0003824 GO:0005975 GO:0016740 GO:0016757 GO:0030246 GO:0047738
6	0.06	0.434	5.97	0.05	0.69	2okxA	GO:0003824
7	0.06	0.362	6.06	0.05	0.59	3pq1A	GO:0000166 GO:0000287 GO:0002134 GO:0003723 GO:0004652 GO:0005524 GO:0005737 GO:0005739 GO:0006351 GO:0006378 GO:0006397 GO:0016740 GO:0016779 GO:0030145 GO:0042802 GO:0042803 GO:0043231 GO:0044822 GO:0046872 GO:0071044
8	0.06	0.329	7.34	0.06	0.66	1yq2A	GO:0003824 GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0009341 GO:0016787 GO:0016798 GO:0030246 GO:0046872
9	0.06	0.435	6.06	0.07	0.70	3acsA	GO:0003824 GO:0005975 GO:0030246
10	0.06	0.312	6.39	0.04	0.53	3pq1B	GO:0000166 GO:0000287 GO:0002134 GO:0003723 GO:0004652 GO:0005524 GO:0005737 GO:0005739 GO:0006351 GO:0006378 GO:0006397 GO:0016740 GO:0016779 GO:0030145 GO:0042802 GO:0042803 GO:0043231 GO:0044822 GO:0046872 GO:0071044
11	0.06	0.332	6.10	0.07	0.55	4ud5B	GO:0000166 GO:0000287 GO:0002134 GO:0003723 GO:0004652 GO:0005524 GO:0005737 GO:0005829 GO:0016740 GO:0016779 GO:0036450 GO:0046872 GO:0050265 GO:0071076
12	0.06	0.312	7.14	0.03	0.59	3nybA	GO:0004652 GO:0005634 GO:0005730 GO:0005829 GO:0006284 GO:0006400 GO:0007049 GO:0007067 GO:0016740 GO:0016779 GO:0031499 GO:0034459 GO:0034475 GO:0042138 GO:0043629 GO:0045910 GO:0046872 GO:0051301 GO:0051575 GO:0071031 GO:0071035 GO:0071036 GO:0071037 GO:0071038 GO:0071039 GO:0071040 GO:0071042 GO:0071044 GO:0071047 GO:0071050 GO:0071051
13	0.06	0.306	6.55	0.06	0.53	3w5gA	GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0016787 GO:0016798
14	0.06	0.338	6.40	0.07	0.58	2guwB	GO:0003824 GO:0008152 GO:0008714 GO:0009116 GO:0016787 GO:0016798 GO:0044209 GO:0046033
15	0.06	0.313	7.08	0.05	0.59	3hj1B	GO:0005739 GO:0006351 GO:0050265
16	0.06	0.332	5.92	0.04	0.53	4e7xD	GO:0000166 GO:0000287 GO:0002134 GO:0003723 GO:0004652 GO:0005524 GO:0005737 GO:0005829 GO:0016740 GO:0016779 GO:0036450 GO:0046872 GO:0050265 GO:0071076
17	0.06	0.273	6.54	0.04	0.47	2j0rA	GO:0006810 GO:0006811 GO:0006826 GO:0055072
18	0.06	0.308	6.14	0.05	0.50	5jnbC	GO:0000166 GO:0004652 GO:0005524 GO:0005737 GO:0006397 GO:0006997 GO:0007275 GO:0009792 GO:0016740 GO:0031379 GO:0043186 GO:0043234 GO:0043631 GO:0046872 GO:0051302 GO:0051321

Consensus prediction of GO terms

Molecular Function	GO:0030246	GO:0000287	GO:0044822	GO:0030145	GO:0004652	GO:0042803	GO:0002134	GO:0005524
GO-Score	0.12	0.07	0.07	0.07	0.07	0.07	0.07	0.07
Biological Processes	GO:0005975	GO:0071044	GO:0006378
GO-Score	0.12	0.07	0.07
Cellular Component	GO:0005739
GO-Score	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.