I-TASSER results

I-TASSER results for job id Rv2825c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (215 residues)
MKLPGAKRLGDDRRPLGTLRCWRHSDIGPARGIVVTPALKEWSAAVHALLDGRQTVLLRK
GGIGEKRFEVAAHEFLLFPTVAHSHAERVRPEHRDLLGPAAADSTDECVLLRAAAKVVAA
LPVNRPEGLDAIEDLHIWTAESVRADRLDFRPKHKLAVLVVSAIPLAEPVRLARRPEYGG
CTSWVQLPVTPTLAAPVHDEAALAEVAARVREAVG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MKLPGAKRLGDDRRPLGTLRCWRHSDIGPARGIVVTPALKEWSAAVHALLDGRQTVLLRKGGIGEKRFEVAAHEFLLFPTVAHSHAERVRPEHRDLLGPAAADSTDECVLLRAAAKVVAALPVNRPEGLDAIEDLHIWTAESVRADRLDFRPKHKLAVLVVSAIPLAEPVRLARRPEYGGCTSWVQLPVTPTLAAPVHDEAALAEVAARVREAVG
Prediction	CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCEEHCCCEEEEHCCCCCCCHHHCCHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEHCCCCEEHCCCCCCCCCCCCHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
Conf.Score	99876544567777776566544445677766544444456899999999799799997488888875766755887566664885557867888877765788997799999999999999699899998876578998899999998688998899999999789868975788778976545588888888888999999999999999989
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MKLPGAKRLGDDRRPLGTLRCWRHSDIGPARGIVVTPALKEWSAAVHALLDGRQTVLLRKGGIGEKRFEVAAHEFLLFPTVAHSHAERVRPEHRDLLGPAAADSTDECVLLRAAAKVVAALPVNRPEGLDAIEDLHIWTAESVRADRLDFRPKHKLAVLVVSAIPLAEPVRLARRPEYGGCTSWVQLPVTPTLAAPVHDEAALAEVAARVREAVG
Prediction	87254364246654324435114445434454350340041120004004514000001123144560425353000000310444741365036205534664564403030003023214064473054037221034630454016136743010000002405421403447613203110516252753410144730551164047328
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCEEHCCCEEEEHCCCCCCCHHHCCHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEEEHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEEEEHCCCCEEHCCCCCCCCCCCCHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHC
MKLPGAKRLGDDRRPLGTLRCWRHSDIGPARGIVVTPALKEWSAAVHALLDGRQTVLLRKGGIGEKRFEVAAHEFLLFPTVAHSHAERVRPEHRDLLGPAAADSTDECVLLRAAAKVVAALPVNRPEGLDAIEDLHIWTAESVRADRLDFRPKHKLAVLVVSAIPLAEPVRLARRPEYGGCTSWVQLPVTPTLAAPVHDEAALAEVAARVREAVG

4m8kA

0.16

0.14

0.87

0.64

MUSTER

ENLYGQKKVFYGHVSPAANLCW-YGVPGEKKENDVTKVEETWWYRFIHEHGFQLERNNSYSG----------------STVCHTGYEKADYSDRSFITRIHNLGTPDIILVFSWAGAPIGAYQYDGWTKADLYSF-RPAFCYLLASLKQLYPAARIYNIT---SELSEEVTDSDERHY-GIEN-IRLDIDKQWGHPSVQ----QSIDAQVWESVS

4bqqA2

0.12

0.09

0.77

0.84

dPPAS

-----------------LDTKNLQRELGGYVGGKAPY--------------GFELVSETKEITRNGRMVNVVINKLAHSTTPLTGPFEFEPDVIRWWWREIKTHKPG----------------SITGLCKRMDADAVWDPATVMRILRDPRIAG--FAAEVIYKKKPDGTPTTKIEGYRIQRDPITLRPVELDCGPIIEPAEWYELQAWLDGRGR

2dp9A

0.19

0.11

0.56

0.70

wdPPAS

--------------------------MDYMERPKLGLIVRE--PYASLIVDGRKVWEIRRRKTRHR-------PLGIVSG-----------------------------RLIGQADLVGVEGPFSVEELLAHQEKHLAEEAFLRAYA----DEPLYAWVLENAFRYEKPLHVPRRP---GRVMFVDLSEVRW-----------------------

3dqzA

0.12

0.10

0.82

0.62

wMUSTER

VELAAS---GIDPRPIQAVETVDE-------------YSKPLIETLKSLPENEEVILVG-GGI--DIFPAKIKVLVFLNAFLPDTTHVP-SHVLDKYMEMPGGLGDCEFSSHETRNGTMSLLKMGPKFMKARLYQNC-PIEDYELAKMLHRQ------GSFFTEDLSKKEKFS-EEGYGSVQRVY-------SEDKAIP----CDFIRWMIDNFN

4m8kA

0.16

0.13

0.83

0.65

wPPAS

ENLYGQKKLGDGHVSPAANLCW--GVPGEKKENDVTKVEETWWYRFIHEHGFQLERNNSYSGVCHTG----------YEKADYSD--------RSFITRIHNLGTPDIILVFSWAGAAYQYDGWTKADLYSFRP-----CYLLASLKQLY-PAARIYNIT----ELSE--EVTDSDE---CRHYIRLDIDKQWGHPSVQQSIDAQVWESVSPI--

4ypiC1

0.22

0.04

0.17

0.74

dPPAS2

KKRDGVKRL-EELLPAVSSGKNIKRTLAAMPEEETTEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4m8kA

0.13

0.11

0.86

0.70

PPAS

LYFQGQKKLGDGHVSPAANLCW-YGVPGEKKENDVTKVEETWWYRFIHEHGFQLERNNSYSGVCHTG----------YEKADYSD--------RSFITRIHNLGTPDIILVFSWAGAPIGAYQYDGWTKADLYSFR---CYLLASLKQLY-PAARIYNIT----SELSEEVTDSDEICRHYGIEIRLDIDKQWGHPSVQ----QSIDAQVWESVS

2pbgA2

0.12

0.10

0.86

0.74

Env-PPAS

MTLPGATHT-DGKGP-VAWDKYLEDN-YWYTAEPASDFYHKYPVDLELAEEY---------GV--NGIRISIAWSRIFPTGYGEVNEKGVEFYHKLFAECHKRHVEPFNGLGYK-DEFVDNTVYDDGRIDYVKQ-----HLEVLSDAIADGAN------VKGYFIWSLMDVFSWSNGYEKRYGLFYVDFDTQERYPKKSAHWYKKLAETIE----

5d2eA2

0.12

0.10

0.82

0.62

MUSTER

HEFKGSKKFPHTKEPI--------EDDS------------MYTVMKRQLEGEAPFIYVTSG----ERFEDCRNRFTMNFTK--------GEDYDALCGVLRSQNIRPRHIIHFLAAGLFK---NTEDAMRKQLNKSLYSLFQMFQAFMANKLCPKAEILYLYENAEVQPITVQANPNFT-CKA-AELKSMFDEP--FTKQHIADVISFEWNNCFR

4b56A3

0.09

0.95

0.82

dPPAS

HGIIDNKMYDPKMNASFSLKSKEKFNPLWYKGQP---------IWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVY-NGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.89

Estimated TM-score = 0.38±0.13

Estimated RMSD = 12.2±4.4Å

Download Model 2

C-score=-3.79

Download Model 3

C-score=-4.21

Download Model 4

C-score=-5.00

Download Model 5

C-score=-4.84

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4m8kA	0.640	3.88	0.079	0.874
2	4nrdA	0.610	4.10	0.071	0.847
3	3pt5A	0.608	4.12	0.043	0.837
4	4xvhA	0.573	4.24	0.062	0.809
5	2wabA	0.572	4.13	0.068	0.800
6	5hoeA	0.572	3.72	0.091	0.763
7	2waaA	0.571	4.19	0.086	0.805
8	2w9xB	0.563	4.21	0.017	0.805
9	2apjA	0.562	4.36	0.077	0.814
10	3dc7A	0.558	3.59	0.067	0.735

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.12	7	1ji5B	FE	Rep, Mult	83,85,93
2	0.05	3	3dhyC	3DH	Rep, Mult	42,43,112,113,159,160,198,203,207
3	0.03	2	3f9cB	DFP	Rep, Mult	110,111,157,158,184,212
4	0.03	2	4dinB	ATP	Rep, Mult	59,61,62
5	0.03	2	2fvkB	ZN	Rep, Mult	83,136
6	0.03	2	3e5uC	3C4	Rep, Mult	203,206,207
7	0.02	1	3d1lA	MPR	Rep, Mult	187,196
8	0.02	1	1gz7D	GOL	Rep, Mult	91,94,98
9	0.02	1	3zvwC	MG	Rep, Mult	188,189
10	0.02	1	1gz7A	GOL	Rep, Mult	47,206,209,210,213
11	0.02	1	2waoA	UUU	Rep, Mult	33,59,60,61,81,163,188,189,194,195
12	0.02	1	2zizA	NAD	Rep, Mult	129,144,150
13	0.02	1	4l8hB	ZN	Rep, Mult	199,200
14	0.02	1	1gz7A	GOL	Rep, Mult	75,77,156,157,158
15	0.02	1	1gw9A	IOD	Rep, Mult	129,132,133,155
16	0.02	1	2ha7A	BCH	Rep, Mult	130,184
17	0.02	1	2od0A	MG	Rep, Mult	37,39,40
18	0.02	1	2ppqA	MG	Rep, Mult	40,106

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1nhdD	0.135	3.93	0.035	0.181	1.3.1.9	158
2	0.060	3d64A	0.519	5.45	0.053	0.847	3.3.1.1	NA
3	0.060	3d64B	0.505	5.30	0.059	0.819	3.3.1.1	39,113
4	0.060	1gz7C	0.526	4.91	0.037	0.809	3.1.1.3	NA
5	0.060	2q0sH	0.564	3.89	0.097	0.767	3.1.1.2	198
6	0.060	1vjpA	0.513	5.14	0.071	0.823	5.5.1.4	NA
7	0.060	2tmdA	0.501	4.93	0.082	0.777	1.5.8.2	73
8	0.060	1np2A	0.508	5.57	0.083	0.833	3.2.1.21	NA
9	0.060	1e5tA	0.519	4.66	0.075	0.763	3.4.21.26	NA
10	0.060	1crlA	0.520	4.75	0.082	0.795	3.1.1.3	NA
11	0.060	1w0cA	0.505	4.86	0.076	0.758	1.5.1.33	NA
12	0.060	1djnA	0.502	5.05	0.075	0.791	1.5.8.2,1.5.99.7	73
13	0.060	1deoA	0.512	4.21	0.096	0.721	3.1.1.-	NA
14	0.060	1f6wA	0.456	5.76	0.065	0.772	3.1.1.13,3.1.1.3	NA
15	0.060	2bklB	0.512	4.51	0.049	0.740	3.4.21.26	NA
16	0.060	2vptA	0.513	4.58	0.091	0.758	3.1.1.72	NA
17	0.060	1de5A	0.503	5.16	0.054	0.828	5.3.1.14	NA
18	0.060	1escA	0.517	4.56	0.074	0.749	3.1.1.-	NA
19	0.060	2waaA	0.571	4.19	0.086	0.805	3.1.1.72	41,57,207

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.572	4.13	0.07	0.80	2wabA	GO:0000272 GO:0003824 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030248 GO:0045493 GO:0046555 GO:0046872 GO:2000884
1	0.07	0.571	4.19	0.09	0.80	2waaA	GO:0000272 GO:0005886 GO:0005975 GO:0008152 GO:0016020 GO:0016787 GO:0016798 GO:0045493 GO:0046555 GO:2000884
2	0.07	0.563	4.21	0.02	0.80	2w9xB	GO:0000272 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016788 GO:0016798 GO:0045493 GO:0046555 GO:2000884
3	0.07	0.562	4.36	0.08	0.81	2apjA	GO:0016787
4	0.07	0.558	3.59	0.07	0.73	3dc7A
5	0.07	0.558	3.85	0.06	0.76	3bzwA
6	0.07	0.481	5.33	0.04	0.77	1uuqA	GO:0005975
7	0.06	0.409	5.03	0.11	0.64	4yo8B	GO:0003824 GO:0008652 GO:0008782 GO:0008930 GO:0009086 GO:0009116 GO:0009164 GO:0009234 GO:0016787 GO:0019509 GO:0102246
8	0.06	0.393	5.71	0.08	0.67	4an4C	GO:0008152 GO:0016740 GO:0016758 GO:0042802
9	0.06	0.367	5.97	0.06	0.67	3orhA	GO:0005634 GO:0005737 GO:0005829 GO:0006600 GO:0006601 GO:0006936 GO:0007283 GO:0008168 GO:0008757 GO:0009887 GO:0016740 GO:0030731 GO:0032259 GO:0040014 GO:0042803 GO:0046498 GO:0046500 GO:0070062 GO:1990402
10	0.06	0.312	5.87	0.03	0.55	4u2vB	GO:0001776 GO:0001782 GO:0001783 GO:0001836 GO:0001974 GO:0002262 GO:0002352 GO:0005622 GO:0005739 GO:0005741 GO:0005783 GO:0005829 GO:0006091 GO:0006915 GO:0006919 GO:0006987 GO:0007420 GO:0007568 GO:0008053 GO:0008218 GO:0008283 GO:0008285 GO:0008630 GO:0008635 GO:0009620 GO:0010046 GO:0010225 GO:0010248 GO:0010332 GO:0010524 GO:0010629 GO:0014070 GO:0016020 GO:0016021 GO:0018298 GO:0019835 GO:0031018 GO:0031072 GO:0031100 GO:0031307 GO:0031966 GO:0032469 GO:0032471 GO:0033137 GO:0034644 GO:0035108 GO:0042493 GO:0042542 GO:0042802 GO:0042803 GO:0042981 GO:0043065 GO:0043496 GO:0043497 GO:0044325 GO:0044346 GO:0045471 GO:0045862 GO:0046872 GO:0046902 GO:0046930 GO:0046982 GO:0048597 GO:0048872 GO:0051087 GO:0051400 GO:0051726 GO:0051881 GO:0060068 GO:0070059 GO:0070242 GO:0071260 GO:0090200 GO:0097190 GO:0097192 GO:0097202 GO:1900103 GO:1901030 GO:1902262 GO:1903896
11	0.06	0.279	6.66	0.05	0.57	4fi1A	GO:0000166 GO:0004672 GO:0004674 GO:0005524 GO:0005654 GO:0005956 GO:0006356 GO:0006359 GO:0006468 GO:0006974 GO:0007535 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0018107 GO:0031167 GO:0034456
12	0.06	0.305	5.65	0.08	0.53	2iuwA	GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0006281 GO:0006307 GO:0006974 GO:0008198 GO:0008283 GO:0016491 GO:0016706 GO:0031418 GO:0035552 GO:0035553 GO:0043734 GO:0046872 GO:0051213 GO:0051747 GO:0055114 GO:1990930
13	0.06	0.265	5.64	0.03	0.46	1z24A	GO:0005576 GO:0018298 GO:0031409
14	0.06	0.271	5.68	0.06	0.46	4n72C	GO:0004742 GO:0006090 GO:0006096 GO:0008152 GO:0016740 GO:0016746 GO:0045254
15	0.06	0.259	5.72	0.03	0.47	2m5bA	GO:0001776 GO:0001782 GO:0001783 GO:0001836 GO:0001974 GO:0002262 GO:0002352 GO:0005622 GO:0005739 GO:0005741 GO:0005783 GO:0005829 GO:0006915 GO:0006919 GO:0006987 GO:0007420 GO:0007568 GO:0008053 GO:0008283 GO:0008285 GO:0008630 GO:0008635 GO:0009620 GO:0010046 GO:0010225 GO:0010248 GO:0010332 GO:0010524 GO:0010629 GO:0014070 GO:0016020 GO:0016021 GO:0019835 GO:0031018 GO:0031072 GO:0031100 GO:0031307 GO:0031966 GO:0032469 GO:0032471 GO:0033137 GO:0034644 GO:0035108 GO:0042493 GO:0042542 GO:0042802 GO:0042803 GO:0042981 GO:0043065 GO:0043496 GO:0043497 GO:0044325 GO:0044346 GO:0045471 GO:0045862 GO:0046872 GO:0046902 GO:0046930 GO:0046982 GO:0048597 GO:0048872 GO:0051087 GO:0051400 GO:0051726 GO:0051881 GO:0060068 GO:0070059 GO:0070242 GO:0071260 GO:0090200 GO:0097190 GO:0097192 GO:0097202 GO:1900103 GO:1901030 GO:1902262 GO:1903896
16	0.06	0.204	5.93	0.04	0.37	4of3B	GO:0005886 GO:0007155 GO:0007267 GO:0007399 GO:0007416 GO:0008039 GO:0016020 GO:0016021 GO:0030054 GO:0030424 GO:0032403 GO:0042995 GO:0045202 GO:0048668 GO:0048755 GO:0050808 GO:0050839 GO:0051017
17	0.06	0.234	5.82	0.05	0.41	4bvuA	GO:0005576 GO:0005615 GO:0009405 GO:0016301 GO:0016310 GO:0016740 GO:0043657 GO:0046777
18	0.06	0.232	4.23	0.06	0.33	1s6dA	GO:0045735

Consensus prediction of GO terms

Molecular Function	GO:0052689
GO-Score	0.37
Biological Processes	GO:0010391	GO:0000272	GO:0045491
GO-Score	0.37	0.37	0.37
Cellular Component	GO:0005576	GO:0005886
GO-Score	0.13	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.